International Journal of Research in Dermatology

Journal Information
ISSN / EISSN : 2455-4529 / 2455-4529
Published by: Medip Academy (10.18203)
Total articles ≅ 870
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Leila Yusuf Hussein Dinle, Ya Qin Zhang
International Journal of Research in Dermatology; https://doi.org/10.18203/issn.2455-4529.intjresdermatol20221814

Abstract:
Ultraviolet (UV) radiation is emitted by the Sun as well as man-made sources such as tanning beds and welding torches. The process of energy being emitted from any source is known as radiation which can take many different forms, from extremely high-energy radiation like X-rays and gamma rays to extremely low-energy radiation like radio waves. UV photons are in the middle of the electromagnetic spectrum. They have higher energy than visible light but a lower energy than X-rays. It is divided into numerous groups based on the amount of energy they contain. Higher-energy UV photons are included in ionizing radiation, which means they have enough energy to ionize an atom or molecule. Ionizing radiation can cause cancer by damaging a cell's DNA; however, it doesn’t have enough energy to penetrate deep into the body, thus it mainly effects the skin only. UV radiations are considered the most carcinogenic factors which leads to skin cancer. Over $50 million each year is estimated to treat the melanoma skin cancer, but the incidences kept rising each year. The tanning and pigmentation in the skin are the main factors to develop skin cancer that rise concerns about ozone depletion. Continuing research should contribute to an improved knowledge of the genetic and immune suppressive mechanisms involved in the role of the tumor suppressor. Research into skin cancer may help raise consciousness about the harmful effects of UV which leads to improved methods of prevention and treatment of skin cancer.
M. Akram Ahasan, Masuma Amanullah, M. Mozibur Rahman, M. Mosharraf Hossain, M. Saiful Akram
International Journal of Research in Dermatology; https://doi.org/10.18203/issn.2455-4529.intjresdermatol20222065

Abstract:
Background: Psoriasis is a prevalent chronic inflammatory skin disease with several clinical symptoms. Psoriasis has clinical forms that resemble a variety of dermatological disorders and may necessitate histological confirmation of the diagnosis. The aim of the study was to assess the proportion of psoriasis among patients with psoriasiform disorders. Methods: This cross-sectional observational study was carried out at the department of dermatology and venereology, Shahid Syed Nazrul Islam Medical College, Kishoreganj during the period from January 2021 to December 2021 on 200 patients with psoriasiform disorders was enrolled in this study. Detailed history along with relevant family history and drug history was obtained. All the patients underwent skin biopsy followed by a histopathological examination to reveal the actual pathology of dermal lesions. Statistical analyses of the results were obtained by using window-based computer software devised with statistical packages for social sciences (SPSS-25).Results: The proportion of psoriasis among the patients with psoriasiform disorders was found at 53.5%. The majority of patients (72.0%) had extensor surfaces and a well-demarcated border was found in 166 (83.0%) patients. Subungual hyperkeratosis was found in 30 (28.0%) and 16 (17.3%) in psoriasis and non-psoriasis groups respectively. Regular epidermal hyperplasia was 2 (1.9%) in psoriasis but not found in non-psoriasis. Spongiosis was 45 (42.1%) in psoriasis and 30 (32.3%) in non-psoriasis. The vertical orientation of the collagen bundle was 2 (1.9%) and 2 (2.2%) in psoriasis and non-psoriasis respectively. Perivascular lymphocyte infiltration was 75 (70.1%) in psoriasis and 63 (67.7%) in non-psoriasis. The difference was not statistically significant (p>0.05) between the two groups. Conclusions: All clinical features were significantly associated with psoriasis in patients who presented with psoriasiform disorders except subungual hyperkeratosis. In histopathology, all features were significantly associated with psoriasis excluding regular epidermal hyperplasia, spongiosis, vertical orientation of collagen bundle, and perivascular lymphocyte infiltration.
Indur Ramchandani, Namrata Mahadkar, Dhiraj S. Dhoot, Hanmant Barkate
International Journal of Research in Dermatology; https://doi.org/10.18203/issn.2455-4529.intjresdermatol20222074

