Open Journal of Organ Transplant Surgery

Journal Information
ISSN / EISSN : 2163-9485 / 2163-9493
Published by: Scientific Research Publishing, Inc. (10.4236)
Total articles ≅ 47
Archived in
SHERPA/ROMEO
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Latest articles in this journal

Coulibaly Noël, Yao Evrard Kouamé, Adebayo Tawakaltu Bolasade, Toure Dramane, Hoang Anh Dung, Ackoundou-N’Guessan Clément
Open Journal of Organ Transplant Surgery, Volume 10, pp 1-6; https://doi.org/10.4236/ojots.2022.101001

Abstract:
A good vascular condition is fundamental for kidney transplantation. A bad arterial or venous supply may compromise graft survival. Discovery in operating theater of vascular anomalies not diagnosed by medical imaging may overwhelm operating protocol. Our cases emphasize the issue of pre operating evaluation. The cases are those of two women, aged 48 and 25 years, with chronic renal insufficiency, for whom living donor kidney transplantation was decided. During the process, a total obstruction of iliac vein was found and led to a change of technique. The dilated ovarian vein was used for the venous anastomosis while the arterial anastomosis was as usually made using the iliac artery. Post-surgical follow up was uneventful. These cases emphasize on the mandatory pre operative evaluation and the respect of guidelines in the process of kidney transplantation. They also open access to other operating strategies. The objective of this publication was to present our experience in dealing with an obstructed iliac vein and emphasize on the necessity to assess accurately vascular state in kidney transplantation.
Reinaldo Fernandes, Klaus Steinbruck, Danielle B. Delai, Júlia R. N. Souza, Igor Duque, Daniel Barbosa, Marcelo Enne, Renato Cano, Marcelo D'Oliveira, Luiza Maciel, et al.
Open Journal of Organ Transplant Surgery, Volume 09, pp 1-10; https://doi.org/10.4236/ojots.2019.91001

Dilushi Rowena Wijayaratne, Dinesha Himali Sudusinghe, Nalaka Gunawansa
Open Journal of Organ Transplant Surgery, Volume 08, pp 1-11; https://doi.org/10.4236/ojots.2018.81001

Abstract:
Introduction: The presence of multiple renal arteries (MRA) in the donor allograft was once a contraindication to transplantation. Despite concerns about risks, these allografts are being increasingly used to overcome a shortage of renal donors. Objectives: To compare the outcomes of live-donor renal allografts with multiple and single renal arteries (SRA) in terms of overall ischemia times, early and late graft function, and vascular and urological complications. Methods: A prospective, non-randomized cohort study was conducted including all live donor renal transplants done by the Vascular and Transplant Unit of the National Institute of Nephrology Dialysis and Transplantation, Sri Lanka between March 2010 and March 2016. 312 recipients of live donor renal allografts were recruited to the study. Patients were divided into three groups: Group 1—SRA: single anastomosis (n = 264, 85%); Group 2—MRA: single conjoined anastomosis (n = 39, 12%); and Group 3—MRA: ≥2 anastomoses (n = 9, 3%). Results: Mean ischaemia times (donor clamping to graft reperfusion) in the three groups were 14, 21 and 17 minutes respectively. Failure to normalize creatinine within 72 hours was seen in 29/264 (11%), 4/39 (10.2%) and 1/9 (11%), (P >0.05). Delayed graft function (attributable to severe rejection) occurred in only one patient who was from group 2. One-year graft survival among the groups was 243/264 (92%), 35/39 (90%) and 8/9 (89%), (P > 0.05). One patient from groups 1 and 2 developed transplant renal artery stenosis. Two patients from group 1 needed stenting for ureteric stenosis. Conclusions: Donor grafts with MRA may be accepted safely with careful surgical reconstruction and close surveillance post-transplant.
Saba Javadi, Joseph T. Brooks, Gian-Angelo Obi-Umahi, Obi Ekwenna
Open Journal of Organ Transplant Surgery, Volume 08, pp 13-20; https://doi.org/10.4236/ojots.2018.82002

Abstract:
Since the first kidney transplant was performed in 1954 immense progress has been made in the world of transplantation. Modern immunosuppressive regimens have led to increasing graft and patient survival after solid organ transplantation. Furthermore, these advances have opened the door to new fields of transplantation such as composite tissue allotransplantation. These developments have made possible numerous types of transplantation including, but not limited to face, penile, and uterine transplantation. Moreover, innovations in genetic engineering and stem cell technology have contributed to rapid developments in the fields of xenotransplantation and the engineering of functional organs from induced pluripotent stem cells. As the prevalence of chronic diseases rises, so too will the necessity for organ transplantation. Thus, the transplant innovations of the modern era need to be expanded upon so as to continue to discover new ways to address organ shortages and the complications of transplantation.
Kihwan Lim, Cheonjae Yoon, Jungsuk Lee
Open Journal of Organ Transplant Surgery, Volume 07, pp 1-11; https://doi.org/10.4236/ojots.2017.71001

Abstract:
One of the most important functions of skins is to protect our bodies from microbes or pollutant sources. Skins containing physical substances serve as a physical barrier which protects our bodies from pathogens. A healthy skin contains a variety of antibacterial substances such as defensin, cathelicidin and psoriasin. However deep and wide burns cause the skin to lose its original functions, so our skins are exposed to various danger factors. For the burn patients, human alloskin graft serves as a very important temporary biological wound dressing. It protects the wound before autograft procedure, forms revascularization and granulation tissues and protects the wound from an invasion of microbes. This study was conducted with the aim to analyze the antimicrobial effect of cryopreserved allograft (CPA) and glycerol-preserved allograft (GPA) which was a type of allograft widely used for burn patients, and measure the difference in comparison with the fresh skin before processing it. The most common contaminants found in burn patients such as S. aureus, P. aeruginosa, C. albicans and E. coli, were used for experiment. The antimicrobial effect against S. aureus and E. coli was observed in fresh skin and some CPA. In some clinical cases, infection is frequently observed in the wounds treated with allograft, indicating the allograft completely block every kind of microbes. To prevent the infection, it is required to use antibiotics and manage wounds thoroughly.
, Masato Minami, , , Tomohiro Kawamura,
Open Journal of Organ Transplant Surgery, Volume 06, pp 1-5; https://doi.org/10.4236/ojots.2016.61001

Abstract:
Phrenic nerve injury can occur as a complication of lung transplantation. A 54-year-old man underwent single-lung transplantation due to interstitial pneumonia. The patient required circulatory support with venoarterial extracorporeal membrane oxygenation and was unable to be weaned from ventilatory support with nitric oxide. Although enhanced CT scanning showed stenotic anastomosis of the right pulmonary artery (PA), pulmonary angiograph findings revealed that PA flow was normal under sedation and considerably decreased with spontaneous breathing. Fluoroscopy showed that the right diaphragm moved inversely to the position of the left diaphragm, indicating that the right phrenic nerve was paralytic. We performed diaphragmatic plication 7 days after lung transplantation and weaning from ventilator support was accomplished soon thereafter. Phrenic nerve dysfunction is an important clinical problem following lung transplantation. In the present case, diaphragmatic plication was effective for treatment of circulatory failure due to phrenic nerve paralysis even in acute phase after lung transplantation.
Joseph R. Whiteley, Jason M. Taylor, John J. Freely Jr., Thomas I. Epperson, Laura Bell, John L. Murray Iv, Charles F. Bratton,
Open Journal of Organ Transplant Surgery, Volume 06, pp 13-21; https://doi.org/10.4236/ojots.2016.63003

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