Biophysical Journal

Journal Information
ISSN / EISSN : 0006-3495 / 1542-0086
Current Publisher: Elsevier (10.1016)
Former Publisher: Elsevier BV (10.1529)
Total articles ≅ 67,733
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Latest articles in this journal

Julia Eckert, Jack J.W. A. van Loon, Lukas M. Eng,
Published: 1 March 2021
Biophysical Journal, Volume 120, pp 773-780; doi:10.1016/j.bpj.2021.01.021

The publisher has not yet granted permission to display this abstract.
Vishram L. Terse,
Published: 1 February 2021
Biophysical Journal, Volume 120, pp 504-516; doi:10.1016/j.bpj.2020.11.2277

The publisher has not yet granted permission to display this abstract.
Yong Liu,
Published: 1 February 2021
Biophysical Journal, Volume 120, pp 517-526; doi:10.1016/j.bpj.2020.12.010

Abstract:
Regulators of G-protein signaling (RGS) proteins play a central role in modulating signaling via G-protein coupled receptors (GPCRs). Specifically, RGS proteins bind to activated Gα subunits in G-proteins, accelerate the GTP hydrolysis, and thereby rapidly dampen GPCR signaling. Therefore, covalent molecules targeting conserved cysteine residues among RGS proteins have emerged as potential candidates to inhibit the RGS/Gα protein-protein interaction and enhance GPCR signaling. Although these inhibitors bind to conserved cysteine residues among RGS proteins, we have previously suggested [J. Am. Chem. Soc. 2018;140:3454–3460] that their potencies and specificities are related to differential protein dynamics among RGS proteins. Using data from all-atom molecular dynamics simulations, we reveal these differences in dynamics of RGS proteins by partitioning the protein structural space into a network of communities that allow allosteric signals to propagate along unique pathways originating at inhibitor binding sites and terminating at the RGS/Gα protein-protein interface.
Neeraja Chilukoti, Timir Baran Sil, Bankanidhi Sahoo, S. Deepa, Sreelakshmi Cherakara, Mithun Maddheshiya,
Published: 1 February 2021
Biophysical Journal, Volume 120, pp 476-488; doi:10.1016/j.bpj.2020.12.019

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, Océane Sénépart, Maxime Schneider, Sophie Malaquin, Emmanuel Péronne, Loïc Becerra, Fannie Semprez, Claire Legay, Laurent Belliard
Published: 1 February 2021
Biophysical Journal, Volume 120, pp 402-408; doi:10.1016/j.bpj.2020.12.021

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Zeliha Kilic, Ioannis Sgouralis,
Published: 1 February 2021
Biophysical Journal, Volume 120, pp 409-423; doi:10.1016/j.bpj.2020.12.022

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Alexander Kihm, Stephan Quint, , Michael D. Menger, Thomas John, Lars Kaestner,
Published: 1 February 2021
Biophysical Journal, Volume 120, pp 432-439; doi:10.1016/j.bpj.2020.12.012

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Palanikumar Loganathan, Mazin M. Magzoub
Published: 1 February 2021
Biophysical Journal, Volume 120; doi:10.1016/j.bpj.2020.11.744

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Khanh D. Nguyen, Michael Vigers, Eric Sefah, Susanna Seppala, Jennifer Hoover, Blake Mertz, Michelle A. O’Malley, Songi Han
Published: 1 February 2021
Biophysical Journal, Volume 120; doi:10.1016/j.bpj.2020.11.760

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Aaron Frederick, Frederick A. Heberle
Published: 1 February 2021
Biophysical Journal, Volume 120; doi:10.1016/j.bpj.2020.11.1084

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