Folia Medica Indonesiana

Journal Information
ISSN / EISSN : 2355-8393 / 2599-056X
Current Publisher: Universitas Airlangga (10.20473)
Total articles ≅ 377
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Puguh Setyo Nugroho, Muhtarum Yusuf, Titiek Ahadiyah Hidayati
Folia Medica Indonesiana, Volume 57, pp 20-26; doi:10.20473/fmi.v57i1.8765

Several studies showed that the index of nasopharyngeal carcinoma (NPC) cell growth could be used to assess the carcinogenesis interaction factor, development and prognosis of NPC. Cell proliferation index could always be assessed with Ki-67 protein expression test. This research was conducted to study the correlation between cell proliferation index with cervical lymphoid node status in NPC in clinical manifestation to asses the progressivity and prognosis on NPC patients. This study used cross sectional design. Biopsy tissue specimen were acquired from 35 NPC patients clinically divided into four criteria of cervical lymphoid node status (N0, N1, N2 and N3). Expression of Ki-67 protein was acquired by immunohistochemistry test using monoclonal rabbit antibody anti-human Ki-67 clone 901-325-091911 (Biocare Medical, LCC. 4040 Pike Line, CA 94520 USA). The measurement of Ki-67 protein was conducted by pathology consultant. Spearman statistic test was performed to asses the correlation between Ki-67 protein expression and cervical lymphoid node status. The statistical significance was defined as p<0.05. Positive expression of Ki-67 protein was found in 33 patients; 4 patients with N0 (11.43%), 5 patients with N1 (14.29%), 9 patients with N2 (25.71%), and 15 patients with N3. Negative expression of Ki-67 protein was found in 2 patients with N0 (5.71%). The Spearman test resulted at p=0.0001 with correlation coefficient of 0.758. The correlation between Ki-67 protein expression with cervical lymphoid node resulted in a significant correlation (p<0.05). In conclusion, cell proliferation index has correlation with cervical lymphoid node status in NPC patients.
Ahmad Suryawan, Hapsari Widya Ningtiar, Irwanto Irwanto, I Dewa Gede Ugrasena
Folia Medica Indonesiana, Volume 57, pp 46-52; doi:10.20473/fmi.v57i1.13664

Thalassemia is a chronic disease with long-term treatment that increases the potential for impact on physical, cognitive, and psychological conditions. About 80% of patients with major thalassemia have at least one psychiatric disorder, depression is one of the most frequently reported, especially in prepubertal and puberty periods. The aim of this study is to evaluate determinant factors of depression in beta mayor thalassemia children. This was a cross-sectional study on patients aged 9 to 17 years at hematology outpatient clinic in Dr. Soetomo General Hospital from September to Desember 2018. Level of depression determinded by Children Depression Inventory (CDI) questionnaire. The data were collected and analyzed using using the IBM SPSS Statistics version 21. It is statistically significant with p<0.05. Forty-five participants were included in this study, 15 participants with mild depression and 30 participants without depression. Gender (p=0.462), age of diagnosis (p=0.385), frequency of tranfussion (p=0.065), family history of depression (p=0,350), physical change (p=0.711), duration of illness (p=0.674) have no significant value as a determinant factor while complication (p=0.049) and serum cortisol level (p=0.037) had significant value as determinant factors of depression in Beta Major Thalassemia children. Mild depression is more common in thalassemia patients who experience complications and had high serum cortisol levels
Anastasia Tjan
Folia Medica Indonesiana, Volume 57, pp 41-45; doi:10.20473/fmi.v57i1.9857

