Rasmussen’s Encephalitis (RE) is a devastating pediatric syndrome. Patients receive different therapies, and eventually undergo functional hemispherectomy as the only treatment to achieve complete control of epileptic seizures. New therapies are needed to improve the prognosis of this rare disease. Since cytotoxic T lymphocytes have an active role in the pathogenic process of RE, we evaluated the feasibility of Mesenchymal Stem Cells (MSCs) for patients with RE based on the known immunomodulatory potential of these cells.