Molecular and Cellular Biology

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ISSN / EISSN : 0270-7306 / 1098-5549
Published by: American Society for Microbiology (10.1128)
Total articles ≅ 31,413
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Latest articles in this journal

Jason M. Berk, Min Jae Lee, Mengwen Zhang, Christopher Lim, Mark Hochstrasser
Molecular and Cellular Biology; https://doi.org/10.1128/mcb.00071-22

Abstract:
Host cell membrane-trafficking pathways are often manipulated by bacterial pathogens to gain cell entry, avoid immune responses, or to obtain nutrients. The 1,369-residue OtDUB protein from the obligate intracellular human pathogen Orientia tsutsugamushi bears a deubiquitylase (DUB) and additional domains.
Li-Ting Jiang, Yu-Hui Chen, Jie-Hong Huang, Wei-Fang Tong, Ling-Jing Jin, Li-Xi Li
Molecular and Cellular Biology; https://doi.org/10.1128/mcb.00559-21

Abstract:
Charcot-Marie-Tooth type 4D (CMT4D) is an autosomal recessive demyelinating form of CMT characterized by progressive motor and sensory neuropathy. N-myc downstream regulated gene 1 ( NDRG1 ) is the causative gene for CMT4D. Although more CMT4D cases have been reported, the comprehensive molecular mechanism underlying CMT4D remains elusive.
Hongge Wang, Pan Wang,
Molecular and Cellular Biology, Volume 42; https://doi.org/10.1128/mcb.00522-21

Abstract:
Ferroptosis is a form of regulated cell death resulting predominantly from catastrophic accumulation of lipid reactive oxygen species (ROS). While the antioxidant systems that counter ferroptosis have been well characterized, the mechanism underlying ferroptosis-associated accumulation of lipid ROS remains unclear. In this study, we demonstrated that protein disulfide isomerase (PDI) is a novel mediator of ferroptosis, which is responsible for the accumulation of lipid ROS and ultimately ferroptosis in MDA-MB-231 human breast cancer cells.
Saman Khan, Nafees Ahamad, Sankhadip Bhadra, Zheng Xu,
Molecular and Cellular Biology, Volume 42; https://doi.org/10.1128/mcb.00045-22

Abstract:
Smc5/6, like cohesin and condensin, is a structural maintenance of chromosomes complex crucial for genome stability. Unlike cohesin and condensin, Smc5/6 carries an essential Nse2 subunit with SUMO E3 ligase activity.
Shuangjiu Zhu, Jingjun Sun, Xiaoqin Liu, Hua Shao, Chuanbo Feng, Zhonglin Wang, Xinwen Zheng, Shaohua Wei
Molecular and Cellular Biology, Volume 42; https://doi.org/10.1128/mcb.00188-21

Abstract:
Triple-negative breast cancer (TNBC) represents one of the subtypes of breast cancer with high aggressiveness. Long noncoding RNAs (lncRNAs) are well-known to function as crucial regulators in human cancers which include TNBC.
Samantha Z. Brown, Grace A. McCarthy, James R. Carroll, Roberto Di Niro, Carl Pelz, Aditi Jain, Thomas L. Sutton, Hannah D. Holly, Avinoam Nevler, Christopher W. Schultz, et al.
Molecular and Cellular Biology; https://doi.org/10.1128/mcb.00018-22

Abstract:
Yes-associated protein 1 (YAP1) is indispensable for the development of mutant KRAS -driven pancreatic ductal adenocarcinoma (PDAC). High YAP1 mRNA is a prognostic marker for worse overall survival in patient samples; however, the regulatory mechanisms that mediate its overexpression are not well understood. YAP1 genetic alterations are rare in PDAC, suggesting that its dysregulation is likely not due to genetic events.
Hong Jiang, Pratik Thapa, Na Ding, Yanning Hao, Aziza Alshahrani, Chi Wang, B. Mark Evers,
Molecular and Cellular Biology, Volume 42; https://doi.org/10.1128/mcb.00051-22

Abstract:
Intracellular antioxidant enzymes are critical for maintenance of redox homeostasis, but whether and how they contribute to the malignancy of cancer cells remains poorly understood.
Bhavana Kayyar, Anjhana C. Ravikkumar, Utsa Bhaduri,
Molecular and Cellular Biology, Volume 42; https://doi.org/10.1128/mcb.00475-21

Abstract:
Sox8 is a developmentally important transcription factor that plays an important role in sex maintenance and fertility of adult mice. In the B-type spermatogonial cells, Sox8 is regulated by the long noncoding RNAs (lncRNA) Mrhl in a p68-dependant manner under the control of the Wnt signaling pathway. The downregulation of Mrhl leads to the meiotic commitment of the spermatogonial cells in a Sox8 -dependant manner.
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