KELUWIH: Jurnal Kesehatan dan Kedokteran

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EISSN : 2715-6419
Published by: Universitas Surabaya (10.24123)
Total articles ≅ 35
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Wirda Anggraini
KELUWIH: Jurnal Kesehatan dan Kedokteran, Volume 3, pp 9-21; https://doi.org/10.24123/kesdok.v3i1.2887

Abstract:
AbstractPneumonia was an inflammation that occurs in the lungs accompanied by exudation and consolidation of microorganisms. In Indonesia, the prevalence of pneumonia continues to increase. Treatment of pneumonia uses antibiotic therapy. The use of antibiotics needs to be controlled by evaluating the quality of antibiotic use to prevent negative effects that can occur on patients, such as antibiotic resistance. The purpose of this study was to determine the rationality of antibiotic use in pneumonia patients. This study did with an observational method with a cross-sectional design. The study was conducted in August-September 2019. Qualitative evaluations did with Gyssen method. The results of 35 medical record samples that fulfill the criteria showed that 13,24% of cases category 0; 10,29% of cases category I; 0% of cases category II C; 20,59% of cases in category II B; 2,94% of cases category II A; 0% of cases category III B; 0% of cases category III A; 0% of cases category IV D; 11,76% of cases category IV C; 2,94% of cases category IV B; 38,24% of cases category IV A; 0% of cases category V; 0% of cases category VI. Rational cases (category 0) were 13,24% and irrational cases (categories I-IV) were 86,76%. Keywords:antibiotic, evaluation, gyssen, pneumoniaAbstrak—Pneumonia adalah peradangan yang terjadi pada paru-paru yang disertai dengan adanya eksudasi dan konsolidasi mikroorganisme. Di Indonesia, prevalensi kejadian pneumonia terus mengalami peningkatan. Pengobatan pneumonia menggunakan terapi antibiotik dan terapi suportif. Penggunaan antibiotik perlu dikendalikan dengan evaluasi kualitas penggunaan antibiotik untuk mencegah dampak negatif yang bisa terjadi pada pasien, salah satunya resistensi antibiotik. Tujuan penelitian ini adalah untuk mengetahui rasionalitas penggunaan antibiotik pada pasien pneumonia. Penelitian ini dilakukan dengan metode observasional dengan desain cross-sectional. Penelitian dilaksanakan pada bulan Agustus-September 2019. Evaluasi kualitatif dilakukan dengan menggunakan metode gyssen. Hasil evaluasi 35 sampel rekam medis yang memenuhi kriteria menunjukkan bahwa 13,24% kasus kategori 0; 10,29% kasus kategori I; 0% kasus kategori II C; 20,59% kasus kategori II B; 2,94% kasus kategori II A; 0% kasus kategori III B; 0% kategori III A; 0% kasus kategori IV D; 11,76% kasus yang masuk kategori IV C; 2,94% kasus kategori IV B; 38,24% kategori IV A; 0% kategori V; 0% kasus kategori VI. Kasus yang rasional (kategori 0) sebanyak 13,24% dan kasus yang tidak rasional (kategori I-IV) sebanyak 86,76%. Kata kunci: antibiotik, evaluasi, gyssen, pneumonia
Elita Halimsetiono
KELUWIH: Jurnal Kesehatan dan Kedokteran, Volume 3, pp 64-70; https://doi.org/10.24123/kesdok.v3i1.4067

