ChemistrySelect

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ISSN / EISSN : 2365-6549 / 2365-6549
Published by: Wiley (10.1002)
Total articles ≅ 9,559
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Liguo Wei, Wei Mao, Furong Yu, Ting Su, Jie Chen, Huiyi He, Mingyue Zou, Shaoji Wang, Jianmin Lin
Published: 12 July 2021
ChemistrySelect, Volume 6, pp 6781-6787; doi:10.1002/slct.202102035

Abstract:
To seek a Pt-free carbon material counter electrode for dye-sensitized solar cells (DSSCs), the electrocatalytic activity of needle coke (NC) for the reduction of triiodide in DSSCs was investigated, and further improved by decorating with Ni to prepare Ni decorated needle coke (Ni-NC) via a one-step solid-state synthesis method. It is found that the NC is a potential carbon counter electrode material for DSSCs due to its high-density anisotropy with considerable conductivity. Although the decoration of Ni may sacrifice certain conductivity of NC, the electrocatalytic activity of Ni-NC towards reduction of triiodide was better than that of NC. To obtain a balanced point of conductivity and electrocatalytic performance for Ni-NC, the loading amount of Ni together with the solid-state synthesis conditions were also studied. It is indicated that these parameters also have some effect on the performance of Ni-NC. Under the optimized conditions, the DSSCs based on Ni-NC counter electrode achieve an 77 % higher energy conversion efficiency of 4.39 % than that of NC counter electrode (2.48 %), and comparable to the value (5.34 %) obtains with Pt counter electrode. It is an efficient way to improve the performance of NC by decorating with Ni via a facile solid-state synthesis method, and promote the application of needle coke as carbon counter electrode materials in DSSCs.
Zhihui Wang, Xiulei Li, Baifu Tao,
Published: 12 July 2021
ChemistrySelect, Volume 6, pp 6652-6660; doi:10.1002/slct.202101516

Abstract:
In this paper, a series of sulfonated polyarylene ether nitriles copolymers (SPEN) with adjustable sulfonic acid groups are synthesized through nucleophilic substitution reaction. Then, the SPEN hollow fiber membrane (SPENH) adsorbents are successfully prepared by dry-wet phase conversion. Due to the increase of hydrophilic groups sulfonic acid (−SO3H) and increases surface roughness, the water contact angle of SPENH-60 is as low as 46.97°, and the wettability of SPENH adsorbent is improved. In addition, SPENH-60 adsorbent has a high porosity of 97.87 % and −SO3H groups (1.53 mmol g−1), which shows an excellent Li+ adsorption uptake of up to 20.54 mg⋅g−1. The adsorption kinetics of Li+ follows the pseudo-second-order adsorption kinetic and the adsorption isotherm data conforms to the Langmuir model. The selectivity factors of Li+ to Na+, K+, Ca2+ and Mg2+ are 5.019, 4.038, 2.726 and 48.348, respectively. After 10 times of adsorption-desorption cycles, the adsorption uptake decrease by only 4.3 %. Therefore, SPENH adsorbent has the potential to selectively separate and recycle Li+ from brine.
Kalpana Tilekar, Jessica D. Hess, Neha Upadhyay, Markus Schweipert, Felix Flath, Denisse A. Gutierrez, Fulvio Loiodice, Antonio Lavecchia, , , et al.
Published: 12 July 2021
ChemistrySelect, Volume 6, pp 6748-6763; doi:10.1002/slct.202102061

Abstract:
Recent evidences highlight the usefulness of small molecule (Histone deacetylase 4) HDAC4 inhibitors in the several preclinical paradigms. Major toxicity and mutagenicity issues associated with hydroxamate HDAC inhibitors, stimulated us to develop potent non-hydroxamate inhibitors. In the present work a novel series of thiazolidinedione (TZD) derivatives with pyridine as cyclic linker and TZD ring as zinc binding group was designed and screened in a panel of isoenzymes of HDACs, wherein the most potent compounds exhibiting HDAC4 IC50-values<5 μM were 5 v, 5 w, 5 y and 5 z (IC50=4.2±1 μM, 0.75±0.03 μM, 4.9±0.5 and 2.3±0.5 μM, respectively). The docking studies displayed the unique binding mode of this series of compound at active site of HDAC4, wherein TZD ring was indicated as zinc binding group. Further, 5 w and 5 y were found as the most potent antiproliferative agent in lymphoblastic leukemia (CCRF-CEM) and breast cancer MDA-MB-231 cells. Compound 5 y was found to induce the apoptosis and DNA fragmentation of CEM cells. The western blotting analysis of 5 y also showed the presence of cleaved caspases supporting their apoptotic nature. Further, Class IIa (HDAC4) selectivity of 5 y was also supported by western blotting observations, wherein 5 y caused the accumulation of acetylated H3 but not of acetylated Tubulin. Thus, our findings endorse the further investigation of this series of compounds for their potential as targeted cancer therapeutic agents.
Gu Liu, Jian Liu, Kejun Xu, Liuying Wang,
Published: 12 July 2021
ChemistrySelect, Volume 6, pp 6803-6810; doi:10.1002/slct.202101207