Hirschsprung disease is a rare developmental disorder of the enteric nervous system. This researched purpose to give an epidemiological database and current trend analysis from radiological perspective of Hirschsprung disease at our center. A prospective descriptive study was conducted for a year in 2017 at Sanglah Public General Hospital Bali. Colon in loop examination using either water-soluble or barium was conducted. All baseline characteristics, contras media used, and HD type were the parameter being evaluated in this study. Hirschsprung accounted for 2.16% from all 1018 newborn. Male is 3.4 times more prone to Hirschsprung disease. Age distribution predominant during 0 – 4 weeks after birth (36.4%). Ultrashort, short, long segments were 45.5%, 45.5%, and 9% respectively. Contras media used was mainly barium rather than water soluble 8:3, due to standard operating procedure adapted by some pediatric surgeon. Ultrashort and short segment HD has the same contribution. Barium is dominated at our center although water soluble is chosen in most literature for infant, due to its ability as diagnostic as well as therapeutic. Hence further research should be done to support and change the perspective in making the diagnosis.
Syahrudi Syahrudi, R Yoga Wijayahadi
Folia Medica Indonesiana, Volume 57, pp 11-15; doi:10.20473/fmi.v57i1.26328

Thyroid cancer is one of the commonest cancer while the incidence of occult thyroid cancer is only 0,05%. Completion total thyroidectomy as one of the treatment choice for thyroid cancer which initially diagnosed preoperatively as benign thyroid mass, remains controversial. The aim of this study is to understand the effectiveness of completion total thyroidectomy after partial thyroidectomy, by analyzing from: proportion of malignant contralateral thyroid tissue, post operative complications, and recurrence of cancer. This retrospective study collected medical record datan between 2011 and 2016. Total sample were 16 patients (15 females, 1 male). There was no significant difference on contralateral thyroid tissue malignancy proportion between completion total thyroidectomy and without total thyroidectomy (p=0,375). It was found 3 surgical complications (50%) from 6 patients with completion total thyroidectomy and 3 complications (30%) from 10 patients without completion total thyroidectomy. The complications were temporary injury of recurrent laryngeal nerve (p=0,511), seroma (p=0,375), and hypoparathyroidism (p=0,375). No recurrence event after 4 years follow up amount both groups. In conclusion, there is no advantage in completion total thyroidectomy analized from proportion of malignant contralateral thyroid tissue, post operative complication and recurrence in 4 years-follow up.
Agung Hadi Endaryanto, Elyana Asnar, Roostantia Indrawati
Folia Medica Indonesiana, Volume 57, pp 16-19; doi:10.20473/fmi.v57i1.26329

Lari sprint atau lari jarak pendek adalah salah satu nomor dalam atletik yang paling bergengsi, pelarinya disebut Sprinter. NMT adalah tehnik aplikasi yang menggunakan elastic adhesif tape yang memberikan kemampuan peningkatan fungsional otot, dan stimulasi sistem saraf. Tujuan penelitian ini, untuk mengetahui pengaruh neuromuscular taping terhadap kekuatan otot, fleksibilitas otot dan waktu tempuh sprinter 100 meter. Penelitian ini menggunakan metode pre test-post test with control grup design dengan total sampel berjumlah 13 orang dengan rentang usia atlet 15-19 tahun, pada tanggal 4-5 Agustus 2016 di GOR Gresik. Metode 1 kelompok dengan 2 perlakuan yaitu perlakuan I sebelum pemberian NMT dilakukan pengukuran kekuatan otot, fleksibilitas otot, dan waktu tempuh berlari 100 meter dan sesudah pemberian NMT dilakukan pengukuran kembali, perlakuan 2 sebagai kelompok kontrol dilakukan tanpa pemberian NMT dilakukan pengukuran kekuatan otot, fleksibilitas otot, dan waktu tempuh berlari 100 meter. Hasil penelitian menunjukkan pada perlakuan 1 kekuatan otot gastrocnemius dengan peningkatan rerata 11,38±7,83kg, nilai p=0,000, fleksibilitas nilai p=0,003 (dorsofleksi), p=0,013 (plantarfleksi) dengan peningkatan rerata 3,46±4,27 derajat, dan pemendekan waktu tempuh dengan nilai p=0-001, pada perlakuan 2 kekuatan otot gastrocnemius dengan penurunan rerata 2,12±2,43kg, nilai p=0,009, fleksibilitas nilai p=1,000 (dorsofleksi), p=0,165 (plantarfleksi) dengan peningkatan rerata 0,77±1,88 derajat, dan waktu tempuh terjadi perpanjangan waktu dengan nilai p=0-001 . Pemberian NMT pada sprinter memberikan hasil yang lebih baik dalam peningkatan kekuatan otot, fleksibilitas otot dan memperpendek waktu tempuh.
Muchammad Rif’At Fawaid As’Ad, Paulus Liben,
Folia Medica Indonesiana, Volume 57, pp 82-89; doi:10.20473/fmi.v57i1.18258