Abstract:
AbstractOne of the impacts of the national developmental success is life expectancy (UHH) that becomes more increasing which results in an increasing number of elderly. To improve the health status and life quality of the elderly, the government should be obliged to provide facilities of health care and facilitate the elderly group so that they can develop properly, to create a productive and independent elderly. In this regard, the government is developing an elderly health center so that health services that are holistic and adequate, as well as emphasizing the proactive, courteous, cross-sectoral collaboration, ease of the process, and appropriateness of service standards, can be obtained by the elderly. Promotive and preventive services can be done through the involvement and active participation of the community in the form of elderly posyandu that comes from the puskesmas or arises from the aspirations of the community itself. With adequate health services for the elderly, it is expected that improvements in the health status and quality of life of the elderly can be achieved, so that the elderly have an efficient and happy old age following their existence, in their lives together with family and community. Keywords:community, elderly, health careAbstrak—Salah satu dampak dari kesuksesan pembangunan nasional adalah Usia Harapan Hidup (UHH) yang makin meningkat yang berakibat pada jumlah lansia yang makin meningkat pula. Demi tercapainya peningkatan status kesehatan dan kualitas hidup lansia, maka seyogyanyalah pemerintah berkewajiban menyediakan sarana pelayanan kesehatan serta melakukan fasilitasi pada kelompok lansia agar dapat berkembang dengan baik, sehingga dapat tercipta lansia yang mandiri dan produktif. Sehubungan hal tersebut, maka pemerintah mengembangkan puskesmas lansia agar pelayanan kesehatan yang sifatnya holistik dan memadai, serta menekankan pada unsur proaktif, santun, kerjasama lintas sektor, kemudahan proses dan kesesuaian standar pelayanan, dapat diperoleh para lansia. Pelayanan promotif maupun preventif dapat dilakukan melalui keterlibatan dan partisipasi aktif masyarakat berupa posyandu lansia yang berasal dari puskesmas atau timbul dari aspirasi masyarakat itu sendiri. Dengan adanya pelayanan kesehatan yang memadai bagi para lansia, diharapkan peningkatan status kesehatan dan kualitas hidup lansia dapat tercapai, sehingga lansia memiliki hari tua yang berdaya guna dan juga bahagia sesuai dengan keberadaannya, dalam kehidupannya bersama dengan keluarga dan masyarakat. Kata kunci:lansia, masyarakat,pelayanan kesehatan
Febri Endra Budi Setyawan, Amalia Wahyu Natasari, Nesrin Zaharah, Divi Aditya Romadhona Putra, Wafiyah Hasanah, Ronty Birnanda Ramadhona
KELUWIH: Jurnal Kesehatan dan Kedokteran, Volume 3, pp 1-8; https://doi.org/10.24123/kesdok.v3i1.4678

Abstract:
AbstractOccupational disease are important topic since they often occur in a long period of time. The purpose of this article is to find out how to prevent occupational diseases in the battery industry. This research is a systematic review of articles obtained through manual search engines from Google Scholars, Proquest, PubMed, Research Gate and has been published nationally and internationally in 2015-2020. The results of a systematic review were obtained from 30 scientific articles that were published nationally and internationally in 2015-2020 related to the battery industry process and related to occupational diseases. The factors contributing are varies from enviromental, biological, ergonomic, and the workers itself. There are several preventive management that can be done according to the analysis of the possible diseases that can be occured. Workers in the battery industry can experience occupational diseases, including: allergic contact dermatitis, bacterial conjunctivitis, noise-induced hearing loss, Low Back Pain and Carpal tunnel syndrome. Some prevention efforts that can be done include: using personal protective equipment, detecting workers who have a history of DKA, maintaining hygiene and cleanliness of the work environment, using furniture that is in accordance with ergonomic standards and not lifting heavy loads, reducing repetitive pressing movements and doing regular exercise.Keywords:preventive, allergic contact dermatitis, conjungtivitis, nihl, lbp, cts, battery industryAbstrak—Penyakit akibat kerja menjadi perhatian penting karena muncul dalam jangka waktu panjang sehingga harus dilakukan upaya pencegahan penyakit. Penelitian ini merupakan review sistematik artikel yang diperoleh melalui melalui mesin pencari manual dari Google Scholars, Proquest, PubMed, Research Gate dan telah terpublikasi nasional maupun internasional pada tahun 2015-2020. Hasil review sistematik diperoleh dari 30 artikel ilmiah yang telah terpublikasi nasional maupun internasional pada tahun 2015-2020 yang terkait dengan proses industry baterai dan terkait dengan penyakit akibat kerja. Faktor penyebabnya juga berbagai macam karena faktor lingkungan, biologi, ergonomi, ataupun dari faktor pekerja. terdapat beberapa upaya preventif yang dapat disesuaikan dengan kemungkinan penyakit akibat kerja yang mungkin akan timbul. Pekerja di industri baterai dapat mengalami penyakit akibat kerja, antara lain: dermatitis kontak alergi, konjungtivitis bakteri, gangguan pendengaran akibat kebisingan, Low Back Pain dan Carpal tunnel syndrome. Beberapa upaya pencegahan yang dapat dilakukan antara lain: menggunakan alat pelindung diri, mendeteksi pekerja yang memiliki riwayat DKA, menjaga kebersihan dan kebersihan lingkungan kerja, menggunakan furnitur yang sesuai dengan standar ergonomis dan tidak mengangkat beban berat, mengurangi penekanan berulang. gerakan dan melakukan olahraga teratur. Kata Kunci: preventif, dermatitis kontak alergi (dka), konjungtivitis, nihl, lbp, cts, industri baterai
Laura Victoria Christina, Astrid Pratidina Susilo
KELUWIH: Jurnal Kesehatan dan Kedokteran, Volume 3, pp 57-63; https://doi.org/10.24123/kesdok.v3i1.4584

