Journal of Oncology Research
EISSN : 2630-5267
Current Publisher: Bilingual Publishing Co. (10.30564)
Total articles ≅ 31
Latest articles in this journal
Journal of Oncology Research, Volume 3; doi:10.30564/jor.v3i1.2830
Mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney is an uncommon recently recognized renal cell carcinoma. We reported A 60 year's old man who presented with right flank pain, abdominal swelling and one attack of hematuria. The intraoperative finding was a huge cystic swelling arising from the right kidney occupying almost all the abdominal cavity displacing the bowel to the left side of the abdomen. There was no ascites or evidences of metastasis. Right radical nephrectomy was done . Then the diagnosis of renal MTSCC was established. General condition of the patient was improved and one year prognosis was satisfactory. This is the first reported case of MTSCC in Sudan, and the outcome of treatment was satisfactory .
Journal of Oncology Research, Volume 3; doi:10.30564/jor.v3i1.2742
It was previously found that the electric charge of water determines its ability to interact with other substances, including biologically significant ones. It is shown here that the electric charge of water can also determine its ability to penetrate and accumulate in living cells. In particular, it has been shown that the high penetrating ability of positively charged water determines both its active penetration into cells and accumulation in them, which creates favourable conditions for cell proliferation. At the same time, it has been shown that the low penetrating ability of negatively charged water determines its ability to slow down cell proliferation. It also discusses how medics can obtain and use water at different charges.
Journal of Oncology Research, Volume 3; doi:10.30564/jor.v3i1.2705
5% of all ovarian tumours are accounted to germ cell tumours (GCT’s). Affecting mostly young women, the highest incidence is seen in second and third decade of life. They are highly malignant but chemosensitive and more curable than their epithelial counterparts. Treating these tumors with effective surgery and combination chemotherapy survival rates have dramatically improved in recent decades. We present our experience of ovarian germ cell tumours in theDepartment of Surgical Oncology, Rajendra Institute of Medical Sciences (RIMS), Ranchi with special emphasis on treatment outcomes. A retrospective review of hospital medical records of patients with ovarian germ cell tumours diagnosed and treated at RIMS from June 2019 to August 2020, was performed. Clinical profile and treatment outcome of patients were recorded. A total of 19 patients met criteria. The median age at diagnosis was 20 years (range 11–42 years) and all had good performance status. All except two patients underwent surgery, 70.6% and 29.4% in upfront and interval debulking surgery (IDS) setting respectively. Fertility preserving surgery was done in 75% patients in the primary surgery group and 60% undergoing IDS. 83.3% patients received BEP as adjuvant chemotherapy whereas 80% as neo-adjuvant chemotherapy. Majority (31.5%) patients had dysgerminoma as final histology, followed by mixed histology(26.3%), yolk sac tumour (15.7%), immature teratoma (15.7%) and choriocarcinoma (10.5%) 47.3% patients were in Stage I at the time of diagnosis. 78.9% patients were alive without disease, 10.5% recurred, and 10.5% were lost to follow up.
Journal of Oncology Research, Volume 3; doi:10.30564/jor.v3i1.2756
Aim: Evaluation of the antitumor activity of the new drug Dekoglitz in animals with tumor strains of Sarcoma 45 in comparison with the drug dekocin, from which it was obtained, as well as with 5-fluorouracil and etoposide, and on ovarian tumors (OT) in comparison with the drug dekocin and identification of the effect of Dekoglitz on NA synthesis and internucleosomal DNA degradation. Methods: The study of preparations was carried out on 68 outbred rats with transplanted C-45 and OT tumors. The alkylating effect of the drugs was studied on cells tumor of Sarcoma 180. Results: The antitumor activity of dekoglitz on Sarcoma 45 was high, about 98/96%, with a remission rate of 80%. Its effect was 28-24% higher than that of dekocin. On OT, the effect of decoglitz with intraperitoneal administration reached 89/76% with a remission rate of 40%, with oral administration 96/86% with a remission rate of 60%. Conclusion: The study of the new drug Dekoglitz on animals with a tumor of Sarcoma 45 revealed its higher activity (by 20-27%) in comparison with the original Dekocin, 5-fluorouracil and etoposide with a lower level of side effects. On OT, the effect of Dekoglitz was 35-40% higher, especially after oral administration. Apparently, the great ability to suppress the synthesis of NA and carry out internucleosomal degradation and fragmentation of tumor DNA by the new drugs dekoglitz explains its antitumor efficacy, which is greater than that of Dekocin (K-18) in experiments on tumors.
