Biomolecular and Health Science Journal

Journal Information
EISSN : 2620-8636
Published by: Universitas Airlangga (10.20473)
Total articles ≅ 126
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Natasya Ariesta Selyardi Putri, R. Haryanto Aswin, Izzatul Fithriyah, Ummi Maimunah, ,
Biomolecular and Health Science Journal, Volume 5, pp 6-10; https://doi.org/10.20473/bhsj.v5i1.31409

Abstract:
Introduction: Chronic hepatitis B raises serious concern due to its high morbidity, such as cirrhosis and hepatocellular carcinoma, and mortality from 267 per 100,000 person-years. Up to now, medical therapy that successfully eradicates the hepatitis B virus is not available. Therapy is given in the long term for suppressing viral replication and disease progression. Nucleoside analog (NA) is a medication that is consumed orally once a day for years. Previous studies showed that patients who were treated with NA had a different quality of life (QoL) compared to naïve patients. This research aimed to analyze the QoL of chronic hepatitis B patients who consumed NA by comparing it with naïve patients at Dr. Soetomo General Academic Hospital Surabaya. Methods: Subjects were recruited consecutively from chronic hepatitis B patients at Dr. Soetomo General Academic Hospital Surabaya during 9 February – 31 May 2021. Data about sociodemographic characteristics, hepatitis B therapy history, and QoL were gained by using the SF-36 questionnaire and medical records. Subjects were divided into NA and naïve groups which responses underwent an analytical comparison. Results: NA group had significantly higher QoL in a physical component score (PCS) and mental component score (MCS), with physical functioning (PF), role limitations due to physical health (RP), role limitations due to emotional problems (RM), energy/fatigue (VT), emotional well-being (MH), social functioning (SF), and general health perception (GH) subscales having p<0.05 Conclusion: The QoL of patients who were treated with NA was significantly higher than that of naïve patients in terms of physical and mental components.
Roy Prasojo Wibowo, , Widati Fatmaningrum, Ahmad Hadi Modi
Biomolecular and Health Science Journal, Volume 5, pp 16-18; https://doi.org/10.20473/bhsj.v5i1.34442

Abstract:
Introduction: Birth weight is often used to evaluate a newborn baby’s health. Low birth weight (LBW) is one of the leading causes of neonatal mortality. Mothers under the age of 20 (early pregnancy) are at a greater risk of affecting the weight and nutritional status of the unborn child. This research aimed to determine the relationship between early pregnancy and LBW. Methods: This was a cross-sectional study of women and newborns at Airlangga University academic hospital from January through December of 2017. Data on characteristics such as maternal age and LBW were collected. The correlation between early pregnancy and infant weight was determined using the Chi-square test, with a significance level of p<0.05. Results: We conducted research on 210 pairs of mothers and their infants. 64 (30.48%) of the pregnancies occurred in women under the age of 20; 61 (29.55%) were born LBW (weighing less than 2,500 grams). Early age pregnancy was linked to a higher proportion of LBW infants (p=0.001). Research indicated that the risk of LBW was more significant in the early groups of pregnancy. Conclusion: This research establishes a relationship between early age pregnancy and LBW. The findings may aid in identifying vulnerable mothers in need of further assistance and personalized treatments.
, Budi Suwarno, Ogi Bahaurini Gumilar, Shaohong Lai
Biomolecular and Health Science Journal, Volume 5, pp 62-66; https://doi.org/10.20473/bhsj.v5i1.31053

Abstract:
The kidney continues to be the most commonly injured organ in the genitourinary system, with the vast majority of cases being caused by blunt trauma. The majority of individuals with renal trauma are managed conservatively. However, hemodynamic instability, such as shock induced by renal hemorrhage or developing retroperitoneal hematoma (showing grade v renal trauma), renal pelvis or ureteral injury, as well as other renovascular pathologies, may signal the necessity for surgical intervention, which may include renorrhapy. Renorrhaphy in the setting of grade V renal trauma is very uncommon and has only been documented in a few cases in the preceding literature. We discuss a unique and complex case that was successfully managed, and we examine the relevant literature to give useful information for the management of blunt renal trauma patients.
Archangela Olivia Eugenia, , Hermawan Susanto,
Biomolecular and Health Science Journal, Volume 5, pp 1-5; https://doi.org/10.20473/bhsj.v5i1.31880

