Jurnal Kedokteran dan Kesehatan Indonesia

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ISSN / EISSN : 2085-4145 / 2527-2950
Total articles ≅ 212
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Yessica Mishellin Awaloei, Nawanto Agung Prastowo, Regina Regina
Jurnal Kedokteran dan Kesehatan Indonesia, Volume 12, pp 52-57; https://doi.org/10.20885/jkki.vol12.iss1.art9

Background: Acne is the most common skin disorder, especially in adolescents and youths. Inflammation due to acne may leave scar tissue. The scar severity may correlate with gender and skin type. Objective: This study aims to investigate the correlation between gender, skin type, and acne scar severity in youth. Methods: This is a cross-sectional study with 132 (81 female) medical college students aged from 18 to 23 participated in the study. Skin type was assessed using a Baumann Skin Type questionnaire. Acne scar severity was evaluated using the Qualitative Global Scarring Grading. Skin examination was conducted through the image from the face photograph. Lambda test was used to confirm the correlation between gender, skin type, and acne scar severity. Multiple logistic regression was applied to determine the odd risk of gender and skin type to moderate-severe acne scar. Significance was set at p<0.05. Results: Most of the participants (80.3%) had oily skin, and 22 participants (16.7%) had moderate-severe acne scar. A weak positive correlation was confirmed between skin type and acne scar severity (p<0.01, r=0.3). Oily skin type has 4.3 times greater risk of developing more severe acne scar (p<0.01, 95%CI = 1.90-9.90). Conclusion: Skin type is correlated with acne scar severity. Oily skin type is at greater risk of developing severe acne scar.
Nurvita Risdiana, Jefry Leo Sandy, Johan Johan
Jurnal Kedokteran dan Kesehatan Indonesia, Volume 12, pp 58-67; https://doi.org/10.20885/jkki.vol12.iss1.art10

Background: Objective Structured Clinical Examination (OSCE) is an instrument for an evaluation test to asses observable skills. However, this situation of the test can lead to anxiety for students expressed in affective and somatic signs. Progressive muscle relaxation technique is one of non-pharmacology therapies and can be used to decrease the affective and somatic signs in the students. Objective: This study aims to determine effects of the progressive muscle relaxation technique on affective and somatic signs in nursing students when taking the OSCE. Methods: This study was a quasi-experimental with a pre-test and post- group design. Fifty eight participants were selected by inclusion criteria and divided into two groups (a treatment group and a control group). The progressive muscle relaxation before the OSCE was conducted for 30 minutes. Zung’s self-rating anxiety (ZSAS) was applied to measure the affective signs. A sphygmomanometer, manual heart rate palpation, and thorax inspection were used to measure the somatic signs. The data were analysed by using a Wilcoxon test. Results: The Wilcoxon test showed that the effects of progressive muscle relaxation technique on the affective signs indicated p-value of 0.0001 (p<0.005). Then it also affected the somatic signs as occurred in systolic blood pressure with p-value of 0.00, diastolic blood pressure with p-value of 0.004, heart rate with p-value of 0.00, and respiration rate with p-value of 0.00. The affective and somatic signs in the treatment group decreased after the treatment was given. However, they were not found in the control group. Conclusion: There are effects of progressive muscle relaxation technique on affective and somatic signs in nursing students when taking the OSCE. The affective and somatic signs in the treatment group were lower than in the control group.
Dhea Aghestya, Nurmasari Widyastuti, Martha Ardiaria, Fillah Fithra Dieny
Jurnal Kedokteran dan Kesehatan Indonesia, Volume 12, pp 19-27; https://doi.org/10.20885/jkki.vol12.iss1.art5

