Journal of Medicine and Pharmacy

Journal Information
ISSN : 1859-3836
Published by: Hue University of Medicine and Pharmacy (10.34071)
Total articles ≅ 930
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Thi Ha Thi Minh, Khanh Huynh Vu Viet, Ngan Nguyen Thi Mai, Huy Tran Van, Thuan Dang Cong
Journal of Medicine and Pharmacy, Volume 11, pp 72-78; https://doi.org/10.34071/jmp.2021.1.10

Abstract:
Background: cagA gene EPIYA motifs of H. pylori play an important role in the pathogenesis of gastroduodenal disease. This study is aimed at (1) Identify patterns of cagA gene EPIYA motifs ofH. pyloristrains from gastric biopsy specimens; (2) Investigate the association between cagA gene EPIYA motifs and gastroduodenal diseases. Patients and methods: Eighty-nine gastroduodenal disease patients infected with cagA-positive H. pylori were enrolled in this study. The patterns of cagA gene EPIYA motifs were determined by PCR. Result: cagA-positive H. pylori strains with East Asian-type EPIYA motif were predominant (89.9%), whereas strains with Western-type EPIYA motif accounted for only 10.1%. There were two strains with rare East Asian-type EPIYA, as -ABDBD and -AABD. In the duodenal ulcer group, the prevalence of East Asian-type and Western-type EPIYA motifs were 80% and 20%, respectively. Meanwhile, East Asian-type and Westerntype EPIYA motifs accounted for 95.8% and 4.2%, respectively in the gastric cancer group. Conclusion: cagA gene EPIYA motifs of cagA-positive H. pylori were quite diverse with the predominance of East Asian-type EPIYA motif. There were two rare motifs as -ABDBD and -AABD. The frequency of strains with East Asian-type EPIYA motif was highest in the gastric cancer group, whereas it was lowest in the duodenal ulcer group. Key words: Helicobacter pylori, cagA gene, EPIYA motif, gastroduodenal diseases
Minh Doan Van, Lien Nguyen Thi Kim, Tam Nguyen Quang, Thao Le Thi Minh, Minh Tran Nhat
Journal of Medicine and Pharmacy, Volume 11, pp 79-86; https://doi.org/10.34071/jmp.2021.1.11

Abstract:
Background: Dysmenorrhea is understood as a woman suffering from menstrual pain. Dysmenorrhea is often manifested with symptoms such as abdominal pain, back pain, vomiting, nausea, diarrhea, dizziness,... it not only causes physical pain for the patient, expensive treatment, but also greatly affects the quality of life. Objective: To stduy characteristics of dysmenorrhea and the need for treatment with traditional medicine of female students of Hue university of medicine and pharmacy. Materials and method: A crosssectional descriptive study was conducted in 409 female students from 8 academic majors at Hue University of Medicine and Pharmacy. Students were instructed and completed a self-administered questionnaire, using the Cox Retrospective Symptom Scale (RSS –Cox) to assess menstrual symptoms, using the VAS pain severity scale to assess the level of pain. Result: The rate of dysmenorrhea among female students of Hue University of Medicine and Pharmacy was 88.8%. Moderate pain (according to VAS) accounts for 51.8%, mild pain 30.3% and severe pain 17.9%. The average RSS-Cox1 score was 16.7 ± 10.6 and the RSS-Cox 2 score was 13.0 ± 9.5. According to traditional medicine, Excess accounts for 65.3%, Deficiency 47.9%, Heat 3.0% and Cold 51.8%. In clinical type, the pattern of stagnation of cold-dampness accounts for 38.3%, stagnation of Qi and blood stasis 30.9%, deficiency of Qi and blood 18.7% deficiency of the liver and kidney 10.5%. The proportion of students who need for treatment with traditional medicine is 14.9%, acupress massage and moxibustion are the two methods with the highest demand for treatment. Conclusion: The rate of dysmenorrhea among female students at Hue University of Medicine and Pharmacy is high, most of them have moderate pain, and menstrual-related symptoms appear more often with quite severe levels. According to traditional medicine, most of them have the manifestations of Excess and Cold, corresponding to stagnation of cold-dampness and stagnation of Qi and blood stasis are higher than the others. Demand for treatment of dysmenorrhea with traditional medicine is relatively low, most of them need treatment with acupress massage and moxibustion methods. Key words: dysmenorrhea, the need for treatment, female students, Hue university of medicine and pharmacy
Tri Nguyen Van, Bao Hoang Bui, Minh Huynh Van
Journal of Medicine and Pharmacy, Volume 11, pp 97-104; https://doi.org/10.34071/jmp.2021.1.13

