International Journal of Research in Pharmaceutical Sciences

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EISSN : 09757538
Current Publisher: GP Innovations Pvt. Ltd. (10.26452)
Total articles ≅ 266
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Asuntha A, Sree Charan Y, Siddartha M, Udhaykumar K, Andy Srinivasan
International Journal of Research in Pharmaceutical Sciences, Volume 10, pp 1821-1823; doi:10.26452/ijrps.v10i3.1325

Abstract:Diabetes is a general illness regularly contaminated in people. Numerous approaches to recognize diabetes, one of them is checking circulatory strain, however, along these lines isn't compelling, in light of the fact that it takes blood first and takes a ton of time. Iridology is a one-way investigation wellbeing dependent on the iris. In this manner, we need an apparatus used to recognize pancreatic harm as a sign of diabetes through iridology. TheBurden picture is the initial step to distinguish pancreatic organs dependent on the iris. The eye picture that we utilized as the info framework originates from the eye facility database. The subsequent stage is a versatile middle sifting utilized in the process preprocessing to lessen the commotion on the picture. After that, the subsequent stage is a division process utilizing Hough circle change technique. The consequences of division will be standardized and take the Region of intrigue. Return for money invested will be done element extraction by utilizing GLCM (Gray Level Co-Occurrence Matrix). To know the state of a pancreas organ utilizing back propagation strategy.
Eman Wahab Kadhum
International Journal of Research in Pharmaceutical Sciences, Volume 10, pp 1566-1570; doi:10.26452/ijrps.v10i2.1358

Abstract:Atopic dermatitis (AD), also called atopic eczema, is a common chronic or recurrent inflammatory skin disease and affects 15–20% of children and 1–3% of adults worldwide; IgE is likely to be of more relevance in pediatric disease than in adult disease, in order to detect the incidence of AD and its association with elevated total serum IgE level, 68 people were involved in the current study, their ages were (1-45) years and from both genders fifty of them was with atopic dermatitis and the other healthy eighteen were considered as control groups. They are all subjected to the estimation of total serum IgE level by using Nephelometry methodology technique in the central health laboratory and Hilla Teaching Hospital the period Nov. 2017 to Feb. 201in Babylon Governorate. A significant increase in the level of IgE in AD patients was detected in all age groups in comparison with the control group. The results also showed that patients of blood group (o+) are the most frequent by percent (28%) followed by B+, AB+, A+ and AB¯ with percent reached (24, 20, 14and 4%) respectively. Furthermore, there is a genetic tendency in the frequency of onset of AD as 10% in both parents and (30& 24%) in mothers and fathers respectively while 36% of the disease does not appear in their families. Results also showed a significant increase in the age groups (31-45) years in comparison with (1-15) and (16-30) years. The disease also rises in males compared with females. A significant increase in IgE for patients with Atopic Dermatitis
Jenifer Ashwini S, Narenderan St, Meyyanathan Sn, Babu B, Gowramma B
International Journal of Research in Pharmaceutical Sciences, Volume 10, pp 1608-1611; doi:10.26452/ijrps.v10i3.1320

Abstract:A simple, sensitive chiral liquid chromatographic method was developed for the separation and quantification of enantiomers Midodrine. A chiral PAK IG-3 (150 x 4.6 mm) 3µm column was used for the separation of the enantiomers. The mobile phase consists of 10 mM ammonium bicarbonate in water and acetonitrile in the ratio of 95:5, v/v with a flow rate of 0.7 ml/min. The detection was done at 290 nm with column temperature maintained at 40°C. The method linear ranged between 10 – 110 μg/ml and 5 – 100 μg/ml for (+) and (-) Midodrine enantiomers. The recovery of the method was found to be in the range of 99.1 to 101.2 %. The detection limit for the (+) and (-) enantiomers was found to be 4 μg/ml and 1 μg/ml, respectively. A simple validated chiral HPLC method with reverse elusion is described for the separation and quantification of the enantiomers of Midodrine in bulk and formulation.
Ramachandran K, Venketnarayanan R
International Journal of Research in Pharmaceutical Sciences, Volume 10, pp 1770-1777; doi:10.26452/ijrps.v10i3.1370

