International Journal of Research in Pharmaceutical Sciences

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EISSN : 09757538
Current Publisher: GP Innovations Pvt. Ltd. (10.26452)
Total articles ≅ 417
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Sunitha G N, Satyavati Dulipala D, Girish Gudi
International Journal of Research in Pharmaceutical Sciences, Volume 10, pp 2591-2601; doi:10.26452/ijrps.v10i3.1515

Abstract:The concomitant administration of drugs and antimalarial drugs is recommended for the treatment of HIV (Human Immunodeficiency Virus) patients with malaria resulting in drug-drug interactions (DDI) causing either lack of efficacy or toxicities. Drug metabolism is often the first step in understanding the DDI potential of either a new chemical entity or a combination of drugs. inhibitor (PI) such as is a potent CYP 3A4 inhibitor and may interact with these antimalarial drugs that are metabolized by CYP3A4 to cause metabolism-related DDI's. the present study is an attempt to evaluate the potential for a drug-drug interaction between and through metabolic stability studies. Metabolic stability of antimalarial and drugs alone and in combination with and without and was evaluated using human liver (HLM). The antimalarial drugs , and were metabolically unstable alone (% metabolism ≥ 80%) and in combination with other antimalarial drugs in HLM. , and were metabolically stable (% metabolism ≤ 30%). drug was metabolically unstable while was moderately stable. intrinsic clearance of antimalarial drugs , and decreased from 106.4, 290.6 and 230 ml/min/kg to 32, 44.8 and 49.5 ml/min/kg in the presence of . However, there was no change in the intrinsic clearance of , and in the presence of . did not alter the clearance of antimalarial drugs. This study suggests that affected the clearance of a few antimalarial drugs in HLM probably by the inhibition of CYP3A4 and findings may need to be further evaluated in clinical studies.
Sunitha G N, Satyavati Dulipala D, Girish Gudi
International Journal of Research in Pharmaceutical Sciences, Volume 10, pp 2477-2486; doi:10.26452/ijrps.v10i3.1497

Abstract:The current treatment for Human Immunodeficiency Virus (HIV) patients coinfected with malaria involves the coadministration of antimalarial and antiretroviral (ARV) drugs. The World Health Organization (WHO) recommends artemisinin-based therapy for malaria that usually consists of artemether, artesunate or dihydroartemisinin with non-artemisinin derivatives such as amodiaquine, lumefantrine and mefloquine. Protease inhibitors (PI) such as ritonavir contribute to the improved health of HIV-positive individuals, and the inclusion of ritonavir in antiretroviral regimens is common in clinical practice. Ritonavir is a potent inhibitor of human CYP3A4, which is the primary enzyme involved in the metabolism of many of artemisinin-based drugs, as well as amodiaquine and proguanil. Upon co-administration, ritonavir can potentially influence the metabolism and thus increase the systemic exposure of these drugs. In order to understand this pharmacokinetic (PK) drug interaction, the current work evaluated the effect of ritonavir (50 mg/kg orally) on the PK of antimalarial drug combinations in Sprague Dawley (SD) rats. When co-administered with ritonavir, the exposure (AUC) of the antimalarial drugs artemether, artesunate and proguanil was increased by approximately 3.5-fold. Correspondingly, peak plasma concentrations (Cmax) of these drugs increased as well. There was no apparent influence of ritonavir on the PK of lumefantrine, amodiaquine and atovaquone. This study demonstrates the potential influence of ritonavir on the pharmacokinetics of at least some anti-malarial drugs, likely a result of inhibition of CYP3A. Further evaluation of clinically relevant drug interaction in humans may be warranted to ensure safe and effective use of anti-malarial and anti-HIV drugs concomitantly.
Meghana M.R, Akshatha Prabhu
International Journal of Research in Pharmaceutical Sciences, Volume 10, pp 2409-2416; doi:10.26452/ijrps.v10i3.1487

Abstract:Leukemia is a blood cancer which features through the ejection of manipulated and strange fabrication of white blood cells which is the way of bone marrow within the blood. The project aims at designing and developing an efficient technique for the detection of luekemia based on image segmentation techniques and nuclei analysis which incorporates the affected percentage and are compared and classified using KNN and SVM. The DNA of youngster cells, for the maximum detail white platelets, subsequently finally ends up harmed here and there. This version from the norm reasons platelets to increase and separate constantly. Sound platelets bypass on inevitably and are supplanted by approach of new cells, which might be brought in bone marrow.
Falah Hassan Shari, Hiba Dawood, Jubran K. Hassan, Qais A. Aljazeari, Mazin A.A. Najm, Ahmad Salahuddin, Al-Salman H N K
International Journal of Research in Pharmaceutical Sciences, Volume 10, pp 2545-2551; doi:10.26452/ijrps.v10i3.1508