Background: Irregular menstrual cycles are a risk factor for developing type 2 diabetes mellitus (DM) in women. Objective: This study aimed to evaluate irregular menstrual cycles as a risk factor of type 2 DM in women of childbearing age with body fat percentage, waist-hip ratio, diet quality, and physical activity as confounding factors. Methods: This was a case-control study. Its subjects were subjects with type 2 diabetes mellitus (n=31) and subjects without any clinical evidence of abnormal glucose regulation (n=31) who attended Puskesmas (Community Health Centre) Rowosari, Tembalang, Semarang with over 30 years of age. Based on their menstrual cycles, they were divided into two groups: women with irregular menstrual cycles, and those with regular menstrual cycles. Cochran Mantel-Haenszel test was used to control their confounding factors. Results: There was an association between irregular menstrual cycles and type 2 DM (p<0.05) with a 7.2 greater risk on women of childbearing age (OR = 7.2, 95% CI=2.18-23.75). By the Cochran Mantel-Haenszel test, the association was still significant; women with over percentage of body fat and central obese with irregular menstrual cycle had 4,85 times and 4,37 times of sequentially greater risk on type 2 DM (OR = 4.85, 95% CI=0.98-23.95 vs OR = 4.37, 95% CI=0.93-20.51). Conclusion: The irregular menstrual cycles was a risk factor of type 2 DM, especially in obese women of childbearing age.
Hermin Aminah Usman, Fauzan Ali Zainal Abidin
Jurnal Kedokteran dan Kesehatan Indonesia, Volume 12, pp 34-43; https://doi.org/10.20885/jkki.vol12.iss1.art7

Background: Today, pathology services are more developed for quantitative diagnostic evaluation. The quantitative diagnostic evaluation requires detailed accuracy and can be done using digital image analysis (DIA). Assessment of the Ki67 labelling index (LI) in breast carcinoma needs to be done quantitatively. A visual evaluation of Ki67 LI using light microscopy has high inter-observer variability. The evaluation of Ki67 LI could be done digitally with the DIA technique to overcome the inter-observer variability. The DIA technique is carried out by counting the Ki67 LI manually or automatically with bioimage analysis software. QuPath is one of the bioimage analysis software, has characteristics of cross-platform, intended for bioimage analysis and digital pathology. Objective: This study aims to compare the manual and automatic calculation of Ki67 LI digitally. Methods: This study was a cross-sectional study; a total of 240 digital Ki67 images from 30 slides were analyzed by counting manually and automatically using QuPath. Results: Statistical analysis using the T-test showed no significant difference between the manual and automatic counting of Ki67 LI (p = 0,801, α = 0,05). Conclusion: Digital image analysis using QuPath can be used to calculate the Ki67 LI automatically.
Ahmad Saepudin, Eveline Margo
Jurnal Kedokteran dan Kesehatan Indonesia, Volume 12, pp 5-10; https://doi.org/10.20885/jkki.vol12.iss1.art3

Background: Data in 2013 states that the prevalence of acute respiratory infections (ARI) is 25%. One of the factors that cause ISPA is air pollution. This factor is one of the risk factors for motorcycle taxi drivers who are always exposed to air pollution. Knowledge of ARI that is sufficient to influence the use of masks can help prevent ARI from occurring. Objective: This study aims to determine the relationship between knowledge of ARI and the behaviour of using masks among online motorcycle drivers. Methods: This study was an analytical observational with a cross-sectional design attended by 139 online motor cycle drivers around Grogol, Petamburan, West Jakarta, from July to December 2017. Data collection was done by filling out a questionnaire that includes demographic data, the use of masks, and knowledge of ARI. Data analysis used Fisher's test with significance level p<0,05. Results: A total of 139 respondents were collected, consisting of 131 (94.2%) men and 8 (5.8%) women. The average age of ≥ 30 years old is 77 (55.4%) people. Most respondents' education level was SMA/SMK/SLTA as many as 111 (79.9%) people. From the results of Fisher's test, it was found that the probability value p=0.362 was greater than the significance value (0.05). Conclusion: There is no significant relationship between the level of knowledge about ARI and the use of masks among online motorcycle drivers.
Farhah Kamilah, Elsye Maria Rosa
Jurnal Kedokteran dan Kesehatan Indonesia, Volume 12, pp 79-91; https://doi.org/10.20885/jkki.vol12.iss1.art12

