International Journal of Nutrology

Journal Information
ISSN / EISSN : 1984-3011 / 1984-3011
Published by: Zotarelli-Filho Scientific Works (10.54448)
Total articles ≅ 254
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Michelle Silva Rocha, Lorenna Lemos de Aquino, Clarice Paiva de Oliveira, Juliana Leite Salviano, Lucas Ramos Patrício, Thiago Rodrigues dos Santos, Vinícius Bezerra Lopes, Weyller Camargo Dias, Ágda Tamires da Silva Rodrigues, Idiberto José Zotarelli-Filho
International Journal of Nutrology, Volume 15; https://doi.org/10.54448/ijn22s101

Abstract:
Introduction: Recent progress has been made to gut microbiota, regenerative nutrition and skeletal muscle metabolism. In this context, regular physical training associated with nutrological health has broad benefits for the health of the intestinal microbiota. The triad physical exercise, nutrition and intestinal microbiota for the process of muscle regeneration, adult stem cells stand out as gut stem cells. Objective: the present study aimed to carry out a systematic review on the main cellular and molecular aspects of regenerative nutrition in the modulation of the intestinal microbiota and the metabolism of skeletal muscle. Methods: The rules of the Systematic Review-PRISMA Platform. The research was carried out from June 2021 to January 2022 and developed based on Scopus, PubMed, Science Direct, Scielo, and Google Scholar. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 215 studies were analyzed, with only 32 medium and high-quality studies selected, according to the rules of the GRADE, and with bias risks that do not compromise scientific development, based on the Cochrane instrument. A current focus in the field of sport and metabolism is the investigation of how specific metabolites and nutrients affect the progression and treatment of muscle injuries. Nutrients can also regulate normal homeostatic processes, altering the decisions of muscle stem cells and satellites. Thus, the implications for understanding how diet influences cellular transitions are immense and will guide precision-based nutrition to improve overall health and therapeutic strategies for muscle injuries. Thus, metabolic pathways and chromatin modifications are closely linked, and hence many changes in metabolism influence epigenetic changes and alter gene expression. For example, signaling pathways including mTORC, AMPK, MAPK, and others are all sensitive to changes in nutrient levels.
Durval Ribas Filho, Carlos Alberto Nogueira-De-Almeida, Idiberto José Zotarelli-Filho
International Journal of Nutrology, Volume 15; https://doi.org/10.54448/ijn22201

Abstract:
Introduction: Polycystic Ovary Syndrome (PCOS) is the most common endocrine disease among women of reproductive age 6 to 15% its presentation is complex and heterogeneous and is characterized by clinical and laboratory findings of hyperandrogenism, oligo-anovulation, metabolic abnormalities such as insulin resistance (IR), overweight, obesity, type 2 diabetes mellitus, dyslipidemia and increased risk of cardiovascular disease. Objective: To evaluate the effects of myo-inositol in pregnant and non-pregnant women with polycystic ovary syndrome in relation to fertility improvement, gestational outcomes, and metabolic and hormonal parameters. Methods: Data from randomized clinical trials on the efficacy of myo-inositol in women with PCOS were used in this review. The PubMed database was used for literature search. Results: Insulin resistance is one of the mechanisms that explain the emergence of metabolic and reproductive changes in women with PCOS. When compared to placebo, myo-inositol was effective in improving fertility, increasing ovulation and fertilization rates, in addition to improving metabolic parameters as indicators of insulin resistance (HOMA index). Even when compared to more traditional insulin sensitizers like metformin, myoinositol showed similar efficacy in restoring fertility. Myo-inositol was also effective when associated with clomiphene acetate and in women undergoing in vitro fertilization processes. There was also an improvement in pregnancy outcomes and a reduction in the risk of developing gestational diabetes with the use of myo-inositol. Conclusions: Myo-inositol improves clinical and laboratory parameters in both pregnant and non-pregnant PCOS patients, increasing the fertility rate and improving pregnancy outcomes.
Mário Flamini Júnior, Idiberto José Zotarelli-Filho, Luiz Gustavo de Quadros, Manoel Galvão Neto, Maurício Vecchi Carmo, Maisa Ramos Buissa, Roberto Luiz Kaiser Junior
International Journal of Nutrology, Volume 15; https://doi.org/10.54448/ijn22204

