Science Translational Medicine

Journal Information
ISSN / EISSN : 19466234 / 19466242
Total articles ≅ 5,217
Google Scholar h5-index: 133
Current Coverage
SCOPUS
PUBMED
MEDLINE
MEDICUS
SCIE
Archived in
SHERPA/ROMEO
Filter:

Latest articles in this journal

Shaon Sengupta
Science Translational Medicine, Volume 12; doi:10.1126/scitranslmed.abd4766

The publisher has not yet granted permission to display this abstract.
Zhenqi Zhou, Timothy M. Moore, Brian G. Drew, Vicent Ribas, Jonathan Wanagat, Mete Civelek, Mayuko Segawa, Dane M. Wolf, Frode Norheim, Marcus M. Seldin, et al.
Science Translational Medicine, Volume 12; doi:10.1126/scitranslmed.aax8096

The publisher has not yet granted permission to display this abstract.
Ioannis Zervantonakis
Science Translational Medicine, Volume 12; doi:10.1126/scitranslmed.abd4769

The publisher has not yet granted permission to display this abstract.
Jouha Min, Lip Ket Chin, Juhyun Oh, Christian Landeros, Claudio Vinegoni, Jeeyeon Lee, Soo Jung Lee, Jee Young Park, Ai-Qun Liu, Cesar M. Castro, et al.
Science Translational Medicine, Volume 12; doi:10.1126/scitranslmed.aaz9746

The publisher has not yet granted permission to display this abstract.
Emily J. Gallagher
Science Translational Medicine, Volume 12; doi:10.1126/scitranslmed.abd4765

The publisher has not yet granted permission to display this abstract.
Zhiping Liu, Jiean Xu, Qian Ma, Xiaoyu Zhang, Qiuhua Yang, Lina Wang, Yapeng Cao, Zhimin Xu, Amany Tawfik, Ye Sun, et al.
Science Translational Medicine, Volume 12; doi:10.1126/scitranslmed.aay1371

The publisher has not yet granted permission to display this abstract.
Barbara Lupo, Francesco Sassi, Marika Pinnelli, Francesco Galimi, Eugenia R. Zanella, Valentina Vurchio, Giorgia Migliardi, Paolo Armando Gagliardi, Alberto Puliafito, Daria Manganaro, et al.
Science Translational Medicine, Volume 12; doi:10.1126/scitranslmed.aax8313

The publisher has not yet granted permission to display this abstract.
Athri D. Rathnayake, Jian Zheng, Yunjeong Kim, Krishani Dinali Perera, Samantha Mackin, David K. Meyerholz, Maithri M. Kashipathy, Kevin P. Battaile, Scott Lovell, Stanley Perlman, et al.
Science Translational Medicine; doi:10.1126/scitranslmed.abc5332

Abstract:
Pathogenic coronaviruses are a major threat to global public health, as exemplified by Severe Acute Respiratory Syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV) and the newly emerged SARS-CoV-2, the causative agent of coronavirus disease 2019 (COVID-19). We describe herein the structure-guided optimization of a series of inhibitors of the coronavirus 3C-like protease (3CLpro), an enzyme essential for viral replication. The optimized compounds were effective against several human coronaviruses including MERS-CoV, SARS-CoV and SARS-CoV-2 in an enzyme assay and in cell-based assays using Huh-7 and Vero E6 cell lines. Two selected compounds showed antiviral effects against SARS-CoV-2 in cultured primary human airway epithelial cells. In a mouse model of MERS-CoV infection, administration of a lead compound one day after virus infection increased survival from 0 to 100% and reduced lung viral titers and lung histopathology. These results suggest that this series of compounds has the potential to be developed further as antiviral drugs against human coronaviruses.
Nazish Sayed, Chun Liu, Mohamed Ameen, Farhan Himmati, Joe Z. Zhang, Saereh Khanamiri, Jan-Renier Moonen, Alexa Wnorowski, Linling Cheng, June-Wha Rhee, et al.
Science Translational Medicine, Volume 12; doi:10.1126/scitranslmed.aax9276

The publisher has not yet granted permission to display this abstract.
Premal D. Lulla, Ifigeneia Tzannou, Spyridoula Vasileiou, George Carrum, Carlos A. Ramos, Rammurti Kamble, Tao Wang, Mengfen Wu, Mrinalini Bilgi, Adrian P. Gee, et al.
Science Translational Medicine, Volume 12; doi:10.1126/scitranslmed.aaz3339

The publisher has not yet granted permission to display this abstract.
Back to Top Top