Jurnal Kedokteran dan Kesehatan Indonesia

Journal Information
ISSN / EISSN : 2085-4145 / 2527-2950
Total articles ≅ 212
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Latest articles in this journal

Asri Hendrawati
Jurnal Kedokteran dan Kesehatan Indonesia, Volume 12, pp 3-4; doi:10.20885/jkki.vol12.iss1.art2

Siti Istianah, Budi Mulyaningsih, Sitti Rahmah Umniyati, Eggi Arguni
Jurnal Kedokteran dan Kesehatan Indonesia, Volume 12, pp 44-51; doi:10.20885/jkki.vol12.iss1.art8

Background: The filariasis elimination program in Indonesia has been conducted, but new cases and some chronic cases are still often found. Objective: This study aims to determine levels of endemicity and to identify filarial worm species in filariasis cases and s and their surrounding communities by using microscopic examination, polymerase chain reaction (PCR), and to examine levels of infection in vectors mosquito by surgery and PCR. Also to to determine that Ae. aegypti can act as vector of filariasis. Methods: This study was conducted at 10 locations in Pekalongan Regency, Central Java Province, with a cross sectional design. Intravenous blood sampling was conducted on 102 respondents consisting of 10 elephantiasis patients and 92 non-elephantiasis patients at night, starting at 8 pm, then examined microscopically and PCR. Mosquitoes in this study were collected by using a human landing collection method for 12 hours from 6 pm to 6 am by volunteers. Artificial infection of microfilaria W. bancrofti was held against Cx. quinquefasciatus and Ae.aegypti from laboratory collection. Results: Results of this study found that there were 5.729 of mosquitos, consisting of 8 species, namely Culex quinquefasciatus, Culex vishnui, Culex tritaeniorhynchus, Aedes aegypti, Aedes albopictus, Anopheles subpictus, Anopheles vagus, and Armigeres kesseli. Microfilarial (mf) rate was 0.89%, and and the blood PCR showed infection rate of 3.92% and the blood PCR showed infection rate of 3.92%. No larva was found in female mosquito dissection. The PCR results showed that the infection rate was 9.10% in Ae. aegypty pool respectively. Artificial infection results was negative both dissecting microscopis and PCR. Conclusion: This study revealed that the locations were low of filariasis endemicity. The mf rate was less than 1%, and there was a moderate density to high density of microfilaria in the patients. The low level of infection rates in mosquito is suggested as an alert to its potential transmission.
Desy Armalina, Bambang Witjahjo, Neni Susilaningsih
Jurnal Kedokteran dan Kesehatan Indonesia, Volume 12, pp 11-18; doi:10.20885/jkki.vol12.iss1.art4

Background: Mosquito repellent technology has changed from conventional technology to electric technology, which is more secure and practical. All insect repellent contains chemical compounds that can endanger health. D-Allethrin, the first pyrethroid generation of mosquito repellent is used commercially. Some studies in multi-ethnic population found transplacental transmission in pregnancy. Objective: This study aims to evaluate influences of D-Allethrin in mosquito repellent on liver and kidney, and teratogenic effects in foetal mice. Methods: An experimental laboratory design was conducted in 18 pregnant female Balb/c mice. They were randomized into 3 groups: Group K, P1 and P2. Group K was not given anything. Group P1 and P2 were given exposure pathways of mosquito repellent with inhalation for 12 and 24 hours, in a period of gestational age (0-18 days). On day 19, a Cesar surgery was conducted to take their foetuses and to count the number of living foetuses, dead foetuses, disability, and morphological abnormalities. Results: The administration of allethrin inhalation with dose 12 hours and 24 hours significantly damage mice’s kidney and liver microscopically (p<0.05). A microscopic result of the liver were necrosis in portal areas, hydropic degeneration of lobules, infiltration of inflammatory cells, and fibrosis in the portal area causing a sinusoidal portal to widen. Kidney examination obtained necrosis and hydropic degeneration, as well as the infiltration of lymphocytes and erythrocytes. Teratogenic effects in the foetuses were prematurity and failure of foetal development. Conclusion: Exposure pathways of D-Allethrin in mosquito repellent affected the microscopic appearance of the liver, kidney, and teratogenic effects in the foetuses.
Giwang Yayi Retnosari, Irwanto Irwanto, Lilik Herawati
Jurnal Kedokteran dan Kesehatan Indonesia, Volume 12, pp 28-33; doi:10.20885/jkki.vol12.iss1.art6

