ISSN / EISSN : 2039-4748 / 2039-4756
Published by: PAGEPress Publications (10.4081)
Total articles ≅ 18
Latest articles in this journal
Eye Reports, Volume 2; https://doi.org/10.4081/eye.2012.e2
We report a case of late onset keratectasia after laser in situ keratomileusis (LASIK) and its quick reversal and stabilization after use of latanoprost and riboflavin/ultraviolet-A corneal collagen cross-linking (CXL). A 39-year-old man with normal intraocular pressure developed a rapid deterioration of vision in his left eye 6 years after LASIK-retreatment for high myopic astigmatism. Keratectasia was diagnosed by corneal topography and ultrasound pachymetry. After two months of treatment with latanoprost and a minor intraocular pressure reduction, uncorrected distance visual acuity improved from 20/100 to 20/20 and corneal topography showed reversal of keratectasia. CXL was performed after the reversal to achieve long-term stabilization. At 1, 3, 6, 13 and 39 months followup exams after the CXL, stable vision, refraction, and topography were registered. This case shows that keratectasia may rapidly occur several years after LASIK and that a quick reversal and stabilization may be achieved by use of latanoprost followed by CXL.
Eye Reports, Volume 2; https://doi.org/10.4081/eye.2012.e1
We report three cases of proptosis, in children aged 6, 10 and 12, whereby in all cases the first clinical, radiologic and ultrasonographic diagnosis was lymphangioma, while the final anatomopathological diagnosis was rhabdomyosarcoma. In presence of a rapidly worsening exophthalmos or eyelid swelling in a child, an early correct diagnosis is very important. Imaging techniques play a very important role in the diagnosis, but are often inconclusive and an excisional biopsy (if feasible) must always be considered
Eye Reports, Volume 2; https://doi.org/10.4081/eye.2012.e3
Neuroendocrine tumors most frequently involve the gastrointestinal tract and bronchopulmonary system. Few cases of presumed primary neuroendocrine tumors in the orbit have been reported so far and most of the orbital cases are actually metastatic. We describe the unusual occurrence of this tumor in the orbit of a 16-year-old boy. The lesion was initially thought to be primary; however, the diagnosis of a metastatic orbital lesion was later supported by the histopathological appearance of his orbital biopsy, characteristic immunohistochemical profile and the presence of a primary mediastinal tumor. The patient did not have any symptoms suggestive of a carcinoid syndrome during the course of his disease. Unfortunately, tests showed lymph node involvement and distant metastatic lesions and he died from these a few months later while on palliative therapy.
Eye Reports, Volume 2; https://doi.org/10.4081/eye.2012.e4
We report a case of a metastatic cutaneous melanoma to the orbit. A 60-year-old Caucasian male presented with a 2-day history of left-sided ocular pain, lid swelling and chemosis. Initially, this was treated as conjunctivitis with no signs of improvement. Four days later, the patient developed left proptosis, mechanical ptosis, left esotropia and diplopia. Computed tomography scan of the orbit demonstrated marked thickening of the lateral rectus muscle. The patient was treated as pseudotumor. Subsequent biopsy revealed malignant cutaneous melanoma. The patient had a history of cutaneous melanoma excised 15 years previously. Further imaging showed advanced metastatic disease in the brain, the lung and the liver. The patient passed away five months after initial presentation. Cutaneous melanoma metastasizing to the orbit has poor prognosis. Patients often have advanced disease at the time of presentation and orbital metastases may be the initial sign. A detailed history is paramount in making timely diagnosis.
Eye Reports, Volume 1; https://doi.org/10.4081/eye.2011.e1
Pterygia are fibrovascular connective tissue overgrowths of bulbar conjunctiva onto the cornea. There is a worldwide distribution of pterygium, but it occurs more commonly in warm, dry climates. Patients younger than the age of 15 rarely acquire a pterygium. We report a case of bilateral nasal pterygium in two siblings. A 10-year-old boy and a 12-year-old girl who are siblings presented with bilateral nasal pterygium. While pterygium is a common disorder, its bilaterality in young people is not a common condition. This report is the first known report in the peer-reviewed medical literature of patients with bilateral nasal pterygium in siblings younger than the age of 15
Eye Reports, Volume 1; https://doi.org/10.4081/eye.2011.e3
Rhegmatogenous retinal detachments associated with proliferative vitreoretinopathy, giant retinal tears, ocular trauma, proliferative diabetic retinopathy, or necrotizing retinitis are considered more complex than those without these factors. The aim of the current review is to address the surgical outcomes and complications of 23-gauge pars plana vitrectomy with scleral buckling (23GPPV/SB) for repair of these complex retinal detachments. This retrospective study involved 54 eyes of 53 patients who underwent 23GPPV/SB between July 2007 and September 2009. Preoperative diagnosis, surgical technique, preoperative and postoperative visual acuities, intraoperative and postoperative complications, and anatomic reattachment rates were examined. Fifty-four eyes of 53 patients were reviewed in this study and indications for surgery varied. Mean logarithm of the minimal angle of resolution (logMAR) pre- and post-operative visual acuities were 1.166 (20/293) and 0.780 (20/120), respectively, which led to a statistically significant improvement in logMAR (P=0.0165). Single operation and final reattachment rates were 87% (47 of 54 eyes) and 100%, respectively. Postoperative complications included choroidal effusion/hemorrhage (14.8%, 8 of 54 eyes) and vitreous hemorrhage (11.1%, 6 of 54 eyes). Other more infrequent complications included hyphema (9.3%, 5 of 54 eyes), hypotony (5.6%, 3 of 54 eyes) and ocular hypertension > 35 mmHg (3.7%, 2 of 54 eyes). A total of 31.5% (17 of 54 eyes) of patients had a complication in the postoperative time period, but 58.8% of these resolved spontaneously without requiring an intervention. 23GPPV/SB may be considered for complex retinal detachment repair with good anatomic reattachment rates, but with relatively high complication rates