Abstract:
Survey serum levels of NT-proBNP and cardiovascular risks in patients with preeclampsia. Methods: A descriptive cross-sectional study. A survey of 52 women with preeclampsia in the Department of Gynecology and Obstetrics - Hue Central Hospital, from August 2019 to September 2020. Results: In preeclampsia patients, the rate of grade 3 hypertension was 46.1%, of grade 2 hypertension was 32.7%, of grade 1 hypertension was 21.2%. The average Sokolow-Lyon index in preeclampsia group with and without severe features was respectively 22.25 ± 7.38mm; 20.16 ± 5.54mm, the average Sokolow-Lyon index were not significantly higher in severe features preeclampsia group compared with without severe features preeclampsia group. The average LVMI in patients with and without severe features preeclampsia was respectively 120.68 ± 16.47g/m2; 92.27 ± 14.56g/m2 and the average EF in patients with and without severe features preeclampsia was respectively 56.21 ± 7.12%; 65.11 ± 3.45%. The average LVMI and the average EF were significantly higher in severe features preclampsia group compared with without severe features preclampsia group (p < 0.05). In additon, the average serum levels of NT-proBNP in patients with preeclampsia were 598.22 ± 234.35pg/ml. Serum NT-proBNP levels were significantly higher in the severe features preeclampsia groups than in the without severe features group (p < 0.05). Conclusion: The NT-proBNP level were statiscally significantly increased in the patients with preeclampsia. Preeclampsia patients are at increased risks of cardivacular diseases later in life. The serum NT-proBNP level appears to be useful marker to evaluate long-term cardivascular risks.
Tuyet Nguyen Thi Hiep, Thuy Bui Thanh, Hue Phan Minh, Hang Hoang Ngoc
Journal of Medicine and Pharmacy, Volume 11, pp 105-112; https://doi.org/10.34071/jmp.2021.1.14

Abstract:
Objectives: (1) To describe sperm kinetics in semen samples in infertile couples; (2) Evaluation of the factors related to sperm kinetics. Subjects and methods: Descriptive study cross-sectional 50 semen samples in the husband of the infertile couple. Sperm motility and kinetics were evaluated using computer‐aided sperm analysis Hamilton Thorne IVOS II. Results: The mean values ​​of VCL, VSL, VAP, ALH in the normal morphological group were higher than in the abnormal morphology group (p < 0.05). There were the positive correlations between VCL (r = 0.373, p = 0.008), VSL (r = 0.343, p = 0.015), VAP (r = 0.381, p = 0.006), ALH (r = 0.311, p = 0.028) with normal sperm morphology; and negative correlation between VCL (r = -0.286, p = 0.044) with head abnormality. The normal morphological in the group with drinking alcohol was lower than in the group that did not drink, (p = 0.027). The neck-tail abnormality in the drinking group was higher than in the non-drinking group (p = 0.124); The neck-tail abnormality in the smoker group was higher than in the non-smoker group (p = 0.001). Sperm kinetics parameters (VCL, VSL, VAP, ALH, LIN, STR) recorded lower than in the drinking and smoker group, (p > 0.05). Conclusion: Motility and kinetics are related to sperm morphology. Sperm kinetics combines semen parameters to evaluate male fertility more totally. Key words: sperm, semen parameters, sperm kinetics, computer‐aided sperm analysis
Thao Pham Vo Phuong
Journal of Medicine and Pharmacy pp 24-29; https://doi.org/10.34071/jmp.2021.1.3

