Advanced Therapeutics

Journal Information
ISSN / EISSN : 2366-3987 / 2366-3987
Published by: Wiley-Blackwell (10.1002)
Total articles ≅ 550
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Latest articles in this journal

Mingyue Cui, Christian Wiraja, Mengjia Zheng, Gurvinder Singh, ,
Published: 13 October 2021
The publisher has not yet granted permission to display this abstract.
Emilia M. Zywot, Natalia Orlova, Song Ding, Rishi R. Rampersad, Emily M. Rabjohns, Victoria A. Wickenheisser, Qunzhao Wang, Joshua G. Welfare, Lauren Haar, Amanda M. Eudy, et al.
Published: 13 October 2021
The publisher has not yet granted permission to display this abstract.
Marian A. Ackun‐Farmmer, Hanan Alwaseem, Michele Counts, Andrew Bortz, Simone Giovani, , ,
Published: 8 October 2021
The publisher has not yet granted permission to display this abstract.
Yingying Li, KaiYuan Ni, Christina Chan, Nining Guo, Taokun Luo, Wenbo Han, August Culbert, Ralph R. Weichselbaum,
Published: 3 October 2021
The publisher has not yet granted permission to display this abstract.
Rosa Catania, Francesca Mastrotto, Chris J. Moore, Cynthia Bosquillon, Franco H. Falcone, Alan Huett, ,
Published: 24 September 2021
Abstract:
Water-soluble antibiotics are largely excluded from therapy of intracellular infections, such as Shigella spp., Listeria spp., or Salmonella spp., due to their inability to permeate mammalian cell membrane. Here, the authors study if targeting offers an advantage to deliver killing doses of membrane-impermeable antibiotics intracellularly to infected cells. Mannose-decorated liposomes, loaded with gentamicin, are fabricated to target mannose receptor, a recognition system of (infected) macrophages. Designing a family of liposomes with varying surface presentation of mannose ligand, the authors show a clear dependence of cellular internalization on the ligand surface presentation. Significantly for the killing of intracellular bacteria, the study demonstrates internalization of mannosylated liposomes by the entire population of macrophages, both Salmonella-infected and non-infected, resulting in an efficient treatment of intracellular infection. This contrasts with non-targeted liposomes, where internalization does not occur by a substantial subpopulation of infected cells. The study points to the significance of targeted delivery of antibiotics for treatment of intracellular infections.
Yinglan Yu, Zhanghan Wu, Jiawei Wu, Xinran Shen, Ruinan Wu, Minglu Zhou, Lian Li,
Published: 24 September 2021
The publisher has not yet granted permission to display this abstract.
Chrysovalantis Voutouri, Myrofora Panagi, Fotios Mpekris, Andreas Stylianou, Christina Michael, Michalakis A. Averkiou, John D. Martin, Triantafyllos Stylianopoulos
Published: 21 September 2021
Advanced Therapeutics, Volume 4; https://doi.org/10.1002/adtp.202170021

Abstract:
Bosentan, an endothelin-receptor blocker, can both normalize the tumor microenvironment, reprograming fibroblasts and reducing collagen thereby decompressing tumor blood vessels, and also increase T cell adhesion to the tumor vasculature. Together these effects significantly improve the efficacy of immune checkpoint inhibition. In addition, mechanical biomarkers derived from ultrasound elastography can predict the tumor response to immunotherapy. This is reported by John D. Martin, Triantafyllos Stylianopoulos, and co-workers in article number 2000289.
Alireza Shahryari, Ingo Burtscher, Zahra Nazari, Heiko Lickert
Published: 21 September 2021
Advanced Therapeutics, Volume 4; https://doi.org/10.1002/adtp.202170023

Abstract:
Recent progresses in discovery, development and exploitation of gene manipulation and delivery tools have dramatically revolutionized the gene therapy field for modern therapies. Alireza Shahryari, Ingo Burtscher, Zahra Nazari and Heiko Lickert summarize and discuss the advances and barriers of the gene editing platforms, viral gene delivery vehicles and non-viral molecular tools in a comprehensive review article, in article number 2100040.
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