Child marriage cases appear to occur in children between 15 and 18 years of age. Girls who are forced into marriage show fear of having sex with their husbands because they are foreign to this situation. Previous research has shown that child marriage causes trauma to girls due to forced sexual intercourse. This study aims to explore sexual aspects from the perspective of married girls. This study uses 3 databases PubMed, EbscoHost, and Proquest. The main keywords are "child marriage", "early marriage", "Sexual", "Experience", and "Qualitative". The search for articles was carried out in accordance with the guidelines of PRISMA. The findings were 5 main themes from 15 articles. The findings are the desire to have children soon after marriage, delay of having children, husband and wife relationship in child marriage, lack of knowledge related to reproductive health, and powerlessness makes reproductive health decisions. The problem of the sexual aspect of child marriage makes it difficult for girls to live their married lives. Girls must quickly adapt to their role as wives and be able to meet everyone's marriage expectations in general. However, another case also explains that families and partners understand the condition of girls who are not ready to face this phase. The views of society and families build perceptions of child marriage, including the fulfillment of sexual needs therein.
Reviono Reviono, Arifin Arifin
Jurnal Kedokteran dan Kesehatan Indonesia, Volume 12, pp 92-97; https://doi.org/10.20885/jkki.vol12.iss1.art13

Coronavirus Disease (COVID-19) has rapidly spread and caused a high number of mortalities. To this day, effective therapy to cure this virus is yet to be found. A number of treatments were tested; however, the result is not satisfactory. Therapeutic plasma exchange (TPE) is one of the supportive therapies applied to treat COVID-19 patients with moderate to severe symptoms. We reported 41 years old male patient diagnosed with severe COVID-19 infection, acute respiratory distress syndrome (ARDS), and thrombophilia. The patient received a therapy following the Ministry of Health’s guideline for COVID-19 handling. On the third day, respiratory failure occurred with a P/F ratio of 255 and the chest X-ray result showed vascular streak and ground-glass opacity; thus, the hospital decided to perform TPE. The TPE was performed twice in 5 days interval. After TPE was administered, clinical development is observed both subjectively in the form of reduced symptoms, normal respiration rate, and objectively, the improvement in blood gas analysis, increased O2 saturation, and a decrease in interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) level significant clinical laboratory and radiological improvement possibly due to cytokine storm which is remedied by TPE action.
Sri Sulistyowati, Nutria Widya Purna Anggraini
Jurnal Kedokteran dan Kesehatan Indonesia, Volume 12, pp 98-104; https://doi.org/10.20885/jkki.vol12.iss1.art14

The number of COVID-19 cases, especially with pregnancy, remains a problem in the world and in Indonesia. The main clinical symptoms include fever (temperature >38oC), cough, and shortness of breath. In addition, it can be accompanied by fatigue, myalgia, gastrointestinal symptoms such as diarrhea, and even recently found manifestations of skin disorders. Skin manifestations in COVID-19 pregnant patients are still a rare condition. Skin manifestations can be an early sign of such infection, which therefore requires clinicians’ notice to allow them to conduct early COVID-19 screening in pregnant women for better outcomes of the mother and the baby. We present a 26-year-old primigravida at 39 weeks of gestational age with premature rupture of membranes and COVID-19 infection. Her complaints included itchy maculopapular rash and urticaria, then the pregnancy was terminated by a caesarean section, and the baby was born with good conditions. The skin lesions were given a mixture of corticosteroid cream and fusidic acid. The mother and the baby were discharged in a good condition.
Kurnia Putri Utami, Widya Wasityastuti, Marsetyawan Hne Soesatyo
Jurnal Kedokteran dan Kesehatan Indonesia, Volume 12, pp 68-78; https://doi.org/10.20885/jkki.vol12.iss1.art11

An immune system recognizes and responds to antigens entering the body. Maintaining these roles, components of the immune system need energy obtained from nutrients such as carbohydrates, proteins, and lipids. This study reviews and discusses roles of lipids, particularly fatty acids, in regulations of the immune system. This study was conducted by conducting a literature study on published research articles written in English. The articles were obtained from PubMed and Google Scholar by using search keywords: lipid, fatty acids, immune, regulation, inflammation, and response. Lipids are a group of biomolecule compounds composed of carbon, oxygen, and hydrogen, and they are classified into simple, compound and complex lipids. Fatty acids are compound lipids that act as a main fuel for metabolism, an essential component for all membranes, and a gene regulator. Fatty acids have a modulating effect on immune cells, such as: acting as a host defence, activating the immune system, interacting with nuclear transcription factors, playing roles in inflammatory responses, promoting apoptosis, as well as influencing lymphocyte proliferation, cytokine production, and Natural Killer (NK) cell activities. However, the modulation of the immune system by lipids is influenced by various factors such as concentration and types of fatty acids, types of immune cells, and species. This study is suggested to provide an overview of beneficial roles of lipids in maintaining immunity.
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