Background: A quarter of child population experiences sleep problems in their first three years of life. Inadequacy and problems of sleep for children may be caused by various causes that impact their mental health, emotional states, physical states, and immune systems. This also may culminate to behavioural problems. Objective: The aim of this study is to identify the prevalence of sleep problems in 0–36 months old Indonesian children. Methods: A cross-sectional study was conducted in Tulungagung, East Java, Indonesia. Children aged 0–36 months old were enrolled by using a quota sampling. Brief Infant Sleep Questionnaire (BISQ) was used in this study to assess the sleep problems. All obtained data were presented as a distribution and percentage of each variable referring to the BISQ indicators. Results: A total of 493 children were enrolled in this study. This study found that there were 153 children (31%) who had experienced sleep problems, 79 children (16%) who had nocturnal sleep duration less than 9 hours, 62 children (12,8%) who had nocturnal waking more than 3 times, and 20 children (4%) who had duration of wakefulness during the night more than 1 hour respectively. Conclusion: Although majority of parents thought that there were no sleeping problems with their children, the prevalence of sleep problems in 0–36 months old Indonesian children was quite high (31%), suggesting low parental awareness towards sleep problems of their children.
Kurnia Putri Utami, Widya Wasityastuti, Marsetyawan Hne Soesatyo
Jurnal Kedokteran dan Kesehatan Indonesia, Volume 12, pp 68-78; doi:10.20885/jkki.vol12.iss1.art11

An immune system recognizes and responds to antigens entering the body. Maintaining these roles, components of the immune system need energy obtained from nutrients such as carbohydrates, proteins, and lipids. This study reviews and discusses roles of lipids, particularly fatty acids, in regulations of the immune system. This study was conducted by conducting a literature study on published research articles written in English. The articles were obtained from PubMed and Google Scholar by using search keywords: lipid, fatty acids, immune, regulation, inflammation, and response. Lipids are a group of biomolecule compounds composed of carbon, oxygen, and hydrogen, and they are classified into simple, compound and complex lipids. Fatty acids are compound lipids that act as a main fuel for metabolism, an essential component for all membranes, and a gene regulator. Fatty acids have a modulating effect on immune cells, such as: acting as a host defence, activating the immune system, interacting with nuclear transcription factors, playing roles in inflammatory responses, promoting apoptosis, as well as influencing lymphocyte proliferation, cytokine production, and Natural Killer (NK) cell activities. However, the modulation of the immune system by lipids is influenced by various factors such as concentration and types of fatty acids, types of immune cells, and species. This study is suggested to provide an overview of beneficial roles of lipids in maintaining immunity.
Sri Sulistyowati, Nutria Widya Purna Anggraini
Jurnal Kedokteran dan Kesehatan Indonesia, Volume 12, pp 98-104; doi:10.20885/jkki.vol12.iss1.art14

The number of COVID-19 cases, especially with pregnancy, remains a problem in the world and in Indonesia. The main clinical symptoms include fever (temperature >38oC), cough, and shortness of breath. In addition, it can be accompanied by fatigue, myalgia, gastrointestinal symptoms such as diarrhea, and even recently found manifestations of skin disorders. Skin manifestations in COVID-19 pregnant patients are still a rare condition. Skin manifestations can be an early sign of such infection, which therefore requires clinicians’ notice to allow them to conduct early COVID-19 screening in pregnant women for better outcomes of the mother and the baby. We present a 26-year-old primigravida at 39 weeks of gestational age with premature rupture of membranes and COVID-19 infection. Her complaints included itchy maculopapular rash and urticaria, then the pregnancy was terminated by a caesarean section, and the baby was born with good conditions. The skin lesions were given a mixture of corticosteroid cream and fusidic acid. The mother and the baby were discharged in a good condition.
Reviono Reviono, Arifin Arifin
Jurnal Kedokteran dan Kesehatan Indonesia, Volume 12, pp 92-97; doi:10.20885/jkki.vol12.iss1.art13

