Universal Journal of Pharmaceutical Research

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EISSN : 2456-8058
Published by: Society of Pharmaceutical Tecnocrats (10.22270)
Total articles ≅ 365
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Jacky Njiki Bikoï, Esther Del Florence Moni Ndedi, Mesmin Yefou Dehayem, Sharonne Ladiff Koko-Ta, Elsa Nguiffo Makue, Alexandra Emmanuelle Membangbi, , Chris André Mbongue Mikangue, Justin Olivier Essindi, Aicha Ngoutane, et al.
Universal Journal of Pharmaceutical Research; https://doi.org/10.22270/ujpr.v7i2.748

Abstract:
Background and objective : Diabetic foot infection is one of the most serious complications of diabetes and its persistence is the result of the ineffectiveness of antibiotic therapy due to the exponentially increasing of antibiotic resistant bacteria. The study aimed at investigating the antibacterial effect of the aqueous extract of some plants on the antibiotic resistant bacteria isolated from diabetic foot wound infections. Methods : A 6-months cross-sectional study from July 2021 to January 2022 at the Yaoundé Central Hospital, was undertaken with diabetic foot wound patients. All samples were appraised to determine presence of infectious agents using standard methods for isolation and identification of bacteria. Subsequently, Antibiotic resistance was done using Kirby-Bauer disc diffusion methods. Finally, extracts of Cannabis sativa leaves, Allium cepa and Allium sativum bulbs were obtained with water and their antibacterial activities were evaluated by the microdillution method on liquid medium. Results : 20 patients whom 14 men were included, with a sex ratio of 2.33, and their mean age was 52.5±9.6 years. 60% of these patients presented wounds in grade III and were of several types : purulent (48.57%), moist (31.43%) and dry (20%). 35 strains were isolated. The predominant GPB were S. aureus (34.29%) followed by Coagulase-negative Staphylococcus (14.29%), and Bacillus Spp (2.86%). Among the GNB, Pseudomonas aeruginosa (11.46%), Serratia Spp. (8.56%), Escherichia coli (8.56%), Enterobacter Spp. (5.71%), Proteus Spp. (5.71%), Klebsiella Spp., Yersinia Spp. and Salmonella Spp. in proportions of 2.86% each. A high rate of antibiotic resistance was recorded for Oxacillin (100%), Vancomycin (83.34%) and Augmentin (55.56%). Sensitivity tests on liquid medium showed that MIC ranged between 3.12-25.00 mg/mL, 6.25-25.00 mg/mL and 1.86-25.00 mg/mL respectivelly for A. sativa, A. cepa and C. sativa. Alliums were much more active on GNB. Although these results are low, they could be an alternative for the diabetic foot infection treatment. Conclusion : Alliums were much more active on GNB Although these results are low, they could be an alternative for the diabetic foot infection treatment. Peer Review History: Received: 28 February 2022; Revised: 15 April; Accepted: 24 April, Available online: 15 May 2022 Academic Editor: Dr. Sally A. El-Zahabyorcid22.jpg, Pharos University in Alexandria, Egypt, [email protected] UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: 6.gif                               Reviewer's Comments:download_logo_r_29189.gifAverage Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewers:orcid22.jpgDr. Sangeetha Arullappan, Universiti Tunku Abdul Rahman, Malaysia, [email protected]orcid22.jpgProf. Dr. Ali Gamal Ahmed Al-kaf, Sana'a university, Yemen, [email protected]Similar Articles:  THE SCOPING REVIEW OF CHINESE AND WESTERN MEDICINE TREATMENT OF DIABETIC FOOT IN ASIA A SURVEY ABOUT THE CURRENT SCENARIO OF DIABETES IN CHATTOGRAM AREA BY DETERMINING PRACTICE OF THE SELF-CARE ACTIVITIES AMONGST PEOPLE WITH DIABETES
Amin Abdulkarem Okbah, , Emad Hassan Al-Shamahi, Azhar Azher Mohammed Al-Ankoshy
Universal Journal of Pharmaceutical Research; https://doi.org/10.22270/ujpr.v7i2.754

Abstract:
