Global Clinical and Translational Research

Journal Information
ISSN / EISSN : 2641-7154 / 2643-8151
Total articles ≅ 35
Filter:

Latest articles in this journal

Xiaowei Qiu, Yehong Tian, Xin Jiang, Qiaoli Zhang, Jinchang Huang
Global Clinical and Translational Research pp 85-99; doi:10.36316/gcatr.02.0035

Abstract:
Coronavirus Disease 2019 (COVID-19), a new respiratory disease caused by severe acute respiratory syndrome virus 2, has emerged as an ongoing pandemic and global health emergency. This article primarily aims to describe laboratory tests, comorbidities, and complications, specifically comprise 1) the incubation period and basic epidemiological parameters, 2) clinical manifestations, 3) laboratory tests, including routine blood tests, inflammatory biomarkers, cardiac biomarkers, liver and renal function, and blood coagulation function, 4) chest imaging features, 5) significant comorbidities and complications. This information on the disease conditions would help dissect the disease heterogeneity for appropriately selecting clinical treatment strategies and therapeutic development.
Cuicui Xia
Global Clinical and Translational Research pp 78-84; doi:10.36316/gcatr.02.0034

Abstract:
Hypertension is a leading chronic risk for population health in China, especially for older and middle-aged adults. However, a representative estimate of hypertension prevalence lacks for general older populations. With datasets from the Chinese Longitudinal Healthy Longevity Study (CLHLS) and China Health and Retirement Longitudinal Study (CHARLS), two nationally representative longitudinal surveys, this report aims to provide some estimates of hypertension prevalence in older and middle-aged adults overall and by social and demographic variables. There had been a marked increase in hypertension prevalence from 41% to 52% among older adults over the past two decades. Older adults, who were females, with urban residence, high income, from eastern China, and engaged in non-agricultural work, were more likely to be hypertensive. About 30% of middle-aged people in China were suffering from hypertension. These findings are significant in identifying potentially vulnerable populations with hypertension, which may have implications for clinical intervention.
Mei Peng, Jian Huang, Yiling Ding
Global Clinical and Translational Research pp 73-77; doi:10.36316/gcatr.02.0033

The publisher has not yet granted permission to display this abstract.
Global Clinical and Translational Research; doi:10.36316/gcatr

The publisher has not yet granted permission to display this abstract.
Fengyu Zhang, Claude Hughes
Global Clinical and Translational Research pp 54-72; doi:10.36316/gcatr.02.0032

The publisher has not yet granted permission to display this abstract.
Global Clinical and Translational Research; doi:10.36316/02.0031

The publisher has not yet granted permission to display this abstract.
Vojislav Kišić, Jennifer Parish
Global Clinical and Translational Research pp 38-45; doi:10.36316/gcatr.02.0029

Abstract:
Background: Misleading diagnostic results, including false-positives, potentially impact both the safety and efficacy profiles of radiopharmaceuticals used for diagnostic purposes. It is unclear, however, if false-positives occurring with radio-pharmaceuticals in lactating breasts are regularly reported as adverse events. Methods: Scientific medical literature (PubMed and Google Scholar) and the EudraVigilance database of suspected adverse drug reaction reports were searched for case reports of false-positives with radiopharmaceuticals appearing in lactating breasts. Medical Dictionary for Regulatory Activities (MedDRA) was reviewed for terms that could be used to capture reports of false-positives occurring in breast nuclear imaging accurately. Results: Literature searches showed that 40 case reports of false-positives have been observed with radiopharmaceuticals in lactating breasts but that these do not appear to be consistently reported to EudraVigilance as adverse events. MedDRA did not contain terms suitable for capturing false-positives in breasts with radiopharmaceuticals, but newly proposed terms were all approved. Conclusion: Increased reporting of false-positives as adverse events could help further clarify the safety specification of radiopharmaceuticals.
Global Clinical and Translational Research pp 46-50; doi:10.36316/gcatr.02.0030

The publisher has not yet granted permission to display this abstract.
Wen Zhang, Mengyuan Yang, Mei Peng, Yanling Ding
Global Clinical and Translational Research pp 29-37; doi:10.36316/gcatr.02.0028

The publisher has not yet granted permission to display this abstract.
Global Clinical and Translational Research pp 27-28; doi:10.36316/gcatr.10.0027

The publisher has not yet granted permission to display this abstract.
Back to Top Top