Abstract:
Introduction: The Roux-en-Y gastric bypass (RYGB) is, currently, the most performed technique in Brazil. Suture threads are classified according to their degradation properties. Objective: To analyze the influence on the size of the gastrojejunal anastomosis performed in Roux-en-Y gastric bypass surgery, as well as the main complications with the use of absorbable or inabsorbable thread. Methods: This study followed a prospective and randomized clinical trial, initially with 40 participants, with only 37 participants being duly selected, 19 of whom underwent gastrojejunostomy closure with an absorbable (Abs) polydioxanone suture (PDS II®) and 18 with the inabsorbable (Inb) ETHIBOND®. Statistical analysis was performed using the ANOVA and logistic regression tools (p<0.05 significant). Results: General complications and Upper Digestive Endoscopy (UDE) were less frequent at the end of 12 months in both groups. At the end of twelve months, the number of complications of the Inb thread decreased considerably, while the number of complications of the Abs thread showed an increase in other complications, including marginal ulcer and intrusive thread. Despite this, there was no significant difference between groups in terms of total weight loss. There was no statistically significant difference between the final values of the anastomotic diameter. The percentage of weight loss over the 12 months was 33.77 ± 6.97% for the Inb group and 36.10 ± 4.89% for the Abs group (p<0.05). Conclusion: Both suture threads (Inb and Abs) presented similar complications and did not present significant differences between the values of weight, gastrojejunal anastomosis, and pouch.
Ana Beatriz Travaini, Gabriela Anjona Gregorini, Giulia Ramos Custódio, Iasmin Ribeiro Payno, João Felipe Pissolito, Lucca Vieira Cerretto, Vinícius Jimenes de Campos, Tainara Costa, Durval Ribas Filho
International Journal of Nutrology, Volume 15; https://doi.org/10.54448/ijn22202

Abstract:
Introduction: when talking about eating disorders (ED), reflects a lot on how it affects young people and, currently, it is known that the most varied types of ED are quite prevalent in the university environment, with medical students being part of this groups that are significantly exposed to the onset of ED. The development of these disorders is commonly associated with self-image disorders, while body dissatisfaction is precisely one of the diagnostic criteria for ED. Objective: identify the prevalence of body dissatisfaction among medical students and how it affects the susceptibility to the development of eating disorders, relating this information to the impact of the pandemic and the gender of the participants. Methods: a cross-sectional observational study, with a quality-quantitative data approach. The research was carried out with medical students of both sexes, over 18 years old, through the application of an online questionnaire, which allowed the sample to be characterized in terms of sociodemographic and anthropometric aspects. In addition, the occurrence of self-image disorders was evaluated through the Kakeshita Silhouette Scale and the risk of developing ED through the Eating Attitudes Test (EAT 26). For statistical analysis, differences in EAT scores between categories were assessed using the Independent T-Test and the proportion of participants with self-image disorder was compared using Fisher's exact test. Results: 268 participants were included in the research, with a mean age of 21.23 years (standard deviation = 2.47), with 216 female participants (80.6%) and 52 male participants (19.4%). The body mass and height were self-reported by the students to calculate the body mass index (BMI), whose mean value was 23.57 (standard deviation = 4.79), showing that 27.6% of the participants are above the weight or obesity (BMI > 25) and 4.85% with low weight (BMI < 18.5). The present study showed a positive correlation between self-image disorders and eating disorders (p = 0.0002), regardless of the individual's gender. For the variables evaluated, there was no significant difference between genders (p = 0). Furthermore, the current COVID-19 pandemic is not an influential factor in the increase in self-image disorders among participants. Conclusion: through the study, it became evident that students who have self-image disorders have a higher risk of developing eating disorders. In addition, a significant part of the participants is dissatisfied with their bodies, regardless of gender or the impacts brought about by the pandemic.
Hayslan Theobaldo Boemer
International Journal of Nutrology, Volume 15; https://doi.org/10.54448/ijn22203

