Biomolecular and Health Science Journal

Journal Information
EISSN : 2620-8636
Published by: Universitas Airlangga (10.20473)
Total articles ≅ 98
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Bramantono Bramantono, Brian Eka Rachman, Erika Marfiani, Neneng Dewi Kurniati, Muhammad Vitanata Arifijanto, Tuksin Jearanaiwitayakul
Biomolecular and Health Science Journal, Volume 4, pp 15-21; https://doi.org/10.20473/bhsj.v4i1.26926

Abstract:
Introduction: As a tropical country, Indonesia has the potential to influence the characteristics of infectious diseases. The purpose of this study was to see how the pattern of pneumonia on various weather components such as rainfall, humidity, and temperature.Methods: This study was carried by retrospective screening in the infectious ward in one of the tertiary referral hospitals.Results: A total of 876 cases of pneumonia from eight treatment rooms were included in the study. The highest pneumonia cases occurred in February with 239 (27.2%) cases followed in April and May with 169 (19.2%) and 159 (18.2%) cases respectively. After microbiological examination, bacterial growth was found in 191 cases. The highest number of bacteria was found in February with 62 (32%), followed by May with 33 (17.2%) and April with 31 (16.2%) samples. Most of the bacterial grown were gram-negative (94.3%), dominated by Klebsiella pneumoniae (35%), followed by Acinetobacter baumanii 17.2% and Pseudomonas aeruginosa 12%. On the examination of antibiotic sensitivity, it was found that amikacin has a consistently high sensitivity (90%) for pneumonia caused by most bacterial causes (Acinetobacter baumanii, Klebsiella pneumoniae, and Escherichia coli).Conclusion: The study did not show any remarkable bacterial patterns based on weather components such as rainfall, humidity, and temperature during the rainy season. However, increasing the surveillance period will provide a better insight into the bacterial pattern and can compare it in the rainy and dry seasons.
Bintang Soetjahjo, Udi Heru Nefihancoro, Rieva Ermawan, Gilang Teguh Pratama
Biomolecular and Health Science Journal, Volume 4, pp 66-72; https://doi.org/10.20473/bhsj.v4i1.26912

Abstract:
Introduction: Femoral neck fractures are a type of intracapsular hip fracture which also be found in younger patients who suffered from high-energy trauma such as vehicle accidents. Non-union and avascular necrosis are the most frequent complications following femoral neck fractures. In this study, we reviewed the outcomes of fibular grafting techniques for femoral neck fractures in adults.Method: Online libraries PubMed, Cochrane Library and Scopus were searched for relevant papers. We searched for scientific publications published between 2009 and 2020. Inclusion and exclusion criteria were used, and prespecified characteristic were extracted from each study.Result: We found 172 papers relevant to the topic. At last, we included 6 papers in this systematic review with a total of 198 patients. Fibular strut graft for femoral neck fractures have shown excellent outcomes, uniting 177 (89,39%) of 198 fractures reviewed. Overall, 15 patients (7,57%) experiencing non-union and 12 patients (6,06%) having avascular necrosis.Conclusion: The outcomes of the intervention turned out to be excellent, assessed by both functional outcome criteria and radiographic bony union. It is important to established a consensus on surgical intervention for femoral neck fractures, specifically including fibular strut grafting.
Putri Rahayu, Yetti Hernaningsih, Heny Arwati
Biomolecular and Health Science Journal, Volume 4, pp 5-9; https://doi.org/10.20473/bhsj.v4i1.26913