Abstract:Taurine is sulfur containing semi-essential amino acid that has important roles in many biological processes, but its effect on glucose homeostasis, weight, growth and bone mineralization weren’t well defined. Objectives: the evaluation of oral Taurine effects has used for 3 months on bone mineralization biomarker, glycemic control and body weight in type ll diabetic patients. Methods: the interventional double-blind placebo-controlled study in which 80 patients with type 2 diabetes mellitus (age range 45-55) assigned in either control (n=40), or study group the (n=40) group. The last group has received a 1000mg capsule of Taurine once a day for three months. Parameters measured were serum calcium, 25(OH) vitamin D and osteocalcin, NTX-1 HbA1C% with fasting blood glucose before and after 3 months. Results: taurine led to significant (p
Essam Mohammed Abd-Alsaid
International Journal of Research in Pharmaceutical Sciences, Volume 10, pp 2558-2566; doi:10.26452/ijrps.v10i3.1510

Abstract:Client satisfaction has been defined as the degree of congruency between a client’s expectation of ideal care and his/her perception of the real care receive. In Iraq, there has been a recent concern at the Ministry of Health (MOH) about improving the quality of Primary Health Care (PHC) services being considered the first health “gate” for the community. This study aimed to assess the level of clients’ satisfaction with PHC services in Basra, Iraq, 2012. A cross-sectional study was performed on 12 randomly selected PHC centers from the total eight PHC districts at Basra Health Directorate, where 1200 clients aged 18 years and above were selected systematically. Data was collected via a direct interview with clients using an Arabic language questionnaire. The satisfaction was rated at a scale of 1-5 points, and the data was analyzed using c. The results of the current study revealed that the overall clients’ satisfaction was 90.8%. The highest score for clients’ satisfaction was for nurses’ staff domain of PHC services (91.9%), and the lowest was for waiting for the domain (74.5%). Old age, females, retired and illiterate clients showed significantly the highest overall satisfaction. Clients reported their main dissatisfaction for the availability of the medicines item (53.4%) and the waiting time to see medical staff item (59%). The present study concluded that overall clients’ satisfaction was relatively high, and socio-demographic characteristics played major roles in deciding the extent of clients’ satisfaction.
Alaa Sameer Neamah
International Journal of Research in Pharmaceutical Sciences, Volume 10, pp 2567-2571; doi:10.26452/ijrps.v10i3.1511

Abstract:A complete number of 100 ear swabs were researched for the present study. This investigation is to discover the microbiological profile and their anti-microbial affectability designs in patients with constant suppurative otitis media in an Al-hububi clinic. Gram recoloring, direct microscopy with KOH, culture affectability and biochemical tests were completed to distinguish the living beings and to realize the affectability design. Every one of the swabs were gathered from patients with the clinical conclusion of unending suppurative otitis media. Pseudomonas aeruginosa (37.21%) was generally secluded life form pursued by Staphylococcus aureus (27.91%) from the samples. Amikacin was found to be the most effective antibiotic with low resistance rate. The investigation of microbial example and their anti-infection affectability decides the predominant living beings causing unending suppurative otitis media in neighborhood begins fitting treatment of otitis media and its intricacies for effective result.
Tram Van Ta, Hai Thanh Tran, Quyen Nguyen Than Ha, Xuong Tuyet Nguyen, Vu Kien Tran, Hien The Pham, Cameron Simmons
International Journal of Research in Pharmaceutical Sciences, Volume 10, pp 2519-2524; doi:10.26452/ijrps.v10i3.1502

Abstract:Dengue shock syndrome (DSS) is a severe complication of dengue hemorrhagic fever (DHF) and can lead to death, but DSS incidence and effects are difficult to predict via clinical examination. With consideration of this issue, this research determined the role of cytokines in the severity and prognosis of DHF in children. This prospective cohort research involved 234 patients who were aged 18 months to 18 years old, admitted to Tien Giang General Hospital, and diagnosed as having DHF. The cytokine levels of the patients were recorded from admission to discharge. Almost all the patients (>67%) exhibited increased interleukin 10 (IL-10), IL-6, and IL-2, whereas only 0.43% (the lowest) presented with elevated IL-12. Concentrations of IL-2, IL-4, IL-13, and tumor necrosis factor-α were highest in the patients infected with DENV-1, followed by those infected with DENV-3 and DENV-2. IL-12 concentration decreased with increasing days of fever occurrence. No correlation was found between cytokine concentrations in the first day of hospitalization and shock in the DHF patients. The concentration of cytokines during the first day of hospitalization (i.e., patients with a fever lasting less than 72 hours) cannot be used as a guide in determining DSS prognosis.
Abbas Kinbar Kuser, Redha Alwan Al-Hashimi
International Journal of Research in Pharmaceutical Sciences, Volume 10, pp 2586-2590; doi:10.26452/ijrps.v10i3.1514