Background: In Yemen there are only a few special epidemiological studies dedicated to malignancy, and for this motivation it is necessary to strengthen, update, construct and continue to afford studies on tumor comportments with the plan of achieving better influence on public health, with early diagnosis and suitable treatment with the plan of enhance survival of living and reducing the feasible subsequent consequences of malignancy. Aims: The study designed to illustrate the different types of kidney cancer (KC), the gender and age distribution of the cancer, and to identify the different types of them and their correlation with invasion and gradation; and its association with age groups and gender. Materials and methods: A retrospective observational study was performed on renal masses patients who were consequently diagnosed selectively by histopathological study in the National Center for Public Health Laboratories (NCPHL) at the Department of Pathology, and the Department of Pathology in Al-Thorah university hospital, Sana'a, Yemen, over a period of 18 years from January 1, 2004 to December 31, 2021. Data were collected from hospital records. The study variables were lesions histological types, benign, malignancy, non-neoplastic lesions, sex, grades and age. The whole data were analyzed by IBM SPSS Statistics 22.Ink. The outcomes for variables were given in the form of rates (%). Chi Square was used for categorical variables that measured association among categorical variables. P-values less than 0.05 were considered significant. Results: Malignant tumors accounted for 177/282 (62.8%) of the total kidney lesions, renal cell carcinoma (RCC) was the most common type of cancer with 126/282 (44.7%), followed by Wilms tumors 47/282 (16.7%), while non-Hodgkin’s lymphoma reported 3 cases (1.1%) and mucinous carcinoma one case (0.35%). Benign tumors accounted for 14/282 (5%), and non-neoplastic lesions accounted for 91/282 (32.3%). Concerning RCC, the average diameter of RCC is 8.9 cm. GI 40/126 (31.7%) with mean tumor diameter equal to 5.8 cm; GII was the most frequent grade 63/126 (50%). Conclusion: Renal cell carcinoma in Yemeni adults presents at an early age with an increased incidence among the female sex with a relatively larger tumor size. It appears that there has been a slight improvement in the diagnosis of kidney cancer in Yemen over the past 18 years. Peer Review History: Received: 4 March 2022; Revised: 12 April; Accepted: 28 April, Available online: 15 May 2022 Academic Editor: Dr. Jennifer Audu-Peterorcid22.jpg, University of Jos, Nigeria, [email protected] UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: 6.gif                               Reviewer's Comments:download_logo_r_29189.gifAverage Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 7.0/10 Reviewers:orcid22.jpgEyassu Mathewos Oridanigo,Department of Nursing, College of Medical and Health Sciences, Wachemo university, Durame Campus, Durame, Ethiopia, [email protected]orcid22.jpgDr. Vanina Doris Edo’o, University of Yaounde I, Yaounde, Cameroun, [email protected]Similar Articles:  SIDE EFFECTS OF CYCLOSPORINE COMPARED TO TACROLIMUS AMONG YEMENI KIDNEY TRANSPLANT PATIENTS WHO SHARE THE SAME ADJUVANT AGENTS: MYCOPHENOLATE MOFETIL AND PREDNISONE MOST IMPORTANT CELLULAR CHANGES INVOLVED IN RENAL ISCHEMIA REPERFUSION INJURY AND THE CONSEQUENT IMPACT ON SELECTED REMOTE ORGANS
Wadhah Hassan Edrees
Universal Journal of Pharmaceutical Research; https://doi.org/10.22270/ujpr.v7i2.747

Abstract:
Background and Objectives: Helicobacter pylori is the most common bacterial infection affecting more than 50% of the population globally, especially in developing countries, while data on its prevalence in Yemen is still limited. Therefore, the current study aimed to estimate the seroprevalence and risk factors of H. pylori among school students in Sana'a city, Yemen.Methods: A cross-sectional study was conducted in primary and secondary schools in Sana'a during the period from October to December 2021 in which two hundred and ninety-three (293) school students aged 11-21 years were enrolled in this study and tested for H. pylori in blood specimens by using a cassette Rapid antibody test. Associated risk factors were collected through a designed questionnaire. Result: Overall, H. pylori antibody was positive in 82/293(27.99%) students. The higher rate of seroprevalence of H. pylori antibodies was reported among male students (29.25%; P˃0.05), age group of 16-21 years (33.69%; P ˂0.05), and secondary students in schools (31.66%; P ˂0.05). Also, the highest rate of H. pylori infection was positive among students who drank untreated water (32.61%), consuming of unwashed vegetables (28.71%) and fruits (30.51%), not been infected previously (28.45%), one of their family infected (28.98%), sometimes eating out of home (32.47%), and non-use antibiotics (29.12%) and there was non-statistical significant difference (P ˃0.05). In addition, there were no significant relationships between seropositivity of H. pylori and clinical signs and symptoms as well as antibiotic use. Finally, most of the students with blood group (O) had H. pylori antibodies (P ˃0.05). Conclusion: It can be concluded that the increasing rate of H. pylori among school students will become a real serious health problem if it is not monitored. Therefore, an effective educational health program is important for the prevention and control of H. pylori infection among school students. Peer Review History: Received: 26 February 2022; Revised: 18 March; Accepted: 22 April, Available online: 15 May 2022 Academic Editor: Dr. Emmanuel O. Olorunsolaorcid22.jpg, Department of Pharmaceutics & Pharmaceutical Technology, University of Uyo, Nigeria, [email protected] UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: 6.gif                               Reviewer's Comments:download_logo_r_29189.gifAverage Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewers:orcid22.jpgProf. Dr. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, [email protected]orcid22.jpgDr. Nkechi Obiofu Ezenobi, University of Port Harcourt, Nigeria, [email protected]Similar Articles:   SEROPOSITIVITY OF HELICOBACTER PYLORI AND ASSOCIATED RISK FACTORS AMONG DYSPEPETIC PATIENTS PREVALENCE OF HELICOBACTER PYLORI AMONG ASYMPTOMATIC POPULATIONS IN SANA'A, YEMEN
Universal Journal of Pharmaceutical Research; https://doi.org/10.22270/ujpr.v7i2.744

Abstract:
Background: Benign (TBN) and malignant (TMN) thyroid nodules are a common thyroid lesion. The differentiation of TMN often remains a clinical challenge and further improvements of TMN diagnostic accuracy are warranted. The aim of this study is to evaluate the possibilities of using differences in trace element contents (TEs) in nodular tissue to diagnose thyroid malignancies and to determine the sensitivity, specificity, and accuracy for most informative TEs in the diagnosis of TMN. Methods: Contents of TEs such as bromine (Br), copper (Cu), iron (Fe), iodine (I), rubidium (Rb), strontium (Sr), and zinc (Zn) were prospectively evaluated in “normal” thyroid (NT) of 105 individuals as well as in nodular tissue of thyroids with TBN (79 patients) and to TMN (41 patients). Measurements were performed using energy-dispersive X-ray fluorescent analysis. Results: It was observed that in TMN tissue the mean mass fractions of I and Zn were lower while the mean mass fraction of Rb was higher than in NT and TBN tissue. It was demonstrated that the I contents is nodular tissue is the most informative parameter for the diagnosis of thyroid malignancy. It was found that “Sensitivity”, “Specificity” and “Accuracy” of TMN identification using the I level in the needle biopsy of affected thyroid tissue (87±5%, 96±2% and 94±2% respectively) were significantly higher than that made using ultrasound screening and cytological test of fine needle aspiration biopsy. Conclusions: It was concluded that determination the I level in a needle biopsy of TNs using energy-dispersive X-ray fluorescent analysis, is a fast, reliable, and informative diagnostic tool that can be successfully used as an additional test of thyroid malignancy identification. Peer Review History: Received: 11 March 2022; Revised: 9 April; Accepted: 28 April, Available online: 15 May 2022 Academic Editor: Dr. Emmanuel O. Olorunsolaorcid22.jpg, Department of Pharmaceutics & Pharmaceutical Technology, University of Uyo, Nigeria, [email protected] UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: 6.gif                               Reviewer's Comments:download_logo_r_29189.gifAverage Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 7.0/10 Reviewers:orcid22.jpgProf. Dr. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, [email protected]orcid22.jpgDr. U. S. Mahadeva Rao, Universiti Sultan Zainal Abidin, Terengganu Malaysia[email protected]
