Infection Control & Hospital Epidemiology

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ISSN / EISSN : 0899-823X / 1559-6834
Published by: Cambridge University Press (CUP) (10.1017)
Total articles ≅ 14,594
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Latest articles in this journal

David J. Weber, Jaffar Al-Tawfiq, Hilary Babcock, Kristina Bryant, Marci Drees, Ramy Elshaboury, Katharine Essick, Mohamad Fakih, David Henderson, Waleed Javaid, et al.
Infection Control & Hospital Epidemiology pp 1-46; doi:10.1017/ice.2021.322

Ming-Yuan Hong, Chia-Lung Kao, Chih-Hsien Chi
Infection Control & Hospital Epidemiology pp 1-5; doi:10.1017/ice.2021.316

, Takaaki Kobayashi, Angelique Dains, Oluchi J. Abosi, Kyle E. Jenn, Holly Meacham, Lorinda L. Sheeler, William Etienne, Mary E. Kukla, Mohammed Alsuhaibani, et al.
Infection Control & Hospital Epidemiology pp 1-13; doi:10.1017/ice.2021.313

Abstract:
The incidence of COVID-19 exposures in shared patient rooms was low at our institution: 1.8/1,000 shared room patient-days. However, the secondary attack rate (21.6%) was comparable to that reported in household exposures. Lengthier exposures were associated with COVID-19 conversion. Hospitals should implement measures to decrease shared room exposures.
, Sara A. Hedderwick, Cara M. McKeating, Peter M. McKee, Jessie C. McNally, Lisa M. Lennon, Orla McGivern, Kevin Lewis, Dominic McKenna, Elizabeth A. Lattyak, et al.
Infection Control & Hospital Epidemiology pp 1-2; doi:10.1017/ice.2021.276

Shuk-Ching Wong, Lithia Lai-Ha Yuen, Veronica Wing-Man Chan, Jonathan Hon-Kwan Chen, Kelvin Kai-Wang To, Kwok-Yung Yuen, Vincent Chi-Chung Cheng
Infection Control & Hospital Epidemiology pp 1-10; doi:10.1017/ice.2021.318

Theodore Spilker, Jens Kratholm, Eliza Depoorter, Peter Vandamme,
Infection Control & Hospital Epidemiology pp 1-3; doi:10.1017/ice.2021.298

Abstract:
We describe the follow-up investigation of an outbreak of endophthalmitis due to Burkholderia contaminans following cataract surgery in a single clinic. Whole-genome sequence analysis of bacteria recovered from affected patients and the clinic identified the clinic’s ventilation system as the source of infection.
Panipak Katawethiwong, Anucha Apisarnthanarak, Kittiya Jantarathaneewat, David J. Weber, David K. Warren,
Infection Control & Hospital Epidemiology pp 1-6; doi:10.1017/ice.2021.296

Abstract:
Background: Limited data are available on the implementation of an area under the concentration-time curve (AUC)–based dosing protocol with multidisciplinary team (MT) support to improve adherence with vancomycin dosing protocol. Objective: To evaluate the effectiveness of an AUC-based dosing protocol with MT support intervention with adherence to a hospital-wide vancomycin dosing protocol at Thammasat University Hospital. Method: We conducted a quasi-experimental study in patients who were prescribed intravenous vancomycin. The study was divided into 2 periods; (1) the preintervention period when the vancomycin dosing protocol was already applied in routine practice and (2) the post-intervention period when the implementation of an AUC-based dosing protocol with MT support was added to the existing vancomycin dosing protocol. The primary outcome was the rate of adherence, and the secondary outcomes included acute kidney injury events, vancomycin-related adverse events, and 30-day mortality rate. Results: In total, 240 patients were enrolled. The most common infections were skin and soft-tissue infections (24.6%) and bacteremia (24.6%). The most common pathogens were coagulase-negative staphylococci (19.6%) and Enterococcus spp (15.4%). Adherence with the vancomycin dosing protocol was significantly higher in the postintervention period (90.8% vs 55%; P ≤ .001). By multivariate analysis, an AUC-based dosing protocol with MT support was the sole predictor for adherence with the vancomycin dosing protocol (adjusted odds ratio, 10.31; 95% confidence interval, 4.54–23.45; P ≤ .001). The 30-day mortality rate was significantly lower during the postintervention period (8.3% vs 20%; P = .015). Conclusions: AUC-based dosing protocol with MT support significantly improved adherence with vancomycin dosing protocol and was associated with a lower 30-day mortality rate.
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