Journal of Thoracic Disease

Journal Information
ISSN / EISSN : 2072-1439 / 2077-6624
Published by: AME Publishing Company (10.21037)
Total articles ≅ 8,836
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Latest articles in this journal

Michelle Li Wei Kam, Pei Yee Tiew, Hui Zhong Chai, Su Ying Low
Journal of Thoracic Disease, Volume 14, pp 2481-2492; https://doi.org/10.21037/jtd-22-40

Abstract:
Original Article Cluster phenotypes in a non-idiopathic pulmonary fibrosis fibrotic interstitial lung diseases cohort in Singapore Michelle Li Wei Kam, Pei Yee Tiew, Hui Zhong Chai, Su Ying Low
Junhong Lin, Sikai Wu, Kanghao Zhu, Jian Zhang, Xiaoshun Shi, Jianfei Shen, Jianfeng Xu
Journal of Thoracic Disease, Volume 14, pp 2493-2510; https://doi.org/10.21037/jtd-22-294

Abstract:
Original Article The role of miR-145-5p in esophageal squamous cell carcinoma tumor-associated macrophages and selection of immunochemotherapy Junhong Lin, Sikai Wu, Kanghao Zhu, Jian Zhang, Xiaoshun Shi, Jianfei Shen, Jianfeng Xu
Francesca Casaluce, Cesare Gridelli
Journal of Thoracic Disease, Volume 14, pp 1748-1752; https://doi.org/10.21037/jtd-22-269

Abstract:
Editorial Critical points in the management of EGFR-mutated non-small cell lung cancer Francesca Casaluce, Cesare Gridelli
Alex Sutter, Dylan Landis, Kenneth Nugent
Journal of Thoracic Disease, Volume 14, pp 1758-1765; https://doi.org/10.21037/jtd-22-39

Abstract:
Editorial The potential role for metformin in the prevention and treatment of tuberculosis Alex Sutter, Dylan Landis, Kenneth Nugent
Seong Yong Park, Jun Hee Lee, Hubert Stein, Seung Young Heo, Hyun Koo Kim
Journal of Thoracic Disease, Volume 14, pp 1933-1940; https://doi.org/10.21037/jtd-21-1739

Abstract:
Video 1 Robotic thymectomy via the subxiphoid approach using the single-port system. Video 2 Excision of a posterior mediastinal mass via the subcostal approach using the single-port system. Authors: Seong Yong Park, Jun Hee Lee, Hubert Stein, Seung Young Heo, Hyun Koo Kim
Takuro Miyazaki, Takeshi Nagayasu
Journal of Thoracic Disease, Volume 14, pp 1744-1747; https://doi.org/10.21037/jtd-2022-06

Abstract:
Editorial Editorial on “robotic versus thoracoscopic combined anatomic subsegmentectomy for early stage lung cancer: early results of a cohort study” Takuro Miyazaki, Takeshi Nagayasu
Georgios Spyropoulos, Kalliopi Domvri, Katerina Manika, Evangelia Fouka, Theodoros Kontakiotis, Despoina Papakosta
Journal of Thoracic Disease, Volume 14, pp 1941-1949; https://doi.org/10.21037/jtd-21-1760

Abstract:
Original Article Clinical, imaging and functional determinants of sarcoidosis phenotypes in a Greek population Georgios Spyropoulos, Kalliopi Domvri, Katerina Manika, Evangelia Fouka, Theodoros Kontakiotis, Despoina Papakosta
Yanhua Zuo, Jing Liu, Huaheng Xu, Yanxia Li, Ran Tao, Zongfang Zhang
Journal of Thoracic Disease, Volume 14, pp 2089-2102; https://doi.org/10.21037/jtd-22-41

Abstract:
Original Article Pirfenidone inhibits cell fibrosis in connective tissue disease- associated interstitial lung disease by targeting the TNF-α/STAT3/ KL6 pathway Yanhua Zuo, Jing Liu, Huaheng Xu, Yanxia Li, Ran Tao, Zongfang Zhang
Xin He, Yaqian Chi, Jingcui Peng, Wenxia Hu, Cuimin Ding, Bin Li
Journal of Thoracic Disease, Volume 14, pp 2103-2111; https://doi.org/10.21037/jtd-22-646

Abstract:
Original Article A systematic review and meta-analysis of circulating cell-free DNA as a diagnostic biomarker for non-small cell lung cancer Xin He, Yaqian Chi, Jingcui Peng, Wenxia Hu, Cuimin Ding, Bin Li
Chen-Kai Hu, Ru-Ping Cai, Lei He, Shi-Rong He, Jun-Yu Liao,
Journal of Thoracic Disease, Volume 14, pp 2158-2168; https://doi.org/10.21037/jtd-22-481

Abstract:
Background: Studies have shown that percutaneous coronary intervention (PCI) is considered as the essential therapeutic strategy for the patients with ST-segment elevation myocardial infarction (STEMI). However; no-reflow could still occur in a few patients after PCI. Studies have reported that biomarkers related to no-reflow pathogenetic components could play a prognostic role in the prediction phenomenon. Hence, this study explored the establishment of nomogram model for predicting the occurrence of no-reflow phenomenon after PCI using the lncRNA TUG1/miR-30e/NPPB biomarkers in patients with STEMI after PCI. Methods: In this observational study, a total of 76 STEMI patients who underwent emergency PCI between January 2018 and December 2021were included. The patients after PCI, were divided into reflow (n=44) and no-reflow groups (n=32). The demographic, environmental and clinical risk factors were assessed and analysed between the groups. Quantitative RT-PCR was used to detect TUG1, miR-30e, and NPPB messenger RNA (mRNA) expression levels in the plasma of patients after PCI. Bioinformatic methods were used to predict the interaction of the plasma TUG1/miR-30e/NPPB axis. The risk factors in the no-reflow group were screened using a logistic-regression analysis, and a nomogram prediction model was constructed and validated. Subsequently, a gene set enrichment analysis revealed the function of lncRNA TUG1. Results: Plasma lncRNA TUG1 and NPPB were more highly expressed and miR-30e was more lowly expressed in the no-reflow group than the normal-reflow group (P<0.001). A negative correlation was observed between lncRNA TUG1 and miR-30e, and between miR-30e and NPPB. However, a positive correlation was observed between lncRNA TUG1 and NPPB mRNA. The bioinformatics analysis predicted multiple binding sites on the lncRNA TUG1 and miR-30e. LncRNA TUG1 [odds ratio (OR): 0.163, 95% confidence interval (CI): 0.021–0.944] and hs-CRP (OR: 2.151, 95% CI: 1.536–3.974) found to be as independent predictors. The C-index of this prediction model was 0.982 (95% CI: 0.956–1.000). Conclusions: TUG1 could function as an effective biomarker for no-reflow among patients with STEMI after PCT and the proposed nomogram may provide information for individualized treatment in patients with STEMI.
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