Samy A. El Assaly, Nagwan S. El Bakary, Mohammed T. Abdel Aal, Wael A. El-Sayed,
Universal Journal of Pharmaceutical Research; https://doi.org/10.22270/ujpr.v7i2.755

Abstract:
Background: In recent papers, it was found that 1,3,4-oxadiazole, 1,3,4-thiadiazoleand 1,2,4-triazole pharmacophores are present in several drugs, tiodazosin and nesapidil (antihypertensive), raltegravir (antiretroviral), Furamizole, cefazolin and ceftezole (antibiotics), acetazolamide and methazolamide (carbonic anhydrase inhibitors), sulfamethizole (antibacterial), fluconazole, ravuconazole, voriconazole, itraconazole, posaconazole, and tebuconazole (antifungal). Methods: Thiosemicarbazide was reacted with ethyl p-substituted-phenyl glycinate; namely, ethyl p-tolylglycinate (1), ethyl p-methoxyphenylglycinate (2) or ethyl p-bromophenylglycinate (3), respectively to give compounds 4-6, which then kept with conc. H2SO4 overnight to yield 1,3,4-thiadiazol-2-amine derivatives 7-9. Compounds 10-18 were yielded by reaction of compounds 7-9 with D-sugars namely, D-galactose, D-glucose and/ or D-xylose in ethanol and catalytic amount of acetic acid. Compounds (10-18) were then acetylated with acetic anhydride to form compounds (19-21). Finely compound 7 was reacted with chloroacetyl chloride and/or acetic anhydride to afford compounds 22 and/or 23 respectively. Results: Six compounds were evaluated in vitro for their cytotoxic activity on the HepG-2 and MCF-7 human cancer cell lines. Conclusion: Among the tested compounds, compounds 6 and 13 were found to be the more potent for their cytotoxic activity on the two cancer cell lines. Peer Review History: Received: 5 March 2022; Revised: 9 April; Accepted: 1 May, Available online: 15 May 2022 Academic Editor: Dr. Asia Selman Abdullahorcid22.jpg, Pharmacy institute, University of Basrah, Iraq, [email protected] UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: 6.gif                               Reviewer's Comments:download_logo_r_29189.gifAverage Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 7.0/10 Reviewers:orcid22.jpgDr. Andrzej Szymański, Poznan University of Technology, Poland, [email protected]orcid22.jpgDr. Bilge Ahsen KARA, Ankara Gazi Mustafa Kemal Hospital, Turkey, [email protected]Similar Articles:   CYTOTOXIC ACTIVITIES IN VITRO OF FLOWER EXTRACTS OF THREE SPECIES OF ALOE GROWING IN YEMEN:ALOE RUBROVIOLACEAE, ALOE VERA AND ALOE SABAEA, AGAINST ELEVEN TYPES OF CANCER CELL LINES IN VITRO GENOTOXICITY OF THREE PLANTS FROM ASTERACEAE FAMILY IN HUMAN LYMPHOCYTES CULTURES
Hüsniye Kayalar, Gökay Arar
Universal Journal of Pharmaceutical Research; https://doi.org/10.22270/ujpr.v7i2.753

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Aim and objective: The aim of this work is to put forward the anatomical features of Haplophyllum cappadocicum, an endemic plant for Turkey. Methods: Plant materials were fixed in 70 % ethyl alcohol. The anatomical studies include transverse sections of roots, stems, leaves, fruits and seeds with illustrations. The investigations were made under microscope and photographs were taken by microphotography apparatus. Conclusion:Haplophyllum genus with potential pharmaceutical interest are worthy of investigation not only for chemical content but also anatomically. This is the first report on anatomical features of Haplophyllum cappadocicum collected from Malatya, Türkiye. Peer Review History: Received: 1 March 2022; Revised: 19 April; Accepted: 1 May, Available online: 15 May 2022 Academic Editor: Dr. Marwa A. A. Fayedorcid22.jpg, University of Sadat City, Egypt, [email protected] UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: 6.gif                               Reviewer's Comments:download_logo_r_29189.gifAverage Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewers:orcid22.jpgAhmad Najib, Universitas Muslim Indonesia, Makassar, Indonesia, [email protected]orcid22.jpgDr. Sangeetha Arullappan, Universiti Tunku Abdul Rahman, Malaysia, [email protected]orcid22.jpgProf. Dr. Ali Gamal Ahmed Al-kaf, Sana'a university, Yemen, [email protected]Similar Articles:  ETHNOBOTANY, PHYTOCHEMISTRY AND PHARMACOLOGY OF OCHNA SCHWEINFURTHIANA: A REVIEW A STUDY ON DIFFERENT PLANTS OF APOCYNACEAE FAMILY AND THEIR MEDICINAL USES A REVIEW ON CONSTITUENTS, PHARMACOLOGICAL ACTIVITIES AND MEDICINAL USES OF GLYCYRRHIZA GLABRA
