Journal of Endocrinology Research

Journal Information
EISSN : 2630-5224
Published by: Bilingual Publishing Co. (10.30564)
Total articles ≅ 36
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Salma Ahi, Mohsen Adelpour, Bahareh Haghdoost, Ali Jaberi
Published: 31 July 2022
Journal of Endocrinology Research, Volume 4; https://doi.org/10.30564/jer.v4i2.4888

Abstract:
Repeated blood transfusions in thalassemia patients is followed by endocrinopathies as diabetes, hypothyroidism, hypogonadism, hypoparathyroidism, and disorders in calcium and vitamin D homeostasis. The aimof this study was to evaluate the association of beta-thalassemia patientsendocrinopathies and osteoporosis. Serum level of some factors related tothe function of gonads, thyroid, adrenal, and pancreas along with serumlevels of calcium, phosphate, albumin, vitamin D, and iron were measured.Bone marrow density was tested via dual-energy x-ray absorptiometry(DXA densitometry). In this study, 56 patients with major thalassemia wereinvestigated. Paraclinical analysis indicated osteopenia in 17 (30.4%) andosteoporosis in 39 patients (69.6%) in addition to other types of endocrinedisorders, such as hypogonadism in 29 (51.8%), hypothyroidism in 13(23.2%), hypoparathyroidism in 1 (1.8%), hypocortisolism in 2 (3.6%), anddiabetes in 9 (16.1%) patients. Endocrinopathies had no significant relationship with osteoporosis and osteopenia in men. However, hypogonadismhad a significant relationship with osteoporosis and osteopenia in womenwith thalassemia. Estradiol level was lower in women with osteoporosisin comparison with women with osteopenia. Ferritin levels had neitherassociation with osteoporosis nor with LH levels (P>0.05). Secondary hypogonadism disorders are the main causes of osteoporosis and osteopeniain female beta-thalassemia patients.
Margarida Marinho, Sílvia Rocha Rodrigues
Published: 31 July 2022
Journal of Endocrinology Research, Volume 4, pp 21-30; https://doi.org/10.30564/jer.v4i2.4943

Abstract:
Chronic stress is a consistent sense of feeling pressured and overwhelmedfor a long period of time and it has been defined as a maladaptive state thatis associated with altered hypothalamic pituitary adrenal (HPA) axis. Thehyperactivity of the HPA axis is commonly assessed by cortisol levels.Physical activity (PA) and exercise have been demonstrated to regulatecortisol patterns in different healthy study populations, but also in BCpatients and survivors. The PA and exercise are related but have distinctconcepts that are commonly misused. Nowadays, the regular practice of PAand exercise has been widely recognized as one main strategy to managechronic stress and its related markers, like cortisol, remains elusive. In thepresent review, the authors focused on the evidence of the PA and exerciseon cortisol patterns of BC patients and survivors.
Onur Oral, Pınar Tatlibal, Evangelia Stavropoulou
Published: 31 July 2022
Journal of Endocrinology Research, Volume 4; https://doi.org/10.30564/jer.v4i2.4955

Abstract:
Background: The study aims to investigate and evaluate the impactof irisin on physical activity and obesity. Materials and Methods: Inthe search for scientific literature related to this review the US NationalLibrary of Medicine (PubMed) used MEDLINE and SportDiscus dataand the terms “irisin”, “physical activity”, and “obesity”, were used. Therelevant literature has also taken its source from the research of relevantarticles from reference lists derived from data studies. Results: Irisin, anemerging myokine in the scientific community, has received high attentionas a potential contributor to obesity. This hormone is also associated withphysical activity. Conclusions: Irisin was recently identified as a myokineknown to respond to physical activity. Adequate recognition of thishormone may play an active role in the prevention and treatment of obesity.
José Filipe Melo, Gonçalo Borrecho, Noelia Martinez-Sánchez, Francisco Tortosa
Published: 4 March 2022
Journal of Endocrinology Research, Volume 4; https://doi.org/10.30564/jer.v4i2.4426

