International Journal of Advanced Biochemistry Research

Journal Information
ISSN / EISSN : 2617-4693 / 2617-4707
Published by: Comprehensive Publications (10.33545)
Total articles ≅ 74
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Mehajabin Tusquin Khan, Ahasan Ali, Obaidullah, Intekhab Rahman, Narayan Roy, Ratna Paul, Fatema Binte Islam, Sayeda Tamanna Tasnim
International Journal of Advanced Biochemistry Research, Volume 6, pp 51-54; https://doi.org/10.33545/26174693.2022.v6.i1a.84

Abstract:
Breast cancer is the commonest malignancy and principal cause of women death. It is more common after menopause. The women are more likely to have biologically aggressive breast cancer, such as higher-grade tumors and more lymph node involvement, thus resulting in a poor prognosis, which results in increased mortality rates. In the study thirty diagnosed breast cancer patients and thirty controls are selected. The information regarding all patients is taken in a data sheet. The breast cancer women are received chemotherapy treatment. The study reveals no significant difference (p>0.05) in RBS (Random Blood Sugar), serum cholesterol and serum estrogen level in the case and control group. ESR (Erythrocyte Sedimentation Rate), serum calcium, HDL (High Density Lipoprotein), LDL (Low Density Lipoprotein) and serum progesterone levels show significant difference (p
Risav Banerjee, Nida Khan
International Journal of Advanced Biochemistry Research, Volume 6, pp 37-42; https://doi.org/10.33545/26174693.2022.v6.i1a.82

Abstract:
Worldwide every year more than 2million women suffer from breast cancer. The food habit and the current lifestyle, lead to an increase in obesity. Obesity is one of the chief causes of breast cancer. Angiogenesis is highly crucial for tumor growth. The tumor development and metastasis are fully dependent on angiogenesis or the newly formed blood vessels, which supply nutrients for the tumor development. Several early diagnosis methods for detection of breast cancer are there like, mammography which is an X-ray technique to visualize inside the breast. This technique is used for the early detection of breast cancer. Antiangiogenic treatment plays a major role in treating breast cancer, as it inhibits the supply of nutrients which is essential for tumor growth. Our review will be focusing on the anti-angiogenic drugs which inhibit the formation of new blood vessels. Inhibiting angiogenesis is an effective way to treat breast cancer as it is a safe and effective method.
Sarala H Tippannavar, Maharudra Shekhanawar
International Journal of Advanced Biochemistry Research, Volume 6, pp 10-12; https://doi.org/10.33545/26174693.2022.v6.i1a.78

Abstract:
Introduction: Thyroid hormones are necessary for growth and development of the kidney and for maintenance of water and electrolyte homeostasis. The kidney normally contributes to the clearance of iodine, primarily by glomerular filtration. Thus iodide excretion is diminished in advanced renal failure, leading sequentially to an elevated plasma inorganic iodide concentration and an initial increment in thyroidal iodide uptake. Materials and Methods: The present study was conducted in a tertiary care hospitals in Belagavi, Karnataka State. 50 cases that were on regular maintenance hemodialysis treatment were selected and 50 controls were taken for study. Age & sex matched controls with normal renal function and no previous history of thyroid dysfunction were included in the study as controls. The quantitative determination of serum T3, T4 & TSH was done. The assay principle combines a one step enzyme immunoassay sandwich method with a final fluorescent detection (ELFA). Serum urea and creatinine was estimated by urease/ glutamate dehydrogenase method and modified. Results: There was a significant difference between the control and study group with respect to serum TSH & T3 levels, serum T4 levels were found to be not statistically significant. The serum TSH level was increased in 8 patients (16%) among those with CKD; the mean serum TSH concentration was 5.49±11.03 in CKD patients which was significantly increased than in controls (3.27 ± 2.06). Serum T3 concentration was less than normal range in 10 of the 50 (20%) CKD patients, the mean serum total T3 concentration was 1.69±0.67 in CKD patients was significantly lower than that in the control subjects (2.03±1.2). Serum concentration of T4 was less in cases (81.34±23.87) than in controls (101.41±19.12) but the results was statistically not significant (P=0.083). Conclusion: The present study finds thyroid dysfunction to be very common in CKD patients and reveals the significant association between CKD progression and thyroid dysfunction and mean of T3, T4 decreases and TSH increases significantly in cases as compared to controls. The diagnosis of hypothyroidism can be easily missed in Haemodialysis patients. Timely diagnosis and treatment of hypothyroidism may prevent deterioration of patient’s condition and prolong survival.
Okoro I Ngozi, Otobo D Daniel
International Journal of Advanced Biochemistry Research, Volume 6, pp 01-04; https://doi.org/10.33545/26174693.2022.v6.i1a.76

