Borneo Journal of Pharmacy

Journal Information
EISSN : 26214814
Current Publisher: Universitas Muhammadiyah Palangkaraya (10.33084)
Total articles ≅ 27
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Chief Editor Of Borneo J Pharm
Borneo Journal of Pharmacy, Volume 2; doi:10.33084/bjop.v2i1.726

Abstract:Starting from this edition, Borneo J Pharm make changes to the template in the article that will be published. The amendment aims to make it easier for readers to observe essential parts of each page of the article.In this edition we succeeded in obtaining several achievements, including publishing all English-language articles, and successfully gaining support from several international reviewers from various countries, such as Brunei Darussalam, Russia, India and Libya. We will ensure this achievement as a start and will continue to improve the quality of Borneo J Pharm in the future.The aim of this journal is to publish high-quality articles dedicated to all aspects of the latest outstanding developments in the field but not limited to Pharmacology-Toxicology, Pharmacognosy-Phytochemistry, Pharmaceutical, Analytical Pharmacy-Medicinal Chemistry, Natural Product Development, Clinical-Community Pharmacy, Management Pharmacy, and other Pharmacy aspects. This edition contains six articles consisting of Pharmacology-Toxicology, Pharmaceutical, Analytical Pharmacy-Medicinal Chemistry, Natural Product Development, and Management Pharmacy topics.Editorial boards are fully aware that there are still room for improvement in this edition, hence with all humility willing to accept constructive suggestions and feedback for improvements to the publication for the next editions. The editorial board would like to thank the University, all editors and reviewers, and contributors of the scientific articles who have provided the repetoire in this issue. We hope that all parties, especially the contributors of the articles, could re-participate for the success of the publication in the next edition on November 2019.
Karunita Ika Astuti, Lusiana Dwi Wulandari, Eka Fitri Susiani
Borneo Journal of Pharmacy, Volume 2, pp 10-14; doi:10.33084/bjop.v2i1.707

Abstract:Leaves of Vernonia amygdalina Del. is one of the alternative plants that people use as antidiarrheal in Martapura, Banjar. The purpose of research to determine the antidiarrheal activity and the effectiveness of ethanolic extract of leaves against male mice. The negative control was given NaCMC 0.5% orally, positive control was given Loperamide HCl 0.005 mg/20 g orally, and groups of ethanolic extract of leaves were given dosages in 100 mg/kg BW, 200 mg/kg BW, and 400 mg/kg BW orally. After 1 hour of treatment, the groups were induced by Oleum ricini orally and were observed for 4 hours. Based on three parameters were frequency, weight, and consistency of diarrhea. From the results observation of that negative control, positive control, EEDA 100 mg/kg BW, 200 mg/kg BW, and 400 mg/kg BW for diarrhea frequency parameter was 7.4 � 2.30; 2 � 1.22; 5.8 � 3.34; 6.2 � 4.08; 2.4 � 1.67; the weight parameter was 1.34 � 0.43; 0.38 � 0.29;0.66 � 0.56; 0.57 � 0.38; 0.49 � 0.33 and then consistency of diarrhea with EEDA 400 mg/kg BW improved the consistency at 180 minutes compared to control group at 210 minutes. In conclusion, from all parameters of ethanolic extract of Vernonia amygdalina Del. leaves can give an antidiarrhea effect with optimum dosage is 400 mg/kg BW.
Yoni Rina Bintari, Rio Risandiansyah
Borneo Journal of Pharmacy, Volume 2, pp 20-23; doi:10.33084/bjop.v2i1.717

Abstract:Increasing antibiotic-resistant pathogenic bacteria is a severe problem in the world. Therefore, there is a need to identify new drugs from natural products and also new drug targets. Cladophora sp. is a marine organism which is known to have bioactive compounds and a potential antibacterial. On the other hand, Peptide Deformylase (PDf) may prove to be a novel drug target since it is crucial for native peptide functioning in most pathogenic bacteria. This study screens for PDf inhibition activity of compounds from Cladophora sp. using molecular docking approach and screening the binding affinity of bioactive compounds against the peptide receptor PDf using Pyrex Autodock Vina software. Docking results were stored and visualized using Biovia Discovery Studio and PyMOL ligand. Ligands were obtained from previous literature in PubChem, and receptor peptide PDf from pathogenic bacteria: Pseudomonas aeruginosa (PDB ID:1N5N), Escherichia coli (PDB ID:1BSK), Enterococcus faecium (PDB ID:3G6N) and Staphylococcus aureus (PDB ID:1LQW), was obtained from the peptide data bank. The results of this screening show with ligand the highest binding affinity against PDf of P. aeruginosa, E. coli, E. faecium, and S. aureus is stearic acid (-5.9 kcal/mol), eicosapentaenoic acid (-6.6 kcal/mol), stearic acid (-5.8 kcal/mol), and stearic acid (-6.2 kcal/mol) respectively. The binding of natural compounds from Cladophora sp. with PDf models may provide a new drug with a different drug target for antibacterial potential.
Wa Ode Sitti Zubaydah, Wahyuni Wahyuni, Sahidin Sahidin, Tian Amalia Halik, Rina Andriani, Astrid Indalifiany, Adryan Fristiohady
Borneo Journal of Pharmacy, Volume 2, pp 1-9; doi:10.33084/bjop.v2i1.694