Journal of Oncology Research, Volume 3; doi:10.30564/jor.v3i1.2851
In the process of biological genetic information transmission, complete and correct genetic information can make cell mitosis proceed normally. In the development of most tumor cells, G2/M cell cycle checkpoint becomes the key checkpoint in the process of mitosis due to the lack of G1/S cell cycle checkpoint, which mainly depends on the abnormal DNA information blocked by Wee1 protein kinase in G2 phase to enter M phase and prolong the time of G2 phase to complete DNA sequencing So that the normal genetic information can be passed on. Wee1 protein kinase expression is significantly increased in most tumor cells, making it a potential target for tumor therapy.
Journal of Oncology Research, Volume 2; doi:10.30564/jor.v2i2.2472
As a traditional Chinese herb, dandelion, containing complicated active ingredients which includes polysaccharide, flavonoid, terpene, pigment, phytosterol, coumarin, organic acid and etc, plays significant roles in various physiological activities in organisms. The active ingredients generally interfere in signal transduction of cancer cells, regulate cell cycle and apoptotic protein expression, inhibits proliferation and migration of cancer cells and etc, to effectively restrain tumor development and deterioration. This article summarizes the anti-tumor mechanism of five active ingredients in dandelion through paper reading which provides thoughts and references for anti-tumor research.
Journal of Oncology Research, Volume 2; doi:10.30564/jor.v2i2.2429
Targeted immune checkpoint-based immunotherapy has achieved remarkable success in the treatment of malignant tumors. Immune checkpoint inhibitor-programmed cell death protein 1 (PD-1) antibody opens a new era of immunotherapy for platinum-refractory recurrent/metastatic oral squamous cell carcinoma (OSCC). The overall survival of patients treated with immunological checkpoint inhibitors was significantly prolonged, and the overall incidence of grade 3-4 drug-related adverse events (AEs) occurred was lower. This article briefly describes the development of PD-1 inhibitors in the treatment of OSCC. The purpose of this review is to briefly highlight the clinical development of PD-1 inhibitors in OSCC therapy to date.
Journal of Oncology Research, Volume 2; doi:10.30564/jor.v2i2.2473
Objective: To summarize the nursing experience of a patient with postoperative intrathoracic hemorrhage after thoracoscopic-assisted resection of the right upper mediastinal tumor through the original incision. Methods: Summarize the main points of nursing care of postoperative intrathoracic hemorrhage after thoracoscopic mediastinal surgery, including observation and nursing when internal hemorrhage occurs after operation, respiratory management, activity management and pain management measures. Result: After careful care, the patient recovered and discharged smoothly. Conclusion: It is particularly important to observe the overall observation and take timely corresponding nursing measures for patients with intrathoracic hemorrhage after thoracoscopic mediastinal surgery.
Journal of Oncology Research, Volume 2; doi:10.30564/jor.v2i2.2480
Objective: Objective To explore the first aid and nursing of patients with anastomotic fistula after radical resection of esophagus carcinoma complicated with major carotid hemorrhage.Methods: The clinical data of anastomotic fistula complicated with carotid artery rupture and massive hemorrhage after radical resection of typical esophageal carcinoma were analyzed and summarized.Results:Through the close cooperation of medical care, the rescue was successful.Conclusion:Earlier prevention observation, raising first aid consciousness and actively cooperating with doctors can improve the success rate of rescue.
Journal of Oncology Research, Volume 2; doi:10.30564/jor.v2i2.2272
Aim: As more and more centers has published their treatment results of pseudomyxoma peritonei (PMP) with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), the data from China is missing. Myxoma Department of Aerospace Hospital is the biggest center treating PMP in China. The purpose of this study is to report the early and long-term outcomes for PMP from this single center.Methods: 801 appendix-derived PMP out of 1008 consecutive patients treated in Myxoma Department of Aerospace Hospital between 2008 and 2019 were retrospectively analyzed.Results: Complete cytoreductive surgery (CCRS) was achieved in 240 (30%) patients with median PCI of 14(1~39), and the rest had maximal tumor debulking (MTD), HIPEC was implemented in 96.3% of CCRS and 78.6% of MTD. The major morbidity (grade III/IV) was 11.4% and the 30-day operative mortality is 0.7%. The 5- and 10-year OS of CCRS was 76.9% and 64.1%, which is significantly higher than MTD (5-, 10-year OS as 36.1%, 27.1%; p20, MTD, high pathologic grade and without HIPEC were independent factors predicting poorer prognosis.Conclusions: CCRS +HIPEC can benefit PMP well with controllable risks. MTD+HIPEC may benefit PMP as well when CCRS cannot be achieved after fully asscessment by an experienced peritoneal maglignacy center, but the surgery should be performed as limited as possible.