Abstract:
The anterior pituitary gland regulates growth, metabolism, and reproductionby secreting hormones. Folliculo-stellate cells (FSC) are non-endocrinecells located among hormone-producing cells in the anterior pituitaryglands, but little is known about the exact roles of those cells. Although,with their net organization, they seem to have an important role in thehormonal cells regulation and maintenance. In this work, the first ever made in this area, 33 pituitaries of three groupsof mice (18 wild type [WT], 11 genetically obese [OB] and 4 under a highfat diet [HFD]) were studied in order to determine if there was any relationbetween the number of FSC and alterations of the basal metabolism in eachgroup of mice. For that, immunohistochemical staining using the S-100protein was used and also the Image-J software, to calculate the percentageof FSC present in each sample. The authors found that, although there wasn’t any significant differencebetween WT and OB mice, the group of HFD mice tend to havesubstantially higher percentage of FSC than the mice from other groups.This might suggest some yet unknown link between diet, precisely with ahigh-fat diet, and the presentation of FSC in the anterior pituitary.
Daxu Peng, Yifan Zhang, Xiuyang Cao, Jianyi Pu
Published: 12 January 2022
Journal of Endocrinology Research, Volume 4; https://doi.org/10.30564/jer.v4i1.3293

Abstract:
Stress hyperglycemia is a strong neuroendocrine reaction in thehypothalamic pituitary adrenal cortex under severe infection, trauma, burns,hemorrhage, surgery and other harmful stimulated, resulting in increasedsecretion of counter-regulatory hormones. These hormones promotedthe production of sugar and cause glucose metabolism disorders withcytokines and insulin resistance. In this condition, the production of sugarexceeds the utilization of sugar by the tissues, which eventually leads to anincrease in blood glucose levels in plasma. In the intensive care unit, stresshyperglycemia is very common and can occur in patients with or withoutdiabetes. The incidence is as high as 96%, and it is an independent factorin the death of critically ill patients. Hyperglycemia not only prolongsthe hospitalization time, mechanical ventilation time and increased theincidence of serious infections in critically ill patients, but can also leadto the occurrence of type 2 diabetes. Therefore, it is very important tolearn the pathological mechanism of stress hyperglycemia, the harm ofhyperglycemia and blood sugar management.
Dilek Geneş, Zafer Pekkolay, Mehmet Şimşek, Hüsna Saraçoğlu, Mehmet Turgut, Alpaslan Kemal Tuzcu
Published: 12 January 2022
Journal of Endocrinology Research, Volume 4; https://doi.org/10.30564/jer.v4i1.4133

Abstract:
Objective: There are limited data in the literature regarding the potentialrelationship between thyroid cancer and ABO blood types and Rh factor.The aim of our study was to investigate whether papillary thyroid cancer(PTC) is associated with blood type.Materials and Methods: The present study included patients who presented to Dicle University Faculty of Medicine between June 2009 andDecember 2020 and were diagnosed with PTC as a result of postoperative(thyroidectomy) histopathological analysis. The control group consisted ofindividuals whose blood type was analyzed at a random blood center.Results: Of the 223 patients diagnosed with PTC, 163 (73.1%) were females and 60 (26.9%) were males. In the comparison of patients based onABO blood types and Rh factor, A Rh positive blood type was found 31%less frequently in the PTC group compared with the control group, and thusit was associated with a lower risk of PTC (OR:0.69; 95% Confidence Interval: 0.50–0.96, p=0.029).Conclusions: In our study, we found A Rh positive blood type to be significantly less frequent among patients with PTC. A Rh positive blood type canbe considered as a protective factor indicating a reduced risk of PTC.
Nino Turashvili, Lali Javashvili, Elene Giorgadze
Published: 12 January 2022
Journal of Endocrinology Research, Volume 4; https://doi.org/10.30564/jer.v4i1.4408

Abstract:
Vitamin D deficiency is a global problem, which has taken the form of apandemic. Existing data indicate that vitamin D is not only a nutrient. Ithas also a hormone-specific activity. Vitamin D is characterized by antiinflammatory and immunomodulatory properties. Chronic autoimmunethyroiditis is a disease of autoimmune genesis, in which lymphocyticinfiltration gradually destroys thyroid tissue. There are some evidencesabout vitamin D deficiency and the development of chronic autoimmunethyroiditis. The article has reviewed the current literature about the impactand the benefits of vitamin D on thyroid antibodies levels.
Kulvinder Kochar Kaur, Gautam Allahbadia, Mandeep Singh
Published: 30 July 2021
Journal of Endocrinology Research, Volume 3, pp 10-33; https://doi.org/10.30564/jer.v3i2.3520

