Journal of Endocrinology Research
EISSN : 2630-5224
Current Publisher: Bilingual Publishing Co. (10.30564)
Total articles ≅ 5
Articles in this journal
Journal of Endocrinology Research, Volume 1; doi:10.30564/jer.v1i1.674
Akt/mTOR/p70S6K1 signaling pathway plays an important role in the pathogenesis of cancer and diabetes. Macrophages and lymphocytes are involved in the pathogenesis of diabetes, diabetic atherosclerosis, formation of insulin resistance as well as immune response to cancer and tumor maintenance. The aim of the study was to determine the Akt activation by mTORC2 in peripheral blood mononuclear cell (PBMC) of patients with type 2 diabetes and cancer.The following groups were studied: control group, patients with type 2 diabetes, cancer patients and patients with both cancer and diabetes. The amounts of phospho-Akt (р-S473) and phospho-p70S6K1 (p-T389) were determined using ELISA kits.The amount of phosphorylated Akt significantly increases in PBMC of patients with cancer. There was no effect in PBMC from patients with type 2 diabetes and significant decrease in the amount of phospho-Akt in PBMC of the patients group both with cancer and diabetes. p70S6K1 activation was observed in PBMC of the groups 2 and 3 patients.Thus, chronic diseases such as type 2 diabetes and cancer can affect the signaling mechanisms in blood cells. The state of Akt phosphorylation in leukocytes can indicate the activity of mTORC1 and its substrates, which may be important for the evaluation of the pathological process and the efficacy of the drugs.
Journal of Endocrinology Research, Volume 1; doi:10.30564/jer.v1i1.671
Objective: To evaluate the effectiveness of Internet and telephone-based telemedicine system managing on patients’ glycemic index, blood pressure, and lipid level control in underserved subjects with type 2 diabetes in Western China. Research designs and methods: In a 3 years, randomized, controlled, single-blind, parallel-group treat-to-target study, 412 subjects with type 2 diabetes were randomized to telemedicine (Tel; n =208) group and usual care (control; n =204) group. We evaluated the effects of the intervention on blood sugar, blood pressure, and lipid levels at 1, 2, 3 years point, and investigated the cause of the loss during follow-up by phone call.Results: Intra-group comparison: in the Tel group, the FBS, 2HPG, HbA1c, and SBP at 1, 2, 3 years and DBP, TC, TG, BMI at 2, 3 years were significantly decreased compared with baseline level (P
Journal of Endocrinology Research, Volume 1; doi:10.30564/jer.v1i1.694
Objectives: To explore the clinical value of applying diabetes health education to endocrinology care. Methods: A total of 122 patients with diabetes admitted to our department from October 2016 to October 2017 were selected. After consulting patients, they were randomly divided into two groups, with 61 cases in each group. The control group performs routine care, and the experimental group provides patients with diabetes-specific health education. After three months, the compliance of the two groups of patients was compared. The ADL scores of the two groups of patients before and after treatment were compared. Results: Experimental group had significantly higher compliance rate than control group in all aspects. The difference was statistically significant (P
Journal of Endocrinology Research, Volume 1; doi:10.30564/jer.v1i1.570
Nowadays, is well established that the benefits induced by exercise training (ET) affects not only skeletal muscle, but also other non-contractile organs over time. One potential mechanism underlying this crosstalk is the synthesis and secretion of several biological active factors, such as irisin, by muscle contractile activity. This hormone has been described to be able to induce a brown adipocyte-like phenotype in white adipose (WAT), increase whole-body metabolic rate, and therefore prevent and/or treat obesity-related metabolic diseases. Thus, the modulatory impact of ET on WAT may also occur through skeletal muscle - adipose organ axis. In this review, we summarize the acute and chronic adaptations to ET-induced irisin synthesis and secretion on the development of browning of white fat and, thus, providing an overview of the potential preventive and therapeutic role of ET on the obesity-related underlying pathways.
Journal of Endocrinology Research, Volume 1; doi:10.30564/jer.v1i1.729
Objective: To analyze the clinical characters of 812 inpatients with infection in the Department of Endocrinology. Methods: Retrospective exhibition of these patients' clinical characters included undergoing diseases, infectious organs, history illness, blood glucose and glycosylated hemoglobin (HbA1C), biochemical indicators, pathogens training description and results, medical imagines, antibiotic utilization, length of stay and hospital costs, final diagnosis and situations. Results: Non-diabetic patients accounted for 176 (21.67%), who were the cases of untreated well hyperthyroidism, mainly suffered with respiratory tract infection. Diabetic patients accounted for 636 (78.33%). In the type2 diabetes patients 376 (59.12) suffered with urinary tract infection. 192 (30.19%) suffered with respiratory system infection, 124 (19.50%) were accompanied with diabetic foot infection, which had 74 (59.67%) patients with HbA1C＞9.0%.Statistical comparisons showed that the days of antibiotic use and average length of stay in hospital per capita in patients with HbA1C≥8% were more than ones with HbA1C＜8% in those with diabetic infections (P＜0.01) . The days of antibiotic use per capita in patients with HbA1C＞9% were more than ones with HbA1C＜7% in those with diabetic foot infections (P＜0.01). Conclusion: Endocrine diseases lack rigid and effective long-term control, which may result in the complications involved with urinary tract, respiratory tract and infections in other organs. The time of hospitalization per capita and the duration of antibiotic use rise are longer in diabetic patients with poor blood sugar control and diabetic foot infection.