Jurnal Respirasi

Journal Information
ISSN / EISSN : 2407-0831 / 2621-8372
Published by: Universitas Airlangga (10.20473)
Total articles ≅ 123
Filter:

Latest articles in this journal

Edward Pandu Wiriansya, , Andi Tiara Salengke Adam
Published: 30 January 2022
Jurnal Respirasi, Volume 8, pp 39-43; https://doi.org/10.20473/jr.v8-i.1.2022.39-43

Abstract:
Introduction: Tuberculous lymphadenitis (TBLN) is a form of extra-pulmonary TB with clinical features ranging from lumps to abscesses. Human Immunodeficiency Virus (HIV) co-infection and diabetes mellitus alongside TBLN made the diagnosis and management exceptionally challenging. We reported 3 cases of TBLN, 2 among them had an existing HIV co-infection, and 1 had preexisting diabetes mellitus. Case: The first case, a 28-year-old man, previously diagnosed with HIV, complained of a lump in the neck; biopsy results suggested TBLN. The second case was a 36-year-old man with a neck abscess and HIV co-infection. Acid Fast Bacilli (AFB) pus was positive & Human Immunodeficiency Virus Enzyme-Linked Immunosorbent Assay (HIV ELISA) was reactive. The third case was a patient with a neck abscess with preexisting diabetes mellitus (DM) underwent wound debridement and was given anti-tuberculosis drugs. Conclusion: TBLN with HIV co-infection or diabetes had clinical features ranging from a painful lump to an abscess. The definitive diagnosis was taken by examining AFB from pus. If the abscess was more extensive than or equal to 3 cm, wound debridement was necessary. The primary treatment for TBLN was anti-tuberculosis drugs and required even greater attention if a patient had any preexisting comorbidities such as HIV and diabetes.
Gracia Dewitacita Tanaya, Ayu Hutami Syarif
Published: 30 January 2022
Jurnal Respirasi, Volume 8, pp 60-68; https://doi.org/10.20473/jr.v8-i.1.2022.60-68

Abstract:
Coronavirus Disease 2019 (COVID-19) happened due to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. It is the third coronavirus causing a pandemic. Cases of COVID-19 have increased rapidly. Epidemiological studies show droplets as a medium of transmission of this virus. The high rate of transmission and the death rate create urgency on the management of COVID-19. Unfortunately, until now there is no definitive therapy for the SARS-CoV-2 virus. Several potential therapies, including antivirals, immunomodulatory agents, convalescent plasma transfusions, and supportive therapies such as vitamin D supplementation, have been applied in the management of COVID-19. As a hormone, vitamin D has an immunomodulatory effect used in supportive therapy for various immune-related diseases and respiratory system infections. The immunomodulatory effects of vitamin D are strengthening the physical barrier (cell junction), the specific immune system (adaptive immunity), and the non-specific immune system (innate immunity). Vitamin D is known to suppress pro-inflammatory cytokines and increase the production of anti-inflammatory cytokines. In addition, vitamin D also performs as a substantial part in the induction of ACE2 receptors which gives a weighty influence on pathogenesis of COVID-19. Vitamin D deficiency can amplify the risk of infections including COVID-19. Presently, clinical trials of vitamin D supplementation and COVID-19 are limited. This literature review further examined the role of vitamin D supplementation in COVID-19.
Hasanudin Hasanudin, , , , Natalia Christin Tiara Revita, Handira Nadhifatul Aini
Published: 30 January 2022
Jurnal Respirasi, Volume 8, pp 15-25; https://doi.org/10.20473/jr.v8-i.1.2022.15-25

