Science Signaling

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ISSN / EISSN : 19450877 / 19379145
Total articles ≅ 12,167
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Wei Wong
Science Signaling, Volume 12; doi:10.1126/scisignal.aba2257

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Ryota Sada, Hirokazu Kimura, Yuko Fukata, Masaki Fukata, Hideki Yamamoto, Akira Kikuchi
Science Signaling, Volume 12; doi:10.1126/scisignal.aat9519

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Sumbul Afroz, Shama, Srikanth Battu, Shaikh Matin, Sabrina Solouki, Jessica P. Elmore, Gillipsie Minhas, Weishan Huang, Avery August, Nooruddin Khan
Science Signaling, Volume 12; doi:10.1126/scisignal.aav4717

Abstract:Specific reduction in the intake of proteins or amino acids (AAs) offers enormous health benefits, including increased life span, protection against age-associated disorders, and improved metabolic fitness and immunity. Cells respond to conditions of AA starvation by activating the amino acid starvation response (AAR). Here, we showed that mimicking AAR with halofuginone (HF) enhanced the magnitude and affinity of neutralizing, antigen-specific antibody responses in mice immunized with dengue virus envelope domain III protein (DENVrEDIII), a potent vaccine candidate against DENV. HF enhanced the formation of germinal centers (GCs) and increased the production of the cytokine IL-10 in the secondary lymphoid organs of vaccinated mice. Furthermore, HF promoted the transcription of genes associated with memory B cell formation and maintenance and maturation of GCs in the draining lymph nodes of vaccinated mice. The increased abundance of IL-10 in HF-preconditioned mice correlated with enhanced GC responses and may promote the establishment of long-lived plasma cells that secrete antigen-specific, high-affinity antibodies. Thus, these data suggest that mimetics of AA starvation could provide an alternative strategy to augment the efficacy of vaccines against dengue and other infectious diseases.
John F. Foley
Science Signaling, Volume 12; doi:10.1126/scisignal.aba1532

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Lisa M. Grove, Maradumane L. Mohan, Susamma Abraham, Rachel G. Scheraga, Brian D. Southern, James F. Crish, Sathyamangla V. Naga Prasad, Mitchell A. Olman
Science Signaling, Volume 12; doi:10.1126/scisignal.aau1533

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Masato Morikawa, Yoshihide Mitani, Katarina Holmborn, Taichi Kato, Daizo Koinuma, Junko Maruyama, Eleftheria Vasilaki, Hirofumi Sawada, Mai Kobayashi, Takayuki Ozawa, et al.
Science Signaling, Volume 12; doi:10.1126/scisignal.aay4430

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Natsumi Maruta, Yuri Trusov, David Chakravorty, Daisuke Urano, Sarah M. Assmann, Jose R. Botella
Science Signaling, Volume 12; doi:10.1126/scisignal.aav9526

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Erin R. Williams
Science Signaling, Volume 12; doi:10.1126/scisignal.aba0502

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Trent D. Evans, Xiangyu Zhang, Se-Jin Jeong, Anyuan He, Eric Song, Somashubhra Bhattacharya, Karyn B. Holloway, Irfan J. Lodhi, Babak Razani
Science Signaling, Volume 12; doi:10.1126/scisignal.aau2281

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