Folia Medica Indonesiana
ISSN / EISSN : 2355-8393 / 2599-056X
Published by: Universitas Airlangga (10.20473)
Total articles ≅ 392
Latest articles in this journal
Folia Medica Indonesiana, Volume 57, pp 262-266; https://doi.org/10.20473/fmi.v57i3.24357
Epispadias as an isolated embryologic defect is a rare anomaly, with an incidence of 1 in 117.000 males. Isolated epispadias with continence is a very rare condition comprising less than 10% of all epispadias cases. Epispadias is a closure defect of the dorsal wall of the urethra. The biggest challenges for epispadias treatment are creating adequate penile length, straightening the severely curved penis, and creating a penopubic angle for allowing comfortable penetration of the penis. An 11-year-old boy underwent surgery for his continent penile epispadias in Dr. Soetomo General Academic Hospital. The surgical technique chosen for this patient was Modified Cantwell-Ransley repair. The dressing was opened on the 3rd day after the operation. The urethral catheter was removed on the 10th day. The patients underwent regular follow-up examinations for 6 months and were evaluated for subjective and objective outcomes. There was no post-operative fistula or urethral narrowing requiring urethral dilatation. The Uroflowmetry and post voiding residual ultrasound result was good. The cosmetic appearance of the penis was satisfying. Outcomes related to sexual activity were not evaluated because the patient had no sexual activity yet.
Folia Medica Indonesiana, Volume 57, pp 256-261; https://doi.org/10.20473/fmi.v57i3.25208
Chondrosarcoma is a rare variant of bladder tumor and one of the rare types of soft tissue sarcoma. This case happened on a 36-year-old male who complained of lumps in his lower abdomen, accompanied by difficulties in passing urine and painful urination, without hematuria. We performed TURBT and histopathological examination showed low-grade chondrosarcoma. The patient was diagnosed with low-grade bladder chondrosarcoma. The patient was treated for chemotherapy and radiotherapy. However, after undergoing one cycle of chemotherapy, the patient refused to continue the therapy.
Folia Medica Indonesiana, Volume 57, pp 192-198; https://doi.org/10.20473/fmi.v57i3.22824
Traumatic brain injury (TBI) is the largest contributor to morbidity and mortality in various parts of the world. Skull base fracture (SBF) is one of the many manifestations that can occur in cases of mild to severe TBI. With varying patterns of TBI, it was necessary to review the characteristics of SBF, clinical manifestations, cerebrospinal fluid leakage, and complications. The data were taken from the medical records of SBF patients who were treated at RSUD (Regional Public Hospital) Dr. Soetomo in the period January 2014 - July 2019. Then, the data obtained were written on the collection sheet and analyzed descriptively using RKward. It was found that SBF most often occurs due to severe TBI (60.14%). 77.7% of SBF patients were male and 35.1% of all patients aged 15-24 years. The most frequent cause was traffic accidents (86.5%). The anterior cranial fossa (ACF) was the most frequently fractured part of the skull base (30.4%). There was a significant relationship between the severity of TBI with the occurrence of CSF leakage and complications. About 33 patients (22.3%) had complications such as pneumocephalus and 9 patients (6.1%) had meningitis. Complications in the form of brain abscess and hydrocephalus in 1 (0.7%) patient each. SBF often occurred in men of productive age 15-24 years. The ACF was the most frequently fractured part. The majority were caused by traffic accidents accompanied by severe brain injuries. The most common complications were pneumocephalus, meningitis, brain abscess, and hydrocephalus.
Folia Medica Indonesiana, Volume 57, pp 226-230; https://doi.org/10.20473/fmi.v57i3.22733
Preeclampsia is hypertension in pregnancy that aﬀects 2% to 8% of pregnancies worldwide and causes significant maternal and perinatal morbidity and mortality. In the pathogenesis of preeclampsia, placental hypoxia plays an important role, associated with excessive trophoblast apoptosis resulting in decreased trophoblast and spiral arteries invasion. This placental hypoxic condition will induce increased expression of Hypoxia Inducible Factor -1-Alpha (HIF-1-A). L-Arginine is a potent vasodilator presumably to improve preeclampsia placental hypoxic conditions and reduce HIF-1-A expression. This study was an experimental study with a parallel-group post-test only design. Thirty-six preeclamptic mice models were divided into 2 groups. The control group (K1) 18 preeclamptic mice model without treatment and the treatment group (K2) 18 preeclamptic mice given L-Arginine. The independent variable was the administration of L-Arginine and the dependent variable is the placental HIF-1-A expression. Statistical analysis used unpaired t-test on normal data distribution, and Mann Whitney test on abnormal data distribution. The mean of placental HIF-1-A expression K1 was 2.47 ± 1.65 with a minimum value of 0.4 and a maximum value of 6.6. At K2 0.93 ± 0.55 with a minimum value of 0.0 and a maximum value of 2.0. Statistical tests showed that the placental HIF-1-A expression in the treatment group was significantly lower than that in the control group (p <0.001). In conclusion, the expression of HIF-1-A in preeclamptic mice model placenta decreased with L-Arginine administration.
