International Journal of Obesity

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ISSN / EISSN : 0307-0565 / 1476-5497
Published by: Springer Nature (10.1038)
Total articles ≅ 8,127
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Laís Vales Mennitti, Asha A. M. Carpenter, Elena Loche, Lucas C. Pantaleão, , , Heather L. Blackmore, Thomas J. Ashmore, Luciana Pellegrini Pisani, , et al.
Published: 18 October 2021
International Journal of Obesity pp 1-10; https://doi.org/10.1038/s41366-021-00985-1

Abstract:
Objective This study investigated the effect of maternal obesity on aged-male offspring liver phenotype and hepatic expression of a programmed miRNA. Methods A mouse model (C57BL/6 J) of maternal diet-induced obesity was used to investigate fasting-serum metabolites, hepatic lipid content, steatosis, and relative mRNA levels (RT-PCR) and protein expression (Western blotting) of key components involved in hepatic and mitochondrial metabolism in 12-month-old offspring. We also measured hepatic lipid peroxidation, mitochondrial content, fibrosis stage, and apoptosis in the offspring. To investigate potential mechanisms leading to the observed phenotype, we also measured the expression of miR-582 (a miRNA previously implicated in liver cirrhosis) in 8-week-old and 12-month-old offspring. Results Body weight and composition was similar between 8-week-old offspring, however, 12-month-old offspring from obese mothers had increased body weight and fat mass (19.5 ± 0.8 g versus 10.4 ± 0.9 g, p < 0.001), as well as elevated serum levels of LDL and leptin and hepatic lipid content (21.4 ± 2.1 g versus 12.9 ± 1.8 g, p < 0.01). This was accompanied by steatosis, increased Bax/Bcl-2 ratio, and overexpression of p-SAPK/JNK, Tgfβ1, Map3k14, and Col1a1 in the liver. Decreased levels of Bcl-2, p-AMPKα, total AMPKα and mitochondrial complexes were also observed. Maternal obesity was associated with increased hepatic miR-582-3p (p < 0.001) and miR-582-5p (p < 0.05). Age was also associated with an increase in both miR-582-3p and miR-582-5p, however, this was more pronounced in the offspring of obese dams, such that differences were greater in 12-month-old animals (−3p: 7.34 ± 1.35 versus 1.39 ± 0.50, p < 0.0001 and −5p: 4.66 ± 1.16 versus 1.63 ± 0.65, p < 0.05). Conclusion Our findings demonstrate that maternal diet-induced obesity has detrimental effects on offspring body composition as well as hepatic phenotype that may be indicative of accelerated-ageing phenotype. These whole-body and cellular phenotypes were associated with age-dependent changes in expression of miRNA-582 that might contribute mechanistically to the development of metabolic disorders in the older progeny.
Amanda Jiménez, , Ainitze Ibarzábal, Ana de Hollanda, Diana Tundidor, Jose Maria Balibrea, Alba Andreu, Judit Molero, Silvia Cañizares, Amadeu Obach, et al.
Published: 18 October 2021
International Journal of Obesity pp 1-8; https://doi.org/10.1038/s41366-021-00986-0

The publisher has not yet granted permission to display this abstract.
J. Caudet, , S. Cifre, J. M. Soriano,
Published: 14 October 2021
International Journal of Obesity pp 1-8; https://doi.org/10.1038/s41366-021-00980-6

The publisher has not yet granted permission to display this abstract.
, Jonathan Y. Huang, , Paul J. Roderick, Keith M. Godfrey,
Published: 13 October 2021
International Journal of Obesity pp 1-9; https://doi.org/10.1038/s41366-021-00979-z

Abstract:
Background Maternal obesity increases the risk of adverse long-term health outcomes in mother and child including childhood obesity. We aimed to investigate the association between interpregnancy weight gain between first and second pregnancies and risk of overweight and obesity in the second child. Methods We analysed the healthcare records of 4789 women in Hampshire, UK with their first two singleton live births within a population-based anonymised linked cohort of routine antenatal records (August 2004 and August 2014) with birth/early life data for their children. Measured maternal weight and reported height were recorded at the first antenatal appointment of each pregnancy. Measured child height and weight at 4–5 years were converted to age- and sex-adjusted body mass index (BMI z-score). Log-binomial regression was used to examine the association between maternal interpregnancy weight gain and risk of childhood overweight and obesity in the second child. This was analysed first in the whole sample and then stratified by baseline maternal BMI category. Results The prevalence of overweight/obesity in the second child was 19.1% in women who remained weight stable, compared with 28.3% in women with ≥3 kg/m2 weight gain. Interpregnancy gain of ≥3 kg/m2 was associated with increased risk of childhood overweight/obesity (adjusted relative risk (95% CI) 1.17 (1.02–1.34)), with attenuation on adjusting for birthweight of the second child (1.08 (0.94–1.24)). In women within the normal weight range at first pregnancy, the risks of childhood obesity (≥95th centile) were increased with gains of 1–3 kg/m2 (1.74 (1.07–2.83)) and ≥3 kg/m2 (1.87 (1.18–3.01)). Conclusion Children of mothers within the normal weight range in their first pregnancy who started their second pregnancy with a considerably higher weight were more likely to have obesity at 4–5 years. Supporting return to pre-pregnancy weight and limiting weight gain between pregnancies may achieve better long-term maternal and offspring outcomes.
Hugh Bidstrup, Leah Brennan, Leah Kaufmann, Xochitl De La Piedad Garcia
International Journal of Obesity pp 1-9; https://doi.org/10.1038/s41366-021-00982-4

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Huijun Chen, Jian Li, Sufen Cai, Suimin Zeng, Chenjun Yin, Weihong Kuang, Kexin Cheng, Yao Jiang, Mingqiu Tao, Chang Chu, et al.
International Journal of Obesity pp 1-9; https://doi.org/10.1038/s41366-021-00978-0

The publisher has not yet granted permission to display this abstract.
Erynn L. Christensen, , Katharina Voigt, ,
International Journal of Obesity pp 1-8; https://doi.org/10.1038/s41366-021-00974-4

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