Abstract:
AbstractInterprofessional collaboration is a collaboration in health services between health professionals from diverse backgrounds. One of the most important aspects of collaborative practice in health services is the communication between health professionals. Lack of communication can cause a delay in treatment and medical errors. Ineffective communication can also represent a lack of coordination. SBAR method is an effective communication technique for health professionals. The SBAR method is useful to improve team communication in general, improve communication skills in certain situations, and also helpful during shift handover. Keywords:interprofessional collaboration, communication, SBAR methodAbstrak—Kolaborasi interprofesional merupakan suatu kerja sama dalam pelayanan kesehatan antara profesional kesehatan yang memiliki latar belakang pendidikan berbeda. Dalam pelayanan kesehatan, salah satu hal terpenting dari praktik kolaborasi yaitu komunikasi antara tenaga kesehatan. Kurangnya komunikasi dapat menyebabkan terjadinya keterlambatan dalam melayani pasien dan kesalahan dalam menangani pasien. Komunikasi yang kurang efektif juga dapat menggambarkan koordinasi tenaga kesehatan yang kurang baik. Teknik komunikasi efektif yaitu SBAR ditetapkan sebagai standar komunikasi antara tenaga kesehatan yang berfokus terhadap pasien. Metode SBAR bermanfaat untuk meningkatkan komunikasi tim secara umum, meningkatkan keterampilan komunikasi saat situasi tertentu, dan juga berguna pada saat operan dinas. Kata kunci: kolaborasi interprofesional, komunikasi, metode SBAR 
Denis Cristian Sudarno, Farida Suhud, Siswandono
KELUWIH: Jurnal Kesehatan dan Kedokteran, Volume 3, pp 35-47; https://doi.org/10.24123/kesdok.v3i1.4803