Abstract:Cancers of the large and small intestine are major contributors to worldwide cancer morbidity and mortality. Out of all the cancers, colon cancer is one of the most common diseases in the world. Every year 1.2 million patients are diagnosed for colon cancer. The rate of colon cancer incidence was low in India but is presently increasing; out of 3.5 million cancer cases, 35,000 have colon cancer. As a part of chemotherapy, lots of anticancer drugs are in the market, but the main problem associated with these drugs is their side effects. Because of chemotherapy treatment side effects, the patient needs secondary palliative care treatment. Plant medicines are well known for their non-toxic side effects, so the objective of the study is to develop a drug from medicinal plant against colon cancer with non-toxic side effects. It plays an important role in the discovery of lead compound for the development of conventional drugs. About 60% of currently used anticancer agents are derived from a natural source. In the present study, Melothoria maderaspatana was used to study the anticancer potential of the extract and to synthesize new anticancer moiety. With the findings of the study, it can be concluded that the plant Melothoria maderaspatana and possess anti-colorectal cancer activity. Before the clinical usage of extract, thorough toxicological profile has to be determined on the crude extracts as well as on isolated compounds to confirm the safety of the drug.
Vishakha Sharma, Rahul C Ranveer, Neelam Jain, Gajender Kumar Aseri
International Journal of Research in Pharmaceutical Sciences, Volume 10, pp 1808-1817; doi:10.26452/ijrps.v10i3.1376

Abstract:Food safety and quality are the major concern for food processing industries. In today's world, people are getting more conscious about food safety parameters. In this regard, bacteriocin plays a major role in ensuring the safety and quality of food products. From those, LAB bacteriocins are of great interest due to their GRAS status. They are widely used in food preservation, agriculture and pharmaceutical industries. They have also been incorporated into food packaging material due to their both antibacterial and antifungal properties. In this review, we highlighted the possible ways to produce and purify bacteriocin and also the potential application to be used as a natural preservative.
Lakshmi Krishnasamy, Priya Santharam, Chitralekha Saikumar
International Journal of Research in Pharmaceutical Sciences, Volume 10, pp 1778-1784; doi:10.26452/ijrps.v10i3.1372

Abstract:Despite the availability of many antifungal drugs in clinical practice, the occurrence of antifungal drug resistance is on the rise. Since the antifungal susceptibility testing (AFST) is not done routinely in many of the microbiology laboratories, it is very difficult to determine which antifungal agent is very effective for a particular infection. There is a real need for precise, reproducible and extrapolative antifungal susceptibility testing methods to aid the therapeutic management. The practice of empirical treatment for fungal infections further promotes the emergence of resistant strains. The AFST practice would essentially help the clinicians in appropriate decision making. Although conventional AFST methods are somewhat cumbersome, many novel AFST methods are currently available in many laboratory settings which would provide a quicker result many times. In essence, the application of AFST along with identification of the fungus up to species level would definitely be very helpful in selecting the primary antifungal agents for treatment especially in difficult to manage and invasive fungal infections. This review will throw light on the various AFST methods available and their issues in the current practice.
Raghdah M. Alwiswasy, Raheem Jameel M, Basim Jasim Hameed
International Journal of Research in Pharmaceutical Sciences, Volume 10, pp 1763-1769; doi:10.26452/ijrps.v10i3.1369

Abstract:A new 2-iminothiazolidin-4-ones compound and its derivatives were synthesized and characterized by FT-IR, CHN, and 1HNMR techniques. The target compounds were assessed for their anti-inflammatory and analgesic activities, and the study was performed using Swiss albino mice (25-30 g) for investigation. A hind edema model caused by , while the analgesic activity was assessed using an acetic acid-induced writhing and a hot plate test evaluated the anti-inflammatory activity.
Sherly Deborah G, Archana R, Suprava Das, Myat Thu Thu Win, Usha Kumari
International Journal of Research in Pharmaceutical Sciences, Volume 10, pp 1587-1591; doi:10.26452/ijrps.v10i3.1315

