ASIAN JOURNAL OF PHARMACEUTICS

Journal Information
ISSN / EISSN : 0973-8398 / 1998-409X
Published by: BRNSS Publication Hub (10.22377)
Total articles ≅ 337
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J. Prarthana
ASIAN JOURNAL OF PHARMACEUTICS, Volume 15; https://doi.org/10.22377/ajpmds

Abstract:
Objectives: Ayurveda is one of the oldest codified medical knowledge systems with equal emphasis on curative, preventive, and promotive aspects of health. Ayurveda pharmaceutics was developed from the quest to administer plants, animals, or metals and minerals products in a palatable and longer shelf life modification. The study aims to evaluate and characterize the microbial sp. and their biochemical properties in extrapolating its use as a potent probiotic formulation with multifaceted use. Materials and Methods: The microbial diversity of the formulation was evaluated by isolation followed by its microbial characterization using Gram’s staining, biochemical characterization using catalase assay, and molecular characterization by sequencing the internal transcribed spacer (ITS) region. Results: The study revealed that the bacteria isolated in the present study were Gram-positive, rod-shaped organism that exhibited catalase-positive test. Further, molecular characterization studies using the ITS sequence analysis revealed that the isolated organism showed similarity with that of Bacillus species. Conclusion: Therapeutic efficacy of any formulation depends on the process of its preparation, the kind of microflora that is established during aging or fermentation, and the kind of bioactive compounds released during fermentation. The present study identifies the microorganism that plays a pivotal role in this fermentation process and renders therapeutic properties to Dhanyamala formulation. This study can form the basis for further investigations on formulating this as a promising probiotic supplement.
Parisa Yousefee Baghbadoranee, H N K Al-Salman, Manish Vyas, K. Venkateshwarlu, A. Mohammadi, Oksana Strus, Mansour Amraei, A.E. Dorofeev, Galina Eduardovna Brkich, Behzad Fouladi Dehaghi, et al.
ASIAN JOURNAL OF PHARMACEUTICS, Volume 13; https://doi.org/10.22377/ajppmds

Abstract:
Aim: A semisolid (avaleha) herbal formulation Drakshavaleha (DKV) was prepared based on the method described in Ayurvedic Formulary of India. It contains Vitis vinifera (Draksha), Piper longum (Pippali), Glycyrrhiza glabra (Yeshtimadhu), Zingiber officinale (Sunthi), Bambusa arundinacea (Vamshalochana), Emblica officinalis (Dhatri Phala or Amalaki), and honey and sugar (Sarkara). Materials and Methods: Methanolic extract of the DKV formulations was used for this study. Methanolic extract of three marketed preparation of DKV also use for the comparative study of DKV. This formulation was known as DKV-1, DKV-2, and DKV-3. A sample of this marketed formulation also used for 2, 2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity. Result and Discussion: The methanolic extract of DKV exhibited a maximum DPPH scavenging activity of 68.24% at 100 μg/ml, and marketed formulations of DKV (DKV-1, DKV-2, and DKV-3) exhibited maximum DPPH scavenging activity 67.90%, 68.35%, and 68.40%, respectively, at 100 μg/ml. With the standard ascorbic acid, it was found to be 84.75% at 100 μg/ml. The IC50 values of the methanolic extract of DKV were 63.27 μg/ml, and marketed formulations (DKV-1, DKV-2, and DKV-3) were 63.13 μg/ml, 62.82 μg/ml, and 62.91 μg/ml, respectively, and ascorbic acid was 40.05 μg/ml. Conclusion: Results obtained suggest the antioxidant and free radical scavenging activity potential of DKV, and further it may be used as an antioxidant in associated diseases.
BhushanArun Patil, ShankarDadasaheb Pol, PrashantKeshav Puranik, PriteeShamrao Ramteke, Nitiraj Ransing-Patil, RajashreeGopal Palasakar, PrajaktaKalidas Khobragade
ASIAN JOURNAL OF PHARMACEUTICS, Volume 9; https://doi.org/10.4103/0973-8398.154707

