Oceana Biomedicina Journal
EISSN : 26140519
Current Publisher: FK Universitas Hang Tuah (10.30649)
Total articles ≅ 20
Latest articles in this journal
Oceana Biomedicina Journal, Volume 2, pp 101-110; doi:10.30649/obj.v2i2.33
Latar Belakang: Artritis Rheumatoid/ Rheumatoid Arthritis (RA) adalah suatu penyakit autoimun dengan prevalensi yang terus meningkat dari tahun ke tahun. Angka kematian RA terus meningkat dalam 1 dekade terakhir akibat belum ditemukannya pencegahan dan terapi yang efektif. Terapi oksigen hiperbarik bisa menjadi terapi adjuvant untuk penderita Rheumathoid Arhtritis.Tujuan: Penelitian ini menggunakan Terapi Oksigen Hiperbarik untuk mengurangi reaksi inflamasi pada penderita Rheumatoid Arthritis.Metode: Sampel yang digunakan adalah Mice BALB/C jantan sebanyak 16 ekor yang dibagi menjadi 2 kelompok, yaitu 1) kelompok mencit yang diinduksi menjadi model Rheumatoid Arthritis, 2) kelompok hewan coba yang diinduksi menjadi model Rheumatoid Arthritis dan diberikan terapi HBO 2,4 ATA 3x30 menit selama 10 hari berturut-turut. Pada hari ke-59 dilakukan pemeriksaan C-Reactive Protein menggunakan metode ELISA.Hasil: Hasil rerata kadar C-Reactive Protein antara 2 kelompok yaitu, kelompok mencit model RA yang tidak diterapi HBO memiliki rerata kadar CRP 0.204 Pg/ml, sedangkan kelompok mencit model RA yang diterapi HBO memiliki rerata kadar CRP 0.113 Pg/ml.Kesimpulan: Terdapat pengaruh terapi oksigen hiperbarik terhadap kadar C-Reactive Protein darah mencit model rheumatoid arthritis.Kata kunci: Rheumatoid Arthritis, Terapi Oksigen Hiperbarik, C-Reactive Protein
Oceana Biomedicina Journal, Volume 2, pp 81-90; doi:10.30649/obj.v2i2.32
Background : The total number of visits of patients with complaints of low back pain in the Medical Rehabilitation Subdepartment of dr. Ramelan Naval Hospital Surabaya from January to November 2018 was 38.7% of all visits. Low back pain is a symptom, not a disease, which is defined as pain between the edge of the ribs and the gluteus fold which can be caused by a variety of causes. It is important to know how the characteristics of LBP sufferers.Material and Methods : This study was a descriptive study, Medical records from the LBP population in July to September 2018 are used, at the Dr. Ramelan Hospital RSAL Medical Rehabilitation Clinic, with sample criteria: There are main symptoms of pain or other unpleasant feelings in the lower spine and surrounding areas. Results : 152 data were analyzed from July to September 2018, patients with pain complaints were (86.84%). The data obtained showed patients with hypertensive comorbidities 30, Diabetes Mellitus 26, and Osteoarthritis 20.Conclusion : Characteristics of patients diagnosed with Low Back Pain (LBP) at the RSAL Medical Rehabilitation Clinic Dr. Ramelan Surabaya is aged 51-60 years, many suffer from women, 80 percent complain of pain, accompanied by hypertensive comorbidities, Diabetes Melitus and Osteoarthritis. Keywords : Low back pain (LBP), pain, comorbidities
Oceana Biomedicina Journal, Volume 2, pp 91-100; doi:10.30649/obj.v2i2.30
Fish is one ofthe example of a comestibles that contains a lot of protein and minerals, one of which is calcium. Calcium functions for the body's metabolism in the bone and tooth formation. Petek and Mujair fish contain calcium that is needed by the human body. The purpose of this study was to determine the levels of calcium contained in Petek and Mujair fish. The sampling was done by purposive sampling, which the sample used was obtained by the market in the Peunayong Banda Aceh. This research used complexometry methods. The samples of Petek and Mujair fish that had been cleared were titrated using Na2-EDTA as the titrator. The result showed that Petek and Mujair fish had different calcium levels where the calcium levels in Petek fish reach an average of 0.853% and the calcium levels in Mujair fish reach an average of 0.616%. Petek fish had higher calcium levels than Mujair fish, it was caused by their habit, where Petek fish was sea fish that contained fat, vitamins and minerals, while Mujair fish was freshwater fish that contained carbohydrates and proteins.Keywords: Calcium, Petek fish, Mujair fish, Kompleksometry.