Abstract:
AbstractIn this study, a new anticancer drug design for non-Hodgkin’s lymphoma was carried out, with a molecular docking approach from the compound 1-benzyl-3-benzoylurea parent and its analog as an anticancer compound. The purpose of the study was to obtain the best quantitative structure-activity relationship (QSAR). The in-silico activity test was carried out on the new 1-benzyl-3-benzoilurea and its analog compound against the Bruton Tyrosine Kinase receptor (BTK) PDB code (5FBN) by using the Molegro Virtual Docker 5.5 program and producing a RS (Rerank Score) value for the test compound and Acalabrutinib was used as a comparison. This study also conducted bioavailability by predicting the value of F (intestinal human absorption) in the pkCSM program and toxicity studies by predicting LD50 values using the Protox II program. Correlation and regression were performed using the RS, F, and LD50 values that we obtained on the physicochemical properties of the test compound using the IBM SPSS version 24 program. The best equation is obtained as follows: (1) F = 0.851 Es Taft - 6.116 σ - 1.969 π² + 3.620 π + 90.809;  (2) RS = 4.376 Es Taft - 88.802; (3) LD50 = 672.518 CMR - 669.385 ClogP - 813.806. From the results of the best equation is obtained that the activity is influenced by the parameters of steric physicochemical properties (Es Taft).Keywords: 1-benzyl-3-benzoylurea, code pdb:5fbn, in-silico, non-hodgkin lymphomaAbstrak—Pada penelitian ini dilakukan rancangan obat baru antikanker Limfoma non-Hodgkin, dengan pendekatan penambatan molekul dari senyawa induk 1-benzil-3-benzoilurea dan analognya sebagai senyawa antikanker.Tujuan penelitian ini untuk mendapatkan persamaan hubungan struktur aktivitas (HKSA) terbaik. Uji aktivitas in-silico dilakukan terhadap senyawa baru 1-benzil-3-benzoilurea dan analognya terhadap reseptor Bruton Tyrosine Kinase (BTK) kode PDB 5FBN dengan menggunakkan program Molegro Virtual Docker 5.5 dan menghasilkan nilai RS (Rerank Score) untuk senyawa uji dan Acalabrutinib digunakan sebagai pembanding. Penelitian ini juga dilakukan studi bioavaibilitas dengan memprediksi nilai F (intestinal human absorbtion) pada program pkCSM dan studi toksisitas dengan memprediksi nilai LD50 menggunakan program Protox II. Korelasi dan regresi dilakukan menggunakan nilai RS, F dan LD50 yang telah diperoleh terhadap parameter sifat fisikokimia senyawa uji menggunakan program IBM SPSS versi 24. Persamaan terbaik yang diperoleh sebagai berikut: (1) F = - 1.969 π² + 0.851 Es Taft - 6.116 σ + 3.620 π + 90.809 (2) RS = 4.376 Es Taft - 88.802 (3) LD50 = 672.518 CMR - 669.385 ClogP - 813.806. Dari hasil persamaan terbaik tersebut diperoleh bahwa aktivitas dipengaruhi oleh parameter sifat fisikokimia sterik (Es Taft). Kata kunci: 1-benzil-3-benzoilurea, in-silico, kode pdb: 5fbn, limfoma non-hodgkin
Abednego Kristande Gwiharto, Cecep Suhandi, Cheryl Alodya, Rano K. Sinurya
KELUWIH: Jurnal Kesehatan dan Kedokteran, Volume 3, pp 48-56; https://doi.org/10.24123/kesdok.v3i1.4063

Abstract:
Influenza is caused by a rapidly mutating viruse that consists of 2 types, namely type A with the H1N1 and H3N2 genotypes and type B. Influenza caused global mortality with 250,000-500,000 death in 2009. The effectiveness of vaccines also changes regarding the mutation of influenza viruses, however, in the development and utilization of influenza vaccines should be supported by the economic status of a country. Up to now, there are many countries that have not prioritized the utilization of influenza vaccines. The target of influenza vaccination are children and adults (> 60 years old). The purpose of this review was to determine the effectiveness of influenza vaccines from various countries and categorized based on their income. This review used Medline, Elsevier, and BMC Public Health as the database with the keywords "Effectiveness" and "Influenza vaccine". Then, the articles are selected based on inclusion and exclusion criteria. Based on the initial search there are 784 articles that match the keywords, and only 13 articles met the criteria. These articles are classified based on the center of the study in order to classify based on their national income; 5 studies in high income countries, 5 studies in upper-middle income countries, 3 studies in lower-middle income countries, and 1 study in low income countries. The results showed that the administration of influenza vaccine in high income and upper-middle income countries is quite effective for type A H1N1 genotypes, where as H3N2 is less effective. In the lower-middle income countries, the utilization of vaccines with type A H3N2 genotypes was effective, however, in the low-income countries, the effectiveness of vaccines has not been justified due to the limited study of type of influenza and the administration of influenza vaccines in those countries.
Puri Safitri Hanum, Qory’ Hanifa
KELUWIH: Jurnal Kesehatan dan Kedokteran, Volume 3, pp 22-34; https://doi.org/10.24123/kesdok.v3i1.4707