Abstract:
Introduction: The prevalence of type 2 Diabetes Mellitus (T2DM) in Indonesia is increasing and is known to cause several complications related to the patient’s glycemic control. A chronic hyperglycemic state will lead to microvascular injury of the brain resulting in cognitive impairment as one of the complications of T2DM. Therefore, our present study observed the correlation between glycemic control and cognitive impairment in patients with T2DM. Methods: This was an observational study with a cross-sectional design of T2DM patients in endocrine outpatient clinics of Dr. Soetomo General Academic Hospital from October 2020 to March 2021. The subjects were recruited consecutively then categorized into groups with controlled (HbA1c < 7%) and uncontrolled (HbA1c ≥ 7%) blood glucose. The cognitive function was evaluated using the AD8 informant-based questionnaire. Results: A total of 43 adult T2DM patients aged < 65 years were recruited. The incidence of cognitive impairment was not significantly different (p=0.127) between controlled and uncontrolled blood glucose groups. However, HbA1c levels were positively and significantly correlated with AD8 scores (p=0.031, R=0.330). Moreover, the duration of T2DM was found to significantly affect cognitive abnormalities in these patients. (p=0.021). Conclusion: Poor glycemic control in T2DM patients increased the risk of developing reduced cognitive function.
Gery Morsales Munthe, David Nugraha, Gabriel Pedro Mudjianto, Etik Ainun Rohmah, Arnoldina Dolfina Dua Weni, Zukhaila Salma, Lynda Rossyanti, Fitriah, Suhintam Pusarawati, Budi Utomo, et al.
Biomolecular and Health Science Journal, Volume 5, pp 19-24; https://doi.org/10.20473/bhsj.v5i1.35278

Abstract:
Introduction: Anopheles mosquito is transmitting malaria, one of the health problems in Indonesia. Understanding Anopheles mosquito behaviour and its breeding preference is one of the crucial keys to prevent malaria transmission. This study aimed to identify the breeding place distribution and bionomics of Anopheles spp. in Runut village, Sikka district, East Nusa Tenggara. Methods: A descriptive observational study was conducted in Runut village, Waigete sub- district, in April 2018. Anopheles spp. larvae were collected in 7 suspected breeding places consisting of 2 rice fields, 3 fish ponds, and 2 puddles. Mosquitos behaviour was observed using bed-net traps located inside and outside the house from 7.15 PM to 1.15 AM after obtaining informed consent. Mosquito collection using bed-net trap were performed for 40 minutes then followed by resting mosquito collection for 10 minutes. Results: Anopheles spp. larvae were found in most of the suspected aquatic habitats, presenting different densities and together with larvae of the other mosquito species. Relatively high number of Anopheles spp. larvae was obtained from a puddle. Only one female mosquito of Anopheles spp. resting on the wall inside house was found around 00.55 – 01.05 AM and resulted in low mosquito density determination. Conclusion: Anopheles spp. larvae were harbouring in most of the aquatic habitats and one puddle contained moderately abundant larvae of Anopheles in Runut village, Sikka district, East Nusa Tenggara, Indonesia. Even only one Anopheles spp. mosquito was detected inside the house, residents in Runut village should regular use insecticide-treated bed nets and continuous observation of mosquito breeding places especially puddles to prevent malaria and other mosquito-borne diseases.
Biomolecular and Health Science Journal, Volume 5, pp 47-53; https://doi.org/10.20473/bhsj.v5i1.35160

Abstract:
Introduction: One liver disease caused by excessive fat in the liver, called non-alcoholic liver disease (NAFLD), commonly occurs with obesity, diabetes, and other disorders. NAFLD is also associated with hepatic insulin resistance, steatosis, non-alcoholic steatohepatitis (NASH), and cirrhosis. Sucrose consumption has increased recently, and known can promotes NAFLD and will accelerate NAFLD development. This study aimed to discuss the effect and mechanism of sucrose intake on liver disease using a systematic literature review. Methods: The author identified the articles from 6 online search engines, including PubMed, Science Direct, Sinta, Garuda, Google Scholar, and EBSCOHost. A total of 2271 retrieved articles were obtained from combined search strings in Indonesian and English from the search through online search engines. Excluded articles include title not relevant, duplicate articles, not open access, secondary study or review articles, research objective not appropriate, abstract not suitable, and the results/findings not relevant to the aims of this paper. Results: A final of twenty-three articles were retrieved using the Mendeley reference manager. Studies included were published studies, types of experimental and observational studies, and their specific findings of sucrose effects on liver disease. Results reveal that most research was primarily conducted experimentally and in case-control study types on male rats. Conclusion: The most common disease related to sucrose is NAFLD, fibrosis/cirrhosis with the indication of NASH, obesity, insulin resistance (IR), triglycerides (TG), hepatic steatosis, hepatocyte ballooning, and weight gain, which we will discuss further in this review.
, Kurnia Penta Seputra
Biomolecular and Health Science Journal, Volume 5, pp 25-28; https://doi.org/10.20473/bhsj.v5i1.32147