Abstract:
Aim: The aim of this study is to understand the pattern of dyslipidemia, lipid radicals and antioxidant activities in women with polycystic ovarian syndrome in reproductive aged Nigerian women. Methodology: Original randomized case control studies assessing the comparative studies of lipid patterns and panels in women with PCOS in Nigeria published within 1st January, 2019 and 31st December, 2020 were identified by searching online databases, including PubMEd, Google Scholar and Research gate, using combination of relevant keywords; PCOS, Polycystic Ovarian Syndrome, Lipid, Panel and Nigeria. Results: LDL-C and TC show a significant increase in women with PCOS when compared to women who do not have PCOS. Amongst these women with PCOS, this panels are higher amongst those who are obese (>25Kg/M2). The TG and HDL-C levels do not show any significant variations. However, the HDL-C levels are lower in obese women with PCOS. There is increase in lipid product radical MDA, and decrease in SOD and TAC. However, no variation in the GSH Px activity. Conclusion: TG and HDL-C panels alone are not recommended parameters for assessment and monitoring of insulin resistance in women with PCOS. TG/HDL-C, TC/HDL-C and LDL-C/HDL-C were more specific and sensitive surrogate markers.
Yashu Saini, Saguna Pandit
International Journal of Advanced Biochemistry Research, Volume 6, pp 05-09; https://doi.org/10.33545/26174693.2022.v6.i1a.77

Abstract:
Objective: To establish correlation between body surface area of newborns at different gestational ages and urine total proteins and urine microalbumin.Methods: Cross sectional study was conducted at tertiary hospital in India. We randomly selected 175 normal newborns of different gestational ages. Systemic random spot second urine samples of normal newborns were selected (urine which baby had passed for first time after birth was not used for sampling. Samples were used to estimate urinary proteins (total) (mg/dl), and urine albumin (mg/dl). Results: Proteinuria is common in newborns at all gestational ages. Tubular proteins are major constituent of urine proteins in neonatal urine, but small amount of albumin is also lost in urine and their amounts increase linearly and proportionately as body surface area of newborn increases. This is clear reflection of renal immaturity in newborns. Conclusion: All newborns have abnormally high proteinuria at all gestational ages, which increase with increase in gestational age. Urine microalbumin also showed very mild increase with age but it was very insignificant in comparison to UTP.
Ako Alwell Chinonso, Nweje-Anyalowu Paul Chukwuemeka, Ejiofor Emmanuel Uchenna, Chigbu Charles Chukwuemeka, Ebere Wisdom Onyedikachi
International Journal of Advanced Biochemistry Research, Volume 5, pp 33-39; https://doi.org/10.33545/26174693.2021.v5.i2a.74

Abstract:
Mappianthus iodoides is a plant remedy exploited in the management of various microbial infections and it is also useful in reducing pain. The present study screened the leaf extracts of Mappianthus iodoides for its phytochemical constituents, anti-microbial and in vitro anti-inflammatory activities. Heat- and hypotonic induced haemolysis of red blood cells were used to access the anti-inflammatory activities and the anti-microbial activity was determined by agar well diffusion method. The plant extracts were screened for qualitative phytochemical constituents and the presence of alkaloids, flavonoids, tannins, cardiac glycosides, phenols, steroids, amino acids, anthraquine and soluble carbohydrates were observed. The results showed that the extracts had significant inhibition of microbial growth against all the organisms tested. The minimum inhibitory concentration (MIC) of the extracts showed that almost all the organisms tested were responsive to the extracts at a given concentration. Also, the extracts significantly (P
Moutawakilou Gomina, Bassitou Dabrigui, Tarik Salifou, Adebayo Alassani, Ibrahim Mama Cisse, Gilbert Djidonou, Stanislas Zinsou, Lamine Baba-Moussa, Simon Akpona
International Journal of Advanced Biochemistry Research, Volume 5, pp 24-28; https://doi.org/10.33545/26174693.2021.v5.i2a.71

