Molecular and Cellular Biology
ISSN / EISSN : 0270-7306 / 1098-5549
Published by: American Society for Microbiology (10.1128)
Total articles ≅ 31,413
Latest articles in this journal
Molecular and Cellular Biology; https://doi.org/10.1128/mcb.00071-22
Host cell membrane-trafficking pathways are often manipulated by bacterial pathogens to gain cell entry, avoid immune responses, or to obtain nutrients. The 1,369-residue OtDUB protein from the obligate intracellular human pathogen Orientia tsutsugamushi bears a deubiquitylase (DUB) and additional domains.
Molecular and Cellular Biology; https://doi.org/10.1128/mcb.00559-21
Charcot-Marie-Tooth type 4D (CMT4D) is an autosomal recessive demyelinating form of CMT characterized by progressive motor and sensory neuropathy. N-myc downstream regulated gene 1 ( NDRG1 ) is the causative gene for CMT4D. Although more CMT4D cases have been reported, the comprehensive molecular mechanism underlying CMT4D remains elusive.
Molecular and Cellular Biology, Volume 42; https://doi.org/10.1128/mcb.00139-22
Molecular and Cellular Biology, Volume 42; https://doi.org/10.1128/mcb.00522-21
Ferroptosis is a form of regulated cell death resulting predominantly from catastrophic accumulation of lipid reactive oxygen species (ROS). While the antioxidant systems that counter ferroptosis have been well characterized, the mechanism underlying ferroptosis-associated accumulation of lipid ROS remains unclear. In this study, we demonstrated that protein disulfide isomerase (PDI) is a novel mediator of ferroptosis, which is responsible for the accumulation of lipid ROS and ultimately ferroptosis in MDA-MB-231 human breast cancer cells.
Molecular and Cellular Biology, Volume 42; https://doi.org/10.1128/mcb.masthead.42-6
Molecular and Cellular Biology, Volume 42; https://doi.org/10.1128/mcb.00045-22
Smc5/6, like cohesin and condensin, is a structural maintenance of chromosomes complex crucial for genome stability. Unlike cohesin and condensin, Smc5/6 carries an essential Nse2 subunit with SUMO E3 ligase activity.
Molecular and Cellular Biology, Volume 42; https://doi.org/10.1128/mcb.00188-21
Triple-negative breast cancer (TNBC) represents one of the subtypes of breast cancer with high aggressiveness. Long noncoding RNAs (lncRNAs) are well-known to function as crucial regulators in human cancers which include TNBC.
Molecular and Cellular Biology; https://doi.org/10.1128/mcb.00018-22
Yes-associated protein 1 (YAP1) is indispensable for the development of mutant KRAS -driven pancreatic ductal adenocarcinoma (PDAC). High YAP1 mRNA is a prognostic marker for worse overall survival in patient samples; however, the regulatory mechanisms that mediate its overexpression are not well understood. YAP1 genetic alterations are rare in PDAC, suggesting that its dysregulation is likely not due to genetic events.
Molecular and Cellular Biology, Volume 42; https://doi.org/10.1128/mcb.00051-22
Intracellular antioxidant enzymes are critical for maintenance of redox homeostasis, but whether and how they contribute to the malignancy of cancer cells remains poorly understood.
Molecular and Cellular Biology, Volume 42; https://doi.org/10.1128/mcb.00475-21
Sox8 is a developmentally important transcription factor that plays an important role in sex maintenance and fertility of adult mice. In the B-type spermatogonial cells, Sox8 is regulated by the long noncoding RNAs (lncRNA) Mrhl in a p68-dependant manner under the control of the Wnt signaling pathway. The downregulation of Mrhl leads to the meiotic commitment of the spermatogonial cells in a Sox8 -dependant manner.