Folia Medica Indonesiana, Volume 57, pp 231-238; https://doi.org/10.20473/fmi.v57i3.25293
A safety sign is a sign of equipment to provide protection for workers or visitors in the workplace. American National Standards Institute Z535 (ANSI Z535) is used as a basic guideline for installing safety signs in the workplace because it is more communicative by using global symbols to overcome language barriers. Occupational Safety Division of Manpower and Transmigration Departement, East Java Province (UPT Keselamatan Kerja Surabaya) is a workplace that has a risk of occupational accidents. The preliminary surveys in the area of the 3rd floor of the Division of Occupational Safety (UPT Keselamatan Kerja) Surabaya revealed that there were many sites with insufficient safety signboards. Many of the installed safety signs did not comply with ANZI Z535 standards. This study aimed to evaluate the installation of safety signs compared to the ANZI Z535 standard on the 3rd floor of UPT K2 Surabaya. This was an observational study examining the installation of safety signs. The data were obtained using the ANSI Z535 safety sign checklist. We found 2 out of 5 types of safety signs were in accordance with ANSI safety sign standards with a comparison percentage of more than 66%, such as the notice sign (67.85%) and safety condition sign (75%). Three other types of safety signs were in the unfavorable category with a percentage of less than 66%, such as danger sign (65.63%), warning sign (50%), and caution sign (46.88%). Some sites required additional safety signs, such as warning signs (at distillation site), caution signs (oven, stairs), notice signs (cylinder storage, elevator, chemical warehouse), and safety condition signs (stair, eyewash).
Folia Medica Indonesiana, Volume 57, pp 214-219; https://doi.org/10.20473/fmi.v57i3.20391
Noise-Induced Hearing Loss (NIHL) is a global health problem, often underestimated, and leads to permanent hearing loss. The prevalence of NIHL in adolescents has increased in line with the increasing use of cell phones. This study aimed to determine the prevalence of NIHL and analyze the population at risk (age, gender, and school) in adolescent students. The study design was a cross-sectional study. A total of 510 students consisting of female, n=288 and male, n=222; junior high school, n=203 and senior high school, n=307 were used as research subjects. This study was conducted on August-October 2015 at Darul Ihsan School, Banda Aceh, Indonesia. An audiometry examination was performed to determine the diagnosis of NIHL. Data analysis was using descriptive analysis and independent sample t-test(p<0.05). The results of this study were the prevalence of NIHL in adolescents aged 11-20 years was 18.88%. The highest percentage of NIHL was at the age of 15 years (34.57%). The number of NIHL was significantly higher (p=0.000*) in males (24.32%) compared to females (9.37%). The prevalence of NIHL was significantly higher (p=0.00*) in senior high school children (26.11%) compared to that in junior high school children (9.12%). In conclusion, the highest prevalence of NIHL was at the age of 15 years. NIHL was more common in male than in female students. NIHL was higher in high school students compared to junior high school students. The NIHL was related to age, gender, and school level.
Folia Medica Indonesiana, Volume 57, pp 245-249; https://doi.org/10.20473/fmi.v57i3.23838
This study aimed to determine the effect of ethanol extract of gemitir flower (Tagetes erecta L.) on total cholesterol levels, Low-Density Lipoprotein C (LDL), Malondialdehyde (MDA), Apolipoprotein B (ApoB). Forty-eight Rattus norvegicus were randomly divided into 6 groups, groups were given standard feed (K-) and 5 groups of hyperlipidemia models (K +, P1, P2, P3, P4) were given High Fat Diet (HFD) for 35 days. On the 36th day, the total cholesterol levels were checked through the tail of Rattus norvegicus, and from day 37 to day 50 were given a normal diet (K-), HFD (K +), simvastatin 10 mg/kgBW (P1), ethanol extract of gemitir flowers (Tagetes erecta L.) 200 (P2), 400 BW (P3), and 800 mg/kgBW (P4). On day 51, the total cholesterol, LDL-C, MDA, and ApoB blood serum levels were checked. The results showed total cholesterol, Low-Density Lipoprotein (LDL), Malondialdehyde (MDA), and Apolipoprotein B (ApoB) given ethanol extract of gemitir flowers 200 and 400 mg/kgBW (P2) had a significant reduction (P < 0.05). Giving ethanol extract of gemitir flower (Tagetes erecta L.) could reduce levels of total cholesterol, LDL, MDA, and Apo B.