Eye Reports, Volume 1; https://doi.org/10.4081/eye.2011.e6
The aim of the report is to assess the risk factors among patients with spontaneous ipsilateral subconjunctival hemorrhage (SCH) who presented to the outpatients’ department in General Hospital of Veria, Veria, Greece. Thirty-five patients with SCH participated in the study. A thorough case history was taken and a full ophthalmic examination was performed to identify the risk factors related to the clinical finding. The common hematological parameters associated with the coagulation profile of each patient were evaluated. With the exception of SCH, the ophthalmic examination was normal in all patients. Identified risk factors include history of systemic hypertension (21 patients [60%], mean systolic value: 170 mmHg±15 mmHg), strenuous exercise [19 patients (54%)] and minor ocular trauma [5 patients (14%)]. Other risk factors [each in 2 patients (6%)] included: diabetes mellitus, smoking, severe cough, straining at stool, and weight lifting. Seven patients (20%) were under medication related to bleeding diathesis. The values of the blood coagulation parameters were within the normal limits in all patients. Twenty-nine patients (83%) had elevated blood pressure during the ophthalmological examination. Our study provides documentation regarding the potential risk factors associated with SCH. It is interesting to observe the high incidence of hypertension among the patients with SCH. Therefore, it is highly recommended that the blood pressure be checked in all patients with SCH and that the patients be referred to a general practitioner for further management if indicated.
Eye Reports, Volume 1; https://doi.org/10.4081/eye.2011.e4
We report a case of the WAGR syndrome associated with the Peter anomaly. A 6-day-old baby boy was found to have bilateral corneal opacities, 360 degrees of iris hypoplasia and cataracts. Physical examination revealed bilateral undescended testicles. Family history was unremarkable and genetic testing revealed a deletion 11p11.2-13 indicating WAGR syndrome. A Wilms tumor developed and was removed at age 2 years. There was moderate developmental delay. The occurrence of WAGR syndrome with Peter anomaly has been reported in three other patients to our knowledge
Eye Reports, Volume 1; https://doi.org/10.4081/eye.2011.e5
The aim of the article is to estimate the intravitreal half-lives of ranibizumab and aflibercept (VEGF Trap-eye; VTE) in human eyes. Using a published mathematical model for rabbits, the intravitreal half-lives of ranibizumab and bevacizumab were calculated and compared to empirical data. The slope coefficient within the model was changed to set the bevacizumab output equal to experimental values to meet 3 goals: firstly, to validate the model in rabbit eyes; secondly, to test the mutability of the model to monkey eyes; thirdly, to calculate the half-lives of ranibizumab and the VTE in human eyes. The half-life calculations for ranibizumab deviate from published rabbit and monkey values by only 8.3% and 4.2%. Using the experimentally determined half-life of bevacizumab in human eyes (8.25 days) to set the equation, the half-lives of ranibizumab and the VTE are calculated to be 4.75 days and 7.13 days in human eyes. The intraocular half-lives of ranibizumab and the VTE are estimated using existing published animal and human data and a mathematical model. The validity of these half-lives and binding activities, however, awaits clinical correlation
Eye Reports, Volume 1; https://doi.org/10.4081/eye.2011.e14
Helicobacter pylori have been detected in sinonasal mucosa in both normal and pathologic condition. The nasolacrimal duct is within the medial wall of maxillary sinus and open into the nasal cavity, so ascending colonization of nasolacrimal duct and lacrimal sac is possible. The aim of this study is to investigate the presence of H. pylori by polymerase chain (PCR) reaction in the nasal and lacrimal sac mucosa of the patients with primary acquired nasolacrimal duct obstruction. Eighty patients with primary acquired nasolacrimal duct obstruction who were scheduled for dacryocystorhinostomy enrolled in the study. The patients were asked if they suffered from the classic symptoms of gastroesophageal reflux disease (heart burn, regurgitation, and acid taste). Tissue samples from the lacrimal sac mucosa and nasal mucosa were obtained during dacryocystorhinostomy surgery. The tissues were analyzed for detection of H. pylori DNA by PCR. The mean age of patients was 41.96±14.7 years (age range, 17-84 Years). PCR for H. pylori DNA was positive in the nasal mucosa in 3 patients, in the lacrimal sac mucosa in 2 patients and in both nasal mucosa and lacrimal sac mucosa in 1 patient. Classic symptoms of gastroesophageal reflux disease were found in 16 patients (20%). It is possible to detect H. pylori in the lacrimal sac mucosa of some patients with primary acquired nasolacrimal duct obstruction. More comprehensive studies are needed to determine whether H. pylori plays an etiopathologic role in the development of primary acquired nasolacrimal duct obstruction