Ameera Saleh Abu-Hurub, Amin Abdulkarem Okbah, Hassan Mohammed Ali Al-Dweelah, Khaled Abdulkareem Al-Moyed, Abdulwahab Ismail Mohamed Al-Kholani, Mohammed Mohammed Ali Al-Najhi,
Universal Journal of Pharmaceutical Research; https://doi.org/10.22270/ujpr.v7i2.745

Abstract:
Background and Aims: Visceral leishmaniasis (VL) is a zoonotic and human disease caused by species of Leishmania. Parasites are transmitted to the vertebrate host by the bite of a sand fly female (Phlebotomus longipalpis), where the infected promastigotes transform into amastigotes; and this is deadly if left untreated. The purposes of the current research were to reveal the prevalence and potential risk factors for VL in adults in Sana’a city, Yemen. Subjects and methods: This cross-sectional study was performed during the period from January 2020 to November 2020. Individuals who come for a regular medical examination at Al-Zahrawi Medical Center, Althobhani Specialist Laboratories, Police Hospital, and University of Science and Technology Hospital. A target sample size of 300 was selected, and serum samples were collected from all subjects to determine the prevalence of anti-VL antibodies in human by immune-chromatographic assay using K39 recombinant antigen. Results: The ages of the participants' ranged from 18-65 years, with a mean of 29.8±8.2 years. The positive rate of antibodies against Leishmania species by immune-chromatographic dipstick strip (rK39) was 6.0%. There was statistically important association linking male gender and contracting VL (8.8%, OR=4.1, CI=1.2-14.4, P=0.01). There was a significant association (<0.001) between the presence of dogs, rats, and goats in or around live houses and positive VL antibodies with an OR equal to 8.8.7.3 and 8.4, respectively. There were significant risk factors for garbage around the living house, there was also a significant association between displacement and the incidence of VL (P<0.001) (OR=8.6, CI=2.8–27.2). Conclusion: Visceral leishmaniasis was highly prevalent in Sana'a city, and potential risk factors for VL were present with displacement, dogs, rats, goats, garbage, sleeping outside enclosed rooms, and sand flies in living houses. Further studies of human VL need to be conducted to clarify this issue in Yemen, to track and confirm potential reservoirs among canines and other animals, as well as to study vectors. Keywords: adults, immune-chromatographic assay, prevalence, potential risk factors, recombinant antigen K39, Sana’a city, visceral leishmaniasis, Yemen. Peer Review History: Received: 9 March 2022; Revised: 14 April; Accepted: 29 April, Available online: 15 May 2022 Academic Editor: Dr. Sally A. El-Zahabyorcid22.jpg, Pharos University in Alexandria, Egypt, [email protected] UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: 6.gif                               Reviewer's Comments:download_logo_r_29189.gifAverage Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 7.0/10 Reviewers:orcid22.jpgDr. Tamer Elhabibi, Suez Canal University, Egypt, [email protected]orcid22.jpgDr. Nicola Micale, University of Messina, Italy, [email protected]orcid22.jpgDr. Rawaa Souhil Al-Kayali, Aleppo University, Syria[email protected]Similar Articles:   PREVALENCE OF HEPATITIS G VIRUS AMONG PATIENTS WITH CHRONIC LIVER DISEASE AND HEALTHY INDIVIDUALS, SANA'A CITY-YEMEN
Nwawuba Stanley Udogadi, Ogbemudia Divine, Ehikhamenor Edeaghe
Universal Journal of Pharmaceutical Research; https://doi.org/10.22270/ujpr.v7i2.750

Abstract:
