Biophysical Journal
Journal Information
ISSN / EISSN :
0006-3495 / 1542-0086
Current Publisher: Elsevier (10.1016)
Former Publisher:
Elsevier BV (10.1529)
Total articles ≅ 67,733
Current Coverage
SCOPUS
PUBMED
MEDLINE
MEDICUS
PMC
SCIE
LOCKSS
Archived in
SHERPA/ROMEO
Filter:
Latest articles in this journal
Biophysical Journal, Volume 120, pp 773-780; doi:10.1016/j.bpj.2021.01.021
The publisher has not yet granted permission to display this abstract.
Biophysical Journal, Volume 120, pp 504-516; doi:10.1016/j.bpj.2020.11.2277
The publisher has not yet granted permission to display this abstract.
Biophysical Journal, Volume 120, pp 517-526; doi:10.1016/j.bpj.2020.12.010
Abstract:
Regulators of G-protein signaling (RGS) proteins play a central role in modulating signaling via G-protein coupled receptors (GPCRs). Specifically, RGS proteins bind to activated Gα subunits in G-proteins, accelerate the GTP hydrolysis, and thereby rapidly dampen GPCR signaling. Therefore, covalent molecules targeting conserved cysteine residues among RGS proteins have emerged as potential candidates to inhibit the RGS/Gα protein-protein interaction and enhance GPCR signaling. Although these inhibitors bind to conserved cysteine residues among RGS proteins, we have previously suggested [J. Am. Chem. Soc. 2018;140:3454–3460] that their potencies and specificities are related to differential protein dynamics among RGS proteins. Using data from all-atom molecular dynamics simulations, we reveal these differences in dynamics of RGS proteins by partitioning the protein structural space into a network of communities that allow allosteric signals to propagate along unique pathways originating at inhibitor binding sites and terminating at the RGS/Gα protein-protein interface.
Biophysical Journal, Volume 120, pp 476-488; doi:10.1016/j.bpj.2020.12.019
The publisher has not yet granted permission to display this abstract.
Biophysical Journal, Volume 120, pp 402-408; doi:10.1016/j.bpj.2020.12.021
The publisher has not yet granted permission to display this abstract.
Biophysical Journal, Volume 120, pp 409-423; doi:10.1016/j.bpj.2020.12.022
The publisher has not yet granted permission to display this abstract.
Biophysical Journal, Volume 120, pp 432-439; doi:10.1016/j.bpj.2020.12.012
The publisher has not yet granted permission to display this abstract.
Biophysical Journal, Volume 120; doi:10.1016/j.bpj.2020.11.744
The publisher has not yet granted permission to display this abstract.
Biophysical Journal, Volume 120; doi:10.1016/j.bpj.2020.11.760
The publisher has not yet granted permission to display this abstract.
Biophysical Journal, Volume 120; doi:10.1016/j.bpj.2020.11.1084
The publisher has not yet granted permission to display this abstract.