Abstract:
Introduction: Malaria is one of the infectious diseases found in tropical countries and sub-tropical countries. In 2016 there were an estimated 445,000 people died to malaria. Alternative medicine is needed, such as natural based ingredient. Morinda citrifolia or noni plant is a medicinal plant found in all parts of Indonesia which has many benefits, such as antibacterial, analgesic, anticancer, antioxidant, and anti-inflammatory. The aims of this study were to determine the antimalarial activity of ethanol extract of noni leaves and its effect on splenomegaly and hepatomegaly.Methods: Extract of noni leaves was prepared by maceration using ethanol solvent. In vivo experiments were conducted using Plasmodium berghei infected BALB/c mice treated with the doses of 100, 10, 1 mg/kg body weight(BW) orally of ethanolic extract of noni leaves. Then, the percentage of parasitemia was calculated from day 1 to day 4 after treatment and at the end of the test, mice were sacrificed then spleen and liver were collected. Results: The highest parasite growth was found in the group treated with noni leaves ethanol extract at a dose of 1 mg/kg WB and vice versa. Probit analysis resulted in ED50 was 0.882 mg/kg WB. Spearmen test showed there was no correlation between doses and the size of splenomegaly with p=0,2 and between doses and the size of hepatomegaly with p=0,6.Conclusion: Ethanol extract of noni leaves possessed antimalaria activity and there was no correlation between doses of extract and t he splenomegaly and hepatomegaly.
Yelvi Levani, Ricky Indra Alfaray, Rahmat Sayyid Zharfan, Astri Dewayani, Kartika Afrida Fauzia, Batsaikhan Saruuljavkhlan, Ayu Lidya Paramita, Maya Rahmayanti, Nur Mujaddidah Mochtar, Kamal Musthofa, et al.
Biomolecular and Health Science Journal, Volume 4, pp 26-29; https://doi.org/10.20473/bhsj.v4i1.25690

Abstract:
Introduction: Indonesia is still among the top three contributors to the number of Tuberculosis (TB) patients in the world in 2017. The awareness about TB can be affected by the presence of other TB patients in the family. Perception and good knowledge in TB patients can increase obedient in treatment. This study aims to relate to the presence of other TB patients in the family environment with knowledge of TB patients.Methods: This study used cross-sectional design. Research respondents have taken using the consecutive sampling technique. Respondents were TB patients on category one anti-tuberculosis treatment at Siti Khadijah Sepanjang Hospital and several primary health centers in Sidoarjo region during February-March 2019. This study used a questionnaire which included sociodemographic, level of knowledge, and perception about TB.Results: The number of respondents in this study was 50 people aged 22-67 years old. The level of knowledge of the respondents was mostly good (82%) as well as perceptions regarding TB (78%). Of the 50 patients, 17 patients (34%) claimed some families also suffered from TB. The comparison between group with other TB patient and group without other TB patients in the family showed significantly different result in the level of knowledge (p=0,000) and perception (p=0,000). The presence of other TB cases in family increased level of knowledge and perception regarding TB significantly.Conclusion: The presence of other TB patients in the family environment can increase awareness so that it can increase the interest of TB patients to find information about TB.
Ida Fitriawati, Manik Retno Wahyunitisari, Risky Vitria Prasetyo, Dwiyanti Puspitasari
Biomolecular and Health Science Journal, Volume 4, pp 38-41; https://doi.org/10.20473/bhsj.v4i1.25392

Abstract:
Introduction: Urinary tract infection (UTI) by extended-spectrum beta-lactamase-producing bacteria often results in a delay in obtaining appropriate antibiotics. The information on patients’ clinical characteristics is necessary for early recognition and the selection of empiric antibiotic therapy. This study aims to investigate the clinical characteristics and the length of therapy of patients with urinary tract infections by those resistant bacteria.Method: This study utilizes a cross-sectional design. Medical records of hospitalized children aged 1-18 months with UTI due to ESBL-producing bacteria at Dr. Soetomo general hospital between January 1, 2017 - July 20, 2020, were reviewed retrospectively. Variables of interest were the demographic data, underlying diseases, causative organism, clinical presentation, maximal body temperature, and length of antibiotic therapy.Results: Among 37 patients enrolled, 25 patients were female. The incidence of urinary tract infection in children was dominated by age 1-12 months old (37.8%). Urological abnormalities were presented in 62.2% of patients. ESBL-producing Escherichia coli was the most common isolated uropathogen (62.2%). High fever was found in 10/28 patients (35.7%). In 17 patients (45.9%), the total duration of antibiotic therapy was 8-14 days.Conclusion: In children with UTI, especially in the infant group, who had urological abnormality or present with a high fever, and who do not respond to empiric therapy should be suspected of developing UTI due to ESBL-producing bacteria.
Rexel Kuatama, Louis Fabio Jonathan Jusni, Christa Karina
Biomolecular and Health Science Journal, Volume 4, pp 61-65; https://doi.org/10.20473/bhsj.v4i1.24432