The justification that behavioral genetic evidence provides in criminality remains a wonder. Scientific evidence suggests that a decreased activity of the enzyme monoamine oxidase (MAOA-L) dubbed the warrior gene surges the possibility for aggressive, antisocial behavior and increased criminality. Ever since the human genome project was completed, breakthrough in genetics and biotechnology are now advancing at a speedy rate. Advancement in genetics and biotechnology has opened a frontier to carry out investigation on the influence of genetics on human behavior at the molecular-genetic level. The interplay between genes and susceptibility to diseases has extensively been accepted, but, the similar link between genes and predisposition to criminal behavior is yet to gain a wide acceptance. Notwithstanding this cynicism, biological studies have revealed that relatives of convicted criminals have higher chances of criminality, suggesting a genetic association to certain criminal behavioral tendencies. Emerging data and evidence indicates that without recourse to genetics, there would be a limited opportunity in elucidating the mechanism and reason for criminal, aggressive and antisocial behavior of some individuals. In this light, reports from some scientific finding revealed that monoamine oxidase A (MAOA) provides the strongest association between genetic variation and aggressive behavior particularly low gene variant monoamine oxidase A (MAOA-L) which has been introduced by experts as evidence for criminal behavior. Beside a satisfaction of scientific curiosity, genetic research portends the potential to contribute to preventive measures and investigation into the genetic etiological correlation of criminal behavior may result to the opening of a new frontier for treatment and intervention. Peer Review History: Received: 27 February 2022; Revised: 22 March; Accepted: 28 April, Available online: 15 May 2022 Academic Editor: Dr. Asia Selman Abdullahorcid22.jpg, Pharmacy institute, University of Basrah, Iraq, [email protected] UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: 6.gif                               Reviewer's Comments:download_logo_r_29189.gifAverage Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewers:orcid22.jpgDr. Dennis Amaechi, MrsFoluBabade Mini Estate , Flat 5 by Old Soldiers Quarter, Sabongari/Bwari, Abuja- Federal Capital Territory, Nigeria. [email protected]orcid22.jpgIdoko Alexander, Caritas University, Enugu, Nigeria[email protected]Similar Articles: IN SILICO ANTIMALARIAL TARGET SELECTION CONSERVED IN FOUR PLASMODIUM SPECIES
Hailu Kebede Kondoro, , Tessema Abera Osse, Teshome Sosengo
Universal Journal of Pharmaceutical Research; https://doi.org/10.22270/ujpr.v7i2.752

Abstract:
Background: Health Management Information System (HMIS) is one of the six building blocks of a health system designed to provide important data for continuous quality improvement at all levels of health care administration. It is a major source of information for monitoring and adjusting policy implementation and resources use. Some studies have been conducted in health data collection and ways to improve data quality, but little is known about utilization of HMIS in health services organization. Therefore, this study aimed to assess the utilization of HMIS and associated factors in the study area. Methods: A facility-based cross-sectional study conducted in public health institutions of Kembata Tembaro zone from March 1 to March 30, 2018. The sample size was calculated using single population proportion formula,and a total of 317 heads of units/departments of district health offices and health facilities were included. Both quantitative and qualitative data were collected using structured questionnaires, observational check-lists and interview guide by trained data collectors. Multivariable logistic regressions were performed using Enter method to identify factors independently associated with dependent variable. Statistical significant variables were declared at P-value less than 0.05 and Odds ratio with 95% confidence interval were used for data interpretation. Result: In this study, overall data utilization was 131(41.59%) with 95% CI of 38.9-46.1%. The data utilization was found to be 98(38.73%) and 33(53.23%) in the health facilities and health administrative units respectively. Training for HMIS [AOR (95% CI)=3.06(2.15-6.75)], availability of procedure manuals [AOR (95% CI)=3.67(1.78-9.01)], and Supportive supervision[AOR (95% CI)=5.30(3.05-11.53)] were found to be significant with HMIS utilization. Conclusion: Utilization of HMIS in public health institution was lower compared to previous