Asian Case Reports in Oncology
ISSN / EISSN : 2169-8821 / 2169-883X
Published by: Hans Publishers (10.12677)
Total articles ≅ 65
Latest articles in this journal
Asian Case Reports in Oncology, Volume 10, pp 1-23; https://doi.org/10.12677/acrpo.2021.101001
脑胶质瘤是一种极度常见颅腔内的原发性恶性肿瘤，患病人群占据所有颅内肿瘤患者的60%。IV级胶质瘤为最高恶性程度，也称为胶质母细胞瘤(胶质母细胞瘤，GBM)，约占全部胶质瘤的55%，且诊断为GBM的患者5年生存率低于6%。许多研究表明，脑胶质瘤中异常表达的lncRNA不仅调控着与癌细胞增殖、凋亡有关的信号转导通路，还与病人的预后有关。利用转录组高通量测序方法，筛选影响脑胶质瘤发生、发展及复发过程中关键通路中的重要基因，对脑胶质瘤的分子诊断、靶向药物的研发及新治疗方案的选择具有重要的价值。本研究通过RNA-seq和生物信息学分析，筛选出在脑胶质瘤组织中差异表达的lncRNA 106种，其中上调表达52种，下调表达54种。microRNA共计15个，其中上调表达8种；下调表达7种。这些差异表达的ncRNA主要参与有机循环化合物代谢过程、胞内运输、细胞蛋白质定位、蛋白质运输、有丝分裂细胞周期、细胞周期调节、DNA代谢过程的正调控、水解酶活性的调节等生物过程、生物调节、应激反应、多细胞有机体过程、细胞成分的组织或生物发生、细胞定位、信号途径、发育过程、生物过程的正调控与负调控。经lncRNA-miRNA-mRNA关联分析，建立了ceRNAs调控网络，明确了lncRNA、miRNA与靶标mRNA之间的对应关系。这些关键lncRNA的筛选，为脑胶质瘤的诊断及治疗提供了新的思路与方向。 Glioma is an extremely common primary malignant tumor in the cranial cavity, which accounts for 60% of all patients with intracranial tumors. Grade IV glioma is the highest degree of malignancy, also called glioblastoma (glioblastoma, GBM), accounting for about 55% of all gliomas, and the 5-year survival rate of patients diagnosed with GBM is lower than 6%. Many studies have shown that the abnormally expressed lncRNA in brain gliomas not only regulates the signal transduction pathways related to cancer cell proliferation and apoptosis, but is also related to the patient’s prognosis. Using transcriptome high-throughput sequencing to screen important genes in key pathways that affect the development, development and recurrence of glioma is of great value for molecular diagnosis of glioma, research and development of targeted drugs and selection of new treatment options. In this study, through RNA-seq and bioinformatics analysis, 106 types of lncRNAs that are differentially expressed in glioma tissues were screened, of which 52 were up-regulated and 54 were down-regulated. There are a total of 15 microRNAs, of which 8 are up-regulated and 7 are down-regulated. These differentially expressed ncRNAs are mainly involved in the metabolic process of organic circulating compounds, intracellular transport, cell protein localization, protein transport, mitotic cell cycle, cell cycle regulation, positive regulation of DNA metabolism, regulation of hydrolase activity and other biological processes and biological regulation, Stress response, multicellular organism process, tissue or biogenesis of cell components, cell location, signal pathway, development process, positive and negative regulation of biological processes. After lncRNA-miRNA-mRNA association analysis, a ceRNAs regulatory network was established, and the correspondence between lncRNA, miRNA and target mRNA was clarified. The screening of these key lncRNAs provides new ideas and directions for the diagnosis and treatment of glioma.