Abstract:
The study's objective was to describe the effect of using high doses of N-acetylcysteine on severe COVID-19 patients. It was evaluated from the length of stay and by monitoring the drug use data, laboratory data, and clinical data at Bhayangkara H.S Samsoeri Mertojoso Hospital Surabaya. The data was collected retrospectively from patients' Health Medical Records who got high dose N-acetylcysteine in October 2020 – February 2021, with standard therapy: antivirus (Remdesivir), antibiotics, vitamins, symptomatic and comorbid therapy, anticoagulant, and corticosteroids (Dexamethasone) as inclusion criteria, then described descriptively. The observation result confirmed that the use of a high dose of N-acetylcysteine (NAC) [1 x 1200 – 5000 mg] po/iv had effective results as seen from the patients' length of stay, which was 12 days for patients without comorbid and 14 days for patients with comorbid like diabetes and/or hypertension. The use of high dose NAC showed improvement in the patients' clinical condition that is evaluated from improved oxygen saturation by 37%. In addition, the laboratory results are shown an improvement in thorax X-ray by 69% and inflammatory markers like CRP and d-dimer by 100%. Further research that uses a prospective method is needed to get a better result on the use of high-dose NAC in patients with severe COVID-19.
Gembong Satria Mahardhika
KELUWIH: Jurnal Kesehatan dan Kedokteran, Volume 2, pp 64-74; https://doi.org/10.24123/kesdok.v2i2.4431

Abstract:
—COVID-19 is a major emerging disease that affects any certain condition. However, a recent report suggests the occurrence of hyperglycemia without any present diabetes in COVID-19 patients. This study aimed to systematically review recent evidence on hyperglycemia in COVID-19 patients. Literature research was done using four search engines, consist of Google Scholar, PubMed, ScienceDirect, and ProQuest, and limited to English manuscript only and published from February 2020 to September 2020. SARS-CoV-2 could damage the pancreas by causing the destruction of the β-cell structure that leads to impairment of glucose metabolism and worsen pre-existing diabetes or determine the appearance of hyperglycemia in non-diabetes. Inflammation also plays a major important role in hyperglycemia related to COVID-19. Hyperglycemia increased the vulnerability of the lung, by promoting and facilitating the entry of the SARS-CoV-2 into the host cells, and decreasing lung function. Moreover, the mortality and morbidity rate conceivable increased due to hyperglycemia. The presence of high glucose levels is linked with the progression of COVID-19 severity. Thus, the glucose level should be concerned, either in a patient with present diabetes or without any presence of diabetes. Examination and monitoring of glucose levels might be a useful tool to prevent the seriousness of COVID-19 Keywords: diabetes mellitus, SARS-CoV-2, high glucose level, pulmonary infection Abstrak—COVID-19 adalah penyakit yang muncul yang mempengaruhi kondisi tertentu.Namun, sebuah laporan baru-baru ini menunjukkan terjadinya hiperglikemia tanpa adanya diabetes pada pasien COVID-19. Penelitian ini bertujuan untuk meninjau secara sistematis bukti terbaru tentang hiperglikemia pada pasien COVID-19. Penelitian literatur dilakukan dengan menggunakan empat mesin pencari, yaitu Google Scholar, PubMed, ScienceDirect, dan ProQuest, dan terbatas hanya pada manuskrip berbahasa Inggris dan diterbitkan dari Februari 2020 hingga September 2020. SARS-CoV-2 dapat merusak pankreas dengan menyebabkan kerusakan pada pankreas. struktur sel β yang menyebabkan gangguan metabolisme glukosa dan memperburuk diabetes yang sudah ada sebelumnya atau menentukan munculnya hiperglikemia pada kelompok non-diabetes. Peradangan juga memainkan peran penting utama dalam hiperglikemia terkait COVID-19. Hiperglikemia meningkatkan kerentanan paru-paru, dengan mendorong dan memfasilitasi masuknya SARS-CoV-2 ke dalam sel inang, dan menurunkan fungsi paru-paru. Selain itu, angka mortalitas dan morbiditas yang diperkirakan meningkat karena hiperglikemia. Adanya kadar glukosa yang tinggi dikaitkan dengan perkembangan keparahan COVID-19. Dengan demikian, kadar glukosa harus diperhatikan, baik pada pasien dengan diabetes saat ini atau tanpa adanya diabetes. Pemeriksaan dan pemantauan kadar glukosa mungkin menjadi alat yang berguna untuk mencegah derajat keparahan COVID-19. Kata kunci: diabetes mellitus, SARS-CoV-2, peningkatan kadar glukosa, infeksi paru
Made Indira Dianti Sanjiwani, I Made Widianantara
KELUWIH: Jurnal Kesehatan dan Kedokteran, Volume 2, pp 102-109; https://doi.org/10.24123/kesdok.v2i2.4189