Abstract:
Background: Bacterial skin infections caused by gram positive bacteria are mostly encountered in paediatric age group. These infections are found to commonly complicate atopic dermatitis with prevalence of 80-100%, and are treated with fixed dose combination (FDC) of topical corticosteroids and antibiotics. Methods: This retrospective study was conducted in patients ≥2 years of age with a diagnosis of atopic dermatitis with secondary bacterial infections and having investigator’s global assessment score of 2 or 3. Patient’s clinical outcomes were analysed on the basis of skin infection rating scale (SIRS) wherein each of signs/symptom were rated on scale of 0 to 3. Results: The 206 patients had received FDC of mometasone and fusidic acid (MF) and 159 patients had received fluticasone and mupirocin (FM). Percentage of patients achieving complete clearance of symptoms/signs was higher in MF group as compared to FM. Percentage of patients achieving clinical success were significantly higher with mometasone. Recurrences and percentage of patients with clinical failure were higher in FP group. Conclusions: Effectiveness of MF FDC was significant as compared to FM, FDC in terms of complete clearance of lesions, increased number of patients achieving clinical success and less number of recurrences.  
Vaishnavi R. Batchu, Vijaya L. Panthalla, P. V. Kiran Kumar, K. Penchalaiah
International Journal of Research in Dermatology; https://doi.org/10.18203/issn.2455-4529.intjresdermatol20222066

Abstract:
Background: Diagnosis of skin disorders that exhibit interface dermatitis is challenging in few scenarios. Despite sincere efforts, clinical examination per se can help us reach a handsome of differential diagnosis but not a gunshot specific diagnosis. Dermatopathology acts as a saviour to clinicians in such cases. Though histopathology is the gold standard, still one cannot make a “specific” diagnosis by histopathology alone because many have overlapping features. Therefore, the present study aims at the importance of clinicopathological correlation. The objectives were to study the clinical and histopathological features of various dermatoses, which exhibit interface dermatitis histopathologically and estimate clinicopathological concordance. Methods: This was a cross-sectional study done on 50 patients attending outpatient department (OPD), with the lesions suggestive of dermatoses known to exhibit interface dermatitis histologically. Strobe guidelines were followed. After a thorough clinical examination, punch biopsies were done and observed microscopically to detect interface dermatitis, if present. Secondary pathological features were studied to assess clinicopathological concordance. Microsoft excel and statistical package for the social sciences (SPSS) 21.0 were used for data analysis.Results: 76.74% cases were cases of lichen planus and its variants. The most common clinical presentation was papules. Among microscopic features, predominant finding was basal cell vacuolar change in epidermis (97.70% cases). Clinicopathological concordance was seen in 43 cases (83%). 7 cases were diagnosed solely based on histological correlation. Conclusions: A myriad of dermatoses exhibit interface dermatitis as a primary pathological feature. Only an apt correlation of clinical features with secondary pathological features can lead to a specific diagnosis from a bunch of differential diagnoses.
Harshini Aishwarya R., Sheba M. Jacob, R. G. Sharada
International Journal of Research in Dermatology; https://doi.org/10.18203/issn.2455-4529.intjresdermatol20222048

Abstract:
Background: Dermatophytosis (tinea) refers to the superficial mycosis of keratinized tissues like hair, skin or nail caused by dermatophytes. It is a problem of significant importance because of the increasing trend in the number of cases that are unresponsive to treatment and presenting with recurrence. Methods: 148 patients with dermatophytosis attending the outpatient department of dermatology were enrolled based on inclusion and exclusion criteria during the 3-month time period between April 2021 and June 2021.Results: Out of the 148 cases, 93 (62.83%) were males and 55 (37.16%) were females. Highest number of cases were seen in the age group 21–30 with 61 (41.21%) cases. Among the 148 cases, 139 (93.91%) cases presented with dermatophytosis at a single site while 9 (6.09%) cases had multiple sites of dermatophytosis. Out of the 139 cases who had dermatophytosis at a single site, 77 cases (55.39%) were found to have corporis pattern. Conclusions: The most common pattern of dermatophytosis found was the annular pattern and young males were the most commonly affected population.
Jose Luis Martinez Arismendi, Jose Maria Zepeda Torres, Felix Osuna Gutierrez, Laura Fischert Melendez, Grecia Jazmín Gutiérrez García, Paola Lizette Padilla
International Journal of Research in Dermatology; https://doi.org/10.18203/issn.2455-4529.intjresdermatol20222049

Abstract:
Since the onset of the SARS-Cov2 pandemic, new data and peculiarities have emerged within the range of manifestations caused by this virus. Multisystem inflammatory syndrome in children (MIS-C) affects a small percentage of pediatric patients infected with SARS CoV 2 and characterized by fever, lab evidence of inflammation, multisystem involvement, and severe illness requiring hospitalization. Cutaneous findings are often present in these patients and are notable for their heterogeneity and poor characterization. We present case of pediatric patient with COVID-19 and cutaneous manifestations consistent with a multisystem inflammatory syndrome.
Prayogi Miura Susanto
International Journal of Research in Dermatology; https://doi.org/10.18203/issn.2455-4529.intjresdermatol20221822