Abstract:
The flexible electrodes are the crucial components for fabricating wearable supercapacitors. In this study, we present a quick and convenient method to prepare graphene paper (GP) as a flexible current collector on a large scale by an easy one-step method. The composite electrode integrated with GP and MnO2 as a flexible supercapacitor was obtained by an electrochemical deposition method without using binder or conductive agent. The substrate (GP) of electrode not only provides mechanical strength, but also contributes energy storage capacity. The MnO2 nanoparticles deposited on the surface of GP further improved the electrochemical performance of composite. The neat GP can give a specific capacitance of 184 F/g at a current density of 1 A/g. At a current density of 1 A/g, the specific capacitance of the GP/MnO2 composite with a deposition time of 30 s is as high as 410 F/g. The method presented here shows great potential for the development of flexible electrode materials in practical energy storage devices.
Narendra Kumar Maddali, , , Vasavi Malkhed, Pradeep Kumar Brahman, Sai Kiran S. S. Pindiprolu, Vani Kondaparthi, Sundara Rao Nethinti
Published: 12 July 2021
ChemistrySelect, Volume 6, pp 6788-6796; doi:10.1002/slct.202101387

Abstract:
A series of novel 4,5-diphenyloxazol-1,2,4-triazole derivatives (6 a–6 l) were synthesized and screened for anticancer activity against the prostate lung cancer cell lines viz., PC-93 and HBT-55. The outcome of the investigation reveals that compounds 6 a, 6 b and 6 j showed potential anticancer activity against PC-93 cell line with the half maximal inhibitory concentration (IC50) values of 13.12, 15.34, and 16.34 μM, respectively. Compounds 6 a, 6 d and 6 j exhibited potential anticancer activity against HBT-55 cell line with IC50 value 17.28, 16.48, and 15.12 μM respectively, when compared to standard drug doxorubicin. Further, docking studies are performed to understand the possible interactions responsible for their potential activity by considering the Fibroblast growth factor receptor 1 (FGFR1) and the Ser-/Thr-specific kinase Akt protein (Akt) as target proteins. The amino acid residues from ALA639 to PRO741 of FGFR1 and from GLU17 to ASP292 of Akt proteins are involved in non-covalent interactions with the ligands 6 a–6 l. The insilico pharmacokinetic properties are predicted for the molecules 6 a–6 l to assess the druggability. The study provides that compounds 6 a, 6 b, 6 d, and 6 j scaffolds serve as promising lead molecules for treating cancer and further structure optimizations.
Tülay Borahan, Nazime Ebrar Karlıdağ, Buse Tuğba Zaman,
Published: 12 July 2021
ChemistrySelect, Volume 6, pp 6797-6802; doi:10.1002/slct.202100405

Abstract:
In this study, an effective and sensitive method was developed for the preconcentration of cadmium in flame atomic absorption spectrometer system combined with a 5-holes cut slotted quartz tube (SQT-FAAS). For this aim, a dispersive solid-phase microextraction method based on a magnetic effervescent tablet consisting of Fe3O4 nanoparticles (EA-MNP-dSPME) was proposed. In the developed microextraction method, the dispersion of the nanoparticles used as adsorbents was assisted by the effervescent tablets generated from a mixture of sodium carbonate and sodium dihydrogen phosphate dihydrate. In order to obtain the highest extraction and instrumental output, all variables that affect the efficiency was investigated comprehensively and optimum conditions were determined with univariate optimization steps. The detection power of the conventional FAAS system was enhanced about 135 folds with respect to the LOD value of the developed method (0.34 ng mL−1) obtained under the optimum conditions. The EA-MNP-dSPME method presented high reproducibility with a low %RSD value calculated as 8.1 %. In order to validate the accuracy and applicability of the method, matrix matching method based recovery studies were carried out using the lake water samples taken from Horseshoe Island. The percent recovery results reported between 99.9–104.3 % with percent relative standard deviation below 7.9 % indicated the developed method‘s applicability for the accurate and precise determination of cadmium.
Bekya T. Harshitha, , Pemmatte A. Pushpanjali, Chimatahalli S. Karthik, Shadakshari Sandeep, Puttaswamappa Mallu, Edwin D'Souza, Nagaraja Sreeharsha, Syed Mohammed Basheeruddin Asdaq, Md. Khalid Anwer
Published: 12 July 2021
ChemistrySelect, Volume 6, pp 6764-6772; doi:10.1002/slct.202101809