Cases of overweight and obesity in the world increased continuously. In 2016, obesity increased by 3% in men and 6% in women compared to 1975. Overweight cases also increased by 20% in men and 23% in women compared to 1975. Overweight and obesity have been linked to an increase in adipose tissue in the body. Increased adipose tissue associated with inflammation, which one of its characteristics is an increase levels of C - Reactive Protein (CRP). This article aim is to describe the mechanism of physical exercise to diminish CRP level in overweight and obesity. Adipose tissue produces and releases various pro-inflammatory and anti-inflammatory factors such as leptin, adiponectin, resistin, TNF-α, IL-6, MCP-1 and CRP. One of the prevention and treatment of inflammatory for overweight and obesity cases is to do physical exercise. In cases of overweight and obesity, the physical exercise aims to increase energy expenditure. Physical exercise decreases the volume and amount of adipose and pre-adipose tissue as well as the number of endothelial cells and macrophages in adipose that contain pro-inflammation such as IL-1, TNF-α, CRP, serum amyloid protein (SAA), and cytokines. Physical exercise rises anti-inflammatory properties such as IL-10, IL-1ra which play a role in inhibiting the transduction of IL-1β signals and inhibiting TNF-α synthesis. Physical exercise also amplifies antioxidant enzymes such as SOD and GPX. The antioxidants play a role in fighting free radicals to reduce inflammation.
Khrisna Adi Pinardi Fundhi
Folia Medica Indonesiana, Volume 57, pp 27-33; doi:10.20473/fmi.v57i1.9035

Brachial Plexus Injury (BPI) results in decreased motor function in upper extremity and leads to reduced hand grasping movement. Orthotic prehension is designed to create artificial grasp movements in paralyzed hand. This study was to compare grasp kinematic improvement between body powered and myoelectric prehension orthosis usage in patients with BPI. This study was a single group without control and post test with experimental study. The subjects of the study (n = 11) were brachial plexus injury patients with non-functional hand strength. Joint motion and angular velocity of metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joint of index finger were evaluated. There was an improvement in joint motion and angular velocity after both orthosis usage. Joint motion in MCP and PIP, Angular velocity in MCP were not significantly different between myoelectric and body powered and myoelectric prehension orthosis usage. PIP angular velocity improvement were better after body powered prehension orthosis usage (p= 0.03).In conclusion, body powered and myolectric prehension orthosis usage improved kinematic parameter of index finger’s MCP and PIP joint. PIP angular velocity was better after body powered prehension orthosis usage.
Indriani Kartika Dewi, Moestidjab Moestidjab, Titut Harnanik
Folia Medica Indonesiana, Volume 57, pp 34-40; doi:10.20473/fmi.v57i1.9310

