Archiv der Pharmazie

Journal Information
ISSN / EISSN : 0365-6233 / 1521-4184
Current Publisher: Wiley (10.1002)
Former Publisher:
Total articles ≅ 88,887
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Latest articles in this journal

Siva Sankar P, Narendra Babu K, Tamatam Rekha, ,
Published: 11 May 2021
by Wiley
Archiv der Pharmazie; doi:10.1002/ardp.202000483

The publisher has not yet granted permission to display this abstract.
Kamilia M. Amin, Gehan H. Hegazy, , Nahla R. Ibrahim, Nada M. Mohamed
Published: 11 May 2021
by Wiley
Archiv der Pharmazie; doi:10.1002/ardp.202100051

The publisher has not yet granted permission to display this abstract.
, Ayca Dedeoglu‐Erdogan, Marwa Bader, , , , Melda Ozgurbuz, ,
Published: 9 May 2021
by Wiley
Archiv der Pharmazie; doi:10.1002/ardp.202000469

The publisher has not yet granted permission to display this abstract.
Published: 8 May 2021
by Wiley
Archiv der Pharmazie; doi:10.1002/ardp.202100082

Abstract:
Small molecules have gained considerable interest in regenerative medicine, as they can effectively modulate cell fates in a spatiotemporal controllable fashion. A continuous challenge in the field represents genuine mimicry or activation of growth factor signaling with small molecules. Here, we selected and profiled three compounds for their capacity to directly or indirectly activate endogenous FGF‐2, VEGF, or SHH signaling events in the context of skin regeneration. Phenotypic and functional analysis of primary skin fibroblasts and keratinocytes revealed unique, cell‐specific activity profiles for the FGF‐2 mimetic SUN11602 and the putative VEGF mimetic ONO‐1301. Whereas SUN11602 exclusively stimulated keratinocyte differentiation, ONO‐1301 mainly affected the proliferation and migration behavior of fibroblasts. In each skin cell type, both compounds selectively enhanced the expression of MMP1 and VEGFA. A combined small molecule FGF‐2/VEGF mimicry may not only improve angiogenesis‐related microcirculation but also reduce early fibrosis while facilitating wound remodeling at later stages. SUN11602 and ONO‐1301 represent valuable tools for improving the management of difficult‐to‐heal wounds, particularly for the design and development of small molecule‐functionalized, next‐generation, engineered skin substitutes.
Published: 3 May 2021
by Wiley
Archiv der Pharmazie, Volume 354; doi:10.1002/ardp.202170010

Published: 3 May 2021
by Wiley
Archiv der Pharmazie, Volume 354; doi:10.1002/ardp.202170009

, , Priyank Kumar, Radhika V. Kumar, Saurabh Dahiya, Suresh Kumar, Renu Saharan, Paramita Basu, Arindam Mitra, Ajay Sharma, et al.
Published: 29 April 2021
by Wiley
Archiv der Pharmazie; doi:10.1002/ardp.202100034

The publisher has not yet granted permission to display this abstract.
Ergün Gultekin, , Yakup Kolcuoğlu, Atilla Akdemir
Published: 26 April 2021
by Wiley
Archiv der Pharmazie; doi:10.1002/ardp.202100058

The publisher has not yet granted permission to display this abstract.
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