Abstract:
Uterine fibroids or leiomyomas are benign neoplasms that occur in the uterus and still become a health problem among women of reproductive age. Predominantly, uterine fibroids are found at productive age but some cases are found after menopause. Based on previous studies, there were 145 cases of uterine fibroids in 2014 and 69.7% were found in women over 40 years. Patients with uterine fibroids show a decreased quality of life with symptoms such as heavy uterine bleeding, pelvic pain, and loss of pregnancy. The pathogenesis of uterine fibroids is still unknown, but genetic factors, cytokines, growth factors, and steroid hormones are weak and play an important role in the development of uterine fibroids. Several studies have shown the effect of resveratrol that can be obtained from grape skins. Resveratrol can reduce extracellular matrix deposition and uterine fibroid cell proliferation. Looking at the induced events then resveratrol is effective in preventing the progression of uterine fibroids.
Devitya Angielevi Sukarno
KELUWIH: Jurnal Kesehatan dan Kedokteran, Volume 2, pp 110-114; https://doi.org/10.24123/kesdok.v2i2.4033

Abstract:
--Insulin resistance underlies the pathogenesis of chronic disease, such as diabetes mellitus which has high morbidity and mortality rate. Insulin resistance is a pathological condition when cells fail to respond normally to the insulin hormone, because of insulin signaling pathway disruption. Bound between insulin and insulin’s receptor cannot phosphorylate tyrosine and fail to activate insulin receptor substrate-1 (IRS-1). This failure decrease Glucose transporter-4 (GLUT-4) expression on the skeletal muscle’s cell membrane, that leads to decrease glucose influx and increase blood glucose level. A routine physical training which does according to adequate training dose, will activate adenosin 5’monophosphate-activated protein kinase (AMPK) and lead to the translocation of GLUT-4 vesicles without insulin and insulin’s receptor bonding.GLUT-4 expression on the skeletal muscle’s cell membrane which is stimulated by muscle contraction will increase glucose influx and decrease blood glucose level. Keywords: insulin resistance; physical training; insulin signaling pathway Abstrak--Resistensi insulin merupakan penyebab yang mendasari terjadinya penyakit kronis seperti diabetes melitus yang memiliki angka morbiditas dan mortalitas tinggi.Resistensi insulin merupakan keadaan patologis dimana terjadi kegagalan respon seluler terhadap hormon insulin akibat gangguan pada jalur sinyal insulin.Ikatan insulin pada reseptornya tidak dapat menyebabkan fosforilasi tirosin sehingga tidak dapat mengaktivasi insulin receptor substrate-1 (IRS-1). Kegagalan aktivasi tersebut akan menyebabkan penurunan ekspresi Glucose transporter-4 (GLUT-4) pada membran sel otot rangka sehingga ambilan glukosa oleh sel menurun dan glukosa darah meningkat. Latihan fisik yang dilakukan secara rutin, teratur dan sesuai dengan dosis latihan yang tepat dapat mengaktivasi adenosin 5’monophosphate-activated protein kinase (AMPK), sehingga menyebabkan translokasi vesikel berisi GLUT-4, tanpa melalui ikatan insulin dengan reseptornya. Ekspresi GLUT-4 pada membran sel yang dirangsang oleh kontraksi otot akan meningkatkan ambilan glukosa dan menurunkan glukosa darah. Kata kunci: resistensi insulin; latihan fisik; jalur sinyal insulin
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