Abstract:
The current endeavour presents the poly(L-serine) modified carbon paste electrode (PLSMCPE) fabricated through an electropolymerization methodology for the electrochemical analysis of catechol (CC). Field emission scanning electron microscopy (FE-SEM) images of unmodified and PLSMCPE were examined to study the surface structure and the formation of polymer layer on the electrode surface. The PLSMCPE was functionalized for the voltammetric detection and quantification of CC in 0.2 M phosphate buffer solution (PBS) with a pH of 6.5. In contrast to unmodified electrode the PLSMCPE presented to have nine-fold enhancement in peak current and shift in anodic peak potential towards negative domain. The CV method showed good linear correlation between the concentration of CC and the oxidation peak current in the range from 2–50 μM, and the corresponding limit of detection (LOD) and limit of quantification (LOQ) were achieved to be 0.259 μM and 0.869 μM, respectively. Furthermore, this sensor is used to determine the analytical response in the co-existence of CC and hydroquinone (HQ). The modified electrode is effectively functionalised for the analysis of CC in coffee powder sample.
, Heping Tan, Lili Meng, Hailang Jia, Wenjuan Zhou, Haiyan Wu
Published: 10 July 2021
ChemistrySelect, Volume 6, pp 6683-6689; doi:10.1002/slct.202100919

Abstract:
Cysteine-functionalized Fe3O4 magnetic nanoparticles were synthesized by thiol-ene click reaction and characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction spectrometry (XRD), thermal gravimetric analysis (TGA), vibrating sample magnetometer (VSM), X-ray photoelectron spectroscopy (XPS), specific surface area (BET) analysis and pore size distribution analysis. The obtained magnetic materials were employed as a magnetic solid phase extraction adsorbent combined with inductively coupled plasma-atomic emission spectrometry (ICP-AES) for determination of Cu2+. Several parameters affecting extraction efficiency, including eluent concentration, adsorption time, adsorbent amounts, and sample pH were investigated. Under the optimized conditions, the method was validated. Within the concentration range of 0.01–20 μg mL−1, The limit of detection (LOD) and the limit of quantification (LOQ) were determined to be 0.002 μg mL−1 and 0.007 μg mL−1, respectively. The adsorption percentage of Cu2+ ions remained above 87.0 % when the adsorption-desorption data of Cu2+ ions through three cycles of the successive adsorption and desorption process. The results show that a reliable and rapid method was established for determination of Cu2+ ions.
Pritam Ghosh, Koushik Pramanik, Suparna Paul, Debanjan Dey, , Subhra Kanti Mukhopadhyay, Naresh Chandra Murmu,
Published: 10 July 2021
ChemistrySelect, Volume 6, pp 6733-6739; doi:10.1002/slct.202100908

Abstract:
The pathogenesis of Pick's disease is feasible by detection of the elevated level of Zn2+ in the body fluids. This work aims towards developing a suitable chemosensor towards detection of Zn2+ in human urine specimen and inside eukaryotic cell line. Fluorescence “turn on” in the presence of Zn2+ makes the chemosensor suitable for its utility in Pick's disease diagnosis. Real urine sample analysis together within cell detection of Zn2+ was successful which leads towards the design and fabrication of a “ready-to-use” test kit for Zn2+ recognition from human urine specimen.
Published: 10 July 2021
ChemistrySelect, Volume 6, pp 6714-6732; doi:10.1002/slct.202101010

Abstract:
Activated carbon (AC), which has attracted considerable attention as an electrode material, holds much promise for electroanalysis. The unique physical and chemical properties of AC, such as the high surface area, good thermal and electrical conductivity, good anti-causticity, high stability, and low cost make it an electrode material which can generate large profits from a commercialization perspective. Number of biomass-derived ACs (BACs) with a variety of pore sizes, porosity, morphology, and crystallinity have been prepared from a range of sources of biomass, including agro-wastes on a large scale. BACs exhibit unique and tunable electrochemical properties depending on their physicochemical properties and thus, have found number of applications in industries, pharmaceutical industry, and water treatment plants. From an electrochemical perspective, researchers have demonstrated the impact of BAC as an electrode material for detecting electroactive drugs, environmental pollutants, and developing electrochemical biosensors. Hence, this paper thoroughly reviews and summarizes the literature published within the last ten years, focusing specifically on the types of analytes detected and electrochemical techniques employed and evaluating their performance (in terms of sensitivity, selectivity, and dynamic ranges) and feasibility for electroanalysis. In addition, the review outlines some constructive advice and scope for further research.
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