Abstract:
Earlier we have been reviewing the etiopathogenesis (EP) of obesity, type2 Diabetes mellitus (T2DM), Metabolic Syndrome (MetS), Non Alcoholic Fatty Acid Liver Disease (NAFLD) non alcoholic steatohepapititis (NASH), along with its propagation to Hepatocellular carcinoma (HCC) in addition to their therapies exhaustively. T2DM continues to be a major health issue with reaching epidemic to pandemic proportions. Liver disease includes a spectrum of liver injury varying from isolated steatosis known as Non Alcoholic Fatty Acid Liver Disease (NAFLD) to HCC. Clinically it has been observed that the coexistence of NAFLD as well as T2DM is prevalent. T2DM aids in the biological events that results in escalation of robustness of NAFLD that constitutes the primary etiology of chronic liver diseases. In the past 2 decades the incidence of nonviral NAFLD/NASH, obtained HCC has been escalating at a fast pace. In view of no appropriate agents for therapy of NAFLD/NASH, a thiazolidenedione group of drug pioglitazone used for T2DM therapy is utilized occasionally.Thus here we conducted a systematic review utilizing search engine pubmed, google scholar; web of science; embase; Cochrane review libraryutilizingtheMeSHterms like T2DM; MetS; NAFLD; NASH; HCC;WAT; BAT; VisceralAT; Obesity; BMI; Adipocytokines; adiponectin;leptin; resistin; visfatin; irisin; Hepatokines; angiopoietin like protein 2; hepatosscin; retinol binding protein 4; treatment like pioglitazone;liraglutide; elafibranor CVC (cerviciroc); obeticholic acid; aramchol;selonosertib; simtuzumab; Oxidative stress(OS); insulin resistance (IR) from 1980’s to 2021 till date. We found a total of 1050 articles out of which we selected 236 articles for this review. No meta-analysis was done. Hence diagnosis avoidance in addition to treatment of the generation as well as propagation of NAFLD/NASH are significant areas needing tackling. Thus here we have summarized the EP of NAFLD/NASH, as well as NAFLD/NASH, obtained HCC along with the present advantageous therapies under trial,for NAFLD/NASH. Moreover how adipocyte obtained adipokines along with liver obtained hepatokines might work as both diagnostic in addition to therapeutic targets from NAFLD to HCC.
Manoj Gedam, Dipti Sarma
Published: 30 July 2021
Journal of Endocrinology Research, Volume 3, pp 34-39; https://doi.org/10.30564/jer.v3i2.3531

Abstract:
Introduction: Acromegaly is chronic progressive disease with multisystem involvement characterised by an excess secretion of growth hormone and increased circulating insulin like growth factor 1 concentration.Aims and Objectives: To assess surgical outcome of acromegaly patients at tertiary care institute using SF 36 quality of life questionnaire. SF-36 scores comprise 3 components: the physical component summary (PCS), the mental component summary (MCS) and role-social component summary (RCS).30 acromegaly patients admitted in Guwahati medical college were enrolled in study and followed up post operatively for surgical remission. All participants completed the SF-36 preoperatively, 1 year and 2 years postoperatively.Material and Method: Out of 30 patients 6 patients had surgical remission post operatively on the basis of postoperative glucose suppressed GH Level done after 12 weeks. Preoperatively subscale scores (physical functioning, role physical, general health) which were below the set standards for the normal population show significant postoperative improvements along with mental health (MH) scores. Similarly, PCS, MCS and RCS scores changed significantly after surgery. We also compared the QOL of 6 patients whose peak GH level was < 0.4 µg/L during postoperative oral glucose tolerance testing with those patients whose nadir GH level was ≥ 0.4 µg/L. There was significant difference between partial and complete remission group in subscale score role physical, social function and mental health. Similarly, PCS and RCS score significantly different in partial and complete remission group than MCS score.Conclusions: QOL is considerably reduced in patients with acromegaly compared to general population which improves significantly after surgical treatment. Patients achieving the new remission criteria had significant improvement in physical and social components than those who did not.
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