International Journal of Analytical Mass Spectrometry and Chromatography

Journal Information
ISSN / EISSN : 2332-1768 / 2332-1776
Published by: Scientific Research Publishing, Inc. (10.4236)
Total articles ≅ 58
Current Coverage
PUBMED
Archived in
SHERPA/ROMEO
Filter:

Latest articles in this journal

Nada H. Binhashim, Syed N. Alvi, Muhammad M. Hammami
International Journal of Analytical Mass Spectrometry and Chromatography, Volume 09, pp 1-11; https://doi.org/10.4236/ijamsc.2021.91001

Abstract:
A simple and reliable high performance liquid chromatography tandem mass spectrometry (LC-MS/MS) assay for the determination of colistin A and colistin B in human plasma was developed and validated. Clarithromycin was used as an internal standard (IS). Plasma extraction was performed using C-18 cartridges and methanol containing 0.1% formic acid. Analysis was performed using Atlantis dC18 (2.1 × 100 mm, 3 μm) column at room temperature and a mobile phase of 0.2% formic acid in acetonitrile and water (50:50, v:v), delivered at a flow rate of 0.2 ml/minute. Eluent was detected in the positive ion mode using electrospray ionization at the following transitions of mass to charge (m/z): colistin A, 585.6 → 101.4; colistin B, 578.7 → 101.3; and IS, 748.6 → 158.4. No interference by components of blank plasma or commonly used drugs was observed. The relationship between colistin A colistin B concentrations and their corresponding peak height ratios to the IS was linear over the range of 0.05 - 10 μg/ml. Inter-day coefficient of variation and bias were, respectively, ≤11.5% and −3.0 to 6.0 for colistin A and ≤9.9 and −4.7 to 3.0 for colistin B. Mean extraction recovery of colistin A, colistin B, and the IS were 97%, 94%, and 97%, respectively. The method was applied to assess the stability of colistin A and colistin B in processed samples (24 hr. at room temperature, 48 hours at −20°C) and unprocessed samples (24 hr. at room temperature, 8 weeks at −20°C) and after three cycles of freeze and thaw found to be ≥87%.
Ilia Brondz
International Journal of Analytical Mass Spectrometry and Chromatography, Volume 08, pp 7-13; https://doi.org/10.4236/ijamsc.2020.82002

Abstract:
When this tragedy ends, it will become clear whether it is a pandemic, epidemic, mass infection, or mass psychosis (initiated by mass media with heavy engagement from political and economic establishments). The USA and other countries are raining accusations upon China, and vice versa. This problem will have future impacts on human society and civilization will be quite different following the “Pandemic of COVID-19”. Although this series of papers will discuss a broad array of related problems, the author contends that the most important priorities are developing medications against diseases and improving our scientific understanding of the social situations and substances that jeopardize human health and increase our susceptibility to viral infection. Later papers in this series will provide support for the Chinese claim that chloroquine may be a useful medication for patients with viral infection.
Ilia Brondz, Paul Harrison
International Journal of Analytical Mass Spectrometry and Chromatography, Volume 08, pp 1-6; https://doi.org/10.4236/ijamsc.2020.81001

Abstract:
Correct grammar, coherent structure, fluent expression, and clear presentation are necessities for academic literature in the sciences and humanities. For scientific papers, these parameters are important to authors as well as to readers, especially for scientists who wish to understand the theory or to replicate the results. Today, most scientific and humanities journals are published in English. There are journals in Chinese, German, Hindi, Russian and other languages; however, for international use in science, business, and computer hardware and software, English is the dominant language. English is also used in diplomacy and for all kinds of international communications by people who have various other native languages. In this paper, we will present one of the leading international providers of high-quality academic English—OnLine English (OLE) and some of the functions of this service will be described.
Ilia Brondz
International Journal of Analytical Mass Spectrometry and Chromatography, Volume 07, pp 35-36; https://doi.org/10.4236/ijamsc.2019.73004

Abstract:
Chemistry is one of the eldest and basic sciences. The technological progress is depending on progress in chemistry. Without evaluation of nature and preparation of a pure substance, it is not imaginable existence of modern biology, medicine, metallurgy and physics. All kind of existing technologies needs distinct in nature and pure in quality substances for existence and further progress. RG aims to bring together leading academic scientists, researchers and research scholars to exchange and share their experiences and research results on all aspects of chemistry and related fields. It also provides an interdisciplinary platform for researchers, practitioners and educators to present and discuss the most recent innovations, trends, and concerns as well as practical challenges encountered, and solutions adopted in the fields of chemistry. One of the nearly developed concepts in liquid chromatography is described in [1], which is a new type of liquid chromatography, the new technology as the Colloidal High-Performance Liquid Chromatography (CHPLC). This type of new technological approach in high-performance liquid chromatography is a simple time- and labor-saving one-step procedure suitable for analytical-, semipreparative-, and preparative-scale preparation of bacteriocins and other cationic antibacterial peptides as well as other cationic small molecular weight species. It allows to suspensions of bacterial cells, other colloidal and fast-particle materials, and dissolved anionic molecules passed through the column; however, cationic bacteriocins, small cationic peptides, organic cationic molecules and metal cations were separated by chromatography. The purity of the target substance generally at more than 95% was achieved by the judgment of spectral, chromatographic, and antimicrobial activity. In [1] was described the preparation, purification and chromatography of bacteriocin, bacitracin and lysozyme. It is my pleasure to invite all the great scientists, academicians, young researchers, students and everyone who is interested in Science, especially in chemistry from all over the world to attend the RG. All who are interested in theoretical and applicational aspects in Chemistry, New Materials Research and Nanotechnology will find them in RG. The topics as: Organic Chemistry and Advances in Organic Chemistry, Analytical Chemistry, Medicinal Chemistry, Clinical Chemistry, Forensic Chemistry, Industrial Chemistry and Occupational Chemistry, Food Chemistry, Green Chemistry and Chemical Renewable Resources, Agricultural and Food Chemistry, Physical and Theoretical Chemistry, Biological Chemistry, Marine Chemistry, Inorganic Chemistry, Environmental Chemistry, Nanoscience and Technology, Polymer Chemistry, Material Chemistry, Natural Resources Chemistry and Natural Products Chemistry, Electrochemistry, Geochemistry, Radio and Nuclear chemistry, Physical Chemistry, Theoretical Chemistry, Space (Interplanetary) Chemistry and many more are present on the pages of RG. At RG you will find the state-of-the-art research and cutting-edge theoretical and applicational technologies. The RG is covering a number of global aspects in Chemistry, New Materials Science and Nanotechnology from purely fundamental research up to practical applications.
Abdlazim Mohamed Ali, Hana Jumma Ali Jumma
International Journal of Analytical Mass Spectrometry and Chromatography, Volume 07, pp 9-17; https://doi.org/10.4236/ijamsc.2019.71002

