Health of Man
ISSN / EISSN : 2307-5090 / 2412-5547
Current Publisher: Professional Event, LLC (10.30841)
Total articles ≅ 262
Latest articles in this journal
Health of Man pp 57-61; doi:10.30841/2307-5090.3.2020.215978
The objective: Study of some aspects in the formation of syndrome of anxious expectation of sexual failure (SAESF), chiefly of the neurotic genesis, were studied in 220 males.Materials and methods. Three variants of its formation were separated (premanifest, manifest, postmanifest: acute-subacute and chronic). This was determined by period of their occurrence in relation to manifestation of sexual disorders. Also twenty groups of psychological traumatic factors, which took part in the development of the syndrome were identified: normal physiological discharge, pains and pathological changes in the genitals, violation of spontaneous sexual indices, violation of adequate sexual manifestations in erotic contacts, copulatory (physiological and pathological) disorders, homosexual episode, reproaches and behaviour of the female partner, unfaithfulness of the wife, fear of dissatisfaction for the wife, fear of appearing disabled before the eyes of an experienced female partner, divulgence of information about sexual disability, onanophobia, fear of consequences of sexual abstinence, iatrogenia, reading of medical literature and acquaintance with medical documents, information about pathogenic influence of microwave frequencies, information about negative effects of anabolic hormones, apprehension of a possible deterioration of sexual functions in prospect, activation of recollections of previous sexual failures, confidence in one’s own unattractiveness.Results. The degree of participation of these factors in the formation of the above SAESF variants as well as proximate causes of sexual «malfunctions» with the resultant postmanifest development of the studied syndrome were analysed.Conclusion. The conclusion is drawn that the obtained results will make it possible to solve problems of SAESF prevention more effectively.
Health of Man pp 47-51; doi:10.30841/2307-5090.3.2020.215964
The objective: effectiveness of the drug PHARMAPROST manufactured by SYSTEM PHARM (Ukraine) in patients with benign prostatic hyperplasia (BPH) I degree in combination with chronic abacterial prostatitis, (NIH USA, category IIIa CP/CPPS – chronic prostatitis and chronic chronic syndrome) pain with signs of inflammation), assessment of the quality of treatment by patients, the study of intolerance and possible side effects of the study drug.Materials and methods. The Ukrainian Institute of Sexology and Andrology studied the clinical efficacy of PHARMAPROST manufactured by SYSTEM PHARM (Ukraine) in patients with grade I BPH in combination with chronic abacterial prostatitis.Study design: examined and treated 60 men with BPH I degree in combination with chronic abacterial prostatitis, aged 48 to 66 years and disease duration from 6 months to 12 years. The treatment program consisted of two courses of rectal suppositories PHARMAPROST for 10 days a night, the interval between courses was 20 days. All 60 patients completed the full course of treatment.Evaluation of effectiveness: the study included two visits (before and after treatment), during which a history was collected, physical examination, laboratory examination of ejaculate (clinical analysis and bacteriological examination), questionnaire, uroflowmetry, ultrasound. The effectiveness of treatment was evaluated 30 days after the end of the course.Results. The obtained data confirm the clinical efficacy of PHARMAPROST presented inUkraine by SYSTEM PHARM (Ukraine) in 60 patients with a combination of grade I BPH and chronic abacterial prostatitis (NIHUSA, category IIIa CP/CPPS – chronic prostatitis/chronic pelvic syndrome) signs of inflammation). High clinical (89.6–91.7 %) efficacy of this drug has been proven. Treatment was accompanied by good tolerability and minimal side effects.Conclusions. The use of the drug PHARMAPROST in the treatment of patients with chronic abacterial prostatitis and BPH I degree is clinically justified and effective (89.6–91.7 %). The use of the drug PHARMAPROST is accompanied by good tolerability and a small number of side effects (8.3 %). The obtained results allow to recommend the use of the drug PHARMAPROST as monotherapy of patients with a combination of BPH I degree and chronic abacterial prostatitis.
