Asploro Journal of Biomedical and Clinical Case Reports

Journal Information
EISSN : 2582-0370
Current Publisher: Asploro Open Access Publications (10.36502)
Total articles ≅ 80
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Latest articles in this journal

Boon B, De Praeter M, Jentjens S, Van Heerden J
Asploro Journal of Biomedical and Clinical Case Reports, Volume 3, pp 234-240; doi:10.36502/2020/asjbccr.6218

Abstract:
This article describes a rare case of isolated focal fibroadipose overgrowth of the forehead in a 15-year-old patient. Various overgrowth syndromes were considered in the differential diagnosis, including Proteus syndrome, facial infiltrating lipomatosis, and macrodystrophia lipomatosa. The diagnosis is primarily based on clinical presentation and imaging modalities. However, for academic and supporting diagnostic purposes a biopsy is advised, yet may not be in the best interest of the patient. Management was conservative with future perspective for surgical management after cessation of growth.
Asploro Journal of Biomedical and Clinical Case Reports, Volume 3, pp 221-224; doi:10.36502/2020/asjbccr.6216

Abstract:
We discuss the case of a 23 years old female with chronic myeloid leukemia. This patient developed keratosis pilaris nearly three months after she was treated with imatinib mesylate for her chronic myeloid leukemia. She was then referred to our dermatology outpatient clinic for assessment of the skin lesions. Prior to initiating the tyrosinase kinase inhibitor, the patient had no skin lesions at all. The skin lesions were widespread and diffuse in distribution and featured a primary morphology of follicular keratotic papules. This clinical picture was in keeping with keratosis pilaris. The further histological evaluation also confirmed features compatible with this diagnosis. The tyrosine kinase inhibitors are considered first-line therapy for the treatment of chronic myeloid leukemia. Imatinib mesylate belongs to the first generation of oral tyrosine kinase inhibitors and has a long-term control on the chronic myeloid leukemia and good safety profile. Most cases of keratosis pilaris are reported to arise from the second generation of tyrosine kinase inhibitors such as Nilotinib. We report a case of keratosis pilaris associated with imatinib mesylate in a patient with chronic myeloid leukemia.
Asploro Journal of Biomedical and Clinical Case Reports, Volume 3, pp 217-220; doi:10.36502/2020/asjbccr.6215

Abstract:
With the advent of the HIV/AIDS pandemic within the South Saharan region, clinicians are faced with accentuated clinical presentations of previously well-known diseases. Bacillary angiomatosis is no exception to this rule. Bacillary angiomatosis is a cutaneous and systemic bacterial infection caused by gram-negative Bartonella species. We report a case of an immunocompromised 44 years old female patient who presented with a solitary tumor-like bacillary angiomatosis that was treated successfully with azithromycin in a bi-weekly pulsed dosing regimen. This patient had a considerably large (12 x 10cm’s) single lesion of the disease. The case highlights the potential that immunosuppressed patients are not only at risk of disseminated disease, but also of developing severe localized disease. Furthermore, Azithromycin pulse treatment may offer a convenient alternative as there is still no clear consensus regarding treatment protocol for using azithromycin in the treatment of cutaneous bartonellosis.
Yamashita H, Kato Y, Bando H, Kanazawa S, Tanaka M, Sueki E, Kanagawa H, Kawata T, Kawahito A, Aihara A, et al.
Asploro Journal of Biomedical and Clinical Case Reports, Volume 3, pp 206-212; doi:10.36502/2020/asjbccr.6213

Abstract:
Authors and collaborators have continued diabetic practice and research on low carbohydrate diet (LCD), continuous glucose monitoring (CGM), and so on. The case is a 64-year-old male with type 2 diabetes mellitus (T2DM) treated with multiple daily insulin injections (MDI). When his HbA1c was 8.2% before, he changed to take tofu instead of rice and bread. HbA1c decreased to 7.1% and 4kg of weight reduction in 2 months. Tofu is a traditional Japanese food made from soybeans, which is a suitable LCD with Protein:Fat:Carbohydrate (PFC) ratio=40:45:15 in this case. His HbA1c is recently unstable, then glucose variability was investigated by CGM using FreeStyle Libre. The glucose pattern was different due to his lifestyle, including working day, off day, playing golf, respectively. The average glucose was 143-167 mg/dL and the estimated HbA1c was 7.1%, whereas HbA1c in outclinic was 8.1%, respectively. This report will hopefully become reference data for future research.
Girgis Am, Chopra A, Finneran Iv Jj, Greenberg Mj
Asploro Journal of Biomedical and Clinical Case Reports, Volume 3, pp 213-216; doi:10.36502/2020/asjbccr.6214