Abstract:The aim of this study was to determine the characteristics of the gel formula based on it�s organoleptic properties, pH, viscosity, dispersion and homogenity by stability test carried out using the cycling test method and to determine the anti-inflammatory activity of the Xestospongia Sp. in male white mice (Mus musculus) by creating an artificial edema on the mice left foot induced by 1% ?-carrageenan. The gel formula from the ethanol extract of Xestospongia Sp. sponge was physically stable in terms of its organoleptic observation, homogenity, pH and viscosity test. However, the results that were obtained after dispersion test did not fulfill the requirements. In this study, the gel formula of the ethanol extract of Xestospongia Sp. sponge was administered on the mice left foot by using the variations in extract concentration of 0.02%, 0.03%, and 0.04%, and the gel without extract as a negative control and Galtaren�gel (1% Diclofenac Sodium) as a positive control. The evaluated data were in the form of mice leg edema volume measured based on its percent of inflammation and percent of inflammatory inhibition and observed for 360 minutes. The data were analyzed by using the Kruskal-Wallis test followed by the Mann-Whitney test with a confidence level of 95%. The results of this study showed that the gel formula of ethanol extract of Xestospongia Sp. sponge has an anti-inflammatory effect on each concentration and the formula that has a large anti-inflammatory effect was obtained at extract concentration of 0.04%.
Agustinawati Umaternate
Borneo Journal of Pharmacy, Volume 2, pp 15-19; doi:10.33084/bjop.v2i1.695

Abstract:Karamunting or Kalimantan Grapes (Rhodomyrtus tomentosa) is a medicinal plant from Central Kalimantan that is easily found in shrubs. Based on hereditary experiences of the people of Central Kalimantan, karamunting can be used for the treatment of various diseases, one of which is diabetes. This study aims to identify the chemical compounds contained in the karamunting stem. The method used is thin layer chromatography with eluent n-hexane : ethyl acetate and methanol : chloroform. Besides, a color reaction was carried out to determine the group of compounds contained in the methanol extract of the karamunting stem. The TLC results show better stain separation in eluent n-hexane : ethyl acetate with the formation of four stains. Positive results are indicated by the content of phenol, saponin, flavonoid and terpenoid compounds. The existence of this group of compounds can be a clue to further research on the truth of the efficacy of karamunting.
Khoirul Ngibad
Borneo Journal of Pharmacy, Volume 2, pp 24-30; doi:10.33084/bjop.v2i1.689

Abstract:Many local plants in Indonesia were used as traditional medicines, such as sunflower (Helianthus annuus) and anting-anting (Acalypha indica Linn) plants. Both of them can be used as an antimalarial, antibacterial, antifungal, analgesic, and antihyperlipidemic. This study aims to provide an overview of the secondary metabolites groups contained in sunflower leaf and anting-anting plants for the testing of alkaloids, flavonoids, tannins, saponins, steroids/triterpenoids, and sesquiterpenoids. This study included the extraction of sunflower leaves and anting-anting plants separately using the maceration method for 24 hours with 80% ethanol solvent. The stirring was aided by a shaker for three hours. Each extract was tested by phytochemicals with reagents. The results of phytochemical tests with reagents showed that 80% ethanol extract of sunflower leaves contained an alkaloid, tannin, steroid, and sesquiterpenoid compounds whereas anting-anting plants contained an alkaloid, flavonoid, and triterpenoid compounds.
Sara Surya, Sefrianita Kamal, Lusia Eka Putri
Borneo Journal of Pharmacy, Volume 2, pp 31-34; doi:10.33084/bjop.v2i1.571