Health of Man pp 35-41; doi:10.30841/2307-5090.3.2020.215909
The relevance of the prevalence of chronic inflammatory diseases of the male genital area is currently quite high. Considering the inflammatory process as a promoter of the development of benign and malignant processes in the tissues of the prostate gland and seminal vesicles, modern pharmacology provides for the effect on pro-inflammatory factors, highlighting immune responses in cellular and humoral immunity, as one of the foundations for controlling inflammatory processes.The use of Flammulina velutipes lyophilized biomass powder-in the above context has significant prospects for both therapeutic and prophylactic purposes, with minimal risks of developing adverse events and excellent compliance. The combination of the obtained pharmacological effects when using the lyophilized biomass powder of Flammulina velutipes indicates the possibility of obtaining a clinical effect in persons with inflammatory diseases of the prostate gland and seminal vesicles. Flammulina velutipes extract can be used both in combination and in monotherapy of inflammatory diseases of the prostate gland and seminal vesicles, given a fairly complete theoretical justification of their pharmacological effectiveness.On the domestic pharmaceutical market there is a medical product Flamulin forte, the main composite of which is F. velutipes lyophilisate, which makes it possible to take advantage of its effects in the treatment of some urological and andrological nosologies. Flamulin forte, like the abovedescribed products from the extract of the fungus flamullin, can be used as an immunotropic and anti-inflammatory agent, the action of which is aimed at reducing the inflammatory response and optimizing some of the immune response in the body of a patient with chronic inflammatory diseases of the prostate vesicular complex.
Health of Man pp 52-56; doi:10.30841/2307-5090.3.2020.215972
A case history is presented, where hypersexuality could be conceptualized as a manifestation of persistent genital arousal disorder/restless genital syndrome [PGAD/ReGS]. Female patient Sh., 75, who sought our medical advice on April 16, 2015, presented complaints about a feeling of a “sexual drive in my pubic region”, burning in her legs (along the inner surface of her thighs), in her pubis and on her abdomen over the pubis in a small area. “I need intimacy, but I understand with my head that it is not necessary for me”. The above burning and sexual desire were felt, but not always. The appearance of the desire coincided with the appearance of the burning. At first, the burning developed and was followed by the desire, or on the contrary. The burning and desire could begin in the morning and trouble her all day long, but when she was engaged into some activity, she changed over and forgot about it. The appearance of the disorder was preceded with the death of her elder brother, who some time before was actually a substitute for her father. He always supported her both morally and financially. He was a rather valued personality for her, she loved him very much. Therefore she took his death, which happened in the beginning of December in 2013, very hard. The disorder, concerning which the patient consulted me, appeared on February 14, 2014. She woke up in the night because of her heavy jittering, she felt a terrible sexual drive and a bad burning in her lower abdomen over the pubis and on the inner surface of her thighs. She could not sleep any more. The arousal, which appeared in the night, did not leave her till the morning and remained during the whole day, but then became weakening. She was treated by different medical specialists. Though some weakening of her symptoms was achieved, she failed to get rid of the disorder, which developed in her. As a result of our analysis we supposed its cerebrovascular genesis, which impacted on functions of the brain. As a weighty contributing factor we regarded her long-term distress caused by a manifested psychological trauma (the death of the person who was extremely significant for the patient).Our treatment (hypnosuggestive therapy, Sonapax, Hydazepam, irrigation of the pubis with 10 % Lidocaine aerosol), where hypnosis was the main component (its 10 sessions were performed), resulted in complete disappearance of the symptoms. The interview performed 5 years after the end of the treatment demonstrated persistence and duration of the obtained results. The presented clinical case is not very bright, but this fact can be explained to a great extent by the patient’s age that excluded appearance of a number of phenomena typical for PGAD/ReGS.
