The Egyptian Journal of Fertility of Sterility

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EISSN : 2536-9768
Total articles ≅ 120
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Hamasat A Alnoury Wagdy M Amer
The Egyptian Journal of Fertility of Sterility, Volume 24, pp 9-19; doi:10.21608/egyfs.2020.116335

Abstract:
Objectives: Estimation of serum ficolin-2 and -3 for normotensive pregnant women to find a relation between ficolin levels and devel- opment of PE. Patients & Methods: Primigravida attending the clinic prior to the 12th gestational week underwent blood pressure (BP) measurements and gave blood sample for estimation of fasting blood glucose (FBG) and ELISA estimation of serum ficolin. Enrolled women were asked to attend 4-weekly for BP measurement; 59 PE women (Group PE), 59 normotensive pregnant women (Group NT) and 59 non-pregnant women (Group NP) were enrolled. Results: At time of PE diagnosis, all pregnant women had higher BP than their baseline measures, with significantly higher measures in PE women. Serum ficolin-2 levels were significantly lower in preg- nant than NP women and in PE than NT women, while serum ficol- in-3 levels were significantly lower in PE than NT women. Devel- opment of PE was positively associated with higher BMI, FBG and BP, while was negatively correlated with ficolin levels. Regression analysis defined low serum ficolin levels as negative predictors for PE development and serum ficolin-2 level Conclusion: Pregnancy has deleterious effect on complement path- way manifested by lower serum ficolin. Low serum ficolin-2 early in pregnancy is a sensitive screening test for pregnant women and can exclude PE development with 100% negative predictive value at level
The Egyptian Journal of Fertility of Sterility, Volume 24, pp 33-40; doi:10.21608/egyfs.2020.116497

Abstract:
Objective: estimation of accurate gestational age correctly remains a crucial step in the antenatal care provided to all pregnant women. Our aim was to find out if transcerebellar diameter (TCD) could aid precisely in detecting accurate gestational age using ultrasound. Patients and methods: One hundred and three healthy women with singleton pregnancy were included. Pregnancies complicated with fetal anomalies, intrauterine growth restriction or death were exclud- ed. Eligible participants were examined extensively by ultrasound to confirm the gestational age using TCD, biparietal diameter (BPD) and femur length (FL). Then, data were collected and statistically analyzed comparing the three measurements. Results: TCD was accurate within in 88.3% of the cases, while FL was accurate in 65% of the cases and BPD was accurate 51.5%. Bland-Altman comparison of actual GA and GA estimated by TCD, FL and BPD showed narrow limits of agreement indicated low bias and better test with TCD, thus GA estimated by TCD was the best .There was good correlation between actual GA and GA estimated by TCD (r=0.989**, p < 0.001). Conclusion: TCD is the highest statistically significant measure- ment which could be used in the third trimester for assessing the ges- tational age compared with FL and BPD without any effect of parity, gestational age or fetal presentation on its accuracy.
The Egyptian Journal of Fertility of Sterility, Volume 24, pp 41-50; doi:10.21608/egyfs.2020.116499

Abstract:
Objective: This study aimed to evaluate the three dimension power Doppler indices together with uterine artery Doppler indices during the day of embryo transfer in predicting the outcome of ICSI cycle. Study design: One hundred and three healthy women with singleton pregnancy werprospective cohort study. Patient and methods: One hundred twenty patients were included in the study during ICSI cycles. This work was done at IVF unite of Dar El Teb hospital, Egypt. All patients included in the work had these criteria; age; 22–35 years, BMI; < 35 kg/m2, oligo- or oligoas- thenospermia. All patients received along agonist protocol of ovarian hyperstimulation and after follicular retrieval; embryos were trans- ferred at the stage of blastocyst. Three D Power Doppler was done at the day of embryo transfer. Quantitative pregnancy tests were done for every patient. The rates of clinical and ongoing pregnancy were estimated. All women were categorized into two categories: with pregnancy and without pregnancy. Results: Thirty-five percent of patients became pregnant. Our study showed non-significant differences in both groups regarding demo- graphic, clinical and laboratory data except for some vascular pa- rameters (endometrial VI, FI, VFI-subendometrial FI- u PI). Our study revealed a significant increase of some vascular parameters (endometrial VI, FI, VFI-subendometrial FI- u PI).and correlated to pregnancy. The endometrial VFI is the most sensitive vascular pa- rameter correlated to pregnancy. Conclusion: 3DPD is a useful non invasive predictor for IVF out- come.
Hanan Nabil
The Egyptian Journal of Fertility of Sterility, Volume 24, pp 20-27; doi:10.21608/egyfs.2020.116343