Abstract:
Introduction: Corona Virus Infection Disease (COVID-19) refers to the infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Most of COVID-19 survivors have residual symptoms after being discharged from the hospital, it then leads to the decreased lung function and quality of life (QoL). Pulmonary rehabilitation is essential because it can reduce the impact of these sequelae. This study aimed to determine the effectiveness of pulmonary rehabilitation in improving lung function among adult patients of COVID-19 survivors. Methods: This study was conducted using 5 databases, namely: CINAHL, PubMed, SAGE, Science Direct, and Scopus from 1 April 2020 to 30 September 2021. The combination of keywords used was: "Pulmonary Rehabilitation", “Pulmonary Function", and "Post-COVID-19". In assessing the bias and methodological quality of the articles obtained, this study used the Joanna Briggs Institute (JBI) critical appraisal checklist tools. Results: From 678 articles, 11 research articles met the criteria. Pulmonary rehabilitation performed in post-COVID-19 patients included the provision of aerobic exercise, breathing exercises, strength training, balance exercises, relaxation, occupational therapy, psychological support, and nutrition consultation. Lung rehabilitation mainly was performed two sessions a week for 3-8 weeks with different proportions for each patient according to clinical conditions and ability limits. Spirometry and the 6-minute walk test (6MWT) revealed that patients who completed the pulmonary rehabilitation program experienced improvements in their lung function. Conclusion: Comprehensive pulmonary rehabilitation programs under supervision and psychotherapists are the right choice in improving lung function among COVID-19 survivor adult patients.
Sharifa Audi Salsabila, , , Ika Nindya Kadariswantiningsih, , Mutiara Rizki Haryati, , Yusuke Suzuki
Published: 30 January 2022
Jurnal Respirasi, Volume 8, pp 44-51; https://doi.org/10.20473/jr.v8-i.1.2022.44-51

Abstract:
Lungs and kidneys are distant organs which are functionally related in physiological and pathological contexts. Acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) are common complications in acute kidney injury (AKI) or acute-on-chronic kidney disease. On the other hand, there is a considerable risk of AKI in respiratory diseases such as ARDS and chronic obstructive pulmonary disease (COPD). From a pathophysiological point of view, the kidney-lung crosstalk involves interdependency in the regulation of fluid hemodynamic, acid-base and electrolyte balance, and carbon dioxide partial pressure. Aside from the closely related function, the crosstalk may also occur by non-classical mechanisms such as through activation of systemic inflammation, excessive cytokine release, and the formation of auto-antibody which targets both kidneys and lungs. This review discussed several disease mechanisms by which kidney and lungs affect each other or are simultaneously affected by pathological processes. Particularly, this review discussed some specific mechanisms in lungs and kidneys, such as how hypoxemia and hypercapnia induced by ARDS may reduce kidney function and how distance injury on kidney may affect the development of non-cardiogenic edema lungs.
, Tiar Oktavian Effendi
Published: 30 January 2022
Jurnal Respirasi, Volume 8, pp 52-59; https://doi.org/10.20473/jr.v8-i.1.2022.52-59

Abstract:
Chronic lung diseases, such as asthma and chronic obstructive pulmonary disease (COPD), are often found with gastrointestinal symptoms or even gastrointestinal diseases as one of its comorbid. Vice versa, many cases of gastrointestinal diseases such as gastroesophageal reflux disease (GERD) have developed respiratory dysfunction later. The connection between these two systems has become interesting lately and has led to several studies to prove the association. Several theories have emerged to explain this association. This includes changes in microbiota, the mucosa-related immune system of both systems, side effects of the therapeutic given, and pathomechanism related to gastrointestinal diseases such as GERD. Many studies try to prove the connection between the microbiota in the respiratory and gastrointestinal system, and changing the abundance in one of the systems can affect another. Both of the systems also have a similar mucosal membrane in their lining. Those membranes have an immune defence called Mucosal-Associated Lymphoid Tissue (MALT). Lymphatic and circulatory systems facilitate the migration between two mucosal, and these interconnections influence each other. Although the side effect of the therapeutic agent in respiratory diseases (such as inhaled corticosteroid, beta-2 agonist, or anti-cholinergic) is thought to be one of the causative mechanisms, discontinuation of therapy is the second option. Probiotic supplementation to improve microbiota is still not a strong recommendation for management.
Andry Wahyudi Agus, Adrianison Adrianison, Dyah Siswanty, Faisal Yunus, Zahtamal Zahtamal
Published: 30 January 2022
Jurnal Respirasi, Volume 8, pp 7-14; https://doi.org/10.20473/jr.v8-i.1.2022.7-14