Abstract:This study was designed to show the rule of Vitamin C in the treatment of Bell's palsy when adding to the treatment of bell's palsy in compares to treatment without ascorbic acid and how its effect of fastening time of recovery. Six months from February to July 2019, and 60 patients were collected for this study, 22 patients treated with classical treatment for Bell's palsy, and on the other side 38 patients, we added Vitamin C (500mg) besides classical treatment for Bell's palsy. The results of the current study revealed that Patients with IFP were treated with vitamin C and classical treatments are gotten complete recovery within 4 weeks (92.1%) as compared to classical treatment alone (14.6%) with significant P value 0.0001. About complete resolution after4 to 6 weeks, there is no difference between both vitamin C and classical treatment (92.1%) and classical treatment alone (86.4%) with non-significant P-value. About facial residual, after 6 weeks, there is no difference between both vitamin C and classical treatment (10.5%) and classical treatment alone (10%) with non-significant P-value. It has been concluded that there is the significant value of vitamin C in the treatment of Bell's palsy as compares with classical treatment alone; but this positive value when treated early and good recovery in the first 4 weeks of IFP. A very good result in the hastening of the recovery period in the first 4 weeks but the same as a classical treatment alone after 4 weeks. In this study, no significant values of vitamin C to prevent complications of IFP.
Pritha L, Valliammal S, Vijayaraghavan R
International Journal of Research in Pharmaceutical Sciences, Volume 10, pp 2507-2514; doi:10.26452/ijrps.v10i3.1404

Abstract:Acupressure is an alternative therapy that uses fingers and hands to stimulate acupoints and maintains the balance of energy. It was well documented that acupressure is effective in relieving different types of pains in patients with different conditions. The present study was undertaken to evaluate the effect of acupressure in pain and improving the bio-physiological parameters among mediosternotomy patients. The present study was conducted at Sri Sathya Sai Institute of Higher Medical Sciences, Whitefield, Bangalore. A total of twenty male and female patients those who undergo open-heart surgery via median sternotomy were part of the study after obtaining the written informed consent. After recording the demographic data, the participants were randomly grouped into control and intervention groups using random numbers generated by computer with 10 participants in each group. The intervention will be provided at PC6 acupressure point, situated on the inner side of the forearm, three fingers below the wrist joint, three times a day for four days. Numerical Rating Scale of pain was used to assess the pain of the Participants. There was a significant decrease in the pain score of the participants, followed by the acupressure. The study provides further evidence for the effectiveness of the acupressure in pain management and also recommends detailed research in this area.
Nguyen The Nguyen Phung, Thi Thai Phien Nguyen, Thanh Liem Bui, Thanh Hung Nguyen, Diep Tuan Tran
International Journal of Research in Pharmaceutical Sciences, Volume 10, pp 2525-2531; doi:10.26452/ijrps.v10i3.1503

Abstract:Precise diagnosis of the severity of dengue fever (DF) and its timely treatment reduce its mortality, but the sensitivity of clinical presentations is low for the classification of severity. Research on biomarkers is ongoing, and some studies in adults have shown the utility of C reactive protein (CRP) in the early diagnosis of dengue severity. However, the role of CRP in children with DF is still unknown. The aim of this study was to determine the value of CRP in distinguishing between DF and severe DF. A cross-sectional study was conducted from May 2016 to April 2017 at Children's Hospital 1 in Ho Chi Minh City, Vietnam. Serum CRP was tested on days 4 and 5 of the disease. Laboratory tests for DF were based on either a positivity for non-structured glycoprotein-1 antigen (NS1Ag) or enzyme-linked immunosorbent assay (ELISA) for immunoglobulin (Ig) M in acute phase serum. Among 270 patients, 29.6% had DF, 26.7% had DF with warning signs, and 43.7% had severe DF. The CRP level was measured in 123 patients on day 4 and 147 patients on day 5 of the illness. The median CRP level for DF was 2.4 mg/L, for DF with warning signs was 6.7 mg/L, and for severe DF was 7.3 mg/L. The CRP level was higher on day 4 than on day 5. The CRP level showed a statistically significant difference between the group with circulatory dysfunctions (p=0.02) or liver dysfunction (p= 0.04) and the other patients. The CRP cut-off point on day 4 that distinguished DF and severe DF was 5.8 mg/L and the area under the receiver operating characteristic curve (AUC) was 0.89, with a sensitivity of 82.9% and specificity of 80%. The CRP concentration in the early stage of illness may, therefore, help to distinguish between DF and severe DF.