Abstract:
Parenteral nutrition (PN) is a vital therapeutic modality for a specific group of patients in need of nutritional support. The proper use of this complex therapy is capable of maximizing its clinical benefits, minimizing the potential risks of adverse events. In certain situations, the clinical lability in which the patient finds himself requires the prescription of customized parenteral formulas. Due to the number of components used in these solutions, the possibilities of Physico-chemical incompatibilities are common and represent a serious problem. For this, prescribers must be familiar with its composition process in order to guarantee a safe formula for infusion. The objective of this work is to present the various inputs (amino acids, carbohydrates, lipids, vitamins, trace elements, electrolytes, and drugs) commonly prescribed in PN formulas, as well as their possibilities of interaction for the formation of precipitates. The concept of osmolarity and its relationship with infusion sites (central or peripheral) will also be addressed. However, an excellent understanding of the different types of inputs used in PN formulas, and also of their physical-chemical interactions capabilities, associated with good clinical judgment in the individualization of these solutions, has reduced sources of errors and ensured greater safety and quality in this type. of intervention to patients.
Erika Bueno Marouelli, Stéfanne Sara Ferreira, Andreia Borges Scriboni
International Journal of Nutrology, Volume 15; https://doi.org/10.54448/ijn22112

Abstract:
Eating disorders are psychological disorders that directly affect the physical health of those who suffer from them, with a high mortality rate. Women are more prone to eating disorders than men, which is why most research focuses on women. Thus, 10% of patients with eating disorders are men. The results of bibliographical research are presented through in-depth interviews about the perception of the body that Social Work and Psychology professionals, who worked in both the public and private sectors, as an element that can influence eating disorders. This perception has been analyzed as an element that influences eating disorders. This research reaches three main conclusions: First, the body is considered by professionals as an instrument to stop time when personal identity problems arise, especially when the patient is a woman. Second, professionals perceive their patients' bodies as a responsibility in open conflict with social perceptions seen as something unattainable, ideal, and subject to unattainable parameters. Finally, the perception of the body is guided by social imaginaries in which morality (taboo and sin) and the biological are predominant.
Glendha Stephanie Martins, Mateus Garcia Zilio, Daniel Pimenta Queiroz, Gabriela Garbuio Vendramini, Marcelo Borgo, Luis Otávio Garcia de Oliveira, Felipe Fonseca Rego, Airton José Mendes
International Journal of Nutrology, Volume 15; https://doi.org/10.54448/ijn22111

Abstract:
Introduction: The prevalence of septic arthritis (SA) is higher in underdeveloped countries than in developed countries, and the number of hospitalizations of children for this cause is decreasing and the most prevalent age group is between 0 and 4 years of age. Clinical history and detailed physical examination are essential to make an accurate diagnosis, but the neonatal period has certain limitations. Objective: To report a case of septic arthritis that occurred in a newborn admitted to the Neonatal Intensive Care Unit (ICU) due to its serious condition, morbidity, and unusual evolution of the pathology in the pediatric population, scarcity of epidemiological data on the subject, still aiming address aspects of the treatment of the disease. Case report: Male patient, born on 09/11/2020 at Santa Casa de Tupã, Sao Paulo, with a gestational age of 36 weeks and 6 days, through cesarean delivery and without complications, obtaining APGAR 9 and 10, and maintained in a room with the mother. The morning after birth, the newborn (NB) began to groan and have mild respiratory distress. The patient evolved with worsening of the breathing pattern and oxygen was concentrated at 6L/min in Hood's Halo, presenting hyperthermia, hyperemia, and edema in the right elbow. Laboratory tests showed an increase in C-Reactive Protein and worsened hematimetric indices of the blood count, and antibiotic therapy was then started with oxacillin 50 mg/kg/dose and amikacin 15 mg/kg/day. The ultrasound of the right elbow showed skin thickening, absence of collections, and no changes in vasculature, being suggestive of cellulite. A new ultrasound of the right elbow showed bulging, intra-articular collection, and discreet collection with extra-articular communication in the medial region, being suggestive of septic arthritis. Blood culture collection resulted in the growth of gram-positive cocci (Staphylococcus aureus) in a pair of samples. The patient received intravenous treatment with Vancomycin for 14 days with clinical and laboratory improvement of the infection and was discharged with the use of oral Clindamycin for another 14 days and physical therapy follow-up for rehabilitation of movement of the affected limb. Final considerations: Due to the unusual evolution of SA in the neonatal period, and the scarcity of literature on the pathology in this age group, the importance of further studies on the subject, and greater surveillance for neonatal diagnosis, in addition to early treatment to reduce of complications.
Liana Carla Albuquerque Peres Martinho
International Journal of Nutrology, Volume 15; https://doi.org/10.54448/ijn22104