MatHusin Norazlin, Basri Mahiran, Hashim Puziah, Abd GaniSiti Salwa
ASIAN JOURNAL OF PHARMACEUTICS, Volume 9; https://doi.org/10.4103/0973-8398.154712

DivyaBhargava Bansal, Dipankar Bhadra, , Nk Jain
ASIAN JOURNAL OF PHARMACEUTICS, Volume 9; https://doi.org/10.4103/0973-8398.150042

Abstract:
PEGylation involves chemically linking polyethylene glycol (PEG) to the therapeutic molecule for the purpose of enhancing its therapeutic value. PEG conjugates of the anticancer agent have been designed to enhance the water solubility and plasma half-life of the drug. Biodegradable polymeric micelles are used for drug delivery to the site of the tumor, as they possess thermodynamic stability, ability to encapsulate and solubilize a hydrophobic guest molecule, biodegradability, as well as size and surface characteristics that facilitate rapid clearance by the reticuloendothelial system. The prepared ester and amide conjugates of PEG with the drug were lyophilized and characterized. The lyophilized formulations were evaluated for drug loading, drug release, hemolytic toxicity, and stability. PEG was found to solubilize methotrexate (MTX) by forming micelles in the nanometric range. This particle size was considered effective for passive targeting of tumors. Drug loading capacity of the micelles was found to increase with an increase in the amount of MTX-PEG conjugate. The rate of drug release from amide derivative of MTX-PEG conjugate was slower when compared to ester derivative of MTX-PEG conjugate. Prepared MTX-PEG conjugate was found to be less hemolytic than the plain drug. The formulation showed maximum stability and minimum drug leakage at 0΀ C. The ester and amide derivatives of MTX with PEG alter the hydrophobicity of the conjugate, thereby modifying micellar stability and controlling drug release. Based on preliminary results, we can conclude that PEGylation of MTX substantially enhances its aqueous solubility. Due to small size, higher solubility, simple sterilization, and controlled release of the drug, polymeric micelles seem to mimic an ideal carrier for poorly water soluble drugs
Akanksha Singh, Vikram Singh, Geeta Rawat, Divya Juyal
Published: 1 January 2015
ASIAN JOURNAL OF PHARMACEUTICS, Volume 9; https://doi.org/10.4103/0973-8398.150031

SwaroopR Lahoti, Shardul Dalal
ASIAN JOURNAL OF PHARMACEUTICS, Volume 9; https://doi.org/10.4103/0973-8398.160312

Abstract:
In the present investigation iontophoretic permeation of risedronate sodium (RS) through optimized gel based formulation was evaluated with respect to various electrical parameters like Current density and type of current. The study also involved enhancement the iontophoretic permeation of RS in combination with electroporation and chemical penetration enhancers with its in-vivo Pharmacokinetic evaluation. The permeation studies were carried through the human cadaver skin by using modified Franz diffusion cell and microcontroller based devices for iontophoresis and electroporation developed in the laboratory. In-vivo Pharmacokinetic studies were carried out in hairless rats. One way ANOVA followed by Tukey-Kramer test for multiple comparisons. The permeation of RS was significantly increased with iontophoresis at 0.5 mA/Cm 2 current density. The iontophoretic permeation was found depend on current density and ON:OFF ratio. The pulsatile current resulted in high permeation than continuous current. Maximum permeation was obtained at 0.5 mA/cm 2 with 1:1 pulsed current. When iontophoresis was coupled with chemical penetration enhancers and electroporation for 100 ms at 220V, synergistic enhancement in permeation was observed with shortened lag time and high flux. The required flux was achieved with area of application 1.55 cm 2 . In-vivo studies in hairless rats revealed high C max, low t max and increased area under the curve with electroporation, followed by iontophoresis indicated increased bioavailability. Relative bio-availability was 4.6 when calculated in comparison to passive studies
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