This study was to compare the effectiveness of hyperbaric oxygen therapy (HBOT) on contrast and macular light sensitivity improvement in dry type age-related macular degeneration (AMD) patients. The subjects were eyes that had been diagnosed with dry type AMD which met inclusion criteria. The subjects were divided into two groups. The first group was given antioxidants and HBOT. The second group was given only antioxidants. Contrast and macular light sensitivity test were done using MARS contrast sensitivity chart and Humphrey Field Analyzer-3 for three times, pre-therapy, day-1 and 14 post- therapy. This study found that 25 eyes were included for analysis, 14 subjects in first group, and 11 subjects in second group. Statistical analysis results showed that there were significant increase on contrast sensitivity in intervention group between one-day post-therapy with pre-therapy, P = 0.003 (P <0.05), and between 14-days post-therapy with pre-therapy, P = 0,015 (P <0.05). From pre- and post-analysis, there were no significant difference found on contrast sensitivity in control group and macular light sensitivity in intervention group. In control group, there were significant increase on superotemporal, superonasal, and inferonasal area between one-day post-therapy and pra-therapy with P = 0.004, P = 0.013 and P = 0.008 (P <0.05), respectively, and there was significant decrease on inferonasal area between 14-days post-therapy and one-day post-therapy, P = 0.003 (P <0.05). In conclusion, patients with AMD who were subjected to HBOT achieved improvement in contrast sensitivity in cases considered as having low prognosis. HBOT should be considered as promising intervention for AMD management adjuvant and further research are needed to find optimal dosage.
Fitry Nachamory Oemar, Irmantara Subagio, Hayuris Kinandita Setiawan, Purwo Sri Rejeki
Folia Medica Indonesiana, Volume 57, pp 58-62; doi:10.20473/fmi.v57i1.16209

The purpose of this research is to describe the physical condition differences between female athletes indoor hockey of East Java Team and National Team. Data sampling is taken from 12 female athletes indoor hockey of PON 2016 with age range 17-28 years old and 12 athletes of indoor hockey of Indonesia’s National Team at SEA Games 2017 with age range 19-28 years old for comparison. Physical condition that measured is VO2max to represent endurance, abdominal muscle strength, speed and flexibility. Obtained data is then analyzed using SPSS. VO2max of East Java Team is (39.54±4.18) ml/kg/minute and for National Team is (43.43±7.59) ml/kg/minute (ρ=0.14). For abdominal muscle strength, East Java Team has (41.50±7.01) kg and National Team has (51.83±3.32) kg (ρ=0.00). For Speed, East Java Team has (3.59±0.30) second and National Team has (3.94±0.38) second (ρ=0.51). For Flexibility, East Java Team has (23.75±5.10) cm and National Team has (29.50±4.91) cm (ρ=0.01). From these data we can conclude that East Java Team physical condition is under National Team and it has significant differences at flexibility and abdominal muscle strength. Furthermore, optimal interventions are needed to improve both of those physical conditions.Keywords: hockey, endurance, flexibility, strength, speed
Gadis Meinar Sari
Folia Medica Indonesiana, Volume 57, pp 70-75; doi:10.20473/fmi.v57i1.23388

Stunting is one of the main nutritional problems that is still common in children under five and has serious health impacts. The results of National Health Research (Riskesdas) in 2018 showed the prevalence of stunting at 30.8%, indicating that 1 out of 3 Indonesian children are still stunted. Probolinggo Regency is a priority area for stunting handling in 2019 with a prevalence of 50.2% according to a report from the National Team for the Acceleration of Poverty Reduction (TNP2K). One of the factors that directly affect the incidence of stunting is low birth weight (LBW), while the mothers' knowledge level of health is an indirect factor that affects the growth conditions of children under five. The purpose of this study was to analyze the effect of providing stunting early detection education on maternal knowledge regarding stunting prevention. This is a pre experimental research study with one group pre-post test design, children aged 0-24 months as the research subjects. The case group consisted of stunted children (BL/A <-2 SD Z-score), while the control group consisted of normal children according to the BL/U indicator. The number of research subjects for the case and control groups was 40 with mothers of the toddlers as research respondents. The samples were selected using total sampling technique. Data were analyzed using dependent T test and linear regression. The results suggested that at the beginning of the session before provided education about early detection of stunting, mothers with stunting toddlers had lower level of knowledge (73.3%) than those with normal toddlers (77%). After provided with education, the knowledge level of mothers with stunted toddlers appreared to be higher (89%) than those with normal children (87.6%), with significant increase in each group (P <0.05). It can be concluded that education on stunting detection can significantly improve mothers' knowledge regarding the prevention of stunting in children aged 0-24 months. Providing regular education, both by nutrition workers at the health center and integrated service post (posyandu) cadres, is necessary as an effort to prevent stunting to the maximum.
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