OncoTargets and Therapy

Journal Information
ISSN / EISSN : 11786930 / 11786930
Current Publisher: Dove Medical Press Ltd. (10.2147)
Total articles ≅ 3,493
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Latest articles in this journal

Linghong Guo, Honghong Ren, Hao Zeng, Yanqiu Gong, Xuelei Ma
OncoTargets and Therapy, Volume 12, pp 3859-3868; doi:10.2147/ott.s193616

Abstract:Proteomic analysis of cerebrospinal fluid in pediatric acute lymphoblastic leukemia patients: a pilot study Linghong Guo,1,2,* Honghong Ren,2 Hao Zeng,2 Yanqiu Gong,3 Xuelei Ma1,* 1Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu 610041, People’s Republic of China; 2West China School of Medicine, Sichuan University, Chengdu, People’s Republic of China; 3State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, People’s Republic of China *These authors contributed equally to this work Purpose: Involvement of central nervous system in acute lymphoblastic leukemia (CNSL) remains one of the major causes of pediatric acute lymphoblastic leukemia (ALL) treatment failure. However, the current understanding of the pathological process of CNSL is still limited. This study aimed to better understand the protein expression in cerebrospinal fluid (CSF) of ALL and discover valuable prognostic biomarkers.Materials and methods: CSF samples were obtained from ALL patients and healthy controls. Comparative proteomic profiling using label-free liquid chromatography-tandem mass spectrometry was performed to detect differentially expressed proteins.Results: In the present study, 51 differentially expressed proteins were found. Among them, two core clusters including ten proteins (TIMP1, LGALS3BP, A2M, FN1, AHSG, HRG, ITIH4, CF I, C2, and C4a) might be crucial for tumorigenesis and progression of ALL and can be potentially valuable indicators of CNSL.Conclusion: These differentially expressed proteins of ALL children with central nervous system involvement and normal children may work as diagnostic and prognostic factors of ALL patients. Keywords: ALL, central nervous system leukemia, CSF, mass spectrometry, proteomics
OncoTargets and Therapy; doi:10.2147/ott

Abstract:An international, peer-reviewed journal focusing on the pathological basis of all cancers, potential targets for therapy and treatment protocols employed to improve the management of cancer patients. In terms of therapy, palliative care is also included as part of the overall patient care process.
Wenze Li, Shuren Li, Jie Yang, Chunyan Cui, Miao Yu, Yadong Zhang
OncoTargets and Therapy, Volume 12, pp 3753-3763; doi:10.2147/ott.s200082

Abstract:ITGBL1 promotes EMT, invasion and migration by activating NF-kappaB signaling pathway in prostate cancer Wenze Li,1,* Shuren Li,1,* Jie Yang,1 Chunyan Cui,2 Miao Yu,3 Yadong Zhang41Department of Urinary Surgery, The First hospital of Xiangtan city, Xiangtan 411101, People’s Republic of China; 2Department of Radiology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, People’s Republic of China; 3Center for Private Medical Service and Healthcare, The First Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, People’s Republic of China; 4Department of Andrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, People’s Republic of China*These authors contributed equally to this work Background: Integrin beta-like 1 (ITGBL1) was extensively demonstrated to contribute the metastasis and progression in a variety of cancers. However, its role of ITGBL1 in prostate cancer (PCa) is still not reported.Methods: Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blot were performed to detect ITGBL1 expression in PCa tissues and cell lines. Immunohistochemical (IHC) staining of ITGBL1 in 174 PCa tissues was performed. The influence of ITGL1 expression in PCa cells epithelial-mesenchymal transition (EMT), migration and invasion was investigated. Notably, the possible mechanisms underlying the action of ITGBL1 in vivo and vitro assays were explored.Results: We analyzed PCa dataset from The Cancer Genome Atlas (TCGA) and found that ITGBL1 was upregulated in PCa tissues. Overexpression of ITGBL1 is positively associated with the progression and lymph node metastasis in PCa patients. Furthermore, upregulating ITGBL1 enhanced the invasion, migration abilities and EMT in PCa cells. Conversely, downregulating ITGBL1 exhibited an opposite effect. Our findings further demonstrated that ITGBL1 promoted invasion and migration via activating NF-κB signaling in PCa cells.Conclusion: Therefore, our results identify a novel metastasis-related gene in PCa, which will help to develop a novel therapeutic strategy in metastatic PCa.Keywords: ITGBL1, EMT, NF-κB signaling, lymph node metastasis and prostate cancer
Chao Wu, Hongxin Ma, Guijun Qi, Fanyu Chen, Jiancheng Chu
OncoTargets and Therapy, Volume 12, pp 3661-3670; doi:10.2147/ott.s200901

