The Laryngoscope
Journal Information
ISSN / EISSN :
0023852X / 15314995
Current Publisher: Wiley (10.1002)
Former Publisher:
Ovid Technologies (Wolters Kluwer Health) (10.1212)
, Ovid Technologies (Wolters Kluwer Health) (10.1288)
, Ovid Technologies (Wolters Kluwer Health) (10.1097)
Total articles ≅ 33,757
Google Scholar h5-index: 53
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The Laryngoscope; doi:10.1002/lary.28545
Laryngoscope Investigative Otolaryngology; doi:10.1002/lio2.366
Abstract:Historically considered a disease of the older male resulting from cumulative tobacco and alcohol use, more recently we have witnessed a rise in the global incidence of oral tongue squamous cell carcinoma in younger adults, particularly those without any identifiable risk factor exposure. These patients appear to be at higher overall risk for locoregional treatment failure and often experience a more heterogeneous clinical course, with some afflicted with particularly aggressive, rapidly progressive disease. Recent research efforts have supported the idea that although this disease may be genomically similar in these groups, and molecular differences in the tumor immune microenvironment may account for biological differences between young and older patients, as well as patients with and without exposure to alcohol or tobacco. In this review, we seek to summarize current knowledge regarding pathogenesis of oral tongue carcinoma in the young adult patient and examine the potential role of the immune response in disease progression and as a target for novel immunotherapies.
The Laryngoscope; doi:10.1002/lary.28576
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The Laryngoscope; doi:10.1002/lary.28587
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The Laryngoscope; doi:10.1002/lary.28546
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The Laryngoscope; doi:10.1002/lary.28578
The Laryngoscope; doi:10.1002/lary.28513
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The Laryngoscope; doi:10.1002/lary.28555
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The Laryngoscope; doi:10.1002/lary.28572
The Laryngoscope, Volume 130; doi:10.1002/lary.28582