Abstract:
Objectives: to optimize the outcome of malignant ovarian tumour via evaluation of the management procedures and protocols in Man- soura university hospitals and how far they are from the international standards. Method: This descriptive, observational analytical study was con- ducted at Mansoura University Hospital, oncology unit of the depart- ment of Obstetrics & Gynaecology from January 2016 to December 2017 and included 94 patients. The participants were chosen from those attending the gynaecology outpatient clinic and diagnosed clin- ically and proven by investigations as having ovarian cancer. Histo- ry, clinical examination and data obtained by abdominal and vaginal ultrasound as well as reports received from MRI and CT scanning we rereserved. Tumour markers were estimated by the same laboratory and technicians and treatment interventions provided with one year follow up results were collected. Results: demographic patients’ data recorded the mean age estimat- ed for all patients is 45.28 ± 15.5 years, 42.5% of which are more than 50 years, and 6.4% younger than 18 years. Patients with low gravidity and parity included near half of the cohort (48.9 % and 44.7 respectively).Family history of ovarian, breast and colon can- cers were positive in 9 patients only. Premenopausal ones recorded the highest number. From all of the cohort 6 cases gave a history of infertility. The main complaint was abdominal discomfort (40 cas- es), followed by abdominal swelling (24). Epithelial ovarian can- cers were the most common (74.5%), with serous cyst adenocar- cinoma constituting the majority (68.6 %) followed by granulosa cell tumour (10.6%) then border line and germ cell tumours(6.4%) for each group. The least reported subclass was immature teratoma (1%). Two cases were found to be Krukenbergmetastasis from co- lonic cancer. CA125 mean was+SD 510.41 ± 131.42 IU/ml. AFP and HCG were elevated in germ cell tumour and sex cord tumour. Most of the patients (74.5%) presented with advanced stage disease III and IV, whereas 25.5% of patients presented with stage I and II. Eighty-eight patients did primary debulking surgery. Two patients received neoadjuvant chemotherapy followed by secondary debulk- ing surgery. The majority of patients (68%) had a combined surgery and chemotherapy.25.5% of the patients had the chance of fertility preserving surgery as they underwent unilateral oophorectomy. Es- timated cancer mortality in our cohort proved 18 cases died (19.1%) within a year after treatment, 76 patients (80.9%) survived beyond a year after the initial treatment. The stage of the disease at presenta- tion was strongly correlated to survival beyond a year after treatment (p < 0.001). Conclusion: mproving the health care system and promoting effective clinical management of ovar- ian cancer is an important issue to eliminate the survival disparities in our locality that requires im- provement in guidelines adherent care.
Hanan Nabil Elsayed ElShamy
The Egyptian Journal of Fertility of Sterility, Volume 24, pp 28-32; doi:10.21608/egyfs.2020.116344

Abstract:
Background and aim: to assess the the posterior colpotomy ap- proach versus laparoscopic approach in the surgical management of ectopic pregnancy in stable patients. Methods: A prospective cohort study conducted on 40 women with ectopic pregnancy, divided into two groups; Group 1 included 20 patients for whom laparoscopic salpingectomy was done and group 2 included 20 patients for whom salpingectomy was done via pos- terior colpotomy approach. Operative and postoperative data were collected and analyzed. Results: Operative time was significantly shorter in group 2; 45 ± 8.1 min versus 56.5 ± 13 min in group 1(P0.05). There was no significant difference between the two groups regarding patient characteristics, clinical data, hospital stay and the need for blood transfusion. Conclusion: Posterior colpotomy is a promising approach for surgi- cal treatment of tubal ectopic pregnancy especially if laparoscopy is not available.
Maysaa El Sayed Zaki. Yasser Abd El Dayem
The Egyptian Journal of Fertility of Sterility, Volume 24, pp 2-8; doi:10.21608/egyfs.2020.115961

Abstract:
The aims of the present study were i. asses the biomarkers of oxi- dative stress including superoxide anion radical, Nitrite measurement and reduced glutathione in female patients with spontaneous abortions Asses the prevalence of C. trachomatis antibodies IgA and IgG in those patients, iii. Correlate the levels of the oxidative biomarkers to the presence of C. trachomatis antibodies. The study included one hundred female patients with 2 or more spon- taneous abortions in addition to one hundred healthy control females with normal gravidity and parity history. Blood samples were obtained from each subject and subjected to laboratory determination of super- oxide anion radical, Nitrite measurement and reduced glutathione by biochemical methods. Determination of specific immunoglobulin A and G (IgA, IgG) was determined by enzyme linked immunosorbent assay (ELISA). The prevalence of IgA and IgG for C. trachomatis in patients was 4% and 8% respectively and, in the control, subjects the prevalence of IgA and IgG were 1% and 2% respectively. The concentration of oxidative stress products was significantly higher in the patients group compared to the control group (P=0.0001). The concentrations of nitrite and reduced glutathione were 27.9± 4.7, 31.4± 1.9 nmol/ml respectively in patients and the concentrations of nitrite and reduced glutathione were 18.9± 2.1 and 27.9± 3.9 respectively in the control group. The concentration of SOD was significantly reduced in the patients group compared to the control group (P=0.0001). The concentration of SOD was 55.1 6.9 in the patients and in the control the concentration was 64.5± 7.7 nmol/ml In the study of oxidative stress markers in the patients with positive serology for C. trachomatis, there was significant increase in nitrite concentrations compared to patients negative for C. trachomatis sero- logical markers (P=0.005). While reduced glutathione concentration had insignificant increase in patients positive for C. trachomatis with reduced SOD compared to patients with negative serology to C. tra- chomatis, P=0.6, P=0.07, respectively. The present study highlights that there was significant increase in oxi- dant stress biomarkers nitrite and reduced glutathione with significant reduction in superoxide dismutase in patients with repeated abortions. The prevalence of IgG to C. trachomatis was significantly prevalent in patients with recurrent abortion compared to control subjects. The nitrite was significantly correlated with positive serology to C. tracho- matis.
Ahmed G. Serour
The Egyptian Journal of Fertility of Sterility, Volume 24, pp 11-21; doi:10.21608/egyfs.2020.105464

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Rafik Ibrahim Barakat
The Egyptian Journal of Fertility of Sterility, Volume 24, pp 27-34; doi:10.21608/egyfs.2020.105466

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Sara Taha Mostafa
The Egyptian Journal of Fertility of Sterility, Volume 24, pp 35-42; doi:10.21608/egyfs.2020.105467

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The Egyptian Journal of Fertility of Sterility, Volume 24, pp 2-10; doi:10.21608/egyfs.2020.105463

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