Clinical Rheumatology

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ISSN / EISSN : 0770-3198 / 1434-9949
Current Publisher: Springer Science and Business Media LLC (10.1007)
Former Publisher: Springer Science and Business Media LLC (10.1007) , Springer Science and Business Media LLC (10.1007) , , Springer Science and Business Media LLC (10.1007) , Springer Science and Business Media LLC (10.1007) , Springer Singapore (10.1007) Springer Science and Business Media LLC (10.1007)
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Antonietta Gigante, Francesco Iannazzo, Luca Navarini, Maria Chiara Sgariglia, Domenico Paolo Emanuele Margiotta, Valentina Vaiarello, Federica Foti, Antonella Afeltra, Rosario Cianci,
Clinical Rheumatology pp 1-6; doi:10.1007/s10067-021-05731-6

Abstract:
Introduction Aims of study were to evaluate the prevalence of metabolic syndrome (MetS) in systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) patients and to evaluate serum level of adipokines in SLE and SSc patients with and without MetS. Methods Fifty SLE patients and 85 SSc patients were enrolled. The diagnosis of MetS was made according to the criteria of the National Cholesterol Education Program (NCEP) Adult Treatment Panel III. Clinical assessment and serum levels of adiponectin and resistin were evaluate in SLE and SSc patients. Results Prevalence of MetS was significantly (p<0.0001) higher in SLE patients than SSc patients (36% vs 10.6%). Median values of resistin were significantly (p<0.001) higher in SLE patients with MetS than SLE patients without MetS [4.01 ng/mL (2.7–4.5) vs 1.92 ng/mL (1.2–3)]. Median values of adiponectin were significantly (p<0.05) lower in SLE patients with MetS than SLE patients without MetS [5.64 ng/mL (4.96–8) vs 8.38 ng/mL (6.54–11.01)]. Systemic Lupus Erythematosus Activity Index [8 (6–12) vs 10 (6–13), p<0.01] and Systemic Damage Index [2 (1–3) vs 2 (0–3), p<0.001] were significantly higher in MetS patients than in patients without MetS. In SSc, the median value of disease severity scale was significantly higher (p<0.05) in MetS patients than in patients without MetS [7 (5–7) vs 5 (3–6)]. Conclusion Prevalence of MetS is higher in SLE patients. In SLE patients, MetS showed an association with adipokine levels and inflammation/activity disease scores. In SSc patients, MetS was associated with severity of disease. Key Points • Prevalence of metabolic syndrome is higher in SLE patients than SSc patients. • Resistin is higher in SLE patients with metabolic syndrome. • Adineponectin is lower in SLE patients with metabolic syndrome. • Disease severity scale is higher in SSc patients with metabolic syndrome.
Tien-Ming Chan, Meng-Jiun Chiou,
Clinical Rheumatology pp 1-8; doi:10.1007/s10067-021-05688-6

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Diana Castillo-Martínez, Zaira Torres, ,
Clinical Rheumatology pp 1-5; doi:10.1007/s10067-021-05724-5

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, Elena Borlandelli, Cecilia Tetta, Marco Miceli, Riccardo Meliconi, Francesco Ursini
Clinical Rheumatology pp 1-2; doi:10.1007/s10067-021-05714-7

, For Ussonar, Karina D. Torralba, Kristal S. Choi, Robert M. Fairchild, Amy Cannella, Lorena Salto, Eugene Y. Kissin, Ralf Thiele, Edward J. Oberle, et al.
Clinical Rheumatology pp 1-10; doi:10.1007/s10067-021-05716-5

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Eleni Pilitsi,
Clinical Rheumatology pp 1-5; doi:10.1007/s10067-021-05725-4

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Shasha Duan, Si Ha, Shujuan Li, Yaxi Wang, Yilu Shi, Haiyue Zhao, Lu Zhang, Xiaoshan Zhang,
Clinical Rheumatology pp 1-9; doi:10.1007/s10067-021-05723-6

Abstract:
Objectives To compare cardiac function and systolic dyssynchrony of fetuses not exposed to and those exposed to maternal autoimmune antibodies using two-dimensional speckle tracking echocardiography (2DSTE). Methods An observational study of 52 fetuses, 18 from mothers with autoimmune antibodies (anti-SSA/Ro60, anti-Ro52 or/and anti-SSB/La) and 34 from healthy mothers without antibodies, was conducted. Maternal baseline characteristics, fetoplacental Doppler parameters, and conventional echocardiographic data were prospectively collected. Systolic global and regional longitudinal strain of left and right ventricle (LV and RV) and the time to peak strain of regional myocardium were measured using 2DSTE. We also calculated the differences in time to peak strain between the LV free wall and RV free wall (two-chamber dyssynchrony, 2C-DYS) and the LV dyssynchrony between the septum and LV free wall (one-chamber dyssynchrony, 1C-DYS). Results There were no significant differences in conventional systolic and diastolic functional parameters for the LV and RV. No effect modification was demonstrated in a myocardial deformation analysis. However, 1C-DYS was significantly more prolonged in the maternal autoimmune disease group (19.50 [8.00 to 29.25] vs. 28.50 [13.50 to 39.25], P = 0.042). Conclusions LV systolic mechanical dyssynchrony in fetuses of mothers with autoimmune antibodies suggests in-utero subclinical damage of the cardiac conduction system. Key points• The left ventricular systolic dyssynchrony was significantly more prolonged in the maternal autoimmune disease (AD) fetuses. • Subclinical damage to the left ventricular conduction system of the fetal heart in maternal AD was observed. • Systolic and diastolic functional of the left and right ventricle were preserved in fetuses exposed to maternal autoimmune disease.
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