Science Immunology

Journal Information
EISSN : 24709468
Total articles ≅ 309
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SCOPUS
MEDLINE
MEDICUS
SCIE
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Rachael A. Clark
Science Immunology, Volume 4; doi:10.1126/sciimmunol.aaz2438

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Lokesh A. Kalekar, Jarish N. Cohen, Nicolas Prevel, Priscila Muñoz Sandoval, Anubhav N. Mathur, Joshua M. Moreau, Margaret M. Lowe, Audrey Nosbaum, Paul J. Wolters, Anna Haemel, et al.
Science Immunology, Volume 4; doi:10.1126/sciimmunol.aaw2910

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Suzanne M. Bal, Ralph Stadhouders
Science Immunology, Volume 4; doi:10.1126/sciimmunol.aay1160

Abstract:T helper 2–skewed regulatory T cells in the skin use GATA3 to suppress local profibrotic type 2 cytokine production. See the related Research Article by Kalekar et al.
Judy Lieberman, Hao Wu, Jonathan C. Kagan
Science Immunology, Volume 4; doi:10.1126/sciimmunol.aav1447

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Louis Gioia, Marie Holt, Anne Costanzo, Siddhartha Sharma, Brian Abe, Lisa Kain, Maki Nakayama, Xiaoxiao Wan, Andrew Su, Clayton Mathews, et al.
Science Immunology, Volume 4; doi:10.1126/sciimmunol.aaw6329

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Ivana R. Ferrer, Heather C. West, Stephen Henderson, Dmitry S. Ushakov, Pedro Santos E Sousa, Jessica Strid, Ronjon Chakraverty, Andrew J. Yates, Clare L. Bennett
Science Immunology, Volume 4; doi:10.1126/sciimmunol.aax8704

Abstract:A dense population of embryo-derived Langerhans cells (eLCs) is maintained within the sealed epidermis without contribution from circulating cells. When this network is perturbed by transient exposure to ultraviolet light, short-term LCs are temporarily reconstituted from an initial wave of monocytes but thought to be superseded by more permanent repopulation with undefined LC precursors. However, the extent to which this process is relevant to immunopathological processes that damage LC population integrity is not known. Using a model of allogeneic hematopoietic stem cell transplantation, where alloreactive T cells directly target eLCs, we have asked whether and how the original LC network is ultimately restored. We find that donor monocytes, but not dendritic cells, are the precursors of long-term LCs in this context. Destruction of eLCs leads to recruitment of a wave of monocytes that engraft in the epidermis and undergo a sequential pathway of differentiation via transcriptionally distinct EpCAM+ precursors. Monocyte-derived LCs acquire the capacity of self-renewal, and proliferation in the epidermis matched that of steady-state eLCs. However, we identified a bottleneck in the differentiation and survival of epidermal monocytes, which, together with the slow rate of renewal of mature LCs, limits repair of the network. Furthermore, replenishment of the LC network leads to constitutive entry of cells into the epidermal compartment. Thus, immune injury triggers functional adaptation of mechanisms used to maintain tissue-resident macrophages at other sites, but this process is highly inefficient in the skin.
Pouya Faridi, Chen Li, Sri H. Ramarathinam, Patricia T. Illing, Nicole A. Mifsud, Rochelle Ayala, Jiangning Song, Linden J. Gearing, Nathan P. Croft, Anthony W. Purcell
Science Immunology, Volume 4; doi:10.1126/sciimmunol.aaw8457

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Zach Rolfs, Markus Müller, Michael R. Shortreed, Lloyd M. Smith, Michal Bassani-Sternberg
Science Immunology, Volume 4; doi:10.1126/sciimmunol.aaw1622

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Zhida Liu, Chuanhui Han, Chunbo Dong, Aijun Shen, Eric Hsu, Zhenhua Ren, Changzheng Lu, Longchao Liu, Anli Zhang, Casey Timmerman, et al.
Science Immunology, Volume 4; doi:10.1126/sciimmunol.aav6473

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Francesco Colucci
Science Immunology, Volume 4; doi:10.1126/sciimmunol.aax9589

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