Biomedical Research

Journal Information
ISSN / EISSN : 0970-938X / 0976-1683
Published by: OMICS Publishing Group (10.4066)
Total articles ≅ 815
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Heidi Abrahamse
Published: 1 January 2019
Biomedical Research, Volume 30; https://doi.org/10.4066/biomedicalresearch-c1-025

Abstract:
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Jaba Tkemaladze
Published: 1 January 2019
Biomedical Research, Volume 30; https://doi.org/10.4066/biomedicalresearch-c1-026

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Ming Pei
Published: 1 January 2019
Biomedical Research, Volume 30; https://doi.org/10.4066/biomedicalresearch-c1-024

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Penka Petleshkova, Maya Krasteva, Snezana Dragusheva, Desislava Bakova, Biyanka Tornyova, Anna Mihaylova, Nikoleta Parahuleva
Published: 1 January 2018
Abstract:
In recent years, the objectification and control of neonatal pain has caused many discussions. Given its early and late effects, researchers' efforts are aimed at minimizing the impact of maternal and childrelated factors, with a possible effect on pain sensitivity in new-borns. Our aim is to study the influence of maternal factors (daily intake of one or more cups of coffee and bacterial vaginosis during pregnancy, birth mechanism, blood group and Rhesus factor) and child-related factors (gestational age, gender, blood group and Rhesus factor) on the severity of procedural pain, caused by puncture of the heel. The present study includes 67 infants carried to term and aged 72-84 h, born by varying birth mechanisms and with an optimal Apgar score. By video surveillance before, during and after the procedure, the pain was assessed using the Neonatal Infant Pain Scale (NIPS). The results were measured 30 s and 5 min after the heel puncture. The following statistical methods were used: Kruskal-Wallis test, X2 assay (Chisquared test), Student’s t-test and Mann-Whitney's u-test, with a factor of significance of p<0.05. At the 30-s mark, there was no statistically significant difference in the severity of pain among the new-borns in the groups: pregnant women, which have consumed coffee and had bacterial vaginosis during the pregnancy. The mechanism of birth, gender and Rhesus factor of the new-born and mother did not change the severity of pain. New-borns with a larger gestational age and those from mothers with the blood group AB showed a significantly increased response to procedural pain. At the 5-min mark, none of the studied factors associated with the mother and new-born had a significant effect on the degree of pain. The influence of maternal and child related factors on the severity of procedural pain in new-borns is limited.
Mustafa Ugur Goktas, Pinar Yesim Akyol, , ,
Published: 1 January 2018
Abstract:
Objective: Inflammatory reaction, which causes tissue damage in Acute Coronary Syndrome (ACS), leads to deterioration. White Blood Cell (WBC), Neutrophil (N), Lymphocyte (L) and Neutrophil/ Lymphocyte (N/L) ratios were used to refer to the inflammation. High neutrophil levels show us acute inflammatory situation and low lymphocyte levels show us physiological stress. That is why N/L ratio is a valuable parameter which enables us to guess patient prognosis in Emergency Department (ED). In this study, white cell and NLR relations with ACS in patients with chest pain is evaluated. Material and Method: Patients referring to ED with chest pain within 3 months were investigated retrospectively. 100 patients were included in the study. Patients' WBC count, NLR and WBC values, gender, Troponin-I and CK-MB positivity, history of Coronary Heart Disease (CHD) and additional diseases were examined according to the final diagnoses. All the patients were divided into three groups according to ACS: Unstable Angina Pectoris (USAP), Non-ST Elevated Myocardial Infarction (NSTEMI), and ST-Elevated Myocardial Infarction (STEMI). Mortality and morbidity levels in hospital and after discharge were also examined in the study. Findings: WBC values in patients with positive Troponin-I were found statistically higher than patients with negative Troponin-I (p<0.05). In STEMI group, WBC values were statistically higher than USAP group (p<0.0083). When patients' N/L ratio average distribution was examined; Troponin-I and CK-MB positive patients' NLR was found to be statistically higher than Troponin-I and CK-MB negative ones (p<0.05). Conclusion: N/L ratio, which is a marker of inflammatory process in the myocardial vascular bed, may be considered as a risk marker. For this reason, N/L ratio at admission can be used as an auxiliary parameter for predicting the diagnosis of ACS.
Nidhi Srivastava, Sipi Dubey
Published: 1 January 2018
Abstract:
Lie detection, also called as deception detection, uses questioning techniques to ascertain truth and falsehood in response. In this paper, features of speech and physical values are used to ascertain truth and lie. The Mel frequency cepstrum coefficient, energy, zero crossing rate, fundamental frequency and frame function of speech signal and physical values like heart-beat, blood pressure and respiratory rate are used to model the linear detector model. The results are validated by support vector machine and artificial neural network.
Spandana Paramkusham, Kunda Mm Rao, Prabhakar Rao Bvvsn, Shivam Sharma
Published: 1 January 2018
