Anadolu Kardiyoloji Dergisi/The Anatolian Journal of Cardiology

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ISSN / EISSN : 1302-8723 / 1308-0032
Published by: AVES Publishing Co. (10.5152)
Total articles ≅ 1,247
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Erkan Yildirim, , Nilgun Yildirim, Kursat Aslan, , Ali Fuat Korkmaz, Fatih Rifat Ulusoy, Engin Hatem
Anadolu Kardiyoloji Dergisi/The Anatolian Journal of Cardiology, Volume 17, pp 184-190; https://doi.org/10.5152/akd.2014.5793

Abstract:
Urocortin 1 (UCN1) has vasodilator, diuretic, and natriuretic effects, and its expression increases in heart failure (HF). Adrenomedullin (ADM) increases cardiac output and lowers blood pressure in healthy men and in patients with heart failure. The aim of the study was to determine UCN1 and ADM levels in patients with HF, to evaluate the relationship of UCN1 and ADM with various clinical parameters, and to assess UCN1 and ADM as diagnostic markers in HF, in comparison with pro-brain natriuretic peptide (pro-BNP).We investigated serum levels of UCN1, ADM, and pro-BNP in 86 consecutive patients with systolic HF [ejection fraction (EF) ≤45%] and 85 healthy controls. Serum UCN1, ADM, and pro-BNP levels were measured with the ELISA method. Transthoracic echocardiography was performed to determine left ventricular EF and pulmonary artery systolic pressure.UCN1 and ADM levels were higher in HF patients (446.2±145.7 pg/mL, p<0.001; 87.9±4.2 pg/mL, p<0.001 respectively). UCN1 was positively correlated with pro-BNP (r=0.963, p<0.001), ADM (r=0.915, p<0.001), and NYHA (r=0.879, p<0.001); ADM was positively correlated with pro-BNP (r=0.956, p<0.001) and NYHA (r=0.944, p<0.001). Receiver operating characteristic curves yielded an area under the curve of 1.00 (p<0.001) for UCN1, 1.00 (p<0.001) for ADM, and 0.99 (p<0.001) for pro-BNP in the diagnosis of HF.UCN1 and ADM increase with worsening HF and left ventricular dysfunction. They may be used as diagnostic biomarkers in systolic HF, but the incremental value of measuring UCN1 and ADM in patients tested for pro-BNP is questionable.
, Yakup Ergul, Hasan Tahsin Tola, Murat Saygi, , , Oyku Tosun, Sinem Ozyilmaz, Mehmet Gul, Alper Guzeltas, et al.
Anadolu Kardiyoloji Dergisi/The Anatolian Journal of Cardiology, Volume 16, pp 290-5; https://doi.org/10.5152/akd.2015.5922

Abstract:
We evaluated autonomic behavior by examining heart rate variability (HRV) in the time domain and frequency domain in pediatric patients who underwent transcatheter closure of atrial septal defect (ASD).A prospective study design was used. Holter ECG was performed in a control group of 30 healthy subjects and a group of 47 patients who underwent transcatheter ASD closure. ECG was taken one day before, one day after, and six months after the procedure to evaluate changes in the time domain [SDNN, rMSSD, NN, pNN50(%), and SDANN] and frequency domain (VLF, LF, HF, VHF, and LF/HF) in the patient group. Student's t-test was used to evaluate changes prior to and after the procedure.There were 28 females (60%) in the patient group and 21 females (70%) in the control group. The mean age and weight of the participants in the patient group were 9.61±4.72 years and 32.40±19.60 kg, respectively; the mean age and weight of the control subjects were 10.43±5.31 years and 32.83±13.00 kg, respectively. In both the time domain and frequency domain analyses, the patient group values were found to be lower than those in the control group prior to the procedure; the values in the patient group were found to approach the values in the control group following the procedure. By the sixth month, the values in the patient group reached the control levels with no statistically significant difference (SDNN: 145±0.84, 137.50±42.50; rMSSD: 72.18±48.22, 58.14±28.49; SDANN: 125.13±13.50, 122.40±41.06; VLF: 112.85±29.07, 114.41±98.39; LF: 50.40±24.09, 45.69±15.13; HF: 39.28±19.86, 44.29±13.14; VHF: 10.29±4.24, 9.99±6.47; LF/HF: 1.90±1.44, 1.24±0.81; p>0.05).The transcatheter closure of secundum ASDs was found to have a positive effect on HRV. Consequently, it may contribute to reduced mortality and morbidity. We can conclude that in children, HRV recovers approximately six months after transcatheter ASD closure.
Hilal Akseki Temur, , Muzaffer Demir, Orkide Palabiyik, Aziz Karaca, Zuhal Guksu, Arif Ortanca, Necdet Sut
Anadolu Kardiyoloji Dergisi/The Anatolian Journal of Cardiology, Volume 15, pp 97-102; https://doi.org/10.5152/akd.2014.5204

Abstract:
Amino-terminal propeptide of C-type natriuretic peptide (NTproCNP) is a synthesis product of C-type natriuretic peptide (CNP). In this study, plasma levels of NTproCNP were compared before and after exercise in healthy young subjects who are physically active (PA) or not physically active (NPA). The study was carried on PA group (n=10) who defined the exercise duration more than 2.5 hours per week for at least one year and NPA group (n = 10) whose exercise duration was lower than 1.5 hours per week. The level of maximal oxygen consumption was determined. Wingate exercise test was applied on the following day. Plasma NTproCNP levels were measured before the exercise and at the 1st, 5th and 30th minute after the exercise. Exercise duration of physically active group was reported as 11.3 ± 5.0 hours per week. Basal NTproCNP levels of the groups were found to be comparable. NTproCNP levels in the 5th minute (0.93 ± 0.23 pmol/L; p<0.05) and in the 30th minute (0.77 ± 0.21 pmol/L p < 0.05) after exercise were higher than the levels before exercise (0.64 ± 0.29 pmol/L) in PA group. Additionally, the plasma levels of NTproCNP after 5th minute of exercise were higher in PA group (0.93 ± 0.23 pmol/L) than NPA group (0.74 ± 0.16 pmol/L, p<0.05). Being physically active may be a fact affecting the secretion of CNP, which plays a protective role in endothelium, following exercise.
, Mustafa Gur, Mehmet Yavuz Gozukara, Ali Kivrak, Zekeriya Kolcu, Selehattin Akyol, , Zafer Elbasan, Durmus Yildiray Sahin, Caner Turkoglu, et al.
Anadolu Kardiyoloji Dergisi/The Anatolian Journal of Cardiology, Volume 15, pp 107-112; https://doi.org/10.5152/akd.2014.5196

Abstract:
Morning blood pressure surge (MBPS) is an independent predictor of atherothrombotic cardiovascular events in hypertensive patients. There is evidence from studies supporting the validity of mean platelet volume (MPV) as a marker of vascular risk and predictor of thrombotic complications. The aim of this study is to investigate the relationship between MPV and MBPS in hypertensive patients. Measurements were obtained from 298 patients with newly diagnosed essential hypertension (Mean age: 51.9 ± 11.7 years). The patients were divided into two groups (MPV(low) group; <10.8 fL, MPV(high) group; ≥ 10.8 fL). The MBPS was calculated as mean systolic BP during the 2 hours after awaking minus the mean systolic BP during the 1 hour that included the lowest sleep BP. MPV was independently associated with MBPS (β=0.554, p<0.001) and hs-CRP level (β=0.286, p<0.001). Finally, higher MPV values related to enhanced MBPS which are associated with atherothrombotic cardiovascular events.
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