Abstract:
Introduction: Chronic obstructive pulmonary disease (COPD) is often associated with cardiovascular disease because it has the same risk factors as smoking. One of the cardiovascular complications in COPD is heart failure. Echocardiography examination is a tool to evaluate changes of the heart both anatomically and functionally. This study aimed to determine the relationship between COPD and heart failure by echocardiography examination in stable COPD patients. Methods: This was a descriptive-analytic study using a cross-sectional design for COPD patients who visited the Lung Polyclinic of Arifin Achmad Hospital, Pekanbaru, Riau, which was conducted from November 2020 to March 2021. Subjects who met the inclusion criteria were examined by spirometry, chest X-rays, and echocardiography. Results: In this study, there were 66 stable COPD subjects. It was found that 15.2% of subjects had right heart failure based on the tricuspid annular plain systolic excursion (TAPSE) assessment and 7.6% of the subjects had left heart failure based on the left ventricular ejection fraction (LVEF) value. Right ventricular dilatation (p = 0.000), right ventricular dysfunction (p = 0.005), and increased probability of pulmonary hypertension (PH) (p = 0.000) were significantly associated with a decrease in the first second forced expiratory volume (FEV1). Conclusion: The severity of COPD with FEV1 <50% had a significant relationship with dilatation, dysfunction of right ventricular, and increased the probability of incidence of PH based on parameters tricuspid regurgitation (TR). A history of exacerbations ≥2 times in a year caused right ventricular dilatation, decreased right ventricular function, and increased the probability of PH.
Yulia Devina Suci Kusumastrini,
Published: 30 January 2022
Jurnal Respirasi, Volume 8, pp 33-38; https://doi.org/10.20473/jr.v8-i.1.2022.33-38

Abstract:
Introduction: Hemoptysis is an emergency condition with high morbidity and mortality which requires immediate treatment. Active tuberculosis (TB) and post-tubercular sequelae can result in hemoptysis with the most common source is from bronchial artery. Case: We reported a 22-year-old man who presented with shortness of breath and recurrent hemoptysis. A chest X-Ray showed total atelectasis right lung due to obstructive airway. After aspiration clotting blood in bronchus and instillation adrenalin with fiber optic bronchoscopy, the atelectasis totally disappeared. Computed tomography angiography (CTA) showed prominent vascular lesions from the apical right pulmonary artery, right brachialis artery, and branch of the posterior intercostal artery. The patient was referred to the interventional unit of the radiology department in Dr. Soetomo General Hospital and underwent bronchial artery embolization. After this procedure, his symptoms resolved completely and he was discharged after a week with 2nd category anti-tuberculosis drugs (ATD). 6 months of follow-up, he no longer experienced hemoptysis. Conclusion: Recurrent hemoptysis needs optimal management, including diagnostic with chest radiography, CT and bronchoscopy. Treatment with bronchoscopy and bronchial artery embolization will reduce mortality and morbidity in patients with hemoptysis.
Ayurveda Zaynabila Heriqbaldi, Rebekah Juniati Setiabudi, Resti Yudhawati Meliana
Published: 30 January 2022
Jurnal Respirasi, Volume 8, pp 1-6; https://doi.org/10.20473/jr.v8-i.1.2022.1-6

