Asian Journal of Pediatric Research

Journal Information
EISSN : 2582-2950
Published by: Sciencedomain International (10.9734)
Total articles ≅ 161

Latest articles in this journal

Randa Abdel Sattar El Hewala, Saleh Mohamed Amin Saleh, Safwat Mohamed Kasem, Maher AhmedAbdel Hafez
Published: 24 September 2022
Asian Journal of Pediatric Research pp 1-11;

Background: NAFLD is a clinical spectrum ranging from steatosis (fatty infiltration) to steatosis with inflammation, necrosis, fibrosis and cirrhosis resembling alcoholic hepatitis in the absence of alcoholic abuse. The aim of this work was to determine early renal functional alterations in overweight / obese children and adolescents with NAFLD, as assessed by estimated glomerular filtration rate using cystatin C, and to evaluate its relation to the degree and various clinic-laboratory parameters of NAFLD. Methods: This case control research included 60 overweight and obese children and adolescent. The Cases were classified into two equal groups: group 1: overweight or obese children and adolescents with NAFLD and group 2: overweight or obese children and adolescents without NAFLD. Twenty healthy age-and-sex matched children with BMI less than the 85th percentile for age and sex were chosen as controls. Results: There was significantly positive correlation among serum cystatin C and weight, BMI, Waist/Hip ratio, ALT, AST, cholesterol, Hip circumference, Fasting plasma insulin and Insulin resistance. There was significantly negative correlation among serum cystatin C and eGFR. There were significant negative correlations between eGFR and weight z score, BMI z score, hip circumference, waist/hip ratio, ALT, AST, cholesterol, fasting plasma insulin, insulin resistance and cystatin C. Conclusions: Serum Cystatin C correlated significantly to the degree of hepatic steatosis. Values of eGFR were significantly lower in NAFLD patients compared to those without NAFLD and controls. The reduction in eGFR was correlated significantly with the degree of hepatic steatosis. There was a statistically significant negative correlation between serum cystatin C and eGFR. Levels of eGFR were significantly correlated with weight, BMI, W/H ratio, ALT, AST, cholesterol and insulin resistance.
, Laura Kuate Makowa, Sonia Zebaze, Christiale Batibonack, Audrey Thérèse Mbang, Aurore Albane Essomba, Christelle Fanmi Tchawa, Raïssa Monayong Mendomo
Published: 19 September 2022
Asian Journal of Pediatric Research pp 30-36;

The baby blues is a precocious psychic impairment that may occur within the first two weeks following delivery. It is considered a trigger point, and sometimes a decompensation towards more serious postpartum psychiatric disorders. It is as well a hazard, predisposing to abnormal psycho-affective development in infants, otherwise intimately dependent on maternal bonding. Although there have been advances in understanding the psychopathology, the clinical presentations, and the inter-relationship of the condition with other disorders of perinatality, the management however remains unclear and poorly described. There seems to be confusion between indications for mere observation with monitoring on one hand, and the need for psychotherapy or pharmacotherapy on the other hand. This is maintained by the ambiguous distinction between primary baby blues which is milder, and severe baby blues with immediate and late complications that are sometimes neglected. Whereas, intervention may be necessary in a number of cases to prevent adverse outcomes in affected mothers and their infants. In this short paper, we review the management of baby blues according to the severity and we give clues for prevention, based on known protective factors.
Hebat Allah Mohammad Ayad, Heba Said El-Mahdy, Maaly Mohammad Mabrouk, Ashraf Mohammed Ibrahim
Published: 19 September 2022
Asian Journal of Pediatric Research pp 22-29;