Abstract:
Background: Chronic Obstructive Pulmonary Disease (COPD) is the third highest leading cause of early death amongst other non-communicable diseases characterized by irreversible limitations of airflow. Current reliable classification relies on forced expiratory volume in the first second (FEV1) and forced vital capacity (FVC) measured on spirometry. In order to provide more effective and individualized management, new markers are needed. Accumulating studies has shown the role of miRNA in the pathogenesis of COPD and the progression of the disease. Aim: This review aims to provide overview of the diagnostic capabilities of miRNA and identify gaps of knowledge for further studies. Method: A review based on Preferred Reporting Items for Systematic Reviews and Meta Analyses (PRISMA) was conducted with the database from Pubmed, Science Direct, and Proquest. Outcome: A total of nine studies has reported diagnostic accuracies of miRNA in distinguishing COPD and normal, COPD and AECOPD, and other subtypes of COPD Conclusion: Retrospective diagnostic analyses of miRNAs have shown several promising AUC and need to be followed up with reliable prospective designs. Further diagnostics studies, in particular those with clinical values, need to be conducted.
Sacharissa Zerlina Tsarwah Thirafi, Zaky Firmawan El-Hakim, Lutfi Dewanda Nugroho, Ayush Khangai,
Biomolecular and Health Science Journal, Volume 4, pp 57-60; https://doi.org/10.20473/bhsj.v4i1.25947

Abstract:
Introduction: Soil-transmitted helminthiasis (STH) is one of the neglected tropical diseases. These worm infections contributed to global child health. Children suffer from chronic disease and fail to reach their full physical and intellectual capacity. Antihelmintic treatment or deworming is recommended for controlling STH. World Health Organization is focusing predominantly on deworming school-age children. Even antihelmintic treatment has to be repeated regularly, children can reinfect if their environment contaminated. It needs a strategy to control STH and treating adults as well as a child.Methods: We searched the literature for relevant clinical research and articles using Google Scholar and PubMed which were published between 2014 and 2018 with keywords “soil-transmitted helminths”, “soil-transmitted helminthiasis”, combined with “eradication” and “elimination”. We excluded research and article which were not written in English. Our study included a total number of ten publications.Results: The studies mentioned that antihelmintic requires the control of STH transmission and need for the treatment in different age groups.Conclusion: According to our findings, the mass drug administration is recommended as a control strategy in both low and middle-income countries to reduce helminthiasis and schistosomiasis. High STH reinfection rate requires an integrated approach including the use of safe pure water, improvement for personal hygiene and sanitation, proper toilets, and reducing the practice of defecation in nature. The previous studies showed that studies focused on deworming using antihelmintic
, Euvanggelia Dwilda Ferdinandus, Rizki Putra Prastio, Indah Fahmiyah, Amila Sofiah, Rodik Wahyu Indrawan, Mochammad Nurul, Gagas Gayuh Aji, , , et al.
Biomolecular and Health Science Journal, Volume 4, pp 42-47; https://doi.org/10.20473/bhsj.v4i1.26910

