International Journal of Medical Laboratory Research

Journal Information
EISSN : 2456-4400
Total articles ≅ 85

Latest articles in this journal

Nidha Gaffoor, Archana Shetty, Nirupama M, Supriya Tr
International Journal of Medical Laboratory Research, Volume 07, pp 49-52;

Lesions of the mesentery encompass a wide variety of neoplastic and non-neoplastic entities. Being a metabolically active tissue, it is often subject to trauma and ischemia, which in turn can give rise to encapsulated masses. Encapsulated fat necrosis is one such nodular lesion which is often encountered by radiologists. It presents clinically with nonspecific abdominal symptoms, and many a times is discovered incidentally when imaging is done for other obvious pathologies. Though the lesion is known to shrink over time, surgical resection is often done to rule out other mimics, liposarcoma being the closest. Encapsulated mesenteric fat necrosis is a rare lesion and more so uncommonly found in association with pregnancy. Vascular hypoperfusion can be one of the hypotheses, although fetal role cannot be ruled out, especially in obese gravid females. We wish to document one such lesion detected intraoperatively, picked up incidentally suspecting to be a mesenteric cyst in a gravid obese female without history of trauma or predisposing factors, who underwent caesarian section at an institute in rural set up. The case also describes histopathological features of this interesting lesion for the pathologists.
Z Et-Tahouri, J Oussaga, A Belmekki, H EL Yahyaoui, Ma Ameur, M Chakour
International Journal of Medical Laboratory Research, Volume 07, pp 44-48;

Macrophage activation syndrome (MAS) belongs to the hemophagocytic lymphohistiocytosis group of diseases. It is an anatomo-clinical condition resulting from the inappropriate proliferation and activation of macrophagic cells. This rare but potentially fatal syndrome can be primary or secondary to certain pathologies dominated by infections and neoplasia. In adults, MAS is rarely associated with systemic lupus erythematosus, but it arises as a complication of several systemic autoimmune diseases. Here we report the case of 30-year-old woman who presented with a pruritic rush. She met the Systemic Lupus International Collaborating Clinics (CLICC) criteria for the diagnosis of Systemic Lupus Erythematosus (SLE). The bone marrow showed the presence of abundant hemosiderophages with focal hemophagocytosis. Due to the overlap in clinical findings, SLE-associated MAS might be underdiagnosed. This case represents the importance of prompt diagnosis and treatment of such a potentially fatal clinical syndrome.
S Rukwal, H Kaur, P Kaur, M Shrivastava
International Journal of Medical Laboratory Research, Volume 07, pp 11-19;

BACKGROUND AND OBJECTIVES: Elevated Troponin-I levels either due to direct or indirect cardiac injury can present as asymptomatic to fulminant myocarditis and circulatory shock in COVID-19 patients. Our objective is to evaluate the Troponin-I levels in covid patients. AIM: To evaluate the possible myocardial involvement in covid-19 patients with the help of Troponin-I levels as an indicator of cardiac injury and its prognostic implication and significance as it is associated with increased mortality in patients with COVID-19. METHORDS: This was a both a prospective and retrospective cohort study done from 1st January 2021 to 1st July 2021. A total of 240 admitted patients were included and whose Troponin-I levels were evaluated and in a comparative analysis was performed for the demography, clinical features, biochemical markers and their outcome with their Troponin-I levels. RESULTS: Out of 250 covid-19 positive hospitalized patients, 15patients have elevated Troponin-I levels. Among these 15 patients 60% had preexisting co morbidities like hypertension, diabetes and history of cardiac disease. Patients with elevated troponin level had mean age of 61.1years, length of stay was >14 days in 60% patients. In 46% patients Troponin-I levels were more than 200ng/L. These patients had a higher need for intensive care with mortality of 73%. CONCLUSION: Etiology of myocardial involvement is multifactorial. Our study also concluded that elevated troponin levels in patients with covid19 have high morality. Therefore, the measurement of cardiac biomarkers, including Troponin-I and brain natriuretic peptide (BNP), should be performed on admission.
Cagla Ayabaktı, Ozkan Aslantas, Mucella Bayırlı, Burcin Ozer
International Journal of Medical Laboratory Research, Volume 07, pp 01-10;

Aim: This study aimed to determine the antibiotic susceptibility of Staphylococcus aureus isolated from different clinical materials sent to the Microbiology Laboratory of Hatay Mustafa Kemal University Hospital, to investigate the mechanisms mediating antibiotic and antiseptic resistance, to determine the SCCmec type of methicillin-resistant isolates. Materials and Method: Overall, 187 S. aureus were included in the study. Antibiotic susceptibilities of the isolates were performed by the disc diffusion method and evaluated according to the European Committee on Antimicrobial Susceptibility Testing (EUCAST) criteria. Antibiotic resistance, antiseptic resistance, and Staphylococcal Cassette Chromosome mec (SCCmec) types in MRSA strains were investigated using polymerase chain reaction (PCR). Results: While all of the isolates were found to be susceptible to linezolid and vancomycin; various rates of resistance for penicillin (87.1%), cefoxitin (49.93%), erythromycin (19.79%), ciprofloxacin (13.37%), tetracycline (11.23%), clindamycin (10.16%), trimethoprim-sulfamethoxazole (8.02%), gentamicin (17.82%), fusidic acid (64.2%) and rifampin (1.07%) were determined. A statistically significant difference was found between MRSA and MSSA strains in terms of MDR phenotype rates (p=0.001). Among S. aureus isolates, single resistance genes or various combinations of resistance genes were detected. SCCmec type III (52.4%) was the most common SCCmec type. Conclusions: The results of this study indicated that current control strategies should be revised to minimize antibiotic resistance and periodic surveillance studies must be carried out.
Geet Bhuyan, Abir Kumar Baruah, Projnan Saikia
International Journal of Medical Laboratory Research, Volume 07, pp 40-43;

INTRODUCTION-Allergic fungal sinusitis (AFS) is a condition commonly occurring in immunocompromised individual. It is commonly characterized by increase eosinophils and increased IgE. CASE DETAILS- A 48-year-old female presented with foul smelling discharge from right nostril and right nasal blockage for one year. A clinical diagnosis of right maxillary sinus polyp was given. CT scan revealed mucosal thickening in right maxillary wall with central area of hyper density and calcification. Nasal swabs were taken and subsequently stained with Pap and MGG stain. Smears revealed fungal hyphae and a provisional diagnosis of allergic fungal sinusitis was given. The patient was operated and the diagnosis was confirmed on histology. DISCUSSION- AFS is a relatively incompletely understood entity with characteristic clinical, radiological and histopathological finding. Fungal elements can be detected from nasal discharge by means of cytology. CONCLUSION- Nasal secretion cytology can be used as a preoperative as well as an intraoperative tool for or early rapid diagnosis of AFS.
Oo Odewusi, Mj Abdulmumin, Oo Olaniyan
International Journal of Medical Laboratory Research, Volume 07, pp 53-61;

Objectives: The goal of this study is to estimate autoimmune biomarkers that characterize the development and severity of arthritis, but probably normalize following successful therapy. Materials and methods: In this study a total of 109 subjects were used out of which treated and untreated arthritics were 48 and 44 respectively, the remaining 17 were healthy individuals which were used as control. Samples were collected from patients attending Rheumatology and Orthopedic clinic of Federal Teaching Hospital Ido-ekiti, Ekiti State Nigeria. Antinuclear antibody was estimated using Enzyme Linked Immunosorbent Assay (ELISA) while Lupus Erythematosus cells were ascertained microscopically using Leishman staining technique. All parameters were assessed in treated and untreated arthritic patients relative to healthy subjects. Body mass index was also calculated. Statistical analysis was done using SPSS. Results: Body mass index and Antinuclear antibodies were significantly higher in treated and untreated arthritics compared to control (P<0.05). When treated and untreated arthritics were compared, Body mass index and Antinuclear antibody were found to be significantly higher in untreated arthritics (P<0.05). Antinuclear antibody and Age correlated directly in untreated arthritics. Lupus Erythematosus cell prevalence was found to be higher in untreated arthritics having a percentage Lupus Erythematosus test positivity of 6.8% compared to the 2.1% seen in treated arthritics. Conclusion: It was found that Autoimmunity in arthritics can be significantly lowered through treatment with Arthritic drugs, diets, life style modifications over a period of time. The study suggests that Antinuclear antibody and Lupus Erythematosus estimations could be adopted as markers of diagnosis, prognosis and monitoring of arthritis.
V Pai, Jp Davis, R Shetty, S Rao, Pl Palatty, Gs Pavankumar, Ms Baliga
International Journal of Medical Laboratory Research, Volume 07, pp 28-39;

Background: Obesity is considered to have increased in epidemic proportions throughout the globe, more so in developing countries like India. Obesity is primarily associated with sedentary lifestyle with poor dietary choices and less physical activity. Television is one of the sedentary activities is often associated with consumption of oily foods. This has compounded the problem of obesity and lead to associated health problems including hypertension, diabetes and metabolic syndrome. Results: The questionnaire study involved 369 subjects in a rural setup. Majority of the studied population watched TV and major chunk of them were middle aged people. The time involved in TV viewing was higher in the same population, which is a sedentary form of activity. Statistical correlation was observed between education, income status, oily food consumption and Television viewing. Physical activity was notably higher in the non-TV viewing subjects. BMI, which is measure of obesity, was increased in the TV viewers, coupled with lifestyle disorders like Diabetes, Hypertension and arthritis. Alcohol and tobacco usage too was shown to increase with Television viewing. The dietary choices of TV watching subjects were of less nutritive value with more sugar and oil consumption. Conclusion: Indian studies correlating television viewing and obesity in the adult population are lacking. The study shows a significant correlation of increased TV viewing with obesity in the middle-aged population and the associated health problems related to it.
F Fazal, Mlj Pais, Rg D’Silva, Nm Geevarghese, S Suresh, Ms Baliga, Rp Jakribettu
International Journal of Medical Laboratory Research, Volume 07, pp 20-27;

Background: Presently, the COVID 19 has made its presence all over the world. Since, there is no definitive cure available, prevention is the only mode to control the increase of the disease. Thus, this study was undertaken to evaluate the knowledge and attitude of medical students towards COVID19 in Mangalore, Karnataka, India. Methods: An online questionnaire was circulated among the medical students using the Google form. The questionnaire contained questions regarding the demographic details, attitude and knowledge of the students to be assessed. The response was typed in Microsoft Excel and analyzed using the Statistical Package for Social Sciences (SPSS) version 17 and data represented as frequency (n) and percentage (%). Results: A total of 321 responses were received from medical students, majority were female (199, 62%), nearly 50% were from Final (Clinical) phase. More than 10% of the students believed that the pandemic will last for more than 1 year. Most of the students were aware of the methods to prevent COVID 19 while most were unsure whether antibiotics (76%), hydroxychloroquine (47%), herbal drugs (97%) useful in prevention of COVID 19. Conclusion: The medical students were aware of the pathogenesis of COVID and IPC practices to be followed to prevent its spread. But they were not sure about the appropriate medication for the disease, which was not clear even to specialist, during the period which the study was undertaken.
Sai Datri A, Lakshmana Rao A, Chandini U, Anil Kumar V, Prudhvi Raj V, Veera Naga Anjali V
International Journal of Medical Laboratory Research, Volume 06, pp 44-51;

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