Abstract:
Obesity is a multifactorial health problem characterized by the excessive accumulation of fat in the body and affects approximately 338 million children and adolescents worldwide. For this reason, this study consisted of a literature review to investigate how the causes and treatments of pediatric obesity are being addressed in light of epigenetic modulation as a factor in metabolic programming. For this, preferentially original articles published in English between the years 2017 to 2021 in the PubMed and Scholar Google databases were searched using the epigenetics descriptors; epigenetic modulation; child obesity; metabolic syndrome, combined with each other. A total of 54,000 articles were returned to searches in PubMed and 16,107,000 in Scholar Google. Fewer than 500 studies jointly addressed epigenetics and aspects of obesity or metabolic syndromes in childhood. Only 14 works matched the search criteria. The most discussed epigenetic mechanism in the literature is DNA methylation, whose rates observed mainly in CpG islands of promoter regions in several genes contribute to the prevention and early diagnosis of obesity and other pediatric comorbidities even before birth, based on the correlation between the epigenetic marks, maternal and paternal health and anthropometric indices. Although experimental studies on infant metabolic programming are scarce, existing knowledge suggests that environmental, nutritional, and energy expenditure changes are capable of modulating the epigenome and reversing marks that induce susceptibility to metabolic comorbidities.
Cristiano Corrêa Batista
International Journal of Nutrology, Volume 15; https://doi.org/10.54448/ijn22103

Abstract:
Introduction: Assessing the hydration status of critically ill patients has been a difficult task over the decades. Determining how much fluid overload a patient has often helped in choosing a therapy. Methods such as bioelectrical impedance have been approached as a useful tool for this purpose. Objective: This study proposes to verify, through research in the literature, what is the real importance of the clinical use of bioelectrical impedance in the diagnosis of fluid overload in critically ill patients hospitalized in intensive care units. Methods: bibliographic search in the main scientific information databases: Scielo, PubMed, Cochrane, and Lilacs from January 2000 to July 2018. The selected languages were Spanish, Portuguese, and English. The keywords used were bioelectrical impedance, hydration, Intensive Care Unit, Intensive Care, bioelectrical impedance analysis, fluid balance, hydration overload. Results and Conclusion: The analysis of fluid overload in critically ill patients can be performed using multifrequency bioelectrical impedance. It is a useful tool in the diagnosis as well as in the quantification of water overload and, therefore, a corroborative method for clinical decision-making.
Thiago Rocha de Pinho, Simone Mayane Mendes dos Santos, Renara Leite Rodrigues Rocha
International Journal of Nutrology, Volume 15; https://doi.org/10.54448/ijn22105

Abstract:
The presence of malnutrition in hospitalized patients is prevalent and studies show its association with a higher incidence of complications, mortality, length of stay, costs, and increased frequency of hospital readmission. Routine use of simple tracking procedures is recommended. Nutritional screening detects individuals who are malnourished or at risk of developing malnutrition, and who can receive specific nutritional support. Nutritional Risk Screening (NRS 2002) is a nutritional screening method recommended by the European Society for Clinical and Metabolism (ESPEN) and identifies the risk of developing malnutrition in hospitalized patients. The aim of this paper is to review the literature on the NRS screening method (2002) and its relationship with clinical outcomes in hospitalized patients.
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