Abstract:
Introduction: Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis and usually attacks the lungs. Indonesia is in the third rank of TB cases in the world. An important concern regarding TB currently is the case of anti-TB drug resistance, hence research on resistance patterns and risk factors is essential. This study aimed to identify the pattern of first-line anti-TB drug resistance at Dr. Soetomo General Hospital, Surabaya. Methods: A descriptive retrospective study was conducted at Dr. Soetomo General Hospital, Surabaya for the period of 2017-2019. The samples were obtained through total population sampling of 239 pulmonary TB patients with first-line anti-TB drug resistance which were registered at MDR-TB Polyclinic Dr. Soetomo General Hospital, Surabaya. Only complete medical records were included. The variables were first-line anti-TB drug resistance (isoniazid, rifampicin, ethambutol, streptomycin) and patients’ characteristics (age, gender, treatment history, and comorbidities). The drug resistance test was performed using certified culture methods. Results: Among 239 patients, the incidences of resistance to H, R, E, and S were 79.08%, 94.14%, 25.94%, and 20.08%, respectively. The most common patterns were HR (42.26%), R (18.83%), and HRE (12.55%). The largest age group was 45-54 years old (38%). The dominant gender was male (56.49%). The most treatment history category was relapsed patients (48%) and there were more patients with comorbidity (57%). Conclusion: The highest incidence rate of resistance was rifampicin and the most common resistance pattern was HR. Most of the patients were of working age, male, relapse patients, and had comorbidities. An appropriate TB therapy treatment plays an important role in preventing resistance.
Ni Wayan Candrawati, Venny Singgih, , Ida Bagus Ngurah Rai
Published: 30 January 2022
Jurnal Respirasi, Volume 8, pp 26-32; https://doi.org/10.20473/jr.v8-i.1.2022.26-32

Abstract:
Introduction: Pin point trachea is a rare case. It is caused by tuberculosis (TB) and trauma due to intubation procedure. Main complication of this abnormality is respiratory failure. It can be diagnosed through bronchoscopy. Managements of this abnormality are interventional bronchoscopy and treating the etiology. Surgery is considered if interventional bronchoscopy failed or cannot be performed. Case: A 29-year-old woman came to the emergency room complaining shortness of breath and hoarseness since two months before hospitalized. The patient also experienced cough, decreased body weight and appetite since 7 months earlier. The patient was diagnosed with bacteriologically confirmed TB and anti-TB drug was given. Cough symptom was decreasing but shortness of breath and hoarseness remained after treatment. Physical examination showed decreased vesicular sound and stridor. Bronchoscopy revealed narrow tracheal lumen (pin point) with fibrosis. Thoracic computed tomography (CT) scan showed severe narrowing of tracheal lumen at thoracic vertebrae 1-2. Surgery was performed to cut the fibrotic tissue and tracheostomy was placed at stenosis area. Conclusion: Pin point trachea is a rare case. One of the causes is tracheobronchial TB. The main managements are optimal administration of anti-TB drugs and interventional bronchoscopy or surgery.
Isa Ansori, Soraya Riefani, Ira Nurrasyidah
Published: 30 September 2021
Jurnal Respirasi, Volume 7, pp 100-105; https://doi.org/10.20473/jr.v7-i.3.2021.100-105

Abstract:
Introduction: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the cause of clinical disease, better known as COVID-19. The most common method to detect COVID-19 is serological testing of IgM and IgG in response to viral infections using rapid diagnostic test (RDT). Several other guidelines consider polymerase chain reaction (PCR) as the gold standard for diagnosis becausePCR has high sensitivity and specificity values in detecting SARS-CoV-2.Methods: This was a descriptive analytical study. The samples were taken from medical records of COVID-19 patients in Ulin General Hospital Banjarmasin from March to October 2020. Statistical Package for the Social Sciences (SPSS) 16.0 software and Chi-Square test were used for data analysis.Results: From 751 COVID-19 patients, 408 patients (54.32%) had rapid antibody with positive PCR, 132 patients (17.57%) had reactive rapid antibody with negative PCR, 152 patients (20.23%) had non-reactive rapid antibody with positive PCR, and 59 patients (7.85%) had non-reactive rapid antibody with negative PCR. The rapid antibody had sensitivity of 72.85% and specificity of 30.89%. From Chi-Square test, reactive rapid antibody was not correlated with PCR positive results; values of p = 0.320, odds ratio (OR) 1.20.Conclusion: The rapid test antibody could not be recommended as a diagnostic tool. In this study, it was also found that there was no relationship between reactive rapid test results and positive SARS-CoV PCR.
Back to Top Top