Biological Trace Element Research

Journal Information
ISSN / EISSN : 0163-4984 / 1559-0720
Published by: Springer Nature (10.1007)
Total articles ≅ 8,529
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Latest articles in this journal

Shihui Guo, Yingying Dong, Xiaoxian Cheng, Zijin Chen, Yingdong Ni, Ruqian Zhao,
Biological Trace Element Research pp 1-11; https://doi.org/10.1007/s12011-022-03269-5

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Pan Zhao, , Zhichao Wang, Weihong Min, Yawen Gao
Biological Trace Element Research pp 1-14; https://doi.org/10.1007/s12011-022-03287-3

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, Trias Mahmudiono, Vahid Ranaei, Mansour Sarafraz, Amene Nematollahi, Amin Mousavi Khaneghah
Biological Trace Element Research pp 1-11; https://doi.org/10.1007/s12011-022-03289-1

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Esam O. Kamel, Wail M. Gad-Elrab, Mohammed A. Ahmed, Zuhair M. Mohammedsaleh, Emad H. M. Hassanein,
Biological Trace Element Research pp 1-18; https://doi.org/10.1007/s12011-022-03286-4

Abstract:
Cadmium (Cd) is a serious pollutant in the environment. Candesartan is an angiotensin II (Ang II) receptor antagonist with promising diverse health benefits. The current study is planned to investigate the hepatorenal protective effects of candesartan against Cd-induced hepatic and renal intoxication. Our results demonstrated that candesartan effectively attenuated Cd-induced hepatorenal intoxication, as evidenced by improving hepatic and renal function biomarkers. Besides, candesartan reversed hepatic and renal histopathological abrasions induced by Cd toxicity. Candesartan antioxidant effect was mediated by Nrf2 activation. Also, candesartan suppressed hepatorenal inflammation by modulating NF-κB/IκB. Moreover, candesartan attenuated Cd hepatorenal apoptosis by upregulating Bcl-2 and downregulating Bax and Cyt-C proteins. Interestingly, these effects are suggested to be an outcome of modulating of Ang II/Ang 1–7 signal. Overall, our findings revealed that candesartan could attenuate Cd-induced hepatorenal intoxication through modulation of Nrf2, NF-κB/IκB, Bax/Bcl-2/Cyt-c, and Ang II/Ang 1–7 signaling pathways.
Jiaming Zheng, Guobin Qiu, Yewen Zhou, KeZhe Ma,
Biological Trace Element Research pp 1-9; https://doi.org/10.1007/s12011-022-03252-0

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Bo-Wen Bao, Zibo Kang, Yu Zhang, Kan Li, Ran Xu,
Biological Trace Element Research pp 1-10; https://doi.org/10.1007/s12011-022-03288-2

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Mohd Aslam Saifi, Rishabh Hirawat,
Biological Trace Element Research pp 1-9; https://doi.org/10.1007/s12011-022-03284-6

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Anna Machoy-Mokrzyńska, Patrycja Kupnicka, Katarzyna Barczak, Jan Korbecki, Izabela Gutowska, Ewa Sobolewska, Dariusz Chlubek,
Biological Trace Element Research pp 1-11; https://doi.org/10.1007/s12011-022-03186-7

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