Journal of Urology

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ISSN / EISSN : 0022-5347 / 1527-3792
Total articles ≅ 138,402
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Latest articles in this journal

Felix Preisser, Philipp Mandel
Journal of Urology; doi:10.1097/ju.0000000000001841.02

Nahid Punjani, Gal Wald, Omar Al-Hussein Alawamlh, Vanessa Dudley, Marc Goldstein
Journal of Urology; doi:10.1097/ju.0000000000001877.03

Chiara Lonati, Agostino Mattei
Journal of Urology; doi:10.1097/ju.0000000000001841.01

Neeraj Agarwal, Kelly McQuarrie, Anders Bjartell, Simon Chowdhury, Andrea J. Pereira De Santana Gomes, Byung Ha Chung, Mustafa Özgüroğlu, Álvaro Juárez Soto, Axel S. Merseburger, Hirotsugu Uemura, et al.
Journal of Urology; doi:10.1097/ju.0000000000001841.03

Scott D. Lundy, Sarah C. Vij
Journal of Urology; doi:10.1097/ju.0000000000001877.01

Dmitriy Nikolavsky, Jay Simhan
Journal of Urology; doi:10.1097/ju.0000000000001870.02

Jason R. Kovac
Journal of Urology; doi:10.1097/ju.0000000000001877.02

Adam C. Calaway, Sean Q. Kern, David Crook, Yan Tong, Timothy A. Masterson, Nabil Adra, Lawrence H. Einhorn, Richard S. Foster, Clint Cary
Journal of Urology; doi:10.1097/ju.0000000000001960

Abstract:
Introduction: Presence of teratoma in the orchiectomy and residual retroperitoneal mass size are known predictors of finding teratoma during post-chemotherapy retroperitoneal lymph node dissections (PC-RPLND). We sought to determine if the percentage of teratoma in the orchiectomy specimen could better stratify the risk of teratoma in the retroperitoneum. Materials and Methods: The Indiana University testis cancer database was reviewed to identify patients who underwent PC-RPLND for non-seminomatous germ cell tumors from 2010-2018. A logistic regression model was fit to predict the presence of retroperitoneal teratoma using teratoma and yolk sac tumor (YST) in the orchiectomy, residual mass size, and log transformed values of pre-chemotherapy AFP and bHCG. The study cohort was split into 60% training and 40% validation sets using 200 bootstraps. A predictive nomogram was developed for predicting teratoma in the retroperitoneum. Results: A total of 422 men were included. Presence of teratoma in the orchiectomy (OR 1.02, p <0.001), residual mass size (OR 1.16, p <0.001) and log transformed pre-chemotherapy AFP (OR 1.12, p=0.002) were predictive factors for having teratoma in the retroperitoneum. The C-statistic using this model demonstrated a predictive ability of 0.77. Training set C-statistic was 0.78 compared to 0.75 for the validation set. A nomogram was developed to aid in clinical utility. Conclusion: The model better predicts patients at higher risk of teratoma in the retroperitoneum following chemotherapy which can aid in a more informed referral for surgical resection.
Gregory M. Amend, Benjamin N. Breyer
Journal of Urology; doi:10.1097/ju.0000000000001840.01

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