Abstract:
Background: The lipid lowering effects of Nigella sativa extracts have been reported in numerous research works. In Benin, Nigella sativa seeds are consumed by the populations in order to treat various ailments and diseases. Objective: This study was aimed to assess the effect of daily consumption of Nigella sativa seed on serum lipids in adult subjects. Methods: This research work, being an interventional study of quasi-experimental category, involved 67 voluntary adult subjects (mean age: 33.51±11.40 years; 32 men; 35 women), conducted in Parakou (Benin), from January 15 to April 14, 2021. Each subject consumed per day two (2) grams of Nigella sativa seed powder during 90 consecutive days. The lipid parameters were measured before starting the experiment, and then during all the 30 days. Student’s t test helped compare the averages of lipid parameters at the threshold of 5%. Results: The intake of Nigella sativa seed powder reduced significantly total cholesterol (1.83±0.47 g/L vs. 1.64±0.32 g/L; P=0.000), LDL cholesterol (1.08±0.44 g/L vs. 0.90±0.29 g/L; P=0.000) and triglycerides (1.01±0.60 g/L vs. 0.87±0.48 g/L; P=0.003). HDL cholesterol experienced a non-significant increase (0.53±0.19 g/L vs. 0.56±0.12 g/L; P=0.146) within a range of 5.70%. The following rates of decline were noted: total cholesterol (10.40%), LDL cholesterol (16.70%) and triglycerides (13.90%). Conclusion: At the end of the 90 days, the Nigella sativa seed powder improves the lipid profile in the adult subject. Its consumption may be helpful in the prevention and management of dyslipidemias.
Ahmed El-Abd Ahmed, Mohammed H Hassan, Abeer S Esmaeel, Nagwan I Rashwan
International Journal of Advanced Biochemistry Research, Volume 5, pp 40-45; https://doi.org/10.33545/26174693.2021.v5.i2a.75

Khan Shanawaz
International Journal of Advanced Biochemistry Research, Volume 5, pp 08-12; https://doi.org/10.33545/26174693.2021.v5.i2a.67

Abstract:
Obesity and dyslipidemia may have a role in the development of cardiovascular disease. Neuropathy has also been linked to obesity. The existence of peripheral nerve injury and the presence of metabolic syndrome and lipoprotein abnormalities were evaluated in patients with severe obesity who did not have type 2 diabetes. Detailed proteomics of neuropathic and an evaluation of lipoproteins and HDL-functionality were performed on 49 patients with extreme obesity and 35 age-matched healthy controls. Compared to healthy controls, participants with extreme obesity exhibited a more excellent neuropathy symptom portfolio, lower sural and peroneal nerve impedance, aberrant temperature thresholds, heart rate with controlled breathing, and corneal nerve characteristics. People with significant obesity suffer from little nerve fiber injury. In comparison to controls, obese patients have abnormal lipoproteins and impaired HDL activity. Obese patients with minor nerve fiber injury showed significantly higher serum triglycerides, decreased PON-1 activity, and a higher frequency of obesity than those without.
Rajiv Nehra, Divijendar Nath
International Journal of Advanced Biochemistry Research, Volume 5, pp 29-32; https://doi.org/10.33545/26174693.2021.v5.i2a.73

Abstract:
Introduction: Acute Kidney Injury (AKI), biochemically characterized as abnormality in kidney function test which causes accumulation of creatinine and blood urea and functionally by a rapid decline in the glomerular filtration rate (GFR). Oxidative stress plays an important role in the development of vascular complications in type 2 diabetes. Oxidant derived tissue injury occurs when production of oxidants or reactive oxygen species (ROS) exceeds local antioxidant capacity. Inflammatory cytokines such as tumor necrosis factor-alpha (TNF-) and interleukin (IL-6) and various growth factors in renal cells modulate the local response are responsible for AKI. Material and Methods: 10 ml of fasting venous blood was collected from the antecubital vein in a plain, fluoride and EDTA vacutainers. The blood sample was centrifuged and stored at 40 C for biochemical and immunological investigations. The study group consisted of n=50 healthy individuals (Group I), n=25 Type II Diabetic without AKI (Group II), n=25 Type II diabetic with AKI (Group III) of either sex aged between 50-65 years. Type II Diabetic presented with clinical signs and symptoms of Acute Kidney Injury without Nephropathy. Serum levels of inflammatory markers (IL-6 & TNF-), antioxidants (Glutathione reductase), plasma malondialdehyde (MDA), hs-CRP were estimated. Results: Concentration of inflammatory molecules such as TNF- 9.32±1.08, 14.04±1.42 and 36.56±10.50; IL-6 9.24±1.20, 14.14±1.50 and 36.76±11.56; hs-CRP 0.90±1.10, 1.96±0.50 and 2.18±0.90 was significantly elevated in Group III. GSH were significantly lower in both the groups of Diabetic with and without AKI when compared to controls. 7.10±0.58, 6.90±0.70 and 5.80±0.80. Mean value of total MDA 2.32±0.98, 8.68±2.50 and 9.80±2.72 was significantly more in Group III as compared to Group I and Group II. Conclusion: Results of the present study indicates that inflammatory markers and oxidative stress are increased with decreased antioxidant defense levels in patients with AKI due to DM induced oxidative stress.
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