Folia Medica Indonesiana, Volume 57, pp 205-209; https://doi.org/10.20473/fmi.v57i3.23601
This study aimed to analyze the differences in Hsp 70 serum levels in patients with primary angle-closure compared to patients with open-angle glaucoma at Dr. Soetomo General Academic Hospital, Surabaya, East Java. This cross-sectional study was conducted on 41 subjects divided into 2 groups consisting of 21 patients with primary angle-closure glaucoma and 20 patients with open-angle glaucoma. Anterior segment examination was assessed by slit-lamp biomicroscope examination. Intraocular pressure on both eyes was measured by Perkin’s tonometry. Posterior segment examination was performed with 78 D lens and anterior chamber angle was assessed by goniolens. The serum level of Hsp 70 was assessed using a human Hsp 70 sandwich ELISA kit. The data were statistically analyzed with the Mann-Whitney test. The mean serum levels of Hsp 70 in the primary angle-closure group was 5.55 4.75 ng/ml, while the open-angle group was 3.62 2.39 ng/ml (p = 0.134). There was no difference in Hsp 70 serum levels between the two groups, although the trend obtained serum levels of Hsp 70 patients with primary angle-closure was higher compared to patients with open-angle.
Folia Medica Indonesiana, Volume 57, pp 220-225; https://doi.org/10.20473/fmi.v57i3.13580
The study was to prove the validity and reliability of the WHODAS 2.0 Indonesian version questionnaire in patients with back pain. This study was an observational cross-sectional study conducted in 2018. The study included the filling of WHODAS 2.0 Indonesian version, Indonesian version of Oswestry Disability Index (ODI) questionnaire, Wong-Baker Scale, conducted at Department of Rehabilitative Medicine, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, against 82 respondents with back pain. Each respondent was given informed consent. The validity of the WHODAS 2.0 Indonesian version questionnaire was measured using Pearson's test on the correlation of WHODAS 2.0 Indonesian version questionnaire and Oswestry Disability Index questionnaire with r >0.3 (0.862). WHODAS 2.0 Indonesian version questionnaire and Wong-Baker Scale had r >0.3 (0.449–0.785). The reliability of the WHODAS 2.0 Indonesian version questionnaire was measured using Pearson's correlation test with r >0.3 (0.764–0.866). WHODAS 2.0 Indonesian version's internal reliability was tested using Cronbach-Alfa Test with alpha >0.6 (0.634–, 853). In conclusion, the WHODAS 2.0 - Indonesian version is a valid and reliable questionnaire for patients with back pain.
Folia Medica Indonesiana, Volume 57, pp 210-213; https://doi.org/10.20473/fmi.v57i3.17697
Cucumber (Cucumis sativus L.). was known for lowering blood pressure agents. Some researches show that Cucumber had a similar mechanism with a loop diuretic (Furosemide), exceeding sodium and potassium excretion. However, a part of Cucumber that gives a better effect on managing water and sodium balance remains unknown. This study was to explain the differences potential diuretic among parts of Cucumber (Cucumis sativus L.). This study was using a post-test only control group designed in animals. There were 44 male Mus musculus tested in this study. All of the animal testings was divided into 9 different treatment groups and 2 control groups. All Mus musculus got 1 mL methanol extract of Cucumber (Cucumis sativus L.) according to their group. The animal testing was put on metabolic cage to measure urine volume for 24 hours. The flesh and rind part of Cucumber (Cucumis sativus L.) showed a similar result with furosemide as diuretics agents. However, whole part of the fruit of Cucumber (Cucumis sativus L.) (flesh, rind, and seed) showed as natriuretic dan kaliuretic, Cucumber (Cucumis sativus L.) has a similar potential diuretic with Furosemide. Even in low concentrations of Cucumber extract, it led to having a potential diuretic, with natriuretic and kaliuretic effects in the whole part of the fruit. This could be suggested to people with chronic kidney diseases to prevent hyperkalemia.