Clinical Studies and Medical Case Reports

Journal Information
EISSN : 2378-8801
Published by: Herald Scholarly Open Access (10.24966)
Total articles ≅ 96

Latest articles in this journal

Igor Smirnov, Global Quantech Sia
Clinical Studies and Medical Case Reports, Volume 7, pp 1-9;

We found the significant protective properties of MRET water confirmed by substantial decrease of Staphylococcus aureus CFU (colony forming units) in homogenate of kidneys of mice on MRET water compared to control group of mice on regular water following the intra-peritoneal staphylococcal infection. Another study relates to a detailed observation of the effect of MRET activated water with the modified molecular structure, physical and electrodynamic characteristics on metabolic activity and growth of conditionally pathogenic microbiological culture Escherichia coli K-12 (E.coli) and on metabolic activity of microbial associations (similar to microbial associations in the intestine). Activated (MRET) water produced significant changes of E.coli morphology: different shape, color and size of cells, disturbance of process of cellular division. We also observed positive results of MRET water complimentary treatment for HIV patients during the clinical trial. There are recent research data which allows pointing to a similar mode of action for the two viral proteins, suggesting that anti-viral strategy that targets the viral-induced membrane fusion step can be adapted from HIV-1 to SARS-CoV. The stability of virus spike protein structure is based on the overall interactions of van der Walls weak electrodynamic forces and hydrogen bonding. It is obvious, that all biochemical formations of proteins require presence of water molecules in biological systems. The overall observed research data suggest that modification of water - based medium electrodynamic parameters of the human tissues (that are favourable for the homeostasis of the body in the range of physiological “window”) can lead to significant change of van der Walls interactions and hydrogen bonding that result in the inhibition and interruption of virus spike proteins formation. Such scenario obviously disables virus life sequence of attachment and fusion with human cell membranes. The same type of mechanism can be adopted for the inhibition of other lines of pathogenic microorganisms. The studies conducted at AltheaDx Technology, USA confirm that MRET activated water based medium did not affect the morphology of normal PBMC cells on genetic level; it affected the morphology of normal PBMC cells in a positive way increasing their viability. MRET Activated Water is produced with the help of patented in the USA Molecular Resonance Effect Technology (MRET, US Patent # 6022479). We suggest that MRET water consumption by human subjects can lead to physiologically favorable modification of dielectric permittivity and hydrogen bonding of water –based medium in the human body tissues. It can provide the initial human body natural defence against intervention and spread of pathogenic microorganisms
, Barzilai University Medical Center
Clinical Studies and Medical Case Reports, Volume 7, pp 1-6;

Background: Imaging techniques used in the last decades, and reported changes in various disease prevalence, may have dramatically influenced causes of Fever of Unknown Origin (FUO) Objectives: Our study’s objectives were to identify changes in prevalence and etiologies of FUO, since our previous study two decades ago, to clarify the most beneficial diagnostic strategies, and to investigate the long-term outcomes of undiagnosed and diagnosed patients Methods: Medical files with “fever” as a cause for admission and at least one-week hospitalization were evaluated. Patients were screened based on Petersdorf’s classic criteria. An interview was performed three months to twelve years after hospitalization Results: 3691 patients fit our primary selection criteria in 2004-2016; 141 patients fit Petersdorf’s criteria for FUO. The most common cause of FUO was infectious disease (39%), mainly bacterial (29%), though decreased from our previous study (39% vs 55%). There were dramatic increases in the incidence of malignancy (19% vs 7.9%) and inflammatory (20% vs 2%) etiologies and less undiagnosed cases (22% vs 32.7%). Weakness and weight loss were the most common co-complaints (80% all coexisted). Elevated ESR (97%), elevated CRP (95%) and anemia (80%), were the most common pathologic laboratory examinations found. Abdominal CT, blood cultures and serology proved to be the most valuable diagnostic tests. Long-term follow up interviews revealed that a final diagnosis was often reached during the patients’ next admission (20% out of 70%). 2% of patients died during the feverish episode and 34% died three months to twelve years after the episode Conclusions: Infections (mainly bacterial) remain the most common cause for FUO in southern Israel in the 21th century; although there is a remarkable increase in the rate of vasculitis and malignancy. When PET is not available, a thorough clinical examination including appropriate laboratory and imagine examination, as well as precise history taking are essential. Blood cultures and abdominal CT are the most useful diagnostic tests. Most undiagnosed cases resolved within days of discharge or are diagnosed in a following admission
Journal of Clinical Studies and Medical Case Reports, Volume 8, pp 1-5;