Abstract:
Essential oils from newly produced (2017) and previous season crop (2016) of cumin (Cuminum cyminum L.) seeds collected from local farmers in Dongla area, north Sudan were extracted and analyzed to determine the effect of storage period on volatile oil yield and quality. The essential oil was extracted using hydro distillation method. Identification of the volatile compounds was performed using gas chromatography-mass spectrometry (GC/MS). Results revealed that oil obtained from cumin (Cuminum cyminum L.) was pale yellow. With respect to oil characteristics, the specific gravity, refractive index, acid value, ester value and other quality characters were not significantly different between the stored and newly harvested seeds. Thirty-eight compounds were separated and identified in cumin seeds essential oil in both seasons with some minor differences in some components between 2016 and 2017 samples. Major effective components of cumin seeds volatile oil were cumin alcohol (4-isopropylbenzyl alcohol), cumin aldehydes as 4-Isopropylbenzaldehyd and 7,7-dimethylbicyclo (4.1.0) hept-3-ene-4-carbaldehyde known as carenal, terpinenes as γ-terpinene and α-terpinene (1,4-Cyclohexadiene, 1-methyl-4-(1-methylethyl) and 1,3-cyclohexadine-1-methanol, 4(1-methethyle)-), β-pinene, o-cymene and p-menthadienol in both stored and newly harvested samples. Differences between the samples season wise were very minor with respect to type of volatile components but percentage oil yield was largely decreased by storage period.
Belén Gastaca, , Fiorella Menestrina, Maricel Caputo, María De Las Mercedes Schiavoni, Jorge Javier Pedro Furlong
International Journal of Analytical Mass Spectrometry and Chromatography, Volume 07, pp 19-34; https://doi.org/10.4236/ijamsc.2019.72003

Yutaka Okada, Masako Tsuchida
International Journal of Analytical Mass Spectrometry and Chromatography, Volume 07, pp 1-8; https://doi.org/10.4236/ijamsc.2019.71001

Abstract:
Ferrocene is an organometallic compound that readily undergoes oxidation in atmosphere under acidic conditions. However, because of its diamagnetic nature, ferrocene does not lend itself to structural analysis by nuclear magnetic resonance (NMR) spectroscopy. In this work, the oxidation of ferrocene and several of its derivatives were analyzed by liquid chromatography-mass spectrometry (LC-MS). An electrospray ionization (ESI) source was used, with picrate serving as the counter ion. This method is particularly effective for studying oxidation of ferrocenes because their reactivity toward oxygen under ambient conditions is low.
Ilia Brondz
International Journal of Analytical Mass Spectrometry and Chromatography, Volume 06, pp 37-39; https://doi.org/10.4236/ijamsc.2018.62003

Abstract:
This short communication is an overview and revision of previous published papers about the relative and absolute stereochemistry of hyperforin and discovery of a new isomer of hyperforin that has been named perforatrin.
Jinlian Lu, Weimin Hu, Weiqun Cao, Sitan Xie, Zhiyu Li, Yi Tao, Xin Zhang
International Journal of Analytical Mass Spectrometry and Chromatography, Volume 06, pp 21-36; https://doi.org/10.4236/ijamsc.2018.62002

Abstract:
A rapid and reproducible method has been developed for the simultaneous quantification of dopamine (DA), norepinephrine (NE), and serotonin (5-HT) in rat brain microdialysates. Derivatization was processed through reductive amination with butyraldehyde and sodium cyanoborohydride at 60℃ for 80 min incubation. Dibutylated monoamine neurotransmitters (MANTs) were directly analyzed with ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The chromatographic run time was shorter (2.1 min/sample) than previous studies [15] [18] [20]. Good linearity (R2 > 0.99) was obtained for DA, NE and 5-HT in the range of 25 - 5000 pg/mL, 5 - 1000 pg/mL and 2.5 - 500 pg/mL, respectively. Acceptable precision (CV, 8.5% - 13.4%) as well as accuracy (recovery, 94.1% - 106.8%) could be acquired by analysis of six batches of quality control samples (QCs) at four different concentrations, which demonstrated the reliability and reproducibility of current method. This method was successfully applied to the simultaneous determination of DA, NE and 5-HT in rat brain microdialysates, where basal levels as well as elevated levels after dosing with amphetamine (AMPH) were quantified for all three MANTs. This study provides a simple and rapid way to analyze MANTs in the biofluid in the future.
Back to Top Top