Abstract:
Introduction: Prostate cancer is a leading global cause of increased mortality and morbidity in men which can be complicated by castrate-resistant prostate cancer (CRPC). Pharmacological therapy by inhibiting the androgen receptor (AR) can inhibit prostate cancer progression. Tea leaves (Camellia sinensis) are believed to inhibit the prostate cancer progression but the mechanism is still unknown. Therefore, research on the mechanism by in silico study is needed with the AR as target protein. Methods: The effectivity of tea leaves’ active compound to inhibit androgen receptor was evaluated by docking server with abiraterone acetate as a control. The tea leaves' active compounds consist of catechin, epicatechin, epigallocatechin gallate, epigallocatechin, gallate epicatechin, gallocatechin gallate, and gallocatechin Results: The result showed that epicatechin, epigallocatechin, and gallocatechin have lower free binding energy (ΔG) and high amino acid residue similarity on AR compared with abiraterone acetate. But, it has lower surface interaction compared with abiraterone acetate. Conclusion: Epicatechin, epigallocatechin, and gallocatechin are predicted to have potential as alternative therapy in CRPC with AR Inhibition.
Erlyta Dian Puspitarini,
Biomolecular and Health Science Journal, Volume 5, pp 42-46; https://doi.org/10.20473/bhsj.v5i1.35279

Abstract:
Introduction: Colorectal cancer is the third most malignant and the fourth-largest cause of death in the world, one of which is caused by cachexia cancer. Sarcopenia is the main diagnostic criterion for cachexia. The inflammatory response, one of the markers of which is C-Reactive Protein (CRP), is also involved in the occurrence of sarcopenia associated with cachexia cancer. This study aimed to determine the occurrence of sarcopenia and its relationship with CRP preoperative colorectal cancer patients. Methods: This type of observational retrospective analytic study assessed sarcopenia based on the Psoas muscle index (IOP) on preoperative CT scan images and CRP levels measured by an integrated automatic tool Dimension RxL Max with Flex liquid reagent preoperative CRP range (RCRP). Results: Sarcopenia occurs in male colorectal cancer patients with a p-value of 0.0010.05 (5%). There was an increase in CRP in 62.5% of colorectal cancer patients, but the relationship between IOP values and CRP values of colorectal cancer patients was still categorized as weak with p value of -0.387 in men and -0.046 in women with α=0.05. Conclusion: There was a nonsignificant relationship between sarcopenia and CRP levels in colorectal cancer patients. Further prospective studies are required to consider the indicators of sarcopenia besides the decrease in IOP and identification of confounding factors known to be associated with CRP, muscle strength, and muscle mass.
, Rofiatun Solekha, Dwi Dianita Irawan, , Karin Alifia Rachmadani, Angella Ananda Saputra
Biomolecular and Health Science Journal, Volume 5, pp 29-32; https://doi.org/10.20473/bhsj.v5i1.31450

Abstract:
Introduction: Male infertility can be caused by many factors. One of which is environmental pollution such as lead acetate. Lead acetate exposure can increase Reactive Oxygen Species (ROS), affecting spermatozoa quality. Natural antioxidants and flavonoid on Lemongrass (C. nardus) have a great potential for protecting the male reproductive system. This study aimed to analyze the effect of giving various dosages of C. nardus extract on the sperm quality of mice. Methods: The Balb/C male mice were divided into five equal groups. The negative control group was injected with 0.01 ml Na-CMC 0.5% within 40 days, and the positive control group was injected with 0.01 ml lead acetate 7 mg/kg BW within 5 days, the treatment groups were injected by 0.01 ml lead acetate 7 mg/kg body weight within 5 days and continuously injected by 0.01 ml of C. nardus extract with various dosage 25 mg/kg BW, 50 mg/kg BW, and 100 mg/kg BW within 35 days. At the end of the experiment, mice were sacrificed, and sperm suspensions were collected from cauda epididymal to measure the morphology, concentration, and motility. Results: The results showed that giving C. nardus extract could repair morphology, concentration, and motility of spermatozoa with significantly different (p<0.05). The 25 mg/kg BW dose has a good protective effect. Conclusion: The C. nardus extract can repair the decreasing sperm quality caused by lead acetate exposure.
, Birgita Maria Ratu Rosari Bas, Robert Dwitama Adiwinoto, Libriansyah Libriansyah
Biomolecular and Health Science Journal, Volume 5, pp 67-70; https://doi.org/10.20473/bhsj.v5i1.34295

Abstract:
Hypocalcemia is a common electrolyte disorder. Acute hypocalcemia is a life-threatening condition that needs prompt evaluation and management. We present a case of a 54-year-old woman presented to emergency room with muscle spasm and involuntary movement. Upon physical examination, the patient was disoriented and the Trousseau’s sign was bilaterally positive when the cuff was inflated. Blood test revealed severe hypocalcemia with albumin-corrected serum total calcium levels 1.77 mg/dL. Following extensive diagnostic workups, there were no alternative explanations other than vitamin D deficiency. Despite aggressive intravenous (IV) calcium correction and high-dose vitamin D supplementation the calcium levels gradually decreased and neurological symptoms relapsed. The use of phenytoin to treat neurological symptoms decreased calcium levels further. The patient was eventually discharged with oral calcium and calcitriol supplementation with minimal symptoms. This case highlights the importance of thorough diagnostic workups and judicious use of anticonvulsant drugs in hypocalcemia for optimal treatment outcome.
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