Introduction: The aetiology of conversion disorder is unknown, though association with emotional stress and with organic brain disorder has been described. Paraplegia as a conversion reaction has been reported infrequently. Combination of motor and sensory disturbance, other than paraplegia, may occur as a manifestation of a conversion reaction, and may suggest Spinal Cord Injury (SCI). Case Report: A 35-year-old Italian woman who had a history of post traumatic SCI which affected her lower limb when she was 29 years old. Patient was unable to empty his bladder completely.The aim of this paper is to describe the correlation between diagnosis of conversion disease and SCI. Clinical Rehabilitation Impact: Chronic conversion disorder can be resistant to rehabilitation treatment. Neurophysiological diagnostic procedures adopted in our study discern the degree of central and peripheral nervous system damage and confirmed the integrity of spinal cord in conversion disorder. Conclusion: Our case report describes the association between conversion disease, SCI, and neurophysiological tests and suggests to apply the neurophysiological tests to validate conversion disorder diagnosis in SCI.
Journal of Clinical Studies and Medical Case Reports, Volume 8, pp 1-3;

A headache is defined as a pain in any area of the head. This pain can be described as a dull or sharp sensation and maybe throbbing or soft, depending on the severity of the headache. Headaches can be unilateral or bilateral, focal or multifocal, or even radiating in a focal point. They can develop gradually or happen abruptly and may last from a few minutes to weeks. Some causes of headache can range from stress and physical or physiological trauma to changes in the weather or environment.
, Aga Khan University And Hospital
Journal of Clinical Studies and Medical Case Reports, Volume 8, pp 1-4;

Hashimoto’s encephalopathy is non-vasculitic autoimmune steroid responsive encephalopathy. It is an uncommon syndrome characterized by altered level of consciousness, confusion, seizures and myoclonus. Exact pathogenesis is yet to be determined though humoral hyper-immune response is favored mechanism rather than dysthyroidism. We present a case of Hashimoto’s encephalopathy in an eighty years old lady who presented with unexplained drowsiness. Extensive workup for the cause of drowsiness was carried outto find structural, metabolic, autoimmune or para-neoplastic etiology only to reveal high titers of anti-TPO antibodies. Patient responded remarkably to high dose steroids.
Robert Skopec, Dubnik Researcher-Analyst
Journal of Clinical Studies and Medical Case Reports, Volume 7, pp 1-7;

Dr. Francis Boyle, who drafted the Biological Weapons Act has given a detailed statement admitting that the 2019 Wuhan Coronavirus is an offensive Biological Warfare Weapon and that the World Health Organization (WHO) already knows about it. Francis Boyle is a professor of international law at the University of Illinois College of Law. He drafted the U.S. domestic implementing legislation for the Biological Weapons Convention, known as the Biological Weapons Anti-Terrorism Act of 1989, that was approved unanimously by both Houses of the U.S. Congress and signed into law by President George H.W. Bush.
, Jinnah Medical College Hospital
Journal of Clinical Studies and Medical Case Reports, Volume 7, pp 1-4;

Reactive arthritis is commonly preceded by a gastrointestinal or a sexually transmitted infection. However, its association with different viral infections has also been reported. Herein, we report a case of a 34 year old male who developed Reactive arthritis few days after the severe acute respiratory Syndrome Corona Virus 2 infection (SARS-CoV-2). The patient was positive for COVID-19 infection from nasopharyngeal swab specimen. He was advised self-isolation/quarantine, considering his mild form of disease, along with medication. Ten days later he developed severe pain and tenderness in his right knee joint. His MRI of the affected joint revealed mild effusion (secondary to inflammation) in the patella-femoral compartment. Patient was diagnosed with Reactive arthritis and was prescribed Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). Intra articular glucocorticoid was injected, to which he responded dramatically. His symptoms completely resolved in next ten days.
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