Coronavirus Disease (COVID-19) has rapidly spread and caused a high number of mortalities. To this day, effective therapy to cure this virus is yet to be found. A number of treatments were tested; however, the result is not satisfactory. Therapeutic plasma exchange (TPE) is one of the supportive therapies applied to treat COVID-19 patients with moderate to severe symptoms. We reported 41 years old male patient diagnosed with severe COVID-19 infection, acute respiratory distress syndrome (ARDS), and thrombophilia. The patient received a therapy following the Ministry of Health’s guideline for COVID-19 handling. On the third day, respiratory failure occurred with a P/F ratio of 255 and the chest X-ray result showed vascular streak and ground-glass opacity; thus, the hospital decided to perform TPE. The TPE was performed twice in 5 days interval. After TPE was administered, clinical development is observed both subjectively in the form of reduced symptoms, normal respiration rate, and objectively, the improvement in blood gas analysis, increased O2 saturation, and a decrease in interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) level significant clinical laboratory and radiological improvement possibly due to cytokine storm which is remedied by TPE action.
Farhah Kamilah, Elsye Maria Rosa
Jurnal Kedokteran dan Kesehatan Indonesia, Volume 12, pp 79-91; doi:10.20885/jkki.vol12.iss1.art12

Child marriage cases appear to occur in children between 15 and 18 years of age. Girls who are forced into marriage show fear of having sex with their husbands because they are foreign to this situation. Previous research has shown that child marriage causes trauma to girls due to forced sexual intercourse. This study aims to explore sexual aspects from the perspective of married girls. This study uses 3 databases PubMed, EbscoHost, and Proquest. The main keywords are "child marriage", "early marriage", "Sexual", "Experience", and "Qualitative". The search for articles was carried out in accordance with the guidelines of PRISMA. The findings were 5 main themes from 15 articles. The findings are the desire to have children soon after marriage, delay of having children, husband and wife relationship in child marriage, lack of knowledge related to reproductive health, and powerlessness makes reproductive health decisions. The problem of the sexual aspect of child marriage makes it difficult for girls to live their married lives. Girls must quickly adapt to their role as wives and be able to meet everyone's marriage expectations in general. However, another case also explains that families and partners understand the condition of girls who are not ready to face this phase. The views of society and families build perceptions of child marriage, including the fulfillment of sexual needs therein.
Ahmad Saepudin, Eveline Margo
Jurnal Kedokteran dan Kesehatan Indonesia, Volume 12, pp 5-10; doi:10.20885/jkki.vol12.iss1.art3

Background: Data in 2013 states that the prevalence of acute respiratory infections (ARI) is 25%. One of the factors that cause ISPA is air pollution. This factor is one of the risk factors for motorcycle taxi drivers who are always exposed to air pollution. Knowledge of ARI that is sufficient to influence the use of masks can help prevent ARI from occurring. Objective: This study aims to determine the relationship between knowledge of ARI and the behaviour of using masks among online motorcycle drivers. Methods: This study was an analytical observational with a cross-sectional design attended by 139 online motor cycle drivers around Grogol, Petamburan, West Jakarta, from July to December 2017. Data collection was done by filling out a questionnaire that includes demographic data, the use of masks, and knowledge of ARI. Data analysis used Fisher's test with significance level p<0,05. Results: A total of 139 respondents were collected, consisting of 131 (94.2%) men and 8 (5.8%) women. The average age of ≥ 30 years old is 77 (55.4%) people. Most respondents' education level was SMA/SMK/SLTA as many as 111 (79.9%) people. From the results of Fisher's test, it was found that the probability value p=0.362 was greater than the significance value (0.05). Conclusion: There is no significant relationship between the level of knowledge about ARI and the use of masks among online motorcycle drivers.
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