Abstract:
Introduction: Since the outbreak of Corona Disease-19 (COVID-19) spreads all over the world, various ways of health attempts have been conducted. However, overflowed information intertwines with mis/disinformation could raise public anxiety and stigma-related diseases. We aimed to assess the help of the young generation of millennials and Gen-Z whom are active college students in debunking hoaxes and myths of COVID-19 into their community.Method: The selected students were given a short course on COVID-19 basic information, prevention, and circulated myths. Later, they become ambassadors and actively educated via offline and online platforms. The impact of outspread information on audiences was investigated through a qualitative survey.Result: The knowledge of students were measured by pre- and post-test within the short course. Prior knowledge showed the least understanding part was prevention and myth of COVID-19. There was a significant improvement of knowledge in post-test after receiving seminar (p=0.0002). There were 97 respondents who filled the online survey that predominantly in young adulthood age. Respondent's insight was enhanced and they likely intend to spread the actual information to their surroundings.Conclusion: Appointing student as the spokesperson for health education can raise their social responsibility. Clarifying misinformation and health behaviour could be more influential within the same sharing community. In addition, the use of various online platforms could efficiently reach massive target, especially young ages.
Sri Ratna Dwiningsih, Samsulhadi Samsulhadi, Arif Tunjungseto, Monika Lijuwardi, Arsana Wiyasa
Biomolecular and Health Science Journal, Volume 4, pp 30-37; https://doi.org/10.20473/bhsj.v4i1.25361

Abstract:
Introduction: Earlier menopause has been associated with increased risk of cardiovascular disease, osteoporosis, shorter life expectancy and even cognitive decline. There are many factors that cause differences in the age of menopause in women, one of these environmental factors is a history of night shift work as a consequence of a job. It is not yet known whether female medical workers, with a history of night shifts, get earlier menopause.Methods: This case control study was conducted among 57 female night workers of the Dr. Soetomo General Academic Hospital. Data collection was conducted from December 2019 - March 2020. The study sample was postmenopausal health workers (nurse and midwife) and administrators. The instrument used in this study was a list of interview questions. The data was processed using SPSS software release 23.Results: The results show that from 45 children diagnosed with ALL, 53% are of the age ≤ 5 years old, with 58% males and 42% females. 13% of the patients are in the high risk group and 87% are in the standard risk group. Nutritional statuses of patients are 2% of them obese experienced remission after induction phase therapy, 56% normal with 80% of them experienced remission. 40% underweight with 89% of them experienced remission and 11% not experienced remission, 2% malnutrition and experienced remission. There is no correlation between the nutritional status of children with acute lymphoblastic leukemia with the outcome of induction phase (p = 0.798).Conclusion: In conclusion, there is no correlation between nutritional status and remission outcome of patients with ALL in the induction phase of therapy. However, high percentage of underweight patients shows nutrition needs special attention to improve therapy outcomes.
Gondo Mastutik, Alphania Rahniayu, Dwi Murtiastutik, Afria Arista, Trisniartami Setyaningrum, Nabiha Missaoui, Suhartono Taat Putra
Biomolecular and Health Science Journal, Volume 4, pp 10-14; https://doi.org/10.20473/bhsj.v4i1.26250

Abstract:
Introduction: Condyloma acuminata that is also known as genital warts are one of the most common sexually transmitted that caused by infection of Human papillomavirus (HPV). Persistent infection of Low Risk (LR) or High risk (HR) HPV is a risk factor for progress into benign or malignant cancer. The objective is to analyze distribution of genotype LR-HPV and HR-HPV at condyloma acuminata in anogenital region. Methods: A cross sectional study using were 36 lesions from men and women of condyloma acuminata patients. All subject signed the informed consent and ethic obtained from our institution, number 382/Panke.KKE/V/2016. The specimen was used to histopathological examination and to identified 40 genotypes of HPV using a reverse line blot assay.Results: The All patients were diagnosed as condyloma acuminata, some with focus dysplasia and koilocytosis. All patients were positive for HPV, including LR-HPV were HPV 6, 11, 42, 54, 61, 81,87,89 and HR-HPV were HPV 18, 26, 45, 51, 52, 66, 67, 68B, 69, 82. The single infection of LR-HPV was 44.4%, multiple infection LR/LR-HPV was 13,9% and the multiple infection of LR/HR-HPV was 41.7%. The LR-HPV infected 70,6% and HR-HPV infected 29,4%. Conclusion: LR-HPV is the major infection of condyloma acuminata, in single infection or multiple infection with HR-HPV. The most common infections were HPV 11, followed by HPV 6, HPV 18, HPV 51, and HPV 82. The determination of genotype of HPV can be used to predict the malignant transformation.
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