Abstract:Patient satisfaction with the quality of pharmaceutical services is an essential indicator in the variety of health services in hospitals. Service quality is said to be enjoyable and satisfying if the services received are by or exceeding expectations. Otherwise, service quality is supposed to be inadequate or unsatisfactory if the service received is lower than expected. This study aims to determine the percentage level of patient satisfaction with pharmacy services at hospital outpatient pharmacies in Padang and to find out the pharmaceutical service system carried out by pharmacists on duty at hospital outpatient pharmacies that were located in Padang. This study used descriptive data collection. Satisfaction was assessed by giving questionnaires to respondents, and then the surveys were analyzed descriptively. Assessment of patient satisfaction was conducted by taking data through a poll of 100 respondents. Satisfaction analysis was carried out using a Likert scale, and then the data was displayed in the cartesian form.
Susi Novaryatiin, Asma'Ul Ayuriska Sari, Evi Mulyani
Borneo Journal of Pharmacy, Volume 1, pp 85-88; doi:10.33084/bjop.v1i2.427

Abstract:One of the plants believed as traditional medicine by the Dayak tribes in Central Kalimantan was Sangkareho (Callicarpa longifolia Lam.). This plant was usually used as traditional medicine by society in Puruk Cahu, Murung Raya Regency, Central Kalimantan and empirically believed could cure skin disease such as wound infection. This study was aimed to determine the antibacterial activity of ethanolic extract of Sangkareho (Callicarpa longifolia Lam). Antibacterial activity of ethanolic extract of Sangkareho was performed using disc diffusion technique, with four variations of concentration of 1%, 5%, 10%, and 15%. In this present study showed that ethanolic extract of Sangkareho has antibacterial activity against Staphylococcus epidermidis, wherein the resulting inhibition zone diameter was 7.3�0.8 mm, 8.3�1.2 mm, 10.5�0.5 mm, and 12.2�0.7 mm, respectively. Further research is needed to obtain an antibacterial activity of the fraction of Sangkareho.
Nurul Chusna, Titra Fetriana, Rabiatul Adawiyah
Borneo Journal of Pharmacy, Volume 1, pp 89-92; doi:10.33084/bjop.v1i2.379

Abstract:This study aims to determine the level of patient satisfaction with pharmaceutical services at the Pahandut Palangka Raya Community Health Center. This research method is descriptive. The sample in this study were 94 respondents, namely outpatients who received pharmacy services at the Pahandut Palangka Raya Community Health Center. The sampling technique in this study used a purposive sampling technique. The results of the study of patient satisfaction with pharmaceutical services based on the type of service obtained a score of 208 data located in the "very satisfied" area on the type of pharmacy staff responsiveness to patients, in the type of hospitality services pharmacy staff obtained a score of 206 data located "very satisfied", the types of clarity of pharmacy services in providing drug information obtained a score of 212 data located in "very satisfied" areas, in the type of drug service speed the score data 199 were found in "very satisfied" areas, in the types of medical services and medical devices the score data was obtained 200 lies in the "very satisfied" area, in the type of waiting room comfort service the 198 score data is located in the "very satisfied" area, and on the type of service the availability of brochures, leaflets, posters, as well as drug/health information is obtained score data 206 lies in the "very satisfied" area. The results of this study indicate that most patients were very satisfied with the pharmaceutical services provided by the Pahandut Community Health Center in Palangka Raya City.
Sefrianita Kamal, Mesa Sukmadani Rusdi
Borneo Journal of Pharmacy, Volume 1, pp 68-71; doi:10.33084/bjop.v1i2.375

Abstract:Skin is the outermost part of the body which is susceptible to solar radiation. Excessive radiation from ultraviolet (UV) rays can harm the skin, such as premature aging effect, erythema, and even skin cancer. Antioxidant compounds are needed to protect the skin from excessive exposure of UV rays. The antioxidant can be useful as a defense system against free radicals, ultraviolet radiation, and air pollution. One source of antioxidant from nature is Catechins. Catechins are obtained from the isolation of gambir (Uncaria gambir Roxb). Besides being useful as an antioxidant, Catechins also have antibacterial, antiseptic and wound healing effect. The antioxidant activity of Catechins can absorb UV rays, provides protection against oxidative stress, inflammation, and skin cancer. Therefore, the research is necessary to utilize the catechins in sunscreen lotion formulation. Catechins are isolated from gambir by maceration with hexane and ethyl acetate (polar, nonpolar and residual fractions). The fraction which yields the most catechins is used as the active substance in the formulation. The formulation is divided into 4 lotion formulas, namely Formula 1 with 0.5% catechins concentration, Formula 2 with 7.5% catechins concentration, Formula 3 with 1% catechins concentration, and Formula 4 without catechins substance. Physical stability test and effectiveness of sunscreen formulation are carried out on 4 lotion formulas. Physical stability tests included organoleptic observation, homogeneity, pH, and assessment of the effectiveness of sunscreen formulation by using UV-Vis Spectrophotometer.