Objectives: The aim of this work was to study the status of serum vitamin D level on the outcome of ventilator associated pneumonia (VAP) in neonates. Methods: This prospective cohort study was carried out on 60 intubated neonates with gestational age > 32 weeks and ventilated for more than 48 h and included two groups, VAP group (n=30) and non-VAP group (n=30). Serum 25-hydroxy Vit D was tested at the start of mechanical ventilation, while blood culture and endotracheal culture were obtained after 2 days of mechanical ventilation and when VAP was suspected. Results: The mean serum level of vitamin D in VAP group was statistically significantly lower than non-VAP group. Also, the total duration of mechanical ventilation, duration of O2 supplementation post extubation and duration of hospital stay were statistically significantly longer in VAP group. Although the mortality was higher in neonates developed VAP, it didn’t achieve a statistically significant difference. A cut off value of ≤17.35 ng/ml of serum 25-hydroxy vitamin D showed a sensitivity of 83.33%, specificity of 100% and area under curve (AUC) was 0.895 to predict neonatal VAP. Conclusion: 25-hydroxy vitamin D deficiency is an important risk factor for VAP development in neonates, and low vitamin D levels is associated with significant longer duration of mechanical ventilation, post extubation O2 support and hospital stay in neonates with VAP.
, Linda Ayedadjou, Nicole Enianloko Tchiakpe, Omoyélé Ladipo, Eurydice Yerima, Adolphe Adjanohoun, Haziz Sina, Lamine Baba-Moussa
Published: 8 September 2022
Asian Journal of Pediatric Research pp 12-21;

Aims: Bacterial meningitis remains a public health problem due to an unfavorable geographical environment and socioeconomic context. Our study aimed to evaluate the epidemiological-clinical, therapeutic and evolutionary profile of children treated for bacterial meningitis in the pediatric department of CHU-MEL in Benin. Methodology: The methodology consisted in carrying out a retrospective and descriptive study of children admitted to the pediatric department of the CHU-MEL in Cotonou from January 2019 to December 2020. All children admitted in the study period were taken in consideration. Data collection (epidemiological, clinical, paraclinical, therapeutic and evolutionary) was made from registers and files and by telephone call. Results: Our data reveal that 68 children were treated for bacterial meningitis between January 2019 to December 2020. It was also noted that the most represented age group was between 3 months and 3 years with a rate of 52.9%. Most (95.6%) of the children had no particular history. The antibiotics used were ampicillin (17.4%), ceftriaxone (52.2%), cefotaxime (4.3%) and ciprofloxacin (8.7%). For the exploration of cases of meningitis, apart from the cytobacteriological examination of the cerebrospinal fluid (CSF), the blood culture, the complete blood count (NFS) and the C-reactive protein (CRP) were the examinations commonly requested. Conclusion: It is observed that children treated as meningitis have varying clinical signs. Meningitis cases have different ends. In case of bacterial meningitis, it is important to determine the germs to ensure proper antibiotic therapy to be conducted.
, Bansal Neha, Ghuliani Ranjit, Mahajan Supriya
Published: 5 September 2022
Asian Journal of Pediatric Research pp 6-11;

We report a case of sepsis caused by Cryptococcus laurentii, a rare human pathogen [1], presenting as purpura fulminans. Cryptococcus laurentii was isolated in blood culture and identified by Vitek -2 yeast identification system. The patient was successfully treated with standard management protocols, including amphotericin B.
G. Hachim, A. Laarej, J. El Mahi, R. Abilkassem, A. Hassani, A. Agadr
Published: 3 September 2022
Asian Journal of Pediatric Research pp 1-5;

Ehlers-Danlos syndrome (EDS) is a group of hereditary collagen diseases characterized by joint hyperlaxity, skin hyperelasticity, and generalized tissue fragility. We present the case of an 8-year-old child with EDS in its arthrocalasic form type VII, according to the Villefranche classification, who was born to first-cousin parents. There is no curative treatment for EDS, but it is important to make an early diagnosis for optimal symptomatic management of patients and prevention of avoidable complications.
, Margaret W. Kukeba, Hilda N. K. Ayamsegna, Rasheed Ofosu-Poku
Asian Journal of Pediatric Research pp 24-31;