Abstract:
Background: Several studies have described the use of ultrasound for the placement of peripheral intravenous catheters (PIV); however, visual and tactile inspection remains the primary clinical tool for the identification of infiltration. An improperly positioned PIV is an avoidable cause of significant morbidity and mortality to a patient. Case: We describe a technique using point of care ultrasound for the assessment of two PIV to confirm functionality in a 68-year-old male scheduled for an above the knee amputation. This technique can be used for both superficial and deep peripheral veins where the detection of catheter infiltration by physical exam alone is often challenging. Conclusion: The ubiquitous use of ultrasonography has revolutionized the field of medicine. Point of care ultrasound for the evaluation of questionable peripheral catheters can help prevent harm to a patient, especially during transitions of care.
Tanaka K, Nagahiro S, Bando H
Asploro Journal of Biomedical and Clinical Case Reports, Volume 3, pp 202-205; doi:10.36502/2020/asjbccr.6212

Abstract:
Art therapy has attracted attention in the medical field. Among them, authors have been engaged in various activities including art in hospitals. We have started the artworks using masking tape, which has various colors and the pattern. It can be also used for craft making, wrapping, decoration, and original goods such as art exhibitions. Our current work was performed on the corridor and staircase walls of Tokushima University hospital. It has psychologically three important perspectives, which are i) healing: relieving anxiety, healing the mind, ii) comfort: creating a pleasant and comfortable image, iii) wayfinding system: the wall sign can give a walk direction guide without confusion such as pilgrim walking. We plan to develop the performance in various opportunities.
Levy G, Zines Y, Paz-Levy D, Zaidin A, Shemer O, Beck A, Pansky M
Asploro Journal of Biomedical and Clinical Case Reports, Volume 3, pp 191-201; doi:10.36502/2020/asjbccr.6211

Abstract:
Aim: In the process of opening a new Pelvic Floor Medicine Unit, we aimed to map the pelvic floor dysfunction and sexual issues using validated quality of life (QOL) questionnaires. Material and Methods: All the patients who attended the Pelvic Floor Medicine Unit clinic in Assuta University Medical Center in Ashdod, Israel, were given a validated Pelvic Floor Distress Inventory 20 (PFDI-20) and Prolapse Urinary Incontinence Sexual Questionnaire 12 (PISQ-12) questionnaires prior to meeting the physician. The patient’s age, parity, and route of delivery were collected from the medical record. All data has been statistically analyzed using Kruskal Wallis Test and Mann-Whitney U Test. Results: 647 patients were included in the study, of them 462 filled out the PFDI-20 questionnaires and 221 completed the PISQ-12 questionnaire filling. In the PFDI-20 results, POPDI-6 higher scores were found to be associated with higher parity (p=0.043) and with higher age (p=0.03). CARD-8 scores were found to be significantly associated with cesarean delivery only in patients’ history (p=0.023) and with higher age (p=0.05). UDI-6 scores were found significantly associated with older age (p
Fernandes Alm, Araujo Ahsl, Fonseca Cc, Pinto Cdc, Mata Ds, Pacheco Gan, Sant-Ana Gmc, Barbosa Inl, Barreto Ic, Gribel Lh, et al.
Asploro Journal of Biomedical and Clinical Case Reports, Volume 3, pp 178-185; doi:10.36502/2020/asjbccr.6209

Abstract:
Cerebrovascular disease (CVD) is a neurological medical emergency and one of the main causes of death worldwide; it is classified as ischemic or hemorrhagic. The disease is one of the most severe clinical events related to pregnancy due to thrombogenesis and thrombophilia; there is an incidence of 25 to 34 CVD per 100 thousand births. The current research reports two cases of stroke episode, one previous and another during pregnancy, as well as their associated complications. The first patient had hereditary thrombophilia caused by PAI 4G/5G polymorphism and previous stroke; however, she had regular pregnancy. The second patient had hereditary thrombophilia caused by protein C deficit, had a stroke during pregnancy, and preeclampsia in the first gestational semester; therefore, she was subjected to the cesarean section on the 35th week of pregnancy. Stroke episodes during pregnancy can be very aggressive because it can lead to death or disabilities, not only in the mother but also in the fetus. Based on the association between thrombotic processes and complications, prophylactic anticoagulant therapy is recommended for women with thrombophilia who had a stroke and/or certain adverse pregnancy outcomes, such as recurrent miscarriages.
Bando H
Asploro Journal of Biomedical and Clinical Case Reports, Volume 3, pp 186-190; doi:10.36502/2020/asjbccr.6210

Abstract:
Sodium-glucose Cotransporter-2 Inhibitors (SGLT2i) has been in focus for the pharmacotherapy of diabetes. SGLT2i contributes to decreasing blood pressure (BP) to some degree. BP changes were analyzed in 4 well-known mega-studies. They are Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients-Removing Excess Glucose (EMPA-REG OUTCOME) study, Canagliflozin cardioVascular Assessment Study (CANVAS), Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) and Dapagliflozin Effect on CardiovascuLAR Events (DECLARE)-TIMI 58. The ultimate goal of antihypertensive and hypoglycemic agents is not the achievement of target values, but the suppression of cardiovascular events. SGLT-2i show excellent strategy for event suppression and adjunct method for hypertension.
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