Asian Case Reports in Oncology, Volume 10, pp 25-32; https://doi.org/10.12677/acrpo.2021.102002
目的：探讨抗结核治疗对含盐酸安罗替尼方案治疗晚期肺癌疗效的影响。方法：回顾性分析2019年3月至2021年3月在广州市胸科医院收治的43例三线及三线以上晚期肺癌患者临床资料，其中6例为肺癌合并结核患者，同时接受抗结核治疗及含安罗替尼方案的治疗，37例为晚期肺癌患者接受安罗替尼方案的治疗，分析其客观总缓解率(ORR)、疾病控制率(DCR)、无进展生存(PFS)及相关不良反应。结果：抗肺癌抗结核同时治疗组ORR 0%，DCR 83.3%、单独使用抗癌药物组ORR 18.9%，DCR 64.9%。药物相关不良血液学不良事件，高血压最为常见，I~II级15例(34.9%)，III~IV级0例；药物相关血液学不良反应事件，血红蛋白下降最常见，I~II级10例(23.2%)，III~IV级0例，1例患者减量，1例患者停药。结论：同时接受抗结核治疗和含安罗替尼方案的晚期肺癌合并结核患者，客观有效率低于仅接受含安罗替尼方案的患者。 Objective: To investigate the effect of antituberculous therapy on the treatment of advanced lung cancer with anlotinib hydrochloride. Methods: A retrospective analysis was performed to analyze the clinical data of 43 patients with advanced lung cancer at or above the third line admitted to Guangzhou Chest Hospital from March 2019 to March 2021. Among them, 6 patients with lung cancer complicated with tuberculosis received anti-tuberculosis treatment and anlotinib treatment at the same time. Thirty-seven patients with advanced lung cancer were treated with the anlotinib regimen. Objective total response rate (ORR), disease control rate (DCR), progression-free survival (PFS) and associated adverse events were analyzed. Results: The ORR and DCR were 0% and 83.3% in the group of anti-lung cancer and anti-tuberculosis treatment, and 18.9% and 64.9% in the group of anti-cancer drugs alone. Hypertension was the most common drug-related adverse hematologic event. There were 15 cases of grade I~II (34.9%), and 0 cases of grade III~IV. Among drug-related hematological adverse events, hemoglobin decline was the most common, with 10 cases (23.2%) in grade I~II and 0 cases in grade III~IV. In the experiment, 1 patient reduced dosage and 1 patient stopped medication. Conclusions: The objective response rate of patients with advanced lung cancer complicated with tuberculosis who received both antituberculous therapy and anlotinib-containing regimen was lower than that of patients who only received anlotinib-containing regimen.
Asian Case Reports in Oncology, Volume 9, pp 13-16; https://doi.org/10.12677/acrpo.2020.93003
甲状腺癌是最常见的甲状腺恶性肿瘤，约占全身恶性肿瘤的1%。甲状腺癌的发病率在我国每年都在攀升，该病的发病率女性大于男性。其发病机制尚在研究中，很多专家学者认为该病与放射线照射或遗传相关。目前最主要的治疗方法是手术。而术后复发率较低，但个别患者会出现术后淋巴漏。因此,本文探讨分析甲状腺癌术后淋巴漏治疗心得体会。 Thyroid cancer is the most common malignant thyroid tumor, accounting for about 1% of malignant tumors in the body. The incidence of thyroid cancer is rising every year in my country, and the incidence of this disease is greater in women than men. Its pathogenesis is still under study, and many experts and scholars believe that the disease is related to radiation exposure or genetics. At present, the main treatment method is surgery. The postoperative recurrence rate is low, but individual patients will have postoperative lymphatic leakage. Therefore, this article discusses and analyzes the experience of lymphatic leakage treatment after thyroid cancer surgery.
