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ISSN / EISSN : 0193-4511 / 1095-9203
Former Publisher: American Association for the Advancement of Science (AAAS) (10.1126)
Total articles ≅ 274,532
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, Sandra C. A. Nielsen, Ramona A. Hoh, , Oliver Fabian Wirz, Emily Haraguchi, Grace H. Jean, Ji-Yeun Lee, Tho D. Pham, , et al.
Science; doi:10.1126/science.abf6648

Vaccination and infection promote the formation, tissue distribution, and clonal evolution of B cells, which encode humoral immune memory. We evaluated convergent antigen-specific antibody genes of similar sequences shared between individuals in pediatric and adult blood, and deceased organ donor tissues. B cell memory varied for different pathogens. Polysaccharide antigen-specific clones were not exclusive to the spleen. Adults had higher clone frequencies and greater class-switching in lymphoid tissues than blood, while pediatric blood had abundant class-switched convergent clones. Consistent with reported serology, pre-pandemic children had class-switched convergent clones to SARS-CoV-2 with weak cross-reactivity to other coronaviruses, while adult blood or tissues showed few such clones. The results highlight the prominence of early childhood B cell clonal expansions and cross-reactivity for future responses to novel pathogens.
Science, Volume 372, pp 210-210; doi:10.1126/science.372.6538.210

Joshua Sokol
Science, Volume 372, pp 120-123; doi:10.1126/science.372.6538.120

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