Circulation

Journal Information
ISSN / EISSN : 00097322 / 15244539
Current Publisher: Ovid Technologies (Wolters Kluwer Health) (10.1161)
Total articles ≅ 45,984
Google Scholar h5-index: 166
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Latest articles in this journal

Michael R. Sayre, Leslie M. Barnard, Catherine R. Counts, Christopher J. Drucker, Peter J. Kudenchuk, Thomas D. Rea, Mickey S. Eisenberg
Circulation; doi:10.1161/circulationaha.120.048951

Eitezaz Mahmood, Robina Matyal, Feroze Mahmood, Xinling Xu, Aidan Sharkey, Omar Chaudhary, Sadia Karani, Kamal R Khabbaz
Circulation; doi:10.1161/circulationaha.119.044642

The publisher has not yet granted permission to display this abstract.
Ambarish Pandey, Muthiah Vaduganathan, Sameer Arora, Arman Qamar, Robert J. Mentz, Sanjiv J. Shah, Patricia P. Chang, Stuart D. Russell, Wayne D. Rosamond, Melissa C. Caughey
Circulation; doi:10.1161/circulationaha.120.047019

The publisher has not yet granted permission to display this abstract.
Ange Maguy, Jean-Claude Tardif, David Busseuil, Camillo Ribi, Jin Li
Circulation, Volume 141, pp 1764-1774; doi:10.1161/circulationaha.119.044408

Abstract:
Background: Cardiac arrest is a tragic event that causes one death roughly every 90 seconds worldwide. Survivors generally undergo a work-up to identify the etiology of arrest. However, 5-10% of cardiac arrest remain unexplained. As cardiac arrhythmias mostly underlie cardiac arrest and increasing evidence strongly supports the involvement of autoantibodies in arrhythmogenesis, a large-panel autoantibody screening was performed in cardiac arrest patients. Methods: This is an observational, cross-sectional study of patients from the Montreal Heart Institute (MHI) hospital cohort, a single center registry of participants. A peptide microarray was designed to screen for IgG targeting epitopes from all known cardiac ion channels with extracellular domains. Plasma samples from 23 patients with unexplained cardiac arrest were compared to 22 cardiac arrest cases of ischemic origin and a group of 29 age-, sex- and BMI-matched healthy subjects. The false discovery rate (FDR), LASSO logistic regression and random forest methods were jointly carried out to find significant differential IgG responses. Results: The autoantibody against the pore domain of the L-type voltage-gated calcium channel (Ca v 1.2) was consistently identified as a biomarker of idiopathic cardiac arrest (P=0.002, FDR=0.007, classification accuracies ≥0.83). Functional studies on human induced pluripotent stem cell-derived cardiomyocytes demonstrated that the anti-Ca v 1.2 IgG purified from patients with idiopathic cardiac arrest is proarrhythmogenic by reducing the action potential duration through calcium channel inhibition. Conclusions: The present report addresses the concept of autoimmunity and cardiac arrest. Hitherto unknown autoantibodies targeting extracellular sequences of cardiac ion channels were detected. Moreover, the study identified an autoantibody signature specific to patients with cardiac arrest.
Xin Zhou, Yongle Li, Qing Yang
Circulation, Volume 141, pp 1736-1738; doi:10.1161/circulationaha.120.046988

Courtney M. Campbell, Rami Kahwash
Circulation, Volume 141, pp 1739-1741; doi:10.1161/circulationaha.120.047419

Shujuan Li, Ngoc Uyen Nhi Nguyen, Feng Xiao, Ivan Menendez-Montes, Yuji Nakada, Wilson Lek Wen Tan, Chukwuemeka George Anene-Nzelu, Roger S. Foo, Suwannee Thet, Alisson Campos Cardoso, et al.
Circulation, Volume 141, pp 1787-1799; doi:10.1161/circulationaha.119.043939

The publisher has not yet granted permission to display this abstract.
Andrew R. Chapman, Anda Bularga, Nicholas L. Mills
Circulation, Volume 141, pp 1733-1735; doi:10.1161/circulationaha.120.047008

Pengwei Hu, Kanika I. Dharmayat, Christophe A.T. Stevens, Mansour T.A. Sharabiani, Rebecca S. Jones, Gerald F. Watts, Jacques Genest, Kausik K. Ray, Antonio J. Vallejo-Vaz
Circulation, Volume 141, pp 1742-1759; doi:10.1161/circulationaha.119.044795

Laura A. Hancock, Graham Nichol
Circulation, Volume 141, pp 1775-1777; doi:10.1161/circulationaha.120.046552

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