Journal Information
ISSN / EISSN : 2150-7511 / 2150-7511
Published by: American Society for Microbiology (10.1128)
Total articles ≅ 5,795
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Latest articles in this journal

, Flore De Wit, Nagma Parveen,
Published: 16 June 2022
Abstract:
A longstanding question exists on the impact of the HIV-1 integration site on viral gene expression. This unsolved question has significant implications for the search toward an HIV-1 cure, as eradication strategies set up to reactivate and eliminate HIV-1 depend on the site where the provirus is integrated.
Karan Choudhary, Ziv Itzkovich, Elisa Alonso-Perez, Hend Bishara, Barbara Dunn, Gavin Sherlock,
Published: 16 June 2022
Abstract:
Sister chromatid cohesion is vital for faithful chromosome segregation, chromosome folding into loops, and gene expression. A multisubunit protein complex known as cohesin holds the sister chromatids from S phase until the anaphase stage.
Mizuki Yamamoto, Jin Gohda, Ayako Kobayashi, Keiko Tomita, Youko Hirayama, Naohiko Koshikawa, Motoharu Seiki, Kentaro Semba, Tetsu Akiyama, , et al.
Published: 16 June 2022
Abstract:
To develop effective therapeutics against COVID-19, it is necessary to elucidate in detail the infection mechanism of the causative agent, SARS-CoV-2. SARS-CoV-2 binds to the cell surface receptor ACE2 via the spike protein, and then the spike protein is cleaved by host proteases to enable entry.
Katarzyna Wacnik, Vincenzo A. Rao, Xinyue Chen, Lucia Lafage, Manuel Pazos, Simon Booth, Waldemar Vollmer, Jamie K. Hobbs, Richard J. Lewis,
Published: 15 June 2022
Abstract:
Bacterial cell wall peptidoglycan is essential, and its synthesis is the target of clinically important antibiotics such as β-lactams. β-lactams target penicillin-binding proteins (PBPs) that assemble new peptidoglycan from its building blocks. The human pathogen Staphylococcus aureus only has two essential PBPs that can carry out all the functions necessary for growth and division.
Karissa J. Muñoz, ,
Published: 15 June 2022
Abstract:
Chlamydia is the most reported cause of bacterial, sexually transmitted infection in the United States. This bacterium infects human cells and reproduces within a cytoplasmic inclusion via an unusual developmental cycle involving two specialized chlamydial forms.
Avan Antia, Amanda N. Pinski,
Published: 14 June 2022
Abstract:
Rotaviruses represent one of the most successful pathogens in the world, with high infectivity and efficient transmission between the young of many animal species, including humans. To overcome host defenses, rotaviruses have evolved a plethora of strategies to effectively evade the innate immune response, establish initial infection in the small intestine, produce progeny, and shed into the environment. Previously, studying the roles and relative contributions of specific rotaviral factors in innate immune evasion had been challenging without a plasmid-only reverse genetics system.
Ethan Iverson, Kira Griswold, Daniel Song, Talita B. Gagliardi, Kajal Hamidzadeh, Mehmet Kesimer, Sanju Sinha, Melissa Perry, Gregg A. Duncan,
Published: 14 June 2022
Abstract:
Influenza A virus (IAV) targets airway epithelial cells for infection. Large, heavily glycosylated molecules known as tethered mucins extend from the airway epithelial cell surface and may physically restrict pathogen access to underlying cells.
Lingaonan He, Zeyu Duan, Muqun Yu, Shaohua Qi, Ying Wang, Huiqiang Lou,
Published: 14 June 2022
Abstract:
Clearance of reactive oxygen species (ROS) is critical to the survival of aerobic organisms. In the model filamentous fungus Neurospora crassa , catalase-3 ( cat-3 ) expression is activated in response to H 2 O 2 -induced ROS stress.
Bin Wang, Guanhua Yue, Rongjing Zhang,
Published: 14 June 2022
Abstract:
The maximum torque the bacterial flagellar motor generates, the stall torque, is a critical parameter that describes the motor energetics. As the motor operates in equilibrium near stall, from the stall torque one can determine how many protons each torque-generating unit (stator) of the motor passes per revolution and then test whether motor rotation and proton flux are tightly or loosely coupled, which has been controversial in recent years.
Karin Hjort, Elin Fermér, Po-Cheng Tang,
Published: 13 June 2022
Abstract:
Our understanding of how and where antibiotic resistance is selected in response to antibiotic exposure is still limited, and this is particularly true for selective processes when bacteria are growing in biofilms, arguably the most significant mode of growth of bacteria in human and animal infections as well as in other settings. In this study, we compared how different types of resistant E. coli strains were selected in response to antibiotic exposure during planktonic and biofilm growth.
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