Abstract:
Background: Mortality of diarrhea have decreased significantly starting in 2000, from about 1.2 million deaths among children under 5 years old to 526,000 in 2015 - a 57% reduction. Despite this, diarrhea remains the second most common cause of death among children under 5, closely following pneumonia. Objectives: To describe clinical and subclinical characteristics of acute diarrhea in children from 2 months to 5 years of age. Subjects and methods: 148 patients from 2 months to 5 years of age who were diagnosed with acute diarrhea for treatment in General Pediatrics Department 1 - Pediatric Center - Hue Central Hospital from April 2018 to April 2019. Set up a cross-sectional study. Results: The group of 2 - 24 months of age accounted for the highest proportion (83.1%), no dehydration (84.5%), dehydration (15.5%), no severe dehydration. The common electrolyte disturbance is hyponatremia (15.5%) and hypokalemia (32.4%). Conclusion: Acute diarrhea in children usually lasts less than 7 days; The common symptoms are vomiting, fever, inflammation of the upper respiratory tract; Laboratory tests showed that peripheral leukocytes were usually not increased and most of them were caused by Rotavirus. Key words: clinical, subclinical, acute diarrhea
Tri Tran Duc Duy, Minh Nguyen Thanh, Tri Truong Van
Journal of Medicine and Pharmacy pp 35-43; https://doi.org/10.34071/jmp.2021.1.5

Abstract:
Objective: To evaluate radiographic and clinical outcomes following anterior cervical discectomy and fusion with cage and plate in patients with degenerative spondylosis. Methods: A prospective study. Patients were performed this technique between August 2013 and October 2017. Radiographic follow-up included static and flexion/extension radiographs obtained to assess fusion, focal and segmental kyphosis, and change in disc space height. The Odom’s criteria and NDI were used to assess outcomes at most recent follow-up. Results: Twenty-two patients with singlelevel degenerative spondylosis underwent ACDF with cage and plate during the study period. The mean duration of follow-up was 17.6 ± 7.3 months. Radiographic evidence of fusion was present in 21 patients (95.5%). The focal alignment at operated level on postoperative radiographs was slightly changed (mean α2 was 4.30 ± 5.50) and segment alignment was a little increased lordosis with mean Cobb angle β2 was 15.70 ± 12.40. Mean decrease in disc space height was 5.4 ± 2.4%. Six patients (27.3%) had dysphagia. Fifteen patients (68.2%) had excellent results according to Odom’s criteria. The mean post-operation NDI score was 5.1 ± 5.8 (median 2.5 range 1-21). Conclusions: Single-level ACDF with cage and plate for cervical spondylosis is an effective treatment, achieves high rate of fusion and preserves the alignments of cervical spine. Key words: Anterior Cervical Discectomy and Fusion, cervical spondylosis
Le Trinh Thi My, Dung Ho Dang Quy, Huy Tran Van
Journal of Medicine and Pharmacy pp 60-65; https://doi.org/10.34071/jmp.2021.1.8

Abstract:
Background: Pancreatic cancer is a common disease of digestive cancers. The tumor progresses rapidly and malignantly, showed a low 5-year survival rate. However, when diagnosed and treated early, the 5-year survival rate of pancreatic cancer improves significantly. Endoscopic ultrasound (EUS) has the advantage that probe can optimal access to the pancreas and surrounding organs, therefore, diagnose pancreatic tumors can be made even when the tumor is small (< 2 cm). Furthermore, Endoscopic Ultrasound- Guided Fine needle aspiration (EUS-FNA) can determine the exact histology of the tumor. Objectives: 1. Investigate some clinical, biological and endoscopic ultrasound characteristics in patients with pancreatic cancer. 2. Evaluate the relationship between endoscopic ultrasound images with clinical and biological characteristics and compare the results between endoscopic ultrasound with computer tomography. Materials and methods: Descriptive cross-sectional studies in 58 patients with pancreatic cancer had endoscopic ultrasound. Results: In 58 patients with pancreatic cancer, we recorded that patients with a history of smoking accounted for 32.8%, and drinking alcohol 31%. Abdominal pain was 89.7%, 44.8% of patients show anorexia, 37.9% have weight loss. 69% of patients had CA 19-9 > 37 UI/ml. EUS found a patient with pancreatic tumor < 2 cm, but CT scan could not detect. Tumors in pancreatic head accounted for 60.3%; in the body 24.1%, 96.6% of pancreatic cancer have a hypoechoic structure, heterogeneous ultrasound. There was a significant relation between pancreatic head tumor and other part with jaundice (p = 0.013). Compatibility in diagnosis of vascular invasion between EUS and CT scan was average (K = 0.483). Conclusion: Smoking and alcohol consumption accounted for the highest proportion, abdominal pain was the most common clinical symptom. Endoscopic ultrasound can diagnose small pancreatic tumors that CT scan can not detect. Key words: Pancreatic cancer, endoscopic ultrasound, clinical characteristics, bio-marker
Huy Tran Van, Thanh Tran Nguyen Ai
Journal of Medicine and Pharmacy pp 66-71; https://doi.org/10.34071/jmp.2021.1.9