Asian Case Reports in Oncology, Volume 9, pp 22-25; https://doi.org/10.12677/acrpo.2020.94005
目的：观察参麦注射液防治恶性血液病化疗中胃肠道反应的疗效。方法：2016年1月~2017年12月，我院选择60例恶性血液病化疗病例，随机分成实验组及对照组2组，实验组化疗过程中应用参麦注射液，对照组不加用参麦注射液，观察化疗过程中胃肠道副反应。结论：应用参麦注射液(正大青春宝药业有限公司生产)静滴防治胃肠道副反应收到明显效果。 Aim: To observe the efficacy of Shenmai injection in preventing and treating gastrointestinal reactions during chemotherapy of hematological malignancies. Methods: From January 2016 to December 2017, our hospital selected 60 cases of chemotherapy for hematological malignancies and randomly divided them into two groups: an experimental group and a control group. The experimental group was treated with Shenmai injection during chemotherapy, and the control group did not use Shenmai injection. Gastrointestinal adverse effects are observed during chemotherapy. Conclusion: The application of Shenmai injection (produced by Zhengda Qingchunbao Pharmaceutical Co., Ltd.) intravenously in the prevention and treatment of gastrointestinal adverse effects has achieved significant results.
Asian Case Reports in Oncology, Volume 9, pp 5-12; https://doi.org/10.12677/acrpo.2020.92002
目标：提高对鼻腔淋巴瘤的认识及其确诊率，总结鼻腔淋巴瘤发病机制、病因、临床表现、诊断、治疗及相关研究进展。方法：回顾性分析一例中年男性鼻腔淋巴瘤患者资料，同时进行相关病例以及文献分析。结果：该患者以“间断鼻塞1月余”之主诉入院，副鼻窦CT显示1) 右侧上窦及鼻腔内软组织密度，和上颌内侧壁骨质吸收：考虑为鼻息肉，请结合镜检。2) 左侧下鼻甲肥大，鼻道阻塞。诊断：1) 鼻腔肿物待诊2) 慢性–鼻鼻窦炎3) 慢性乙型肝炎。患者拒绝术前鼻腔肿物活检以明确肿物性质，并签署拒绝治疗同意书。择期行经鼻内镜下行鼻腔肿物切除术 + ESS术，术后常规肿物病检免疫组化结果考虑为NK/T细胞淋巴瘤。结论：鼻腔肿物应尽早完善相关影像学检查与肿物活检，早期明确诊断，若明确鼻腔淋巴瘤，应结合相关放化疗方式进行治疗。 Aim: To summarize the pathogenesis, etiology, clinical manifestations, diagnosis, treatment and related research progress of nasal lymphoma, and to improve their awareness and diagnosis rate. Methods: Retrospective analysis of a patient with mid-life nasal lymphoma in men, as well as, related cases and literature analysis. Results: The patient was admitted to the hospital with “intermittent nasal congestion more than 1 month”, the secondary sinus CT show 1) The density of soft tissue in the upper sinus and nasal cavity on the right side, and the upper jaw inner wall bone absorption: considered as nasal polyps; please combine with the mirror examination. 2) The left lower nasal armor is large and the nasal passage is blocked. Diagnostics: 1) Nasal swelling swollen to be diagnosed 2) Chronic rhinosinusitis 3) Chronic hepatitis B. The patient refused preoperative nasal cavity swollen biopsy to clear the nature of the swelling, and refused to sign the consent form of refusal to treat. The elective period was through the nasal endoscopic downward nasal cavity tumor excision and ESS surgery, and the results of the general swelling disease detection immunohistochemistry were considered NK/T cell lymphoma. Conclusion: The nasal swelling should improve the relevant imaging examination and swelling biopsy as early as possible, and it should be diagnosed early and clearly, and if it is clear lymphoma in the nasal cavity, it should be treated in combination with the relevant chemotherapy method.