Health of Man pp 28-31; doi:10.30841/2307-5090.3.2020.215688
Stricture of the bowl-ureter segment (BUS) is one of the common pathologies in urology. Quite often in urological practice narrowing of BUS is accompanied by urolithiasis. In adults, according to various authors, the combination of these two serious pathologies occurs in 16-25 % of observations. For a long period, reconstructive-plastic surgery on BUS was a category of complex surgical interventions, required long-term intubation anesthesia, accompanied by a wide opening of the retroperitoneal space with careful allocation of the BUS area. Patients were in the hospital for a long time. Progress in the development of endoscopic equipment has contributed to the active introduction into clinical practice of minimally invasive techniques. Today, an increasing number of urologists are favoring different methods of laparoscopic plastics of BUS structures. But, both in the domestic and in the foreign literature, there are few works that would present advantages, complications, disadvantages of laparoscopic BUS plastic in combination with laparoscopic pyelolithotomy in patients with BUS complicated. This paper presents an analysis of our treatment of patients with BUS strictures in combination with urolithiasis.The objective: analysis and evaluation of the effectiveness of laparoscopic MCC plastics in combination with laparoscopic pyelolithotomy in patients with MCC obstruction complicated by SCC.Materials and methods. For the period from 2013 to 2019 41 patients with the above pathology were laparoscopically operated in the clinic of theInstitute ofUrology of the National Academy of Medical Sciences ofUkraine, including 25 men and 16 women. Their age ranged from 18 to 66 years. The length of the strictures – from 0.3 to1 cm. The size of the concretions varied from 0.5 to1.5 cm. One patient was found to be a coral stone of8.6 cm in size. There were no complications. The average length of stay in the hospital was 5.4 days.Results. In the distant postoperative period, there was no recurrence of BUS stricture and stone formation, stabilization or improvement of the secretory function of the kidney on the side of the plastic was noted. The effectiveness of our use of this method was 90.2 %, which allows us to consider it as the «gold» standard in the treatment of the above pathology.Conclusion. The use of laparoscopic plastics in combination with laparoscopic pyelolithotomy has made it possible to achieve good clinical results both in the immediate and long-term postoperative period. Timely surgery allowed us to achieve positive results in all patients with hydronephrotic transformation due to BUS stricture and complicated urolithiasis.
Health of Man pp 80-84; doi:10.30841/2307-5090.3.2020.216083
The objective: to evaluate the performance of portable pneumatic contact lithotripter LMA Stonebreaker (USA) for cystolithotripsy as compared to electrohydraulic cystolithotripsy (Urat-1M).Materials and methods. Contact cystolithotripsy was performed on 63 patients (49 men, 14 women). 27 patients underwent contact pneumatic cystolithotripsy, 36 patients underwent electrohydraulic cystolithotripsy. The effectiveness of the applied methods was evaluated in groups of patients not only by the size of the stones, but also by the mineral composition of the removed stone fragments (uric acid, phosphates, oxalates, ammonium urate). The number of strokes required to initiate fragmentation, complete fragmentation, and total cystolithotripsy time was determined.Results. The stones were fragmented in all 63 (100%) patients, regardless of the method of cystolithotripsy, mineral composition and size, and the stone fragments were completely removed and diagnosed by X-ray structural analysis. The lowest number of strokes to start the fragmentation process was in patients whose stones were diagnosed as ammonium urate and phosphates. Oxalate and uric acid stones required the greatest number of strokes. The number of strokes for complete disintegration of the stone, regardless of the method of cystolithotripsy, depends on the size of the stone, their number, and also the stone’s mineral composition. Conclusion: Transurethral contact pneumatic cystolithotripsy using a portable pneumatic lithotripter LMA Stonebreaker is not inferior to electrohydraulic cystolithotripsy (Urat-1M), however it is safer, taking into account the applied physical effects for stone destruction. It is also less costly.Conclusion. Effectiveness of applying both pneumatic and electrohydraulic cystolithotripsy depends not only on size and quantity of the stones, but also on their mineral composition. There are peculiarities in the process of cystolithotripsy of stones of different mineral composition.
Health of Man pp 32-34; doi:10.30841/2307-5090.3.2020.215689
The objective: to study the long-term results of organ-preserving surgeries when removing cystic kidney tumors of category III – VI according to Bosniak.Materials and methods. The study was carried out with the participation of 16 patients with verified cystic renal tumors of the category III – VI according to Bosniak. Indications for surgery were: clinical manifestations, laboratory, ultrasound, Doppler and radiation methods (MSCT with bolus contrast or MRI). The diagnosis of renal tumor process was also confirmed using histological and histochemical research methods.Results. Long-term studies after 18 and 36 months showed no signs of recurrence of cysts or tumor process in the kidneys. Signs of a tumor process in the lymph nodes or in other organs during these periods of the study were also not found. Removal of cysts and tumors in the long term after surgery leads to a significant improvement in blood circulation in the kidneys.Conclusion. Organ-preserving resection of a part of the kidney affected by Bosniak category III–VI cystic tumors is a modern effective method of treatment and should be an alternative to surgical removal of affected kidneys in such patients.