Abstract:
Background: The introduction of a new generation of direct acting antiviral agents (DAAs) is a revolution in the treatment of hepatitis C, opening the prospect of eliminating HCV in the future. In Vietnam, the combination of NS5A/NS5B drugs is officially circulated, which has very few studies assessing the therapeutic efficacy and drug tolerance of these drugs in hepatitis C. On the other hand, there are also fewer data on treatment efficiency of patients with genotype 1.6 in the world. Objective: We survey clinical, biochemical and viral response in patients with hepatitis – C, genotype 1,6 treated with the combination of sofosbuvir and ledipasvir (LDV/SOF). Methods: A prospective descriptive study was performed on 48 diagnosed patients who had chronic hepatitis C and/or compensated cirrhosis genotypes 1 or 6 and they were treated for 12 weeks with the combination of sofosbuvir and ledipasvir (LDV/SOF) at Internal Medicine Department, Thu Duc District Hospital. Results: ALT decreased from 72.3 ± 31.9U/L to 29.4 ± 9.3 U/L, AST decreased from 72.9 ± 40.3U/L down to 35.2 ± 23.5 U/L after 12 months of treatment. Albumin and bilirubin maintained 3.64 ± 0.61 g/dL and 0.69 ± 0.26 g/dL. Platelets increase from 145.0 ± 36.3 to 173.9 ± 36.7 after treatment. Percentage of HCV RNA below threshold at the 4-week period later treatment achieved 93.3% and reached 95.5% achieved by SVR12. The incidence of drug side effects is 18.7%. Most are mild, transient symptoms such as fatigue, nausea, diarrhea or loss of appetite... Conclusion: LDV/SOF is an effective, improved interferonfree treatment, good biochemical and microbiological aspects. LDV/SOF therapy is safe and has little effect serious side effects due to medication. Key words: chronic hepatitis C, ledipasvir, sofosbuvir, viral response
Duon Nguyen Thi Thuy, Phuong Le Thi Hoai
Journal of Medicine and Pharmacy, Volume 11, pp 44-51; https://doi.org/10.34071/jmp.2021.1.6

Abstract:
Background: In order to treat cervical lesion of teeth, class V cavity is prepared and filled with restored materials. However, class V restoration is a common challenge to clinicians: low retention capacity, marginal defect and secondary caries due to microleakages. The aim of this study was to compare microleakage of class V cavities restored by glass ionomer cement and composite restoration with or without protective coating material. Materials and Methods: 60 extracted premolars were randomly divided into 6 groups (n=10/ group). Each group were prepared and restored with one of three materials: conventional glass ionomer (CGIC), resin-modified glass ionomer (RMGIC) and composite, with or without G-Coat Plus. All samples were thermocycled, immersed in 0.5% Fuschin solution and evaluated microleakage by dye penetration. Results: Gingival margin showed higher microleakage than occlusal margin in Composite group and CGIC groups with G-Coat Plus (p < 0.05). RMGIC showed lower microleakage than CGIC and Composite when assessed on gingival margin (p < 0.05). G-Coat Plus reduced the microleakage in the RMGIC and Composite groups when compared with the uncoated group (p < 0.05). Conclusions: Microleakage depends on evaluated site and restored materials. Protective coating material reduces microleakage, especially on RMGIC and Composite restorations. Key words: microleakage, class V cavity, glass ionomer cement, composite, provetive coating
Quynh Vo Nhu, Thao Nguyen Thanh
Journal of Medicine and Pharmacy pp 7-15; https://doi.org/10.34071/jmp.2021.1.1

Abstract:
Carpal tunnel syndrome is the most common condition of peripheral nerve compression. Most carpal tunnel syndrome is primary, also known as idiopathic carpal tunnel syndrome. Modern imaging techniques play an important role in the diagnosis of carpal tunnel syndrome as well as in assessing and predicting surgery outcome. Ultrasound and magnetic resonance imaging are becoming important diagnostic techniques and should be widely indicated for patients with clinically suspected carpal tunnel syndrome. Key words: Carpal tunnel syndrome
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