Asian Case Reports in Oncology, Volume 9, pp 17-21; https://doi.org/10.12677/acrpo.2020.94004
原发性肝癌(Hepatocellular carcinoma, HCC)起病隐匿，虽然手术治疗是首选，但患者因出现临床症状而就医时大多已进入中晚期，选择单纯的手术治疗不能达到预期的目的。针对这部分患者，肝动脉化疗栓塞术(transcatheter arterial chemoembolization, TACE)已成为首选。然而，采用此治疗方式，虽然能一定程度上缓解病情，但治疗效果有限。多项研究表明采用TACE联合索拉非尼的治疗方法，可以使中晚期原发性肝癌患者获益颇多，本文参考相关资料，探讨TACE联合索拉非尼治疗原发性肝癌的相关研究进展。 Hepatocellular carcinoma (HCC) has an insidious onset. Although surgical treatment is the first choice, most of the patients have entered the middle and advanced stages when they seek medical attention due to clinical symptoms, and surgical treatment alone cannot achieve the expected goals. For these patients, transcatheter arterial chemoembolization (TACE) has become the first choice. Although this treatment method can relieve the condition to a certain extent, the treatment effect is limited. A number of studies have shown that the use of TACE combined with sorafenib can benefit patients with advanced Hepatocellular carcinoma. This article refers to related materials to discuss the research progress of TACE combined with sorafenib in the treatment of Hepatocellular carcinoma.
Asian Case Reports in Oncology, Volume 8, pp 23-27; https://doi.org/10.12677/acrpo.2019.83004
Asian Case Reports in Oncology, Volume 8, pp 29-38; https://doi.org/10.12677/acrpo.2019.84005
硼中子俘获治疗是一项二元性的肿瘤治疗方式，主要原理是先透过注射含硼-10的药物入患者体内，待其肿瘤吸收后，再施以热中子照射肿瘤区块，后续的裂解反应会产生两个高生物效应的肿瘤破坏性粒子：α粒子以及锂核。这些高能量释放的粒子不但能有效破坏肿瘤细胞的双股螺旋DNA，且其由于影响范围小，对于周边正常组织亦有安全保护的效果。本次主要报告一位77岁来自上海的男性患者，其罹患巨大复发性下咽癌，经反复性各式治疗失败后，后续尝试透过硼中子俘获治疗来提供补救性的处置。由于复发肿瘤包覆右颈动脉，本团队首先提供其右颈动脉血管保护性支架处置，后转介前往清华大学原子反应堆硼中子癌病治疗中心进行治疗安排，患者首先安排施打含硼-10药物BPA (4-10borophenylalanine; BPA)后并接受热中子照射。执行治疗结束后复发的右颈肿瘤大幅缩小改善，追踪检查的正子检查并呈现无肿瘤活性的反应表现。患者治疗完后无不适身体主诉表示，治疗成果高度表现出这个治疗的优异性，特别适合对于浸润性的肿瘤，可以提供肿瘤患者一个高质量的治疗协助。 Boron Neutron Capture Therapy (BNCT) is a binary cancer treatment. The principal mechanism is to deliver a B-10 containing drug into tumor cells firstly and then irradiate tumor lesion specifically with thermal neutron. The fission reaction will generate two particles, α particle and lithium nucleus, which have high biological effectiveness and will damage tumor cells effectively. These high linear energy transfer (LET) particles can not only destroy double strand DNA of tumor cells but it can also protect adjacent normal tissue because it possesses very short reaction area. This time we are trying to report a 77-year-old Shanghai male patient who suffered from huge recurrent hypopharyngeal cancer. After failure of several kinds of treatments, BNCT was chosen for him as a salvage management. Because the recurrent tumor encased his right carotid artery, our BNCT group first helped him to perform a stentgraft placement to protect his right carotid artery. Then he was referred to cancer center in Tsing-Hua University Open Pool Reactor (THOR) for BNCT management. He underwent B-10 drug (4-10borophenylalanine; BPA) infusion first and then was irradiated by thermal neutron. After BNCT, significant tumor regression was observed. Followed Positron Emission Tomography (PET) scan revealed there was no viability of tumor cells. Patient didn’t have any uncomfortable complaints after BNCT. The treatment results showed outstanding outcomes, especially for the tumors with infiltrating characteristics. It’s really an effective therapy with good post-treatment quality of life.