Abstract:
Juvenile dermatomyositis (JDM) is a rare autoimmune disease that affects mostly children's muscles and skin. The small number of patients with JDM, heterogeneous disease phenotype, and few clinical trials for JDM pose challenges for clinicians in developing standard treatment protocols. Although there has been some consensus, the obstacles to JDM therapy, especially in refractory cases, have not been resolved. Dapsone is one of the anti-inflammatory agents that can provide significant clinical improvement in patients with dermatomyositis. This aim of the study was to discuss various previous studies to determine the potential use of dapsone in cases of refractory JDM.
Diego M. Contreras, Grecia J. G. Gutiérrez, José M. Z. Torres, Félix O. Gutiérrez
International Journal of Research in Dermatology; https://doi.org/10.18203/issn.2455-4529.intjresdermatol20221832

Abstract:
Langerhans cell histiocytosis is a condition of exceptional onset characterized by a proliferative event of dendritic cells with mono or multisystem involvement that predominates in the pediatric population and is identified in a smaller proportion in adults. It has a clinical impact and variable prognosis according to its location and number of organs affected. A 68-year-old male patient with clinical and immunohistochemical criteria for Langerhans cell histiocytosis with multisystem settlement with fatal outcome. It is a very rare disease, it is not exclusive to the pediatric population, with little understood pathogenesis and does not have specific treatment. In adults, the clinical impact is more aggressive, with a poorer prognosis and greater short-term complications.
Pradnya S. Mahajan, Venkata S. Nanduri
International Journal of Research in Dermatology, Volume 8, pp 403-410; https://doi.org/10.18203/issn.2455-4529.intjresdermatol20221638

Abstract:
Vitiligo is a skin condition with patches of white color occurring on any area of the human body and several treatment approaches are recommended in main stream medicine as well as alternative modes of treatments. Patients suffer psychosocial stress due to social rejection and consequent loss of self-esteem and self-confidence. This paper presented an in-depth case study of a 29-year-old female vitiligo patient, who used and practiced Yoga Prana Vidya (YPV) protocols for self-healing. Case series method is used examining full case papers and narration of major events by the patient on what worked well for her using YPV system intervention. The patient persistently healed herself with 2 to 4 sessions a day and within a time span of 1½ months her all the vitiligo patches had healed almost by 50%. After a year of continuing the YPV intervention, the recovery was sustained and further recovery of 30% was seen as she continued with her practices of YPV techniques. As a result, she regained self-esteem and self-confidence overcoming the accumulated psychosocial stress. During this period, she was not taking any medications, but only doing self-healing using YPV protocols. The overall improvement over a period of one year and three months was nearly 80% and a complete life changing experience with self-acceptance after a prolonged traumatic phase in life. YPV system is proving to be a versatile approach to resolving a variety of health issues, as is evident from the published literature.
M. Morshedur Rahman, M. Kamruzzaman, Manashi Baidya, M. Rezwan Kaiser, M. Mahmudul Hasan, Mohammad Faisal Hasan Bhuiyan, Mehdi Pervez, Biplab Kumar Das
International Journal of Research in Dermatology, Volume 8, pp 375-380; https://doi.org/10.18203/issn.2455-4529.intjresdermatol20221634

Abstract:
Background: Sexually transmitted diseases (STDs) affect men and women of all backgrounds and economic levels. CDC estimates that 19 million new infections occur each year, almost half of them among young people ages 15 to 24. Common STDs are acquired immune deficiency syndrome (AIDS), chancroid, genital HPV infection, gonorrhea, syphilis, trichomoniasis and viral hepatitis. The aim was to see the pattern of STDs in the skin and VD outpatient department (OPD), Sher-E-Bangla Medical College Hospital, Barishal, Bangladesh. Methods: The prospective observational study was conducted among 100 patients with STDs both male and female patients in the OPD of dermatology department of Sher-E-Bangla Medical College Hospital during the period from July 2015 to December 2015 irrespective of sex and age >15 years to assess the prevalence of sexually transmitted diseases. Results: In this study, prevalence of STDs such as gonorrhea, syphilis, non-gonococcal urethritis, chancroid, genital herpes and genital warts were observed. Gonorrhea was 28%, 13% were syphilis, non-gonococcal urethritis (NGU) was 43% and chancroid, genital herpes, genital warts were 5%, 7% and 4% respectively. Conclusions: STDs are becoming a major public health problem in our county. So, STDs have to be wiped in the bud by early diagnosis, efficient treatment and appropriate preventive and control measures.
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