International Journal of Clinical and Diagnostic Pathology

Journal Information
ISSN / EISSN : 2617-7226 / 2617-7234
Published by: Comprehensive Publications (10.33545)
Total articles ≅ 383
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Padmaja Korti, Alka Kalgutkar
International Journal of Clinical and Diagnostic Pathology, Volume 4, pp 93-98; https://doi.org/10.33545/pathol.2021.v4.i3b.394

Abstract:
Aim: The aim of the present study was to analyze congenital central nervous system (CNS) malformations from paediatric autopsies and from surgical specimens, to recognise, record, categorise the congenital CNS malformations and to study its association with various maternal and fetal factors. Materials and Methods: This is both prospective (June 2009 to May 2011) and retrospective study conducted during period of two and half decades i.e. from 1987 to May 2011 in a tertiary care hospital. Cases were selected from both pediatric autopsies and surgical specimens as per inclusion and exclusion criteria. Pediatric autopsy was conducted as per standard protocol after obtaining consent from parents. Results: Out of 3492 pediatric autopsies, the CNS malformations were seen in 58 cases and out of 5639 pediatric surgical specimens, 85 were of CNS anomalies. In autopsy study neural tube defects (NTD), 20 cases (34.48%) were the most common followed by congenital hydrocephalus, 14 cases (24.14%). In surgical specimen study all were NTD except for one neuroenteric cyst. Conclusion: Neural tube defects were the most common CNS anomalies; majority of which could be surgically treated. CNS anomalies are associated with preterm births, low birth weight and younger maternal age.Although radiological investigations have high sensitivity in diagnosing CNS malformations, autopsy findings are essential to arrive at a definitive diagnosis.
Fernandez Vinola S, Erli Amel Ivan, Sriram V
International Journal of Clinical and Diagnostic Pathology, Volume 4, pp 107-109; https://doi.org/10.33545/pathol.2021.v4.i3b.399

Abstract:
Introduction: Mature cystic teratomas otherwise called dermoid cysts, are the most common ovarian tumors and account for a vast majority of germ cell tumours with highest incidence in women of reproductive age group. They contain elements originating from all three embryonic germ cell layers.Case report: A 14 years old female presented with complaints of abdominal pain and vomiting since 1 week. On further investigations, USG showed features suggestive of dermoid cyst-right ovary. Right sided oophorectomy was performed and the specimen was sent for histopathological examination. Grossly, the specimen showed multi loculated cyst filled with pultaceous material and tuft of hair. Microscopy showed fibro-collagenous cyst wall lined by stratified squamous epithelium containing adnexal structures and complete small intestine composed of all four layers of mucosa, sub mucosa, muscular is propria and serosa. Foci of well-formed mucosa showing mild dysplastic changes was also noted.Conclusion: Mature cystic teratoma of the ovary frequently contains intestinal-type tissues, but these rarely organize into complete intestinal wall with all layers. We hereby report a case of mature cystic teratoma with a rare presentation of complete small intestinal structure showing mild dysplastic changes.
Archanaba Gohil, Sanjay Dhotre, Bhavesh Faldu, Hansa Goswami
International Journal of Clinical and Diagnostic Pathology, Volume 4, pp 79-82; https://doi.org/10.33545/pathol.2021.v4.i3b.391

Abstract:
Introduction: Diabetes Mellitus (DM) is a pandemic health problem. It is considered as a prothrombotic state with enhanced platelet activity. The increased platelet activity is emphasized to play a role in the development of vascular complications of the metabolic disorder. Mean platelet volume (MPV) is an indicator of average size and activity of platelets. This study was conducted to find correlation of platelet indices with HbA1c in diabetic patients with absence/presence of vascular complications. Material and Method: Total of 150 patients who were suffering from Type 2 DM and attended Outpatient Department (OPD) in civil hospital Ahmedabad were studied from December 2020 to March 2021. Platelet Indices were measured using automated haematology analyser. The statistical evaluation is done using SPSS version 22. Analysis of variance (ANOVA) is used to compare two variables namely HbA1c 7) and in those with vascular complications in compare to patient with HbA1c
Keyuri Patel, Mustafa Ranapurwala, Anjali Patel, Neelofarbanu Mansuri
International Journal of Clinical and Diagnostic Pathology, Volume 4, pp 103-106; https://doi.org/10.33545/pathol.2021.v4.i3b.396

Abstract:
Background: Grey zone samples with optical density (OD) lying between cut-off OD and 10% below the cut-off OD were identified during routine transfusion transmissible infectious disease screening by Enzyme-linked immunosorbent assay and its application in blood transfusion services. Materials and Methods: The present is an observational study where blood donors samples have been screened by performing repeat ELISA testing on Grey zone samples in duplicate at the A.D Gorwala Blood Centre, Karamsad between January 2018 to December 2020. Results: A total of 20560 blood donors were screened during the study period, out of which 12 blood donors were found to be in grey zone. On repeat testing of these, 02 were found to be reactive and 01 was found to be in grey zone again. Conclusion: Appropriate quality control measures can improvise the current screening methodologies in TTIs of blood bank centres, especially in resource constrained settings, where the NAT technology is not financially feasible.
Mustafa Ranapurwala, Keyuri Patel, Krishna Panchal, Munira Jhabbuawala
International Journal of Clinical and Diagnostic Pathology, Volume 4, pp 83-85; https://doi.org/10.33545/pathol.2021.v4.i3b.392