Abstract:
Breast cancer is the most common cancer among women. Our paper mainly focuses on classification of breast masses with the Triangular Area Representation (TAR) signatures. Breast masses are characterized by its gray level values and shape complexity. So, shape descriptors are calculated from the TAR signature of mass contours and given to different classifiers for the classification of benign and malignant contours .We tested our proposed method on 148 mass contours which are taken from DDSM mammogram database. Out of the total images used for evaluation 74 images were malignant and other 74 images were benign. The proposed method attained accuracy of 90.9% and 0.95 AUC (Area Under Curve) value with SVM (support vector machine) classifier
, Fangda Li, Jiang Shao, Bao Liu, Yu Chen, Changwei Liu, Yuehong Zheng
Published: 1 January 2018
Abstract:
Objective: This study aimed to observe the therapeutic effect of angiogenic factor with G-patch and FHA domain 1 (AGGF1) in mice with lower limb ischemia and determine the corresponding molecular mechanism. Methods: A total of 40 C57BL/6 male mice were selected. 32 mice were chosen to establish the lower limb ischemia model and divided into the low-dose, middle-dose, high-dose, and model groups. The remaining 8 mice comprised the sham-operation group and underwent separation of the left arteria femoralis and arteria iliaca externa (same with the model group). AGGF1 was injected once every day for 4 weeks. Tissue necrosis, dyskinesia scores, and recovery percentage of lower limb bloodstream at 1, 2, and 4 weeks after AGGF1 injection were compared. All mice were killed after 4 weeks of treatment. AGGF1, hypoxia-inducible factor 1α (HIF-1α), and vascular endothelial growth factor (VEGF) mRNA and protein levels in the musculus gastrocnemius at the operation side were measured and compared. Results: Tissue necrosis and dyskinesia scores at 1, 2 and 4 weeks after AGGF1 injection and AGGF1, HIF-1α, and VEGF mRNA and protein levels in the musculus gastrocnemius of different groups were compared. The sham-operation group achieved the lowest values, followed by the middle-dose, highdose, low-dose, and model groups successively. Statistically significant differences between any two groups were found (P0.05). The dyskinesia scores of the sham-operation group and the three dose groups sharply dropped as time passed (P<0.05), whereas those of the model group dramatically increased (P<0.05). Conclusions: AGGF1 (2 μg/mL) can improve tissue necrosis and dyskinesia and accelerate lower limb bloodstream recovery of mice with lower limb ischemia. The mechanism is speculated to be related to an upregulated expression of AGGF1, HIF-1α, and VEGF mRNA and proteins.
Rifat Urnal, Pinar Yesim Akyol, , , , Eylem Kuday Kaykisiz
Published: 1 January 2018
Abstract:
Background: Pulmonary embolism (PE) is one of the major causes of mortality, morbidity and hospitalizations. We aimed to investigate the effect of neutrophil/lymphocyte ratio (NLR) on 1-year mortality. Material and Methods: Among the patients, were referred to the emergency department of our hospital within 1-year who underwent computed tomography pulmonary angiography (CTPA), patients who were interpreted as PE after CTPA were included in the study. Results: The optimal NLR cutoff value for the power in predict 1-year mortality was determined as 4.74 with ROC analysis. The NLR cutoff value of 4.74 had sensitivity of 61%, specificity of 75%. There were statistically significant differences between groups in terms of NLR on 1-year mortality and mortality in patients with a NLR greater than 4.74 was statistically significant higher than in patients with a NLR of 4.74 or less. Conclusion: We believe that NLR can be used in evaluating 1-year mortality of pulmonary embolism.
Lili Jiang, Weihua Zhu
Published: 1 January 2018
Abstract:
Background: Helicobacter pylori (Hp) infection was prevalent all over the world, but the Hp eradication rate remained low. This randomized controlled double blinded study aimed investigated the effectiveness and safety of probiotics combined with the standard regimen in eradicating Hp infection. Methods: Consecutive adult patients who had C14 breath test positivity (>100) and endoscopically diagnosed as chronic active gastritis or gastric ulcer were enrolled and randomized into control group (n=111) and experimental group (n=111). Demographic and clinical characteristics were recoded. The Hp eradication rate and adverse events were compared between two groups. Results: The demographic and clinical characteristics were comparable between the control and experimental group (all P values>0.05). The effectiveness rate of control group was 84.7%, which was obviously lower than that of the experimental group (84.7% vs. 94.6%, P=0.041). The total incidence of the adverse events in control group was also statistically higher than that in experimental group (P=0.023). There were no statistically significant differences on the rate of taste disorders and anorexia between the two groups (P>0.05). The incidences of abdominal distension, diarrhoea and constipation in control group were greatly higher than those in experimental group (all P values<0.05). Conclusion: These findings proved that the probiotics can improve the effectiveness and safety of the standard Hp eradication regimen.
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