Science Immunology

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EISSN : 24709468
Total articles ≅ 427
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Latest articles in this journal

E. K. Grasset, A. Chorny, S. Casas-Recasens, C. Gutzeit, G. Bongers, I. Thomsen, L. Chen, Z. He, D. B. Matthews, M. A. Oropallo, et al.
Science Immunology, Volume 5; doi:10.1126/sciimmunol.aat7117

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Dustin D. Flannery, Sigrid Gouma, Miren B. Dhudasia, Sagori Mukhopadhyay, Madeline R. Pfeifer, Emily C. Woodford, Jeffrey S. Gerber, Claudia P. Arevalo, Marcus J. Bolton, Madison E. Weirick, et al.
Science Immunology, Volume 5; doi:10.1126/sciimmunol.abd5709

Limited data are available for pregnant women affected by SARS-CoV-2. Serological tests are critically important for determining SARS-CoV-2 exposures within both individuals and populations. We validated a SARS-CoV-2 spike receptor binding domain serological test using 834 pre-pandemic samples and 31 samples from COVID-19 recovered donors. We then completed SARS-CoV-2 serological testing of 1,293 parturient women at two centers in Philadelphia from April 4 to June 3, 2020. We found 80/1,293 (6.2%) of parturient women possessed IgG and/or IgM SARS-CoV-2-specific antibodies. We found race/ethnicity differences in seroprevalence rates, with higher rates in Black/non-Hispanic and Hispanic/Latino women. Of the 72 seropositive women who also received nasopharyngeal polymerase chain reaction testing during pregnancy, 46 (64%) were positive. Continued serologic surveillance among pregnant women may inform perinatal clinical practices and can potentially be used to estimate exposure to SARS-CoV-2 within the community.
Lauren J. Howson, Wael Awad, Anouk Von Borstel, Hui Jing Lim, Hamish E. G. McWilliam, Maria L. Sandoval-Romero, Shamik Majumdar, Abdul Rezzak Hamzeh, Thomas D. Andrews, David H. McDermott, et al.
Science Immunology, Volume 5; doi:10.1126/sciimmunol.abc9492

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Daniel M. Altmann, Rosemary J. Boyton
Science Immunology, Volume 5; doi:10.1126/sciimmunol.abd6160

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Lea Seidel, Bertram Bengsch
Science Immunology, Volume 5; doi:10.1126/sciimmunol.abc8644

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Lawrence P. Andrews, Ashwin Somasundaram, Jessica M. Moskovitz, Andrea L. Szymczak-Workman, Chang Liu, Anthony R. Cillo, Huang Lin, Daniel P. Normolle, Kelly D. Moynihan, Ichiro Taniuchi, et al.
Science Immunology, Volume 5; doi:10.1126/sciimmunol.abc2728

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Stacey N. Harbour, Daniel F. DiToro, Steven J. Witte, Carlene L. Zindl, Min Gao, Trenton R. Schoeb, Gareth W. Jones, Simon A. Jones, Robin D. Hatton, Casey T. Weaver
Science Immunology, Volume 5; doi:10.1126/sciimmunol.aaw2262

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Leticia Kuri-Cervantes, M. Betina Pampena, Wenzhao Meng, Aaron M. Rosenfeld, Caroline A.G. Ittner, Ariel R. Weisman, Roseline S. Agyekum, Divij Mathew, Amy E. Baxter, Laura A. Vella, et al.
Science Immunology, Volume 5; doi:10.1126/sciimmunol.abd7114

Although critical illness has been associated with SARS-CoV-2-induced hyperinflammation, the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively analyzed peripheral blood immune perturbations in 42 SARS-CoV-2 infected and recovered individuals. We identified extensive induction and activation of multiple immune lineages, including T cell activation, oligoclonal plasmablast expansion, and Fc and trafficking receptor modulation on innate lymphocytes and granulocytes, that distinguished severe COVID-19 cases from healthy donors or SARS-CoV-2-recovered or moderate severity patients. We found the neutrophil to lymphocyte ratio to be a prognostic biomarker of disease severity and organ failure. Our findings demonstrate broad innate and adaptive leukocyte perturbations that distinguish dysregulated host responses in severe SARS-CoV-2 infection and warrant therapeutic investigation.
Jeong Seok Lee, Seongwan Park, Hye Won Jeong, Jin Young Ahn, Seong Jin Choi, Hoyoung Lee, Baekgyu Choi, Su Kyung Nam, Moa Sa, Ji-Soo Kwon, et al.
Science Immunology, Volume 5; doi:10.1126/sciimmunol.abd1554

Although most SARS-CoV-2-infected individuals experience mild coronavirus disease 2019 (COVID-19), some patients suffer from severe COVID-19, which is accompanied by acute respiratory distress syndrome and systemic inflammation. To identify factors driving severe progression of COVID-19, we performed single-cell RNA-seq using peripheral blood mononuclear cells (PBMCs) obtained from healthy donors, patients with mild or severe COVID-19, and patients with severe influenza. Patients with COVID-19 exhibited hyper-inflammatory signatures across all types of cells among PBMCs, particularly up-regulation of the TNF/IL-1β-driven inflammatory response as compared to severe influenza. In classical monocytes from patients with severe COVID-19, type I IFN response co-existed with the TNF/IL-1β-driven inflammation, and this was not seen in patients with milder COVID-19. Interestingly, we documented type I IFN-driven inflammatory features in patients with severe influenza as well. Based on this, we propose that the type I IFN response plays a pivotal role in exacerbating inflammation in severe COVID-19.
Luigi D. Notarangelo, Rosa Bacchetta, Jean Laurent Casanova, Helen C. Su
Science Immunology, Volume 5; doi:10.1126/sciimmunol.abb1662

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