Abstract:Insulin-like growth factor II mRNA-binding protein 3 promotes cell proliferation, migration and invasion in human glioblastoma
Han-Xue Li
OncoTargets and Therapy, Volume 12, pp 3645-3660; doi:10.2147/ott.s203144

Abstract:The role of circadian clock genes in tumors
Qiong Wu, Bo Zhang, Yidan Sun, Ran Xu, Xinyi Hu, Shiqi Ren, Qianqian Ma, Chen Chen, Jian Shu, Fuwei Qi, et al.
OncoTargets and Therapy, Volume 12, pp 3545-3563; doi:10.2147/ott.s198621

Abstract:Identification of novel biomarkers and candidate small molecule drugs in non-small-cell lung cancer by integrated microarray analysis Qiong Wu,1,2 Bo Zhang,1,2 Yidan Sun,3 Ran Xu,1 Xinyi Hu,4 Shiqi Ren,4 Qianqian Ma,5 Chen Chen,6 Jian Shu,7 Fuwei Qi,7 Ting He,7 Wei Wang,2 Ziheng Wang21Medical School of Nantong University, Nantong 226001, People’s Republic of China; 2The Hand Surgery Research Center, Department of Hand Surgery, Affiliated Hospital of Nantong University, Nantong 226001, People’s Republic of China; 3Department of Oncology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, People’s Republic of China; 4Department of Biochemistry & Molecular Biology, Nantong University, Nantong, Jiangsu 226001, People’s Republic of China; 5Emergency Office, Wuxi Center for Disease Control and Prevention, Wuxi 214023, People’s Republic of China; 6Department of Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, People’s Republic of China; 7The First People‘s Hospital of Taicang City, Taicang Affiliated Hospital of Soochow University, Suzhou 215400, People’s Republic of ChinaBackground: Non-small-cell lung cancer (NSCLC) remains the leading cause of cancer morbidity and mortality worldwide. In the present study, we identified novel biomarkers associated with the pathogenesis of NSCLC aiming to provide new diagnostic and therapeutic approaches for NSCLC.Methods: The microarray datasets of GSE18842, GSE30219, GSE31210, GSE32863 and GSE40791 from Gene Expression Omnibus database were downloaded. The differential expressed genes (DEGs) between NSCLC and normal samples were identified by limma package. The construction of protein–protein interaction (PPI) network, module analysis and enrichment analysis were performed using bioinformatics tools. The expression and prognostic values of hub genes were validated by GEPIA database and real-time quantitative PCR. Based on these DEGs, the candidate small molecules for NSCLC were identified by the CMap database.Results: A total of 408 overlapping DEGs including 109 up-regulated and 296 down-regulated genes were identified; 300 nodes and 1283 interactions were obtained from the PPI network. The most significant biological process and pathway enrichment of DEGs were response to wounding and cell adhesion molecules, respectively. Six DEGs (PTTG1, TYMS, ECT2, COL1A1, SPP1 and CDCA5) which significantly up-regulated in NSCLC tissues, were selected as hub genes according to the results of module analysis. The GEPIA database further confirmed that patients with higher expression levels of these hub genes experienced a shorter overall survival. Additionally, CMap predicted the 20 most significant small molecules as potential therapeutic drugs for NSCLC. DL-thiorphan was the most promising small molecule to reverse the NSCLC gene expression.Conclusions: Based on the gene expression profiles of 696 NSCLC samples and 237 normal...
Bin Wu, Rongyu Liu
OncoTargets and Therapy, Volume 12, pp 3625-3633; doi:10.2147/ott.s181432

Abstract:PAQR4 promotes cell proliferation and metastasis through the CDK4-pRB-E2F1 pathway in non-small-cell lung cancer
Ge Gao, Dianhui Xiu, Bin Yang, Daju Sun, Xin Wei, Youpeng Ding, Yanan Ma, Zhixin Wang
OncoTargets and Therapy, Volume 12, pp 3531-3544; doi:10.2147/ott.s183435

Abstract:MiR-129-5p inhibits prostate cancer proliferation via targeting ETV1
Yao Dai, Dietmar Siemann
OncoTargets and Therapy, Volume 12, pp 3519-3529; doi:10.2147/ott.s201320

Abstract:C-Src is required for hypoxia-induced metastasis-associated functions in prostate cancer cells
Jiayu Zhou, Shizhen Zhang, Guoxiang Fu, Zhengfu He, Yong Xu, Weiwen Ye, Zhoumiao Chen
OncoTargets and Therapy, Volume 12, pp 3361-3362; doi:10.2147/ott.s212589

Abstract:Overexpression of APC11 predicts worse survival in lung adenocarcinoma [Corrigendum]