Asian Case Reports in Oncology, Volume 8, pp 15-21; https://doi.org/10.12677/acrpo.2019.82003
目的：研究成人实体型腺泡状横纹肌肉瘤(alveolar rhabdomyosarcoma, ARMS)的病理学特征、治疗以及鉴别诊断。方法：观察1例实体型腺泡状横纹肌肉瘤的病理学特征及免疫表型，并查阅相关文献。结果：肿物位于左侧腹股沟，肿瘤由实性瘤细胞巢组成，腺泡状结构不明显。部分瘤细胞因富含糖原透明，类似肾透明细胞癌或软组织透明细胞肉瘤，称为透明细胞变型。免疫组化示肿瘤细胞desmin Myoglobin, MyoD1, CD99, CD56均(+), Syn, CgA, Fli-1, LCA, TTF-1, CK, CD20均(−)，瘤细胞Ki-67增殖指数约70%。结论：ARMS是发生自胚胎间叶组织的恶性肿瘤，多发生于四肢深部软组织，形态学上以腺泡状结构为特征，需与恶性淋巴瘤、透明细胞肉瘤、尤文氏肉瘤(ES)/原始神经外胚层肿瘤(PNET)等鉴别。 Objective: To investigate the pathological features, treatment and differential diagnosis of adult solid alveolar rhabdomyosarcoma (ARMS). Methods: The pathological features and immunophenotype of 1 case of solid alveolar rhabdomyosarcoma were observed and the related literatures were consulted. Results: The tumor was located in the left groin, and the tumor con-sisted of solid tumor cell nests with no obvious alveolar structure. Some tumor cells are rich in glycogen, similar to renal clear cell carcinoma or soft tissue clear cell sarcoma, called clear cell variant. Immunohistochemical staining showed that tumor cells desmin, Myoglobin, MyoD1, CD99, CD56 all (+), Syn, CgA, Fli-1, LCA, TTF-1, CK, CD20 all (−), tumor cell Ki-67 proliferation index of about 70%. Conclusion: ARMS is a malignant tumor from embryonic mesenchymal tissue, which occurs in deep soft tissues of the extremities. It is morphologically characterized by a vesicular structure. It needs to be associated with malignant lymphoma, clear cell sarcoma, and Ewing’s sarcoma (ES)/primitive neuroectodermal tumor (PNET) and other identification.
Asian Case Reports in Oncology, Volume 8, pp 7-13; https://doi.org/10.12677/acrpo.2019.81002
目的：总结ERAS在1例胸壁肿物行3D打印胸肋骨(PEEK材料)个体化胸壁重建术围手术期的应用。方法：针对患者的情况，结合患者个体化的1:1仿真3D打印胸肋骨模型，介绍3D打印的优势以及选择的必要性，针对其疾病特点以及患者的个体情况制订实施护理措施，包括胸壁缺损重建围手术期护理、患者肢体功能锻炼。结果：经多学科通力协作，患者顺利恢复出院。结论：多学科通力协作下实施个体化的ERAS围手术期的护理是对此患者顺利痊愈的关键。 Objective: To summarize the nursing methods of individualized chest wall reconstruction with osteosarcoma of the sternum using material of 3D printing. Methods: According to the patient’s condition, combined with the patient’s individualized 1:1 simulated 3D printing model of sternum and ribs, the advantages of 3D printing and the necessity of selection were introduced. Nursing measures were formulated and implemented according to the disease characteristics and patient’s individual conditions, including post-operative nursing of chest wall defect reconstruction, nursing of osteosarcoma of the sternum and patient’s function exercise of limbs. Results: The patient was smoothly discharged from hospital after recovery through multi-disciplinary cooperation. Conclusion: Individualized preoperative and postoperative nursing is the key to the successful recovery of this patient.