Aim: To assess the adherence of health professionals to guidelines on inpatient management of children aged 6-59 months admitted with severe acute malnutrition (SAM) Study Design: Retrospective descriptive study Place and Duration of Study: Paediatric Unit of the Upper East Regional Hospital, Ghana. Records of children seen from 1st January, 2016 to 30th April, 2018 were reviewed. Methodology: Hospital records of 75 children discharged after treatment for SAM were assessed in the study. The records were selected using convenient sampling. Data analysis was done with SPSS version 20 and results presented using descriptive statistics. Results: Eighty-eight percent (88%) of the patients were treated for presumed infections. Of this, only 8% of the children received the recommended Ampicillin and Gentamycin therapy. Over 97% of patients were given therapeutic diets (F-75), and 90.7% of patients were assessed for dehydration. However, only one (1.3%) of the children had their blood glucose levels checked on admission. None 0(0%) of the children were given 10% IV glucose to prevent hypoglycaemia on admission and only 21.2% of patients with dehydration received the recommended ReSoMal Conclusion: There is inadequate adherence to the recommended guidelines for inpatient management of children with SAM. This requires exploring explanations to inform strategies that promote compliance.
Aleswa Z. Swai, , Rehema Idris Mzimbiri, Ruth Kumidi Mkopi, Mlemba Abbas Kamwe, Francis Levira
Asian Journal of Pediatric Research pp 11-18;

Background: Diarrhea disorders account for a significant portion of the morbidity and mortality burden among children in resource-constrained settings, and they are economically significant to both families and health systems. In real sense, any intervention that has shown the potential to reduce diarrhea-related mortality and morbidity is valuable in terms of the global child health agenda. Objective: To explore the role of nutrition based risk and protective factors on diarrhea morbidity among children aged less than two years in Tanzania. Methods: We analyzed household-based data on risks and preventive interventions including exclusive breastfeeding, complementary feeding, water, sanitation hygiene, and vitamin A supplementation. Data from the Tanzania Demographic Health Survey (TDHS) of 2015/2016 were used to describe odds of diarrhoea morbidity in children aged 0-5 months and 6-23 months. Multivariate logic regression models were developed to identify risk factors. Results: Children aged less than 5 months, who were exclusively breastfed experienced a reduction in the odds of having diarrhoea by 72% (P-value <0.001), compared to those who were not exclusively breastfed. Children aged between 6 months and less than 23 months, from families with detergent at hand washing facility, experienced a reduction in the odds of having diarrhoea by 37% (P-value <0.01), compared to their peers in the other group. Diarrhoea odds were predicted to be higher in higher wealth quintile as compared to lowest group by 1.39 (P-value =0.028), 1.53 (P-value <0.01), 1.74 (P-value <0.01) and 1.78 (P-value =0.01) for second, middle, fourth to highest groups respectively. Conclusions: The data has demonstrated the important role of exclusive breastfeeding and sanitation on diarrhoea occurrence amongst children aged less than 23 months in Tanzania. Yet there are areas for which it remains inconclusive and requires further work to improve insights and strength of available evidence so far.
, A. Ayad, R. Abilkassem, A. Agadr
Asian Journal of Pediatric Research pp 19-23;

We present different cases of cardiovascular abnormalities in 3 patients with WS aged between 8months and 7 years. Williams-Beuren Syndrome is characterized by specific facial dysmorphism that may look like an “elfin face”, congenital heart diseases, cognitive disorder, social personality disorder and endocrinological abnormalities. WBS is generally sporadic, it is caused by de novo deletions, and has a recurrence risk lower than 5%. Early diagnosis of this syndrome is important to start therapy for other medical problems that may develop. Lifelong cardiac follow up is necessary because of the risks of developing vasculopathy or arterial hypertension. The importance of research during the neonatal period is pointed up in order to reduce morbidity and mortality rates and ensure a better quality of life during the development of these children.
, Rachid Abilkassem, Anass Ayad, Aomar Agadr
Asian Journal of Pediatric Research pp 7-10;

Macrophage Activation Syndrome (MAS), or Haemophagocytosis Syndrome, is a clinical-biological entity characterized by the proliferation and non-specific activation of macrophages of the reticulo-histiocytic system, with phagocytosis of the blood elements formed. This syndrome can be primary in children or secondary to various conditions at any age. Its association with Hodgkin's lymphoma is exceptional. We report here a case of MAS that revealed Hodgkin's lymphoma in a 5-year-old child. And we underline the interest of an urgent diagnosis and a fast care because risk of evolution towards a fatal multivisceral failure.
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