Abstract:Obesity is a global public health problem because of its increased prevalence and health effects. It is the most common disorder encountered in clinical practice, which has serious social and psychological dimensions that affect all age groups. A 28-year old married obese male whose body weight and height were 97 kilograms and 5.9 feet respectively showed a body mass index (BMI) of 30. All the examinations and tests were normal before the study. There were 3 weight reduction regimes that included only walking in the morning during the first month, followed by walking with dieting in the second month and in addition to dieting and walking, two tablets of Navaka Guggulu was prescribed to be taken daily. The vital signs, bowel habits, micturition habits and appetite were assessed daily. After the interventions, the weight reduction was observed at 0.5, 0.8 and 4.7 kgs at the end of the first, second and fourth month, respectively. The results of routine blood parameters, autonomic function tests and respiratory function tests were normal with an increase in the haemoglobin level, high-density lipids and a decrease in the total cholesterol level, triglycerides, low-density lipids and very low-density lipids. The present study showed that Navaka Guggulu was not only beneficial but also safe and efficacious in the treatment of obesity.
Siva T, Girija Sivakumar, Sankaran Pk, Yuvaraj Maria Francis, Gayathri T, Lakshmi Thangavelu, Karunakarn Balaji
International Journal of Research in Pharmaceutical Sciences, Volume 10, pp 1660-1666; doi:10.26452/ijrps.v10i3.1334

Abstract:This study was done to show the changes in the liver following diclofenac treatment and to study the hepatoprotective effects of Vitamin E and A in diclofenac treated rats. Rats were divided into four groups of six rats each. Group-1: Control rats (n= 6), Group-2: Rats (n= 6) treated with diclofenac at dose of 50 mg/kg IM for 7 days, Group-3: Rats (n= 6) treated with Vitamin A at dose of 400 IU/kg orally followed by diclofenac at 50 mg/kg IM 2 h later for 7 days, and Group 4: Rats (n= 6) treated with Vitamin E at dose of 200 IU/kg orally followed by diclofenac at 50 mg/kg IM 2 h later for 7 days. Later it was analysed with standard biomarkers, and it was histologically interpreted. The results showed that there was an rapid increase in the levels of liver function test in diclofenac treated group, which was significantly decreased after pre-treatment with vitamin E than vitamin A. The liver acinus showed centriacinar necrosis of hepatocytes after 7 days of diclofenac treatment, which was prevented by administration of Vitamin E and A. Drug-induced liver injury possesses a major clinical problem and has become a leading cause of acute liver failure and transplantation. Overstressed liver compromises its detoxification role which may expose it to a variety of diseases and disorders. Diclofenac sodium is a phenylacetic acid derivative, a widely used nonsteroidal anti-inflammatory drug (NSAID) for the treatment of inflammatory conditions such as osteoarthritis, rheumatoid arthritis, polymyositis, dermatomyositis, dental pain and spondyloarthritis. Although the exact mechanism by which diclofenac injuries in liver is not understood, some studies explain the toxicity by affecting cytochrome P 450 leading to the production of active metabolites. Hepatoprotective effects of Vitamin E were better compared to Vitamin A following treatment with NSAIDS. Hence, it may be necessary to administer Vitamin E in patients treated with diclofenac.
Sharanya S, Sridhar Pa, Poornakala J, Muppala Vasishta, Tharani U
International Journal of Research in Pharmaceutical Sciences, Volume 10, pp 1626-1630; doi:10.26452/ijrps.v10i3.1327

Abstract:Classification of Electrocardiogram (ECG) signals plays a significant role in the identification of the functioning of the heart. This work pertains with the ECG signals, where the classifier is developed for identification of normal or abnormal conditions of the heart. The raw ECG signals are collected from an online database (www.physioNet.org) for classification. The raw ECG signal is pre-processed for noise removal, and the frequency spectrum is analysed to compare raw and denoised ECG signal. Attributes (P, Q, R, S, T time intervals) from denoised ECG signal is analysed and classified using Convolution Neural Network (CNN). The paper reports a classification technique to differentiate ECG signals from the MIT-BIH database (arrhythmia database, arrhythmia p-wave annotations, atrial fibrillation). The CNN analyses the deviation between nominal ranges of attributes (amplitude and time interval) and classifies between the abnormality and normal ECG wave. This work provides a simple method for interpreting ECG related condition for the clinician and helps medical practitioners to make diagnostic decisions.