Abstract:
Background: Gaucher disease (GD) is an uncommon lysosomal storage disorder with an autosomal recessive inheritance pattern. Gaucher disease can affect anyone, occurring in up to 1 in 40,000 live births in the general population. It results from the accumulation of glucocerebrosidase in the cells of macrophage-monocyte system because of a deficiency in lysosomal glucocerebrosidase. Here we report a case of Gaucher Disease, rare in the Indian subcontinent. Case Report: We present a case of a young female who presented with a fracture due to a minor road traffic accident with a history of pallor, weakness, and gum bleeds with massive splenomegaly. Final diagnosis of G.D. was reported after examining the bone marrow smears.Conclusion: We report this case of GD to emphasize the clinical presentation that it might present with GD should be considered in the differential diagnosis of young adults with unexplained splenomegaly.
Shekha Subba, Rama D Sathawane, Sunil Y Swami
International Journal of Clinical and Diagnostic Pathology, Volume 4, pp 36-38; https://doi.org/10.33545/pathol.2021.v4.i3a.387

Abstract:
Congenital pulmonary lymphangiectasis [CPL] is a rare, poorly documented disease, characterized by abnormal dilatation of pulmonary lymphatics without lymphatic proliferation. This disease is seen almost exclusively in infancy and early childhood. It can usually be divided into primary [congenital] and secondary forms. The primary form presents in neonates, and the patients mostly die due to the respiratory distress, shortly after birth. Here we present a case of pulmonary lymphangiectasia in an one month old child as incidental finding on autopsy.
Khan Shanawaz, Khan Saima Rais
International Journal of Clinical and Diagnostic Pathology, Volume 4, pp 46-49; https://doi.org/10.33545/pathol.2021.v4.i3a.389

Abstract:
Aim: To assess the health care workers practice perspectives barriers and need for the training related to tobacco cessation. Methods: A cross-sectional descriptive study was conducted among all the health care workers of Birsa Munda Tribal University, Renton Village, Rajpipala, Gujarat, India, from May 2018 to April 2019. A pre-tested, pre-structured self-administered questionnaire was delivered in person to all health care workers. The study included all health care workers that had contact with smokers, as well as patients who were interviewed to assess their smoking status, willingness to quit, and counselling by health care workers using a pre-structured oral questionnaire. Results: Almost 86 percent of health care workers stated they inquire about patients' smoking habits, but just 50 percent claimed they assess their patients' readiness to quit smoking. 32 percent assisted patients in quitting smoking, and 28 percent scheduled follow-up appointments. All agreed that it is their responsibility to assist, inspire, discuss, communicate with, refer, and monitor patients who smoke in order for them to quit smoking. Conclusions: The majority of health care workers thought that they play a critical role in cigarette cessation efforts. The study revealed a need for smoke cessation recommendations to be followed and reinforced.
Anshika Saini, Sushma Belurkar, Seemitr Verma, Karthik S Udupa, Deepak Nayak M
International Journal of Clinical and Diagnostic Pathology, Volume 4, pp 16-22; https://doi.org/10.33545/pathol.2021.v4.i3a.383

Abstract:
Multiple myeloma is a plasma cell neoplasm associated with features of hypercalcemia, renal dysfunction and acquired immune abnormalities. We are reporting a rare case of an 80-year-old multiple myeloma patient with progressive disease with standard chemotherapy and developed cutaneous nodular lesion and pleural effusion. Biopsy of the skin nodule and pleural fluid cytology was suggestive of myelomatous infiltration. Simultaneous pleural and skin involvement is rarely reported in the literature. Such cases are scarcely reported, poorly understood and thus we intend to add to the scientific committee.
Gaikwad Sheela Lakshmanrao, Kamble Nitin Gautam, Bagate Arvind Namdeorao
International Journal of Clinical and Diagnostic Pathology, Volume 4, pp 10-15; https://doi.org/10.33545/pathol.2021.v4.i3a.382

Abstract:
Introduction: Soft tissue is composed of fibrous (connective) tissue, adipose tissue, skeletal muscle, blood and lymph vessels and peripheral nervous system. Soft tissue tumours are diverse group of lesions that arises from the supporting soft tissue of the body. Aims: To study histomorphology of soft tissue tumours and to evaluate pattern of distribution of the soft tissue tumours in relation to different age groups, sex and sites. Setting and Design: Comprises of soft tissue tumours studied during period of 2 years. Prospective and observational study. Result: Out of 125 cases of STTs recorded, 117 (93.6%) were benign and 08 (6.4%) were malignant. STTs in general had male preponderance. Of all benign STTs, the commonest was lipoma (39.2%). Conclusion: Molecular diagnosis have started to gain momentum in the field of soft tissue tumours, however clinicopathological evaluation still remains the gold standard.
Sangeeta Yadav, Rati Mathur, Suresh Singh
International Journal of Clinical and Diagnostic Pathology, Volume 4, pp 99-102; https://doi.org/10.33545/pathol.2021.v4.i3b.395

Abstract:
Aim: To determine the usefulness of serum Matrix metalloproteinase-13 (MMP-13) along with Carbohydrate Antigen 15.3 (CA15.3) as an early tumor marker in female patients with breast cancer.Method: The breast cancer patients were recruited from OPD/IPD of Surgery and Oncology department of SMS Hospital, and evaluated serum MMP-13 and CA15.3. Total 180 subjects were included in this study.90 breast cancer Patients were divided according to different stages and 90 control subjects also included.Results: Serum MMP-13 and CA15.3 level raised significantly in breast cancer patients. Further increases with the advanced stage of the breast cancer.Conclusion: Both MMP-13 and CA15.3 can be useful diagnostic tumor marker in breast cancer.
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