studies. HMIS training, supportive supervision and availability of procedure manuals were positively associated with utilization of HMIS. Health facilities and offices should avail HMIS manuals and capacity building of health workers through training and supportive supervision was recommended. Peer Review History: Received: 7 March 2022; Revised: 11 April; Accepted: 27 April, Available online: 15 May 2022 Academic Editor: Dr. Marwa A. A. Fayedorcid22.jpg, University of Sadat City, Egypt, [email protected] UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: 6.gif                               Reviewer's Comments:download_logo_r_29189.gifAverage Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 7.0/10 Reviewers:orcid22.jpgDr. Awofisayo, O Abosede, University of Uyo, Nigeria, [email protected]orcid22.jpgDr. A.A. Mgbahurike, University of Port Harcourt, Nigeria, [email protected]Similar Articles:   INVESTIGATING THE OBSTACLES OF IMPLEMENTING HEALTH INFORMATION SYSTEMS FROM VIEWPOINT OF PERSONNEL OF MEHRIZ HEALTHCARE SYSTEM IN 2017
Essam Yahiya Al-Shamahi, Najeeb Mothana Muhsin, Emad Hassan Al-Shamahi,
Universal Journal of Pharmaceutical Research; https://doi.org/10.22270/ujpr.v7i2.743

Abstract:
Background: Uveitis is described as a disorder of the eye so as to leads to the iris, ciliary body, choroid, and adjacent parts of the eye inflammation. The disturbances may produce impermanent or continuing visual impairment or sightlessness. Purpose: The main purpose of the study was to reveal the causes of uveitis in a referral center in Sana'a city, Yemen. Sequentially the study was conducted to assist in the development and design of preventive policies and diagnostic methods for uveitis in Yemen. Methods: This cross-sectional, retrospective analysis integrated 65 uveitis patients who were referred to the Eye Consulting Center clinic, from January 2021 to the end of December 2021. Data concerning patient gender, age and anatomical location of disease, clinical and pathological manifestations were collected then evaluated. Results: The mean patient age at onset of uveitis was 36.3 ± 13.4 (range: 9-75) years. The female to male ratio was 2.6: 1. Sixty-seven percent participated uveitis patients suffered from bilateral involvement. The predominant type was Pan-uveitis (46.2%), anterior acute uveitis (36.9%), intermediate acute uveitis (12.3%) while posterior acute uveitis was less common (4.6%). Considering medical conditions, 53.8% of patients had acute uveitis and 46.2% had chronic uveitis. Laterality, 38.5% had unilateral uveitis while most patients had bilateral uveitis. Also, 53.8% of patients developed complications. Given the possible causes, the most common diagnoses were 'idiopathic' (32.3%), HLA-B27-positive (21.5%), Behçet‘s syndrome (13.8%), and granulomatous uveitis (TB) (9.2%)., seronegative spondyloarthropathy (6.2%), Fuch’s uveitis (6.2%), followed by less common Vogt Koyanagi Harada (4.6%), herpetic uveitis (3.1%), and toxoplasmosis (3.1%). Conclusion: On the contrary to most uveitis epidemiologic studies the uveitis etiologic and clinical patterns were diverse in a tertiary referral center in Sana’a city, Yemen. Pan-uveitis and anterior acute uveitis were the most frequent clinical pattern in this study, and the most common related causes were HLA-B27 positive and Behçet's syndrome. Peer Review History: Received: 12 March 2022; Revised: 17 April; Accepted: 30 April, Available online: 15 May 2022 Academic Editor: Dr. Asia Selman Abdullahorcid22.jpg, Pharmacy institute, University of Basrah, Iraq, [email protected] UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: 6.gif                               Reviewer's Comments:download_logo_r_29189.gifAverage Peer review marks at initial stage: 6.5/10 Average Peer review marks at publication stage: 7.5/10 Reviewers:orcid22.jpgDr. Jucimary Vieira dos Santos, Hemonorte Dalton Barbosa Cunha, Brazil, [email protected] orcid22.jpgDr. Bilge Ahsen KARA, Ankara Gazi Mustafa Kemal Hospital, Turkey, [email protected]Similar Articles:   PREVALENCE OF CNS TUMORS AND HISTOLOGICAL RECOGNITION IN THE OPERATED PATIENTS: 10 YEARS EXPERIENCE IN YEMEN
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