Health of Man pp 12-15; doi:10.30841/2307-5090.3.2020.215555
Health of Man pp 42-45; doi:10.30841/2307-5090.3.2020.215938
The objective: was to determine in the urine of patients with calcium-oxalate nephrolithiasis (Ca-Ox NL) and phosphoric acid nephrolithiasis PhAU) and in the rabbit kidney parenchyma with simulated ischemia, the activity of lysosome enzymes N-acetyl-β-D-glucosaminidase (NAG) and β-galactosidase (β-Gal) as enzymatic indicators of the ischemic origin of the kidney parenchyma.Materials and methods. In the urine of 151 patients with nephrolithiasis with preserved renal function (45 with Ca-Ox NL and 106 with PhANL), the activity of the lysosomal enzymes NAG and β-Gal was examined. Patients are divided into groups depending on the type of NL, the size of the calculus and its mineral composition. The reference group – 25 healthy persons. An experimental study was conducted on 10 rabbits with modeled left kidney ischemia, which developed 3.5 to 5.0 months after ligature was applied to its upper pole, and 3 healthy rabbits (6 kidneys). The activity of NAG and β-Gal was determined in the homogenate of the cortical layer of the upper pole of the ischemic kidney and the kidneys of healthy rabbits.Results. All patients with nephrolithiasis have ischemic damage to the kidney parenchyma of varying severity. The most significant ischemic damage to the kidney parenchyma by calculus according to the definition of NAG and β-Gal was recorded in patients with PhANL with magnesium-containing calculi, which had the largest stone sizes. In the experiment on rabbits, a significant decrease in the enzyme activity in the renal parenchyma of animals with ischemia was shown to be compared with similar parameters in healthy rabbits.Conclusion. The results obtained indicate the feasibility of determining the activity of lysosomal enzymes of urine NAG and β-Gal as non-invasive enzyme indicators of ischemic damage to the tubular epithelium of the kidney in patients with nephrolithiasis, which is confirmed by experimental studies. The severity of ischemic damage to the kidney parenchyma in patients with nephrolithiasis according to the determination of the activity of the NAG and β-Gal enzymes in urine depends on the type of nephrolithiasis, the size of the calculus and its mineral composition.
Health of Man pp 62-64; doi:10.30841/2307-5090.3.2020.215984
Antioxidants are recommended for the treatment of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). The efficacy and safety of quercetin in the treatment of patients with CP/CPPS have been studied most. To increase the effectiveness of treatment, we propose to use acetylcysteine, which, along with antioxidant properties, has secretolytic properties.The objective: to provide a comparative assessment of the efficacy and safety of quercetin and acetylcysteine in the treatment of patients with CP/CPPS.Materials and methods. The study involved 60 patients with CP/CPPS aged 18–45 years. Patients were randomized into two comparison groups. Patients in group 1 (n=30) were prescribed quercetin1 g per day for 1 month. Patients in group 2 (n=30) received acetylcyteine orally at a dose of 600 mg per day for 1 month. The condition of patients was assessed according to the NIH-CPSI scale, spermogram parameters and dynamics interlekin-10 (IL-10) and tumor necrosis factor α (TNF-α) in ejaculate. The efficiency criterion was considered to be a 25 % decrease in the NIH-CPSI.Results. As a result of the treatment of patients with CP/CPPS with the use of antioxidants in both groups symptoms of the prostatitis were reduced: NIH-CPSI total (group 1 – 22,5±0,5 vs. 15,0±0,8; group 2 – 22,7±0,5 vs. 15,1±1,1); pain (group 1 – 11,5±0,3 vs. 7,1±0,4; group 2 – 10,0±0,5 vs. 6,6±0,6); urinary symptoms (group 1 – 3,4±0,3 vs. 2,1±0,2; group 2 – 4,8±0,4 vs. 2,2±0,4), quality of life (group 1 – 7,7±0,4 vs. 5,8±0,3; group 2 – 7,8±0,3 vs. 6,3±0,4). The fertility was improved significantly (p<0,05): increased sperm concentration, progressive sperm motility, decreased number of pathological sperm, leukocyte TNF-α concentration and increased IL-10 concentration in ejaculate. In group 2 only ejaculate viscosity decreased significantly (p<0,05), improved sperm motility, decreased white blood cell count, decreased TNF-α concentration in ejaculate were significantly greater than in group 1. The clinical efficacy of acetylcysteine and quercetin in the treatment of patients with CP/CPPS was 63,3 % and 60,0 % respectively (subject to the efficacy criterion of reducing the NIH-CPSI score by 25 %).Conclusion. The use of acetylcysteine can be useful for patients with CP/CPPS.