Oceana Biomedicina Journal, Volume 2, pp 52-65; doi:10.30649/obj.v2i2.28
The prevalence of periodontal disease in Indonesians is very high, which is around 95%, and 70% of these values occur above 30 years or the adult age group. There is controversy about whether dental calculus is an etiological factor in periodontal disease, or is it just a predisposing factor. Dental Calculus is a calcified oral ecosystem or dental plaque, can accumulate on supragingival or subgingival. Plaque is a bacterial biofilm complex on the tooth surface, including pathogenic microorganisms that invade periodontal tissue. Periodontal disease is the result of interactions between pathogens and the host immune system. Damage to periodontal tissue can occur if the pathogenicity of the microflora is more dominant in the immune response. In calcified conditions, these microorganisms lose their pathogenicity. The dental calculus is one form of the body's defense mechanism against pathogens. But the accumulation of dental calculus, with its rough surface, is a predisposing factor for plaque accumulation. The oral ecosystem trapping on the unique calcified material which are called dental calculus.
Oceana Biomedicina Journal, Volume 2, pp 66-80; doi:10.30649/obj.v2i2.29
Terapi dengan memanfaatkan sel punca belakangan ini dianggap menjadi terobosan ilmiah untuk dunia kedokteran dan kedokteran gigi, serta dianggap sebagai senjata penting dalam memerangi berbagai macam penyakit. Sel punca mesenkimal merupakan sel yang memiliki kemampuan untuk memperbaharui dirinya sendiri, bersifat multipoten, mampu berdiferensiasi dan berproliferasi, serta bersifat immunosupresif, sehingga dapat dimanfaatkan dalam memperbaiki dan meregenerasi berbagai jaringan melalui terapi regenerative.Tujuan dari makalah ini adalah untuk memberikan gambaran singkat mengenai berbagai sumber sel punca dan temuan terbaru serta implikasinya untuk meningkatkan kesehatan rongga mulut melalui regenerasi berbagai jaringan di rongga mulut. Pemanfaatan sel punca mesenkimal di bidang kedokteran gigi dianggap bahwa era baru kedokteran gigi sedang dimulai dan diharapkan dapat merubah paradigma dalam melakukan perawatan terhadap penyakit di rongga mulut. Sel punca mesenkimal dapat diisolasi dari berbagai jaringan yang dapat digunakan dalam terapi regenerative melalui teknologi rekayasa jaringan untuk memperbaiki dan meregenerasi jaringan di rongga mulut. Pada pemanfaatan teknologi ini, diperlukan sel punca, regulator, dan matriks sebagai kerangka yang dapat memfasilitasi sel untuk melekat, berdiferensiasi, berproliferasi, membentukan matriks, dan meningkatkan interaksi spesifik antar sel.Simpulan, sel punca mesenkimal dapat dimanfaatkan dalam terapi regenerative di rongga mulut untuk memperbaki dan meregenerasi jaringan yang rusak melalui teknologi rekayasa jaringan. Kata kunci: sel punca mesenkimal; terapi regenerative; teknologi rekayasa jaringan
Oceana Biomedicina Journal, Volume 2, pp 27-43; doi:10.30649/obj.v2i1.21
Background: Most people in Indonesia still negatively regard mental patients as someone who is dangerous and the disease cannot be cured. This happens because people do not understand well the causes and methods of care for patients with mental disorders. Negative views that exist in the community cause mental patients to get less appropriate and humane treatment in the community even in their own families, such as being installed, ignored, insulted, and alienating family members who experience mental disorders.Objectif: This study aims to determine the differences in positive or negative views of mental patients between students of the Faculty of Medicine, Hang Tuah Surabaya, 5th semester with 7th semester.Methods: The population in this study were students of the Faculty of Medicine, University of Hang Tuah Surabaya in semester 5 with semester 7. with a large sample taken as many as 136 people. The independent variables in this study were positive or negative views about mental patients while the dependent variables in this study were students of semester 5 and semester 7 students. Analysis of the data of this study using Chi Square statistical tests.Results: Obtained results of respondents from semester 5 with a positive outlook that is 38 people (55.9%) and negative views namely 30 people (44.1%), then the results of respondents from 7th semester with a positive outlook that is 53 people (77.9%) and negative view of 15 people (22.1%). Where the total number of all respondents who answered a positive view was 91 people (66.9%) and all respondents who answered negative views were 45 people (33.1%). And based on gender, male respondents who looked positively about mental patients were 51 people (66.2%) and those who viewed negativity were 26 people (33.8%). Whereas female respondents who viewed positively regarding mental patients were 40 people (67.8%) and those who viewed negatively were 19 people (32.2%).Conclusions: The results showed a significant difference regarding the differences in positive or negative views of mental patients between semester 5 students and 7th semester students, as evidenced by the acquisition of the Sig. = 0.006 (
Oceana Biomedicina Journal, Volume 2, pp 15-19; doi:10.30649/obj.v2i1.19
Tikus liar merupakan satwa liar yang paling sering bersosialisasi dengan masyarakat dan merupakan salah satu vektor serta penyebar penyakit yang beberapa diantaranya bersifat zoonosis. Pengendalian tikus liar sangat penting dilakukan guna mengurangi terjadinya penyakit zoonosis yang diakibatkan oleh hewan tersebut. Metode yang efektif digunakan sebagai pengendali populasi tikus liar adalah melalui mekanisme antifertilitas. Salah satu bahan yang memiliki mekanisme antifertilitas adalah biji pepaya. Kandungan saponin, flavonoid, alkaloid, dan papain pada biji pepaya terbukti memberikan efek infertil pada mencit dan tikus putih, dimana mencit dan tikus putih merupakan hewan yang semarga dengan tikus liar. Hewan yang semarga memiliki susunan anatomi dan fisiologis yang serupa, sehingga pengaruh antifertilitas tersebut menjadi sebuah prospek untuk mengembangkan biji pepaya sebagai biomaterial pengendali populasi tikus liar. Populasi tikus liar yang dihambat akan berdampak pada penurunan angka kejadian zoonosis dalam masyarakat.
Oceana Biomedicina Journal, Volume 2, pp 1-14; doi:10.30649/obj.v2i1.23
Contamination of pathogenic bacteria in food can lead to the emergence of foodborne disease. One of foodborne disease which often occurs in some developing countries such as Africa, Southeast Asia, and Latin America is cholera which is caused by Vibrio cholerae. The disease is transmitted through beverages and food, especially contaminated seafood. V. cholerae has several virulence factors including the outer membrane protein W (ompW) and cholerae toxin (ctx).The ompW acts as a protective barrier and can also be used as a marker specific species of V. cholerae and cholerae toxin is an enterotoxin responsible for the incidence of diarrhea in a cholera outbreak produced by pathogenic V. cholerae. This study was an observational study to determine the level of contamination of V. cholerae by detecting the outer membrane protein W (ompW) and cholerae toxin subunit A (ctxA) gene of V. cholerae in shrimp and shellfish sold at Kedonganan fish market. Samples were taken using total sampling technique and obtained 24 samples consisting of 14 shrimp samples and 10 shellfish samples. Samples were examined using culture methods and biochemical tests, and then further tested using Duplex Polymerase Chain Reaction (dPCR) to detect ompW and ctxA gene. The dPCR assay results showed 8 out of 14 (57.1%) samples from shrimp and 1 out of 10 (10%) samples from the shellfish positive carried ompW gene, and found no positive samples carrying the ctxA gene in samples derived from shrimp and shellfish. Chi square test analysis results indicated contamination of V. cholerae in shrimp was higher than shellfish based on ompW gene (p
Oceana Biomedicina Journal, Volume 2, pp 44-51; doi:10.30649/obj.v2i1.22
Apple vinegar is estimated to be able to cure diabetes. Vinegar is able to control the increase of glicemic index. Apple has antioxidant substance such as quercetin and chlorogenic acid. Manalagi apple could be found easily in Indonesia. This research aims to reveal the effect of Manalagi apple vinegar (Malus sylvestris Mill) towards blood glucose level of alloxan induced Wistar white male rats (Rattus norvegicus). This research is experimental laboratory using Experimental methods. The samples are 30 white rats divided into three groups for 31 days, 1) group which only given standard diet; 2) group that induced by 120mg/dL alloxan; 3) group that induced by 120mg/dL alloxan and Manalagi apple vinegar 0.27ml/100gram weight for 14 days. The measurement of blood serum glucose level is done on day twenty four using homogenous colorimetric enzymatic test method for all groups. Blood glucose average in group with only given standard diet as negative control group (182.33 mg/dL), group which induced by 120mg/dL alloxan as positive control group (205.2 mg/dL), group which induced by 120mg/dL alloxan and Manalagi apple vinegar as treatment group (212.25 mg/dL). The result of One-Way Anova significance is 0.229. The conclusion of this research is that Manalagi apple vinegar treatment doesn’t able to decrease the blood glucose level of white Wistar male rats significantly. Keywords : Malus sylvestris Mill, Blood glucose, Alloxan.
Oceana Biomedicina Journal, Volume 2, pp 20-26; doi:10.30649/obj.v2i1.20
Anxiety is an unpleasant feeling of insecure tension and fear that arises because it feels something will happen that is disappointing but the source is largely unaware by the person concerned. Various studies have shown a high frequency of anxiety symptoms in medical students.The aim of this study is knowing the comparison of the level of anxiety to the medical skills test between students of Medical Faculty of Hang Tuah University Surabaya in 1ST semester who have received mental health tests during the entrance test with 3RD semester who have not received a mental health test during the entrance test.This study was an observational analytic study with a cross-sectional study design. The sampling technique used in this study is stratified random sampling. The population in this study were the first and third semester students of the Medical Faculty of Hang Tuah University Surabaya in the 2017/2018 school year, while the samples taken were 374 students meeting the inclusion criteria, Assessment of anxiety levels was carried out using the Hamilton Rate Scale for Anxiety (HRSA) questionnaire.Mild anxiety levels are more numerous in first-semester students (75%) compared to third-semester students (50%), while moderate-to-severe anxiety levels are more numerous in third-semester students (40%) compared to first-semester students (12.5%) who have received mental health tests during the entrance test.This study concluded there is a difference of ansiety level on medical skill examination between students of medical faculty of Hang Tuah University Surabaya in 1st semester who have received mental health tests during the entrance test with 3rd semester who